This thesis is focused on the decadent form of Czech symbolist literature at the turn of the 19th century and the beginning of the 20th century. The main task is to present a complex catalogue of motifs and images used by Czech decadents in their works and also to analyse the main methods and strategies they used - in particular interstatuality, also connected with the decadent effort to capture the uniqueness of each passing moment, and synaesthesia. The thesis also focuses on the radical individualism of decadent authors and its connection with both the motifs used and the symbolist style in itself - in the form of self-stylization of the decadent authors who tend to identify with their own works and become (even in real life) their own literal subjects. Because of the prominent visual aspect of decadent literature, the thesis also takes into consideration contemporary art works and the relations between words and images.

Doctorat en philosophie et lettres / info:eu-repo/semantics/nonPublished

The thesis "Biblical motifs in Czech pop music of the 1960s and the 1970s of the twentieth century: The function and using of biblical motifs for pop music lyrics with the original biblical background and message" introduces the academic framework of the topic within the first chapter: the definition of the terms, the criteria and method for selecting the motifs and lyrics used. Then, the position of Czech pop music in the cultural and political context of the period is explained, which is a relevant part of the topic itself. Also an outline of the academic reflection of the related topic is referred to as well as the function of biblical motifs in other styles of music (rock, folk and underground music) with the emphasis on the projection of the stylistic differences into using these topics for the lyrics. The following four chapters are probes into the pop music and biblical motifs issue.They are meant as the reflection of the the inner dynamics of the genre as well: in the second and third chapters the selected biblical motifs (general motifs, prayers, biblicisms and biblical characters) are enlisted and the anylysis of their funcion and using for various lyrics is provided in comparison with their biblical message and introducing the original loci in the B ible. The fourth chapter is focused on...

The outer dynein arm-docking complex (ODA-DC) specifies the outer dynein arm-binding site on the flagellar axoneme. The ODA-DC of Chlamydomonas contains equimolar amounts of three proteins termed DC1, DC2, and DC3 (Takada et al., 2002). DC1 and DC2 are predicted to be coiled-coil proteins, and are encoded by ODA3 and ODA1, respectively (Koutoulis et al., 1997; Takada et al., 2002). Prior to this work, nothing was known about DC3. To fully understand the function(s) of the ODA-DC, a detailed analysis of each of its component parts is necessary. To that end, this dissertation describes the characterization of the smallest subunit, DC3. In Chapter II, I report the isolation and sequencing of genomic and full-length cDNA clones encoding DC3. The sequence predicts a 21,341 D protein with four EF hands that is a member of the CTER (Calmodulin, Troponin C, Essential and Regulatory myosin light chains) group and is most closely related to a predicted protein from Plasmodium. The DC3 gene, termed ODA14, is intronless. Chlamydomonas mutants that lack DC3 exhibit slow, jerky swimming due to loss of some but not all, outer dynein arms. Some outer doublet microtubules without arms had a "partial" docking complex, indicating that DC1 and DC2 can assemble in the absence of DC3. In contrast, DC3 cannot assemble in the absence of DC1 or DC2. Transformation of a DC3-deletion strain with the wild-type DC3 gene rescued both the motility phenotype and the structural defect, whereas a mutated DC3 gene was incompetent to rescue. The results indicate that DC3 is important for both outer arm and ODA-DC assembly. As mentioned above, DC3 has four EF-hands: two fit the consensus pattern for calcium binding and one contains two cysteine residues within its binding loop. To determine if the consensus EF-hands are functional, I purified bacterially expressed wild-type DC3 and analyzed its calcium-binding potential in the presence and absence of DTT and Mg2+. As reported in Chapter III, the protein bound one calcium ion with an affinity (Kd) of ~1 x 10-5 M. Calcium binding was observed only in the presence of DTT and thus is redox sensitive. DC3 also bound Mg2+ at physiological concentrations, but with a much lower affinity. Changing the essential glutamate to glutamine in both EF-hands eliminated the calcium-binding activity of the bacterially expressed protein. To investigate the role of the EF hands in vivo, I transformed the modified DC3 gene into a Chlamydomonas insertional mutant lacking DC3. The transformed strain swam normally, assembled a normal number of outer arms, and had a normal photoshock response, indicating that the E to Q mutations did not affect ODA-DC assembly, outer arm assembly, or Ca2+-mediated outer arm activity. Thus, DC3 is a true calcium-binding protein, but the function of this activity remains obscure. In Chapter IV, I report the initial characterization of a DC3 insertional mutant having a phenotype intermediate between that of the DC3-deletion strain and wild type. Furthermore, I suggest future experiments that may help elucidate the specific role of DC3 in outer arm assembly and ODA-DC function. Lastly, I speculate that the ODA-DC may play a role in flagellar regeneration.

