Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-10-04T21:58:21Z No. of bitstreams: 1 ZairaBrunaBorgesDeOliveira_DISSERT.pdf: 558082 bytes, checksum: 8a6b37de39eb5c7535dd747f52825d2b (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-10-11T23:47:56Z (GMT) No. of bitstreams: 1 ZairaBrunaBorgesDeOliveira_DISSERT.pdf: 558082 bytes, checksum: 8a6b37de39eb5c7535dd747f52825d2b (MD5) / Made available in DSpace on 2017-10-11T23:47:56Z (GMT). No. of bitstreams: 1 ZairaBrunaBorgesDeOliveira_DISSERT.pdf: 558082 bytes, checksum: 8a6b37de39eb5c7535dd747f52825d2b (MD5) Previous issue date: 2016-06-03 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) / O Teorema-H relativ?stico, incluindo efeitos n?o-extensivos, foi calculado usando o q-c?lculo. A hip?tese de caos molecular foi generalizada com o objetivo de introduzir fortes correla??es estat?sticas entre as fun??es de distribui??es relativ?sticas. A positividade da fonte de entropia conduz a um v?nculo termodin?mico sobre o par?metro entr?pico, q 2 [0; 2]. Tamb?m foi provado que os estados de equil?brio colisional (termo da fonte de entropia nula) s?o descritos por uma lei de pot?ncia relativ?stica que estende a distribui??o exponencial de Juttner, que se reduz, no dom?nio cl?ssico, a fun??o lei de pot?ncia de Tsallis. Todos os resultados fornecem os resultados padr?es no limite extensivo (q = 1), mostrando assim que o formalismo de Tsallis ? compat?vel com as quest?es abordadas na teoria da relatividade especial. / The relativistic H theorem, by including nonextensive effects, has been calculated using the so-called q-calculus. The molecular chaos hypothesis was generalized in order to capture the strong statistical correlations between the relativistic distributions functions. The positiveness of the source of entropy leads to thermodynamical constraint on the entropic parameter, q 2 [0; 2]. It was also proven that the collisional equilibrium states (null entropy source term) are described by the relativistic q power law extension of the exponential Juttner distribution which reduces, in the nonrelativistic domain, to the Tsallis power law function. All results provide to the standard ones in the extensive limit (q = 1), thereby showing that the Tsallis framework is compatible with the issues addresed in the special relativity theory.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-10-18T20:33:18Z No. of bitstreams: 1 EliangelaPaulinoBento_TESE.pdf: 2042041 bytes, checksum: 74823d35762c444109f5c6d2de459ac3 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-10-23T23:34:52Z (GMT) No. of bitstreams: 1 EliangelaPaulinoBento_TESE.pdf: 2042041 bytes, checksum: 74823d35762c444109f5c6d2de459ac3 (MD5) / Made available in DSpace on 2017-10-23T23:34:52Z (GMT). No. of bitstreams: 1 EliangelaPaulinoBento_TESE.pdf: 2042041 bytes, checksum: 74823d35762c444109f5c6d2de459ac3 (MD5) Previous issue date: 2016-04-22 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / Com base na terceira lei da Termodin?mica, questionamos se as entropias generalizadas satisfazem ou n?o esta propriedade fundamental. Em linhas gerais, a terceira lei afirma que, para sistemas com estados fundamentais n?o degenerados em equil?brio, a entropia se aproxima de zero conforme a temperatura (em escala absoluta) tamb?m se aproxima de zero. No entanto, a entropia pode desaparecer apenas com a temperatura no zero absoluto. Neste contexto, propomos um procedimento anal?tico direto para testar se uma entropia generalizada satisfaz a terceira lei, assumindo apenas uma forma geral de entropia S e energia U de um sistema de N n?veis cl?ssico arbitr?rio. Matematicamente, o m?todo depende do c?lculo exato do par?metro _ = dS=dU em termos das probabilidades de microestados pi. Finalmente, determinamos a rela??o entre o limite m?nino da entropia S ! 0 (ou, mais geral, S ! Smin) e o limite m?nimo de temperatura _ ! 1. A n?vel de compara??o, aplicamos o m?todo para as entropias de Boltzmann-Gibbs (modelo padr?o), Kaniadakis e Tsallis (modelos generalizados). Para as duas ?ltimas, ilustramos o poder do m?todo calculando os intervalos dos par?metros entr?picos em que a entropia satisfaz a terceira lei. Os resultados obtidos mostraram que, para a _-entropia, os valores usualmente atribu?dos ao par?metro _ satisfazem a terceira lei ( - 1 < _ < 1). Entretanto, para a q-entropia o mesmo n?o ocorre. Mostramos que, a q-entropia pode desaparecer a temperaturas diferentes de zero para certos valores de q. Como exemplo concreto, consideramos o modelo de Ising unidimensional com intera??es de primeiros vizinhos, o qual ? um dos mais importantes modelos em toda a f?sica. Classicamente, o modelo de Ising ? resolvido por meio do ensemble can?nico, por?m ele tamb?m pode ser resolvido por meio de ensembles generalizados. / Based on the third law of Thermodynamics we ask whether or not generalized entropies satisfy this fundamental property. The third law states that the entropy approaches zero as the temperature (in absolute scale) also approaches zero. However, the entropy can vanish only at absolute zero temperature. In this context, we propose a direct analytical procedure to test if the generalized entropy satisfies the third law, assuming only very general assumptions for the entropy S and energy U of an arbitrary N-level classical system. Mathematically, the method relies on exact calculation of the parameter _ = dS=dU in terms of the microstate probabilities pi. Finally, we determine the relation between the low entropy limit S ! 0 (or more generally Smin) and the low-temperature limit _ ! +1. For comparison, we apply the method to the entropy Boltzmann (standard model), and Kaniadakis Tsallis (generalized models). For the latter two, we illustrate the power of the method by unveiling the ranges of their parameters for which the third law is satisfied. For _-entropy, the values usually assumed in the literature to _ parameter obeys the third law ( - 1 < _ < 1). However, for the q-entropy the same is not true. We show that the q-entropy can vanish at nonzero temperature in certain ranges of q. These results and their consequences are discussed in this thesis. As a concrete example, we consider the paradigmatic one-dimensional Ising model, which is one of the most important models in all of physics. Classically, the Ising model is solved in the canonical ensemble, but it can also solved exactly in nonstandard ensembles using generalized entropies.