L’Internet a été initialement conçu pour servir des usages fixes et sédentaires, cependant les projections montrent que les futurs utilisateurs d'Internet seront de plus en plus mobiles. A l'heure actuelle, la rapidité avec laquelle cette évolution se déroule et la gestion souvent insuffisante des réseaux d'accès représentent un obstacle majeur au développement de services avancés. Afin de résoudre ces problèmes et répondre aux besoins de l'Internet mobile, les fournisseurs de services ont besoin de maîtriser l'expansion de la capacité nécessaire dans leurs réseaux de collecte, sinon le trafic de donnés va pouvoir boucher leurs réseaux dans le futur. Le déploiement des nouvelles générations de réseaux fournit des hautes bandes passantes et débits mais implique souvent des grandes dépenses en capital et en exploitation. Une alternative économiquement et techniquement viable est représentée par les solutions de déchargement du trafic mobile. Ces solutions peuvent réduire la surcharge sur le spectre radio et sur les stations de base et sur le réseau de collecte. Les solutions de déchargement les plus couramment utilisées sont le déchargement sur les réseaux de femtocellules et les réseaux Wi-Fi. Dans le même contexte, pour résoudre le problème de congestion dans le réseau cellulaire, une nouvelle solution est récemment apparue: Information Centric networking permettant la mise en cache des contenus dans le réseau ce qui minimise le temps d'accès aux contenus. L'objectif de cette thèse est donc d'étudier ces nouvelles solutions de déchargement de trafic et de contenu dans les réseaux cellulaires en prenant en considération les schémas de mobilité et les comportements humains. / The Internet was initially conceived to serve fix and sedentary usages, while current socio-technological trends clearly show that future Internet users will be increasingly mobile and nomadic. At present, the speed at which this evolution takes place and the inadequate management of access networks represent a major obstacle in the development of advanced services. To solve these problems and to meet the needs of mobile Internet, service providers need to master the needed capacity expansion in their backhauling network, otherwise the data traffic will clog their networks in the future. Next-generation network deployments promise to deliver higher bandwidth and speed, but they often imply high capital and operational expenditures. An alternative economically and technically viable way is represented by mobile data offloading solutions. These solutions can reduce the load on radio spectrum, on base stations and on backhauling network. The most commonly used offloading solutions are over small-networks and over Wi-Fi networks. In the same context, and in order to solve the problem of congestion in the cellular network, a new solution has emerged recently : Information Centric Networking for in-network caching that permits to minimize content access latency. The objective of this thesis is to study these new traffic and content offloading solutions in cellular networks while taking into account the mobility patterns and human behavior.