Submitted by JOELMA MAIA (ebmsp-bibliotecacp2@bahiana.edu.br) on 2018-08-21T13:14:49Z No. of bitstreams: 1 Jeov?? Cordeiro.pdf: 1929100 bytes, checksum: 173adc656bcdaec38329ea9e6219af5e (MD5) / Approved for entry into archive by JOELMA MAIA (ebmsp-bibliotecacp2@bahiana.edu.br) on 2018-08-21T13:16:03Z (GMT) No. of bitstreams: 1 Jeov?? Cordeiro.pdf: 1929100 bytes, checksum: 173adc656bcdaec38329ea9e6219af5e (MD5) / Made available in DSpace on 2018-08-21T13:16:03Z (GMT). No. of bitstreams: 1 Jeov?? Cordeiro.pdf: 1929100 bytes, checksum: 173adc656bcdaec38329ea9e6219af5e (MD5) Previous issue date: 2017-12-01 / Objetivo: Explorar o potencial valor da deforma????o mioc??rdica como preditor do primeiro epis??dio de Acidente Vascular Encef??lico (AVE) isqu??mico. M??todos: Indiv??duos entre 40-80 anos com o primeiro epis??dio de AVE isqu??mico, sem doen??a card??aca e com ecocardiograma normal foram pareados com controles saud??veis por sexo, idade e hipertens??o na propor????o 1:2. A t??cnica ecocardiogr??fica de rastreamento de pontos (TERP) foi utilizada para avaliar a deforma????o mioc??rdica longitudinal global (DLG) a qual serviu como marcador de doen??a card??aca subcl??nica. Na an??lise univariada foi utilizado o valor de p menor que 0,1 para a vari??vel entrar na analise multivariada de regress??o log??stica. Resultados: A amostra consistiu de 29 casos e 62 controles, m??dia de idade foi 60 ??? 4 anos; 54% foram do sexo masculino. Tabagismo foi mais prevalente nos casos comparado aos controles (34% versus 9%; p = 0,001). Dislipidemia teve tamb??m uma preval??ncia maior nos casos (54% versus 37%, respectivamente; p = 0,09). Casos tiveram menos deforma????o mioc??rdica comparado aos controles (DLG -16,7 ?? 3,4% versus -19,2 ?? 2,8%; p < 0,001). N??o houve diferen??a em rela????o aos par??metros ecocardiogr??ficos tradicionais. Ap??s ajuste para tabagismo e dislipidemia, a DLG permaneceu um preditor independente para AVE (OR = 1,3; 95% IC: 1,1 ??? 1,6; p = 0,005). A capacidade discriminat??ria dos preditores cl??nicos foi representada por uma ??rea sob a curva ROC de 0,62, com incremento para 0,78 ap??s feita a adi????o do DLG (p = 0,001). Conclus??o: Deforma????o mioc??rdica longitudinal reduzida ?? um potencial preditor ??til do primeiro epis??dio de AVE isqu??mico em indiv??duos sem doen??a card??aca.

Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2017-06-13T14:24:57Z No. of bitstreams: 1 2016 - Nilcileny da Silva Batista.pdf: 1300906 bytes, checksum: 7fcd57ffebf02aa316ae9107cf971e8d (MD5) / Made available in DSpace on 2017-06-13T14:24:57Z (GMT). No. of bitstreams: 1 2016 - Nilcileny da Silva Batista.pdf: 1300906 bytes, checksum: 7fcd57ffebf02aa316ae9107cf971e8d (MD5) Previous issue date: 2016-02-25 / Ag?ncia Norueguesa de Coopera??o para o Desenvolvimento, NORAD, Noruega. / The soil management in organic production systems requires the use of technologies that allow maintaining and improving their properties. In this sense, the use of alternatives such as intercropping, biochar, organic fertilization and inoculation with plant growth promoting bacteria in agriculture has been associated with improvements in productivity. In a first experiment, we evaluated the production of cassava in an intercropping system with maize and beans in different arrangements under organic farming. The experiment was carried out in SIPA, "Fazendinha Agroecol?gica Km 47", Serop?dica, RJ. The experimental design was randomized blocks, with five treatments and four replications. The treatments were: cassava, maize, cassava + maize + beans, cassava + maize, beans and maize. The dimension of the experimental plots was 6 x 5 m and 8 linear meters were sampled to evaluate the productivity of beans and maize. Twelve plants per plot were evaluated for cassava. The sowing of beans and maize took place at the same day cassava was planted. Beans were harvested at 90 days and the following variables were evaluated: yield, number of pods per plant, number of seeds per pod and weight of 100 grains. The maize was harvested at 91, 92 and 100 days after sowing (DAS) and the productivity of husked and dehusked spikes, spike length and spike diameter were measured. The cassava was harvested at 354 DAP after planting and the following variables were evaluated: productivity of roots and shoots, length and diameter of the roots. There was no significance for cassava production. However, the area equivalency index for the maize and cassava intercrop indicated an advantage of this system over the others. In a second experiment, we evaluated the potential of biochar and its interaction with microbial inoculants and organic fertilizer on crop performance. These tecnologies were evaluated in a crop rotation system: maize (Zea mays) var. Caatingueiro and beans (Phaseolus vulgaris) cv. Alessa were used in the first and second cycles, respectively. Maize seeds were inoculated with Azospirillum brasilense and beans with both Rhizobium tropici and Azospirillum brasilense. The experiment was in a 2 x 2 x 2 factorial scheme, with eight treatments and three replications, and the experimental design was a randomized block design. The treatments were the combinations of the presence or absence of three factors (biochar, fertilizer and inoculation. The biochar was applied at the dose of 15 Mg ha-?. The organic fertilizer ?Bokashi? was applied at the dose of 113 kg ha-? N. The plots were 3.0 x 3.50 m. The maize was harvested at 90 DAP and the following variables were measured: yield, weight of 100 g, length and diameter of spikes. The snap beans were harvested at 60 DAP and pod productivity and shoot biomass were evaluated. In maize fertilization and inoculation influenced weight of 100 grains under the conditions studied. For coinoculation beans green influenced dry matter mass and pods number, biochar influenced number of pods and dry mass of shoots in the presence of residual fertilization. We can conclude that the intercrop system and that the use biochar, Bokashi fertilization and, especially, inoculation with plant growth-promoting bacteria are possible alternatives for the production of cassava, maize and beans in organic farming. / O manejo do solo em sistemas org?nicos de produ??o requer o uso de tecnologias que permitam manter e aumentar sua produtividade. Neste sentido, o cons?rcio de culturas e o uso de biocarv?o, fertiliza??o com adubos org?nicos e a inocula??o com bact?rias promotoras do crescimento de plantas est?o entre as alternativas dispon?veis que t?m sido associadas ao aumento de produtividade. Num primeiro experimento, objetivou-se avaliar o consorcio de mandioca var. Ouro da Bahia, feij?o (Phaseolus vulgaris) cv. Valente e milho (Zea mays) var. Eldorado em diferentes arranjos, sob manejo org?nico. O experimento foi conduzido no SIPA ?Fazendinha Agroecol?gica Km 47?. O delineamento foi de blocos ao acaso, com cinco tratamentos e quatro repeti??es a saber: Mandioca solteira, Mandioca + milho + feij?o, Mandioca + milho, Milho + feij?o e Milho solteiro. As parcelas tinham 6x5 m. com oito metros lineares de ?rea ?til para feij?o e milho por parcela. Para mandioca, foram analisadas doze plantas por parcela. O plantio dos consortes ocorreu no mesmo dia do plantio da mandioca. O feij?o foi colhido aos 90 dias e foram avaliados: produtividade, n?mero de vagens por planta, n?mero de gr?os por vagem e peso de 100 