Internet est une source infinie de données émanant de sources telles que les réseaux sociaux ou les capteurs (domotique, ville intelligente, véhicule autonome, etc.). Ces données hétérogènes et de plus en plus volumineuses, peuvent être gérées grâce au web sémantique, qui propose de les homogénéiser et de les lier et de raisonner dessus, et aux systèmes de gestion de flux de données, qui abordent essentiellement les problèmes liés au volume, à la volatilité et à l’interrogation continue. L’alliance de ces deux disciplines a vu l’essor des systèmes de gestion de flux de données sémantiques RSP (RDF Stream Processing systems). L’objectif de cette thèse est de permettre à ces systèmes, via de nouvelles approches et algorithmes à faible coût, de rester opérationnels, voire plus performants, même en cas de gros volumes de données en entrée et/ou de ressources système limitées.Pour atteindre cet objectif, notre thèse s’articule principalement autour de la problématique du : "Traitement de flux de données sémantiques dans un contexte de systèmes informatiques à ressources limitées". Elle adresse les questions de recherche suivantes : (i) Comment représenter un flux de données sémantiques ? Et (ii) Comment traiter les flux de données sémantiques entrants, lorsque leurs débits et/ou volumes dépassent les capacités du système cible ?Nous proposons comme première contribution une analyse des données circulant dans les flux de données sémantiques pour considérer non pas une succession de triplets indépendants mais plutôt une succession de graphes en étoiles, préservant ainsi les liens entre les triplets. En utilisant cette approche, nous avons amélioré significativement la qualité des réponses de quelques algorithmes d’échantillonnage bien connus dans la littérature pour le délestage des flux. L’analyse de la requête continue permet d’optimiser cette solution en repèrant les données non pertinentes pour être délestées les premières. Dans la deuxième contribution, nous proposons un algorithme de détection de motifs fréquents de graphes RDF dans les flux de données RDF, appelé FreGraPaD (Frequent RDF Graph Patterns Detection). C’est un algorithme en une passe, orienté mémoire et peu coûteux. Il utilise deux structures de données principales un vecteur de bits pour construire et identifier le motif de graphe RDF assurant une optimisation de l’espace mémoire et une table de hachage pour le stockage de ces derniers. La troisième contribution de notre thèse consiste en une solution déterministe de réduction de charge des systèmes RSP appelée POL (Pattern Oriented Load-shedding for RDF Stream Processing systems). Elle utilise des opérateurs booléens très peu coûteux, qu’elle applique aux deux motifs binaires construits de la donnée et de la requête continue pour déterminer et éjecter celle qui est non-pertinente. Elle garantit un rappel de 100%, réduit la charge du système et améliore son temps de réponse. Enfin, notre quatrième contribution est un outil de compression en ligne de flux RDF, appelé Patorc (Pattern Oriented Compression for RSP systems). Il se base sur les motifs fréquents présents dans les flux qu’il factorise. C’est une solution de compression sans perte de données dont l’interrogation sans décompression est très envisageable. Les solutions apportées par cette thèse permettent l’extension des systèmes RSP existants en leur permettant le passage à l’échelle dans un contexte de Bigdata. Elles leur permettent ainsi de manipuler un ou plusieurs flux arrivant à différentes vitesses, sans perdre de leur qualité de réponse et tout en garantissant leur disponibilité au-delà même de leurs limites physiques. Les résultats des expérimentations menées montrent que l’extension des systèmes existants par nos solutions améliore leurs performances. Elles illustrent la diminution considérable de leur temps de réponse, l’augmentation de leur seuil de débit de traitement en entrée tout en optimisant l’utilisation de leurs ressources systèmes / Internet is an infinite source of data coming from sources such as social networks or sensors (home automation, smart city, autonomous vehicle, etc.). These heterogeneous and increasingly large data can be managed through semantic web technologies, which propose to homogenize, link these data and reason above them, and data flow management systems, which mainly address the problems related to volume, volatility and continuous querying. The alliance of these two disciplines has seen the growth of semantic data stream management systems also called RSP (RDF Stream Processing Systems). The objective of this thesis is to allow these systems, via new approaches and "low cost" algorithms, to remain operational, even more efficient, even for large input data volumes and/or with limited system resources.To reach this goal, our thesis is mainly focused on the issue of "Processing semantic data streamsin a context of computer systems with limited resources". It directly contributes to answer the following research questions : (i) How to represent semantic data stream ? And (ii) How to deal with input semantic data when their rates and/or volumes exceed the capabilities of the target system ?As first contribution, we propose an analysis of the data in the semantic data streams in order to consider a succession of star graphs instead of just a success of andependent triples, thus preserving the links between the triples. By using this approach, we significantly impoved the quality of responses of some well known sampling algoithms for load-shedding. The analysis of the continuous query allows the optimisation of this solution by selection the irrelevant data to be load-shedded first. In the second contribution, we propose an algorithm for detecting frequent RDF graph patterns in semantic data streams.We called it FreGraPaD for Frequent RDF Graph Patterns Detection. It is a one pass algorithm, memory oriented and "low-cost". It uses two main data structures : A bit-vector to build and identify the RDF graph pattern, providing thus memory space optimization ; and a hash-table for storing the patterns.The third contribution of our thesis consists of a deterministic load-shedding solution for RSP systems, called POL (Pattern Oriented Load-shedding for RDF Stream Processing systems). It uses very low-cost boolean operators, that we apply on the built binary patterns of the data and the continuous query inorder to determine which data is not relevant to be ejected upstream of the system. It guarantees a recall of 100%, reduces the system load and improves response time. Finally, in the fourth contribution, we propose Patorc (Pattern Oriented Compression for RSP systems). Patorc is an online compression toolfor RDF streams. It is based on the frequent patterns present in RDF data streams that factorizes. It is a data lossless compression solution whith very possible querying without any need to decompression.This thesis provides solutions that allow the extension of existing RSP systems and makes them able to scale in a bigdata context. Thus, these solutions allow the RSP systems to deal with one or more semantic data streams arriving at different speeds, without loosing their response quality while ensuring their availability, even beyond their physical limitations. The conducted experiments, supported by the obtained results show that the extension of existing systems with the new solutions improves their performance. They illustrate the considerable decrease in their engine’s response time, increasing their processing rate threshold while optimizing the use of their system resources

Les radiologues utilisent au quotidien des solutions d'imagerie médicale pour le diagnostic. L'amélioration de l'expérience utilisateur est toujours un axe majeur de l'effort continu visant à améliorer la qualité globale et l'ergonomie des produits logiciels. Les applications de monitoring permettent en particulier d'enregistrer les actions successives effectuées par les utilisateurs dans l'interface du logiciel. Ces interactions peuvent être représentées sous forme de séquences d'actions. Sur la base de ces données, ce travail traite de deux sujets industriels : les pannes logicielles et l'ergonomie des logiciels. Ces deux thèmes impliquent d'une part la compréhension des modes d'utilisation, et d'autre part le développement d'outils de prédiction permettant soit d'anticiper les pannes, soit d'adapter dynamiquement l'interface logicielle en fonction des besoins des utilisateurs. Tout d'abord, nous visons à identifier les origines des crashes du logiciel qui sont essentielles afin de pouvoir les corriger. Pour ce faire, nous proposons d'utiliser un test binomial afin de déterminer quel type de pattern est le plus approprié pour représenter les signatures de crash. L'amélioration de l'expérience utilisateur par la personnalisation et l'adaptation des systèmes aux besoins spécifiques de l'utilisateur exige une très bonne connaissance de la façon dont les utilisateurs utilisent le logiciel. Afin de mettre en évidence les tendances d'utilisation, nous proposons de regrouper les sessions similaires. Nous comparons trois types de représentation de session dans différents algorithmes de clustering. La deuxième contribution de cette thèse concerne le suivi dynamique de l'utilisation du logiciel. Nous proposons deux méthodes -- basées sur des représentations différentes des actions d'entrée -- pour répondre à deux problématiques industrielles distinctes : la prédiction de la prochaine action et la détection du risque de crash logiciel. Les deux méthodologies tirent parti de la structure récurrente des réseaux LSTM pour capturer les dépendances entre nos données séquentielles ainsi que leur capacité à traiter potentiellement différents types de représentations d'entrée pour les mêmes données. / Radiologists use medical imaging solutions on a daily basis for diagnosis. Improving user experience is a major line of the continuous effort to enhance the global quality and usability of software products. Monitoring applications enable to record the evolution of various software and system parameters during their use and in particular the successive actions performed by the users in the software interface. These interactions may be represented as sequences of actions. Based on this data, this work deals with two industrial topics: software crashes and software usability. Both topics imply on one hand understanding the patterns of use, and on the other developing prediction tools either to anticipate crashes or to dynamically adapt software interface according to users' needs. First, we aim at identifying crash root causes. It is essential in order to fix the original defects. For this purpose, we propose to use a binomial test to determine which type of patterns is the most appropriate to represent crash signatures. The improvement of software usability through customization and adaptation of systems to each user's specific needs requires a very good knowledge of how users use the software. In order to highlight the trends of use, we propose to group similar sessions into clusters. We compare 3 session representations as inputs of different clustering algorithms. The second contribution of our thesis concerns the dynamical monitoring of software use. We propose two methods -- based on different representations of input actions -- to address two distinct industrial issues: next action prediction and software crash risk detection. Both methodologies take advantage of the recurrent structure of LSTM neural networks to capture dependencies among our sequential data as well as their capacity to potentially handle different types of input representations for the same data.