gr?os. O milho foi colhido aos 91, 92 e 100 DAP e foram avaliada produtividade de espigas, comprimento e di?metro das espigas. Aos 354 DAP, colheu-se a mandioca para avaliar: produtividade de ra?zes e parte a?rea, comprimento e di?metro das ra?zes. N?o houve diferen?a significativa para produtividade da mandioca, mais houve diferen?a para produtividade de feij?o e do milho. O ?ndice de Equival?ncia de ?rea (IEA) de 1,26 para o cons?rcio mandioca e milho, indicou vantagem. Num segundo experimento, objetivou-se avaliar o potencial do biocarv?o e sua intera??o com inoculantes e fertiliza??o org?nica no desempenho de cultivos. Para tal, foi realizado um cultivo em sucess?o onde, no primeiro ciclo foi utilizado o milho var. Caatingueiro e no segundo ciclo o feij?o vagem cv. Alessa. As sementes de milho foram inoculadas com Azospirillum brasilense e as de feij?o vagem com Rhizobium tropici e Azospirillum brasilense. O experimento foi um fatorial 2 x 2 x 2, com oito tratamentos entre combina??es dos fatores biocarv?o, aduba??o e inocula??o (presen?a e aus?ncia) e tr?s repeti??es. O delineamento experimental foi em blocos ao acaso. Aplicou-se a lan?o15 Mg ha-? de biocarv?o por parcela. A fertiliza??o, com composto Bokashi, foi 113 kg ha-? de N. As parcelas tinham 3,0 x 3,50 m. O milho foi colhido aos 90 DAP e analisou-se: produtividade, peso de 100 gr?os, comprimento e di?metro de espigas. O feij?o vagem foi colhido aos 60 DAP e foram analisados produtividade de vagem e parte a?rea. Para o milho a aduba??o e a inocula??o influenciaram massa de 100 gr?os, nas condi??es estudadas. No feij?o vagem, a inocula??o influenciou massa seca de vagens e numero de vagens, o biocarv?o influenciou n?mero de vagens e massa seca de parte a?rea na presen?a de aduba??o residual. Pode-se concluir que o cons?rcio, a inocula??o, aduba??o org?nica s?o alternativas poss?veis para incrementar produtividade de culturas, a renda e seguran?a alimentar do produtor

Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2017-07-12T18:54:47Z No. of bitstreams: 1 2016 - Angelo Gomes de Oliveira Junior.pdf: 1739096 bytes, checksum: 0add068fbe6a3c053e8c653b8b2f1829 (MD5) / Made available in DSpace on 2017-07-12T18:54:47Z (GMT). No. of bitstreams: 1 2016 - Angelo Gomes de Oliveira Junior.pdf: 1739096 bytes, checksum: 0add068fbe6a3c053e8c653b8b2f1829 (MD5) Previous issue date: 2016-08-31 / The aim of this research was study the use of simplified irrigation controller (SIC) in 4 tensions values to determine the best tension for the development of seedlings of Schinus terebinthifolius in protected environment. The treatments were: T 1 = 4 kPa of tension, T 2 = 6 kPa of tension, T 3 = 8 kPa of tension and T 4 = 10 kPa of tension. The seedlings were grown in plastic bags with 3534 cm3 of a volume. The parameters evaluated were diameter at breast height (D), height (H), relation H / D, dried mass weight of roots (DMWR), dried mass of aerial part (DMAP), Dickson quality index (DQI), water use efficiency (WUE) and chlorophyll content (IFC). The evaluations were performed every two weeks, from 30 days after transplanting up to 105 days. The results indicated that the 6 kPa of tension consists in optimum operating value for the system proposed in terms of experimental conditions studied because it represents the best growth ratio by volume of water used for irrigation. In this treatment the average results per plant were: D= 5.61 mm; H= 33.20 cm; H / D= 5.97; DMAP= 4.78 g; DMWR= 2.44 g; DQI= 0.91; WUE= 1.53 and IFC= 56.55. It's not recommended the production of seedlings of Schinus terebinthifolius using 10 kPa of tension because there was a high mortality. / O objetivo deste trabalho foi avaliar a utiliza??o do acionador simplificado de irriga??o (ASI) em 4 (quatro) diferentes tens?es de ?gua no substrato para determinar a melhor tens?o para o desenvolvimento das mudas de Aroeira-Pimenteira (Schinus terebinthifolius) em ambiente protegido. Os tratamentos utilizados foram: T 1 = Tens?o de 4 kPa, T 2 = Tens?o de 6 kPa, T 3 = Tens?o de 8 kPa e T 4= Tens?o de 10 kPa. As mudas foram produzidas em sacos pl?sticos com volume de 3.534 cm3. Os par?metros avaliados foram di?metro de colo (D), altura (H), rela??o altura por di?metro de colo (H/D), fitomassa seca das ra?zes (MSR), fitomassa seca parte a?rea (MSPA), ?ndice de qualidade de Dickson (IQD), efici?ncia de uso de ?gua (EUA) e clorofila total (IFC). As avalia??es foram realizadas quinzenalmente, a partir dos 30 dias ap?s o transplante at? os 105 dias. Os resultados obtidos indicaram que a tens?o de 6 kPa compreende a tens?o ?tima de opera??o para o sistema proposto diante das condi??es experimentais estudadas e isso deve-se a melhor rela??o crescimento por volume de ?gua utilizado na irriga??o. Neste tratamento os resultados m?dios por planta foram: D= 5,61 mm; H= 33,20 cm; H/D= 5,97; MSPA= 4,78 g, MSR= 2,44 g; IQD= 0,91; EUA= 1,53 g L-1 e IFC= 56,55. N?o se recomenda a produ??o de mudas de aroeira utilizando uma tens?o de 10 kPa pois houve uma alta taxa de mortalidade das mudas.

Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2017-07-12T19:09:00Z No. of bitstreams: 1 2015 - Daiana de Fatima Portella Franco.pdf: 10785257 bytes, checksum: 88b5e7659327980d96446ec26df23a79 (MD5) / Made available in DSpace on 2017-07-12T19:09:00Z (GMT). No. of bitstreams: 1 2015 - Daiana de Fatima Portella Franco.pdf: 10785257 bytes, checksum: 88b5e7659327980d96446ec26df23a79 (MD5) Previous issue date: 2015-08-27 / CAPES / CNPq / FAPERJ / Cancer is a generic term related to more than 100 types of diseases which resemble each other by their disorganized cellular growth. HSP90 are ATP-dependent chaperones responsible for the activation and stabilization of more than 200 proteins. Most of these proteins are connected to cancer and need HSP90 to execute their activities. Thus, HSP90 inhibitors may indirect inhibit plenty oncogenic proteins. According to the literature, there are N-terminal and C-terminal domains, nevertheless, C-terminal inhibitors present more advantages. Then, the advancement of C-terminal inhibitors represents an applicable alternative and an intense field of study. Novobiocin is the first compound identified as C-terminal domain inhibitor. Nowadays, Novobiocin analogues have been synthesized, besides its structure-activity relationship elucidated in order to develop more potents analogues. For that reason, the goal of this project is to obtain 2 analogue series of Novobiocin. The scheme of these series was based on maintaining the coumaniric part presented on Novobiocin: isosteric replacement of the amide group that binds coumarin to the 4-hydroxy-3-(3-methylbut-2-yl)-benzamide, by the [1,2,3]-triazole; and exploration of methyl groups (AN1) and hydroxyl (AN2) in substitution of subunit noviose. AN1 series (76a-g) and AN2 (77a-g) were synthesized from the followed reactions: 7-hydroxy-coumarine o-methylation (83); 7-methoxy-coumarine 3-bromation (82); Sonogashira cross-coupling from 3-bromo-7-R-coumarine (81a-b); 7-R-3-((trimethylsilyl)ethynyl-coumarine trimethylsilyl deprotection (88a-b); and lastly, synthesis of the triazole ring, through cicloaddition reaction, 1,3-dipolar catalysed by copper (CuAAc), using 3-ethynyl-7-R-coumarine (80a-b) and aromatic azides. It is worth taking into consideration that 3-bromo-7-R-coumarine (81b) was obtained from the key compound, 3-bromo-7-R-methoxy-coumarine (81a) by o-demethylation reaction. 12 compounds were obtained (76a-g) and 8 of them (76a-b, 77d) were nicely purified and then, characterized by spectroscopic techniques (IR, 1H and 13C NMR). The ?one-pot? synthesis of 7-methoxy-3-(1H-1,2,3-triazole-4-phenyl)-coumarine 76b from 88a compound (Yield=86%) was more efficient than the one realized in two steps (global yield=47,2%). Results are potential and satisfactory, moreover there is no citation in any literature about biological activities of the synthesized compounds. Continuing this work, the pure compounds (76a-b, 77d) will be tested on breast cancer cell lines SkBr3 and MCF-7. / O c?ncer ? um termo gen?rico que se refere a um conjunto de mais de 100 tipos de doen?as, as quais se assemelham pelo crescimento celular desordenado. As HSP90 s?o chaperonas ATP-dependente respons?veis pela ativa??o e estabiliza??o de mais de 200 prote?nas. Muitas destas prote?nas s?o relacionadas ao c?ncer e necessitam da HSP90 para exercerem suas atividades. Assim, inibidores da HSP90 s?o promissores, pois possibilitam inibir de maneira indireta v?rias prote?nas oncog?nicas simultaneamente. S?o descritos inibidores dos dom?nios N-terminal e C-terminal, sendo estes mais vantajoso que aqueles. O Novobiocin foi o primeiro composto identificado como inibidor do dom?nio C-terminal da HSP90. Atualmente, diversos an?logos ao Novobiocin tem sido sintetizados, afim de se estabelecer a rela??o estrutura-atividade, objetivando desenvolver an?logos mais potentes. Assim, o objetivo deste trabalho foi obter duas s?ries an?logas ao Novobiocin. O planejamento das s?ries foi baseado na manuten??o do n?cleo cumar?nico presente no Novobiocin; troca isost?rica do grupo amida, que liga a cumarina ao anel 4-hidroxi-3-(3-metillbut-2-il)-benzamida, pelo anel [1,2,3]-triazol; e explora??o de grupos metoxila (AN1) e hidroxila (AN2) em substitui??o ? subunidade noviose. As s?ries AN1 (76a-g) e AN2 (77a-g) foram sintetizadas a partir das rea??es de: O-metila??o da 7-hidroxi-cumarina (83); broma??o da posi??o 3 da 7-met?xi-cumarina (82); rea??o de acoplamento cruzado de Sonogashira, a partir da 3-bromo-7-R-cumarina (81a-b); desprote??o do grupamento trimetilsilila da 7-R-3-((trimetilsilil)etenil)-cumarina (88a-b); e por fim, s?ntese do anel triaz?lico, atrav?s da rea??o de cicloadi??o 1,3-dipolar catalisada por cobre (CuAAc), utilizando 3-etenil-7-R-cumarina (80a-b) e azidas arom?ticas. Vale ressaltar que, a 3-bromo-7-hidr?xi-cumarina (81b) foi obtida a partir do composto chave, 3-bromo-7-met?xi-cumarina (81a) via rea??o de O-demetila??o. Obteve-se 12 compostos (76a-g e 77a-g) sendo que 8 (76a-b, 77d) foram, satisfatoriamente, purificados e, ent?o, caracterizados por t?cnicas espectrosc?picas (IV, RMN H e C). Tamb?m foi constatado que a s?ntese ?one-pot? de 7-metoxi-3-(1H-1,2,3-triazol-4-fenil)-cumarina 76b partir do composto 88a (R=86%) foi mais eficiente que a realizada em duas etapas, desilina??o/CuAAc (Rglobal= 47,2%). Os resultados s?o satisfat?rios e promissores, al?m disso n?o h? na literatura descri??o das atividades biol?gica dos compostos sintetizados. Em continua??o a este trabalho, os compostos puros (76a-b, 77d) ser?o devidamente ensaiados frente a c?lulas das linhagens de c?ncer de mama SkBr3 e MCF-7.

Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2017-07-12T19:19:51Z No. of bitstreams: 1 2015 - Matheus Gomes Ferreira.pdf: 3047516 bytes, checksum: 3232f27bdf2c2fd0b3942a410158e76e (MD5) / Made available in DSpace on 2017-07-12T19:19:51Z (GMT). No. of bitstreams: 1 2015 - Matheus Gomes Ferreira.pdf: 3047516 bytes, checksum: 3232f27bdf2c2fd0b3942a410158e76e (MD5) Previous issue date: 2015-07-10 / CAPES / In this work were prepared by coprecipitation and characterized by powder XRD and FTIR compounds of the hydrotalcite type, known as Layered Double Hydroxides (LDH), intercalated with the glyphosate anion (GLYP), and the conditions of preparation and the stoichiometric ratio Mg:Al:GLYP were studied. The best condition observed was under reflux for 30 hours and stoichiometric ratio 2: 1: 1 for Mg+2, Al+3 and GLYP, as indicated by the characteristic bands of LDH intercalated with glyphosate and no other bands present, which could be assigned to other intercalated ions or to free glyphosate. Under those preparation conditions the LDH interlamellar spacing was 0.62 nm, compatible with the intercalation of glyphosate. The controlled release of glyphosate was studied using ion exchange reactions of Layered Double Hydroxides containing glyphosate with an aqueous medium containing carbonate, chloride or nitrate anions. In those cases the glyphosate was quantified spectrophotometrically by Ruhemann's purple method (?max = 570 nm), and the initial releasing rates of 0.65 mg/ml/h (carbonate), 0.14 mg/ml/h (nitrate) and 0.08 mg/ml/h (chloride) were measured. Regarding the XRD patterns of the ion-exchanged products, it was observed that the structure of HDL was maintained, but with the reduction of the interlayer spacing in all cases, having a sufficient size for the anion of the involved ion exchange, but not enough for the presence of GLYP, demonstrating so that the exchange was successful. / Neste trabalho foram preparados por coprecipita??o e caracterizados por DRX de p? e FTIR compostos do tipo hidrotalcita, conhecidos como Hidr?xidos Duplos Lamelares (HDL), intercalados com o ?nion glifosato (GLYP), e foram estudadas as melhores condi??es de prepara??o e a raz?o estequiom?trica Mg:Al:GLYP. A melhor condi??o foi sob refluxo por 30 horas e raz?o estequiom?trica 2:1:1 para Mg+2, Al+3, e GLYP, a partir da observa??o das bandas caracter?sticas no espectro de FTIR de um HDL intercalado com glifosato, sem outras bandas presentes que pudessem ser atribu?das a outros ?ons intercalados ou ao glifosato livre. Nessas condi??es de preparo o espa?amento interlamelar do HDL foi de 0,62 nm, compat?vel com a intercala??o do glifosato. A libera??o controlada do glifosato foi estudada atrav?s de rea??es de troca i?nica dos Hidr?xidos Duplos Lamelares contendo glifosato com um meio aquoso contendo os ?nions carbonato, cloreto ou nitrato. Nestes casos o glifosato foi quantificado espectrofotometricamente pelo m?todo do p?rpura de Ruhemann (?max = 570 nm), e foram obtidas as taxas de libera??o iniciais de 0,65 mg/ml/h para carbonato, 0,08 mg/ml/h para cloreto e 0,14 mg/ml/h para nitrato. Nos difratogramas de raios-X dos produtos das trocas i?nicas, em todos os casos foram observadas a manuten??o da estrutura do HDL e a diminui??o do espa?o interlamelar, de 0,62 nm para valores entre 0,33 e 0,35 nm, tamanho suficiente para o ?nion da troca i?nica envolvido, mas n?o suficiente ainda para a presen?a de GLYP, demonstrando assim que a troca foi bem sucedida.

Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2017-07-18T11:39:10Z No. of bitstreams: 1 2016 - Maria Otavia Battaglin Loureiro.pdf: 4025778 bytes, checksum: e7d43b2a8bfdc8b74bfe2178ec6dbf5c (MD5) / Made available in DSpace on 2017-07-18T11:39:10Z (GMT). No. of bitstreams: 1 2016 - Maria Otavia Battaglin Loureiro.pdf: 4025778 bytes, checksum: e7d43b2a8bfdc8b74bfe2178ec6dbf5c (MD5) Previous issue date: 2016-07-22 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq / This dissertation deals with ways of life and trajectories of small fruit farmers of Alvorada, in the municipality of Nova Tebas in the state of Paran?. The text itself is based on the ethnographic study between sites, crops, homes and kitchens of farmers linked to Cooperatvama ? cooperative of small producers of organic fruit ? during the months of March and April 2015. Through the narratives of families accompanied, we seek to understand their ways of being and living in the world. In the relation between the cooperative members, we'll see how their reading of life and daily practices pervade the religious, and incorporate a speech of balance and care associated with organic farming and agro-ecological practice. In this sense, we can think in this work as an attempt to organization of the facts in my ethnographic experience, that as the plot unfolds indicates tracks of important components of the sociality of my interlocutors. Through the descriptions of the daily practices of the investigated group we seek to show how one forms and modulates collectivities. We seek thus rescue the ?domestic? spaces and activities putting the house and the woman / Esta disserta??o trata do cotidiano, dos modos de vida e trajet?rias dos agricultores e agricultoras de Alvorada, no munic?pio de Nova Tebas no interior do Paran?. O texto apresentado tem como base o estudo etnogr?fico realizado entre os s?tios, lavouras, casas e cozinhas dos agricultores ligados a Cooperatvama ? cooperativa de pequenos produtores de frutas org?nicas ? durante os meses de mar?o e abril de 2015. Atrav?s das narrativas das fam?lias acompanhadas buscamos compreender seus modos de ser e viver no mundo. Na trama entre os cooperados e cooperadas, vemos como suas leituras de vida e pr?ticas cotidianas perpassam pela religiosidade, e incorporam um discurso do equil?brio e do cuidado, associados com a agricultura org?nica. Nesse sentido, podemos pensar nesta disserta??o como uma tentativa de organiza??o dos fatos vividos e narrados a partir de minha experi?ncia etnogr?fica, que conforme o enredo se desenrola indica pistas de componentes importantes da socialidade de meus interlocutores. Atrav?s das descri??es das pr?ticas cotidianas do grupo investigado procuramos evidenciar como se constituem e se modulam coletividades. Buscamos, assim, resgatar atividades e espa?os ?dom?sticos? descentrando o debate que outrora colocou ? margem a casa e a mulher

Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2017-07-25T18:59:26Z No. of bitstreams: 1 2017 - Gerson Jos? Yunes Antonio.pdf: 1945359 bytes, checksum: c4d13f26bf950174b314d3a74f465ab8 (MD5) / Made available in DSpace on 2017-07-25T18:59:26Z (GMT). No. of bitstreams: 1 2017 - Gerson Jos? Yunes Antonio.pdf: 1945359 bytes, checksum: c4d13f26bf950174b314d3a74f465ab8 (MD5) Previous issue date: 2017-02-22 / This dissertation analyzed strategy of endogenous territorial development - ETD for the establishment of social technology as from process at participatory construction of agroecological knowledge at the hills enviroment in the mountain region of Rio de Janeiro and, demonstrated competitive advantages, local potential and challenges after climate tragedy of January 2011. The study characterized and evaluated potential methodological used or with potential, as well as identify determinants for the adoption of agroecological practices in their production systems, especially regarding the use of cover crop. It were considered, in proposing strategies to expand the adoption of agroecological practices, the 3rd section' microcatchments in Nova Friburgo district. It were used secondary data, literature review, semi structured interviews with actors involved processes in the study area and focus groups with key people in order to observe social behavior, where it became clear the need to improve the efforts of institutions and adaptation to time and the wishes of farmers, with exemplification of the economic gains from the agroecological transition. The way to expand the role and conscious participation in social capital formation will inevitably require organizational, structural and training activities. / A presente disserta??o analisa estrat?gia de desenvolvimento territorial end?geno - DTE para a constitui??o de tecnologia social a partir de processo de constru??o participativa de conhecimentos agroecol?gicos nos ambientes de montanha da Regi?o Serrana Fluminense. S?o evidenciadas vantagens competitivas, potencialidades locais e desafios, ap?s trag?dia clim?tica que acometeu a regi?o em janeiro de 2011. A partir da caracteriza??o e avalia??o das propostas metodol?gicas utilizadas ou com potencial, s?o apresentados determinantes para a ado??o de pr?ticas agroecol?gicas nos sistemas de produ??o, em especial quanto ao uso de plantas de cobertura. Foram consideradas, na proposi??o de estrat?gias para a amplia??o da ado??o de pr?ticas agroecol?gicas, as microbacias do 3? distrito do munic?pio de Nova Friburgo. Utilizou-se dados secund?rios, revis?o bibliogr?fica, entrevistas semiestruturadas com atores participantes dos processos na ?rea de estudo e grupo focal com pessoas-chave, com objetivo de observar o comportamento social. ? evidenciada a necessidade de aprimoramento dos esfor?os das institui??es e adequa??o ao tempo e aos anseios dos agricultores, com exemplifica??o dos ganhos econ?micos decorrentes da transi??o agroecol?gica. O caminho para ampliar o protagonismo e a participa??o consciente com forma??o de capital social passa necessariamente por a??es organizativas, estruturais e formativas.

Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2017-07-26T16:23:58Z No. of bitstreams: 1 2016 - Tayana Galv?o Scheiffer de Paula Antunes.pdf: 886909 bytes, checksum: 3d81bdb995e369056c9a96e210803d4c (MD5) / Made available in DSpace on 2017-07-26T16:23:58Z (GMT). No. of bitstreams: 1 2016 - Tayana Galv?o Scheiffer de Paula Antunes.pdf: 886909 bytes, checksum: 3d81bdb995e369056c9a96e210803d4c (MD5) Previous issue date: 2016-05-31 / Aiming to obtain information to support the biodiversity management that enable sustainable production systems and ensure the quality of natural resources, this study contribute to increasing agricultural productivity based on the use of green manure in a sustainable manner, aiming to evaluate the behavior of winter green manures lupines albus, black oats and the consortium between those two in mountain environment, and the influence of the herbicide decomposition rate of straws from these plants and diversity and abundance of soil fauna. The experiment was conducted in the area of EscolaT?cnicaAgr?colaEstadualRei Alberto I, located in the Watershed Barrac?o dos Mendes, Municipality of NovaFriburgo, mountainous region on the state of Rio de Janeiro at an altitude of 1,065m. The experimental design was a randomized complete block design with four treatments: black oat, lupines albus, consortium and weeds, with four replications each, totaling 16 plots in the first stage of work, experiment 1. On the experiment 2, the plots were subdivided into two management systems, mechanical, where the plants were mowed and chemical, which occurred application of glyphosate herbicide, for the deposition of the straws on the ground. On the first part, productivity of green manure was evaluated, as well as the accumulation of nutrients and the epigaeous fauna associated to vegetation. The second part, after the management of the green manure, aimed the evaluation of mass loss of plant residues, epigaeous fauna and associated soil macrofauna. The main results showed that the lupine, single or consortium obtained satisfactory productivity, both in terms of biomass and the amount of accumulated nutrients, presenting potential for use in the mountainous region of Rio de Janeiro. The loss of mass of the residues was affected by the use of herbicide. The community of epigaeous fauna was not a good indicator because it didn?t suffer significant changes before or after the green manure management. The colembolas population was negatively afected by the herbicide. The soil macrofauna was more sensitive to the diferent forms of management, and the reduction of the density soil organisms could be observed up to 10 times when the plants were sprayed with herbicide. It was also noted the reduction on the macrofauna diversity. There was no difference in the chemical composition of the soil due to different covers and forms of management / Visando obter informa??es que ap?iem a proposi??o de manejos de gest?o da biodiversidade, que viabilizem sistemas de produ??o sustent?veis e garantam a qualidade dos recursos naturais, este estudo pretende colaborar com o aumento da produtividade agr?cola com base no uso da aduba??o verde, de forma sustent?vel. Nesse sentido, o presente trabalho teve como objetivo avaliar o comportamento dos adubos verdes de inverno tremo?o-branco, aveia-preta e do cons?rcio entre os dois, em ambiente de montanha, e a influ?ncia do herbicida na taxa de decomposi??o das palhadas dessas plantas e na diversidade e abund?ncia da fauna do solo. O experimento de campo foi conduzido na ?rea da Escola T?cnica Agr?cola Estadual Rei Alberto I, localizada na Microbacia do Barrac?o dos Mendes, Munic?pio de Nova Friburgo, Regi?o Serrana do Estado do Rio de Janeiro, a uma altitude de 1.065 m. O Delineamento experimental adotado foi o de blocos casualizados, com quatro tratamentos: aveia-preta, tremo?o-branco, cons?rcio e plantas espont?neas, com quatro repeti??es cada, totalizando 16 parcelas na primeira etapa do trabalho, etapa I. Na etapa II, as parcelas foram subdivididas em duas formas de manejo, mec?nico, onde as plantas foram ro?adas, e qu?mico, onde ocorreu aplica??o do herbicida glifosato, para a deposi??o das palhadas sobre o solo. Na etapa I, estudou-se a produtividade das plantas de cobertura, bem como o ac?mulo de nutrientes e a fauna ep?gea associada ?vegeta??o. Na segunda etapa, ap?s o manejo das plantas de cobertura, foi realizada a avalia??o da perda de massa dos res?duos vegetais, fauna ep?gea e macrofauna ed?fica associadas a esses res?duos. Como principais resultados, observou-se que o tremo?o, solteiro ou consorciado, obteve produtividade satisfat?ria, tanto em termos de fitomassa, quanto de quantidades de nutrientes acumulados, apresentando potencial para o uso na Regi?o Serrana do Rio de Janeiro. A perda de massa dos res?duos vegetais foi afetada com o uso de herbicida. A comunidade da fauna ep?gea n?o foi um bom indicador, pois n?o sofreu significativas modifica??es antes ou ap?s o manejo das plantas de cobertura. No entanto, as popula??es de col?mbolos foram afetadas negativamente pelo herbicida. J? a comunidade da macrofauna ed?fica se mostrou mais sens?vel ?s formas de manejo, sendo observada a redu??o da densidade dos organismos do solo ? metade e em at? 10 vezes, quando as plantas foram manejadas com herbicida. Observou-se tamb?m redu??o da diversidade da macrofauna. N?o houve diferen?a na composi??o qu?mica do solo em fun??o das diferentes coberturas e formas de manejo