BACKGROUND: A long-standing challenge in the post-genomic era of Bioinformatics is the prediction of protein-protein interactions, and ultimately the prediction of protein functions. The problem is intrinsically harder, when only amino acid sequences are available, but a solution is more universally applicable. So far, the problem of uncovering protein-protein interactions has been addressed in a variety of ways, both experimentally and computationally. MOTIVATION: The central problem is: How can protein complexes with solved threedimensional structure be utilized to identify and classify protein binding sites and how can knowledge be inferred from this classification such that protein interactions can be predicted for proteins without solved structure? The underlying hypothesis is that protein binding sites are often restricted to a small number of residues, which additionally often are well-conserved in order to maintain an interaction. Therefore, the signal-to-noise ratio in binding sites is expected to be higher than in other parts of the surface. This enables binding site detection in unknown proteins, when homology based annotation transfer fails. APPROACH: The problem is addressed by first investigating how geometrical aspects of domain-domain associations can lead to a rigorous structural classification of the multitude of protein interface types. The interface types are explored with respect to two aspects: First, how do interface types with one-sided homology reveal convergently evolved motifs? Second, how can sequential descriptors for local structural features be derived from the interface type classification? Then, the use of sequential representations for binding sites in order to predict protein interactions is investigated. The underlying algorithms are based on machine learning techniques, in particular Hidden Markov Models. RESULTS: This work includes a novel approach to a comprehensive geometrical classification of domain interfaces. Alternative structural domain associations are found for 40% of all family-family interactions. Evaluation of the classification algorithm on a hand-curated set of interfaces yielded a precision of 83% and a recall of 95%. For the first time, a systematic screen of convergently evolved motifs in 102.000 protein-protein interactions with structural information is derived. With respect to this dataset, all cases related to viral mimicry of human interface bindings are identified. Finally, a library of 740 motif descriptors for binding site recognition - encoded as Hidden Markov Models - is generated and cross-validated. Tests for the significance of motifs are provided. The usefulness of descriptors for protein-ligand binding sites is demonstrated for the case of "ATP-binding", where a precision of 89% is achieved, thus outperforming comparable motifs from PROSITE. In particular, a novel descriptor for a P-loop variant has been used to identify ATP-binding sites in 60 protein sequences that have not been annotated before by existing motif databases.

Denna uppsats syftar till att kritiskt undersöka de akademiska diskurserna kring den symboliska tolkningen av förhistoriska Komari-motiv på Rapa Nui (Påskön). Genom att undersöka ett antal olika källor kommer uppsatsen att ge en översiktlig genomgång av de aktuella akademiska diskurserna samt diskutera de olika tolkningarna av symboliken hos komari-motiven. Genom att kombinera diskursanalys med ett feministiskt arkeologiskt perspektiv och ett postkolonialt perspektiv är huvudsyftet med uppsatsen att bedöma i vilken utsträckning den sociala konstruktionen av kön och sexualitet samt koloniala idéer har påverkat tolkningarna av symbolerna. / This essay aims to critically examine the academic discourses surrounding the symbolic interpretation of prehistoric Komari-motifs in Rapa Nui (Easter Island). The analysis will draw on a variety of sources and will give a brief overview of the academic discourses in question and discuss the different interpretations of the symbolism behind the komari-motifs. Combining discourse analysis with a feminist archaeology perspective and a postcolonial perspective, the main aim of the essay is to assess to what extent the social construction of gender, sexuality and colonialist ideas influenced the development of theories regarding the symbols.

INTRODUCTION: Obtenir un résultat orthodontique idéal et un profil facial équilibré peut nécessiter un traitement combinant orthodontie et chirurgie orthognathique. Bien que les avantages esthétiques et fonctionnels de ces procédures soient évidents pour l'orthodontiste, il ne décide pas du traitement. Malgré les connaissances, les recommandations et la bienveillance de l’orthodontiste, le dernier mot revient au patient. Il peut donc évidemment refuser un traitement orthodontique chirurgical. L’obtention du consentement éclairé, avant de débuter le traitement, est une première étape décisive. Afin d’améliorer ce processus, il est essentiel de connaître et de comprendre davantage les facteurs décisionnels qui influencent le choix du patient face à un traitement orthodontique chirurgical. OBJECTIFS: Cette étude qualitative vise à déterminer les motifs pour lesquels les patients refusent le traitement orthodontique chirurgical lorsqu’il est l’option privilégiée par l’orthodontiste. Une meilleure compréhension du raisonnement et des motivations des patients permettra d’améliorer et de rendre l’approche du praticien davantage proactive afin de favoriser un réel consentement éclairé. MÉTHODES: Cette étude a été menée par entrevue verbale semi-structurée immédiatement suivant la consultation orthodontique initiale. Les entretiens individuels ont été enregistrés, retranscrits et analysés en continu. À l’aide du logiciel NVivo 12, les données ont été catégorisées par codage ouvert. RÉSULTATS: Quatre thèmes sont ressortis de cette étude : l'inconfort, la vision facultative du traitement par le patient, le changement d'apparence du visage et les contraintes à débuter le traitement. L'inconfort était un thème récurrent exprimé par tous les participants. CONCLUSION: Bien que les motifs contribuant au refus d'un traitement orthodontique chirurgical soient multiples, l’inconfort est un sujet qui interpelle tous les patients. Sans être forcément la raison principale menant au refus de ce type d'intervention, l'inconfort est un thème répétitif et à intensité variable dans la prise de décision. Il est particulièrement modulé par le vécu personnel du patient, mais aussi fortement influencé par celui de son entourage. Afin de favoriser un consentement plus éclairé, il est pertinent pour le praticien en orthodontie d’aborder ce sujet en profondeur au moment de la consultation. D’autres sujets devraient aussi être couverts selon les circonstances: la vision facultative du traitement par le patient, le changement d'apparence du visage et les contraintes. / INTRODUCTION: Achieving ideal orthodontic results and a balanced facial profile may require a combined orthodontic and orthognathic surgical treatment. Although the esthetic and functional advantages of these procedures are obvious to the orthodontist, patients may opt for a nonsurgical approach. Despite the knowledge, recommendations and good intentions of the orthodontist, the fact remains that the decision to proceed with treatment ultimately rests with the patient. Providing informed consent is a decisive step in the course of initiating treatment. To improve this process, it is essential to better understand the decision-making factors that influence the patient's choice for surgical orthodontic treatment. OBJECTIVES: The main objective of this study was to determine the motives that influence patients’ refusal of surgical orthodontic treatment even when it is the option of choice according to the orthodontist. Learning and understanding these factors can improve how we explain our treatment options by addressing information correctly, thus improving the process of obtaining informed consent. METHODS: This study was conducted using semi-structured verbal interviews immediately following the initial orthodontic consultation. Individual interviews were recorded, transcribed, and continuously analyzed. Using NVivo 12 software, an open coding analysis method was used. RESULTS: Four themes emerged from this study: discomfort, treatment viewed as elective by the patient, change in facial appearance and constraints to beginning treatment. Discomfort was a recurrent theme expressed by all participants. CONCLUSION: Although the reasons for refusing surgical orthodontic treatment are numerous, discomfort is a subject that concerns all patients. Without necessarily being the main reason for refusing surgical orthodontic treatment, discomfort is variable in intensity and a recurring theme in the patient's decision-making. It is particularly modulated by the patient's personal experience, but it is also strongly influenced by the experience of people around them. To promote a betterinformed consent, it is relevant for the orthodontic practitioner to cover this subject in depth during a consultation. Depending on the circumstances, other subjects should also be covered such as: the optional view of the treatment by the patient, the change in appearance of the face and the constraints.