Thesis (Ph. D.)--Königl. Universität Breslau, 1910. / Cover title. Vita. Includes bibliographical references.

Abh.--Zürich. / Vita. Bibliography: p. 5.

Akad. avhandling--Stockholm, 1994.

La signalisation cellulaire induite par les récepteurs à sept domaines transmembranaires(R7TM) contrôle les principales fonctions physiologiques humaines. Ces R7TMs sont cibles de médicaments et initient de larges réseaux d'interactions. Nous avons modélisé dynamiquement les réseaux de signalisation du récepteur à l'hormone folliculo-stimulante(FSH) régulant la fonction de reproduction et du récepteur angiotensine, un R7TM modèle régulant la tension pour comprendre le fonctionnement de ces réseaux et prédire des données inaccessibles expérimentalement. Notre modélisation a utilisé des équations différentielles ordinaires, en assimilant une variable par espèce et un paramètre par constante cinétique. Les paramètres manquants ont été déterminés par optimisation paramétrique.Puis, nous avons développé un environnement afin de comparer plusieurs algorithmes d'optimisation et créer une nouvelle méthode hybride plus performante et adaptée à la paramétrisation des réseaux de signalisation. / Seven transmembrane receptor (7TMR) signaling controls the main human physiological functions. R7TMs are targeted by drugs and initiate large and complex networks responsible for physiological effects. In this thesis, we dynamically modelled the FSHR induced network that have critical role in reproduction and the angiotensin receptor induced network which regulates blood presure and is considered as a model 7TMR with the objective to understand their mechanisms of functionning and to predict experimentally unreachable data. Our modeling, based on ODE formalism, assumes each species as a variable and each kinetic rate as a parameter. Some parameters were unknown and requiered an adjustment. This led us to develop an environement allowing the comparaisonof existing adjustment methods and to create a novel and efficient hybrid method well-adapted to parametrization of signaling networks.

The aim of the thesis is to study the pseudonymous letters of Aeschines, all of which purport to give an account of his sojourn in exile. There is a strong consensus among scholars that all the letters are forgeries, and their date of composition tends to be located in the first few centuries CE on linguistic grounds. Embracing a variety of literary forms, these letters were probably composed by multiple hands and may for convenience be divided into three categories: Letters 2, 3, 7, 11, 12 imitate the ‘Demosthenic’ letters in a manner similar to the Hellenistic (and beyond) historical declamations and progymnasmata; Letters 1, 5, 6, 8, 9, 10 come to us with features reminiscent of what German scholars would call Briefromane, or ‘epistolary novels’, and are normally deemed typical of the so-called Second Sophistic; and Letter 4 is a showpiece assuming the form of a Pindaric exegesis. The thesis consists of two parts. The first gives an extensive account of the letters, including their background, history of scholarship, and basic features, to seek to present the ‘forger’ and the text in their proper historical and cultural contexts. The second part, which constitutes the basis for the reflections developed in the first, provides a detailed commentary in thematic sequence. It begins with the ‘Demosthenic’ counterparts (Epp. 2, 3, 7, 11, 12), and stylistic comparisons are made throughout. The analysis of the fictional letters (Epp. 1, 5, 6, 8, 9) pays particular attention to their consistency of narrative and engagement with other literary genres. The commentary on Letter 4 foregrounds the Pindaric elements and completes the thesis. Letter 10 is discussed at sporadic points: it is a later attachment to the corpus and the erotic content is inconsistent with the ‘original’ forgeries. The overall focus of the thesis is on two overlapping aspects of Aeschines’ early reception in antiquity – as ‘the other orator’ beside Demosthenes and as inspiration for later rhetorical education. Existing studies, however, are more concerned with textual criticism and linguistic analysis and have left the letters almost unproductive in these respects: so Drerup (1904), Schwegler (1914), and, most recently, García Ruiz and Hernández Muñoz (2012). In his classic work Goldstein (1968) took the parallel passages in the pseudonymous letters as evidence for authenticating Demosthenes’ letters, and scholars are now able to take advantage of a more reliable reference when studying Ps.-Aeschines. Holzberg (1994), on the other hand, established a set of generic criteria for the Briefromane and has substantially changed the way we read Ps.-Aeschines: it is now possible to appreciate the literary value of the letters without scrutinising their authenticity. Yet both these studies tell us only half the story: while Goldstein left more remarks on the imitative counterparts of Demosthenes’ letters, Holzberg focused on the way the letters reflect the epistolary narrative. Following Rohde (1876/1960), moreover, it seems common sense to characterise the pseudo-historical tale as seen through the letters as a product of the ‘Second Sophistic’, though discoveries of new papyri, e.g. the Ninus romance c. first century BCE, undermined this assumption. My study is built on these investigations in an attempt to form the most extended analysis. The study of the ‘Demosthenic’ counterparts will contribute to a better understanding of Ps.-Aeschines’ intertextual engagement with Demosthenes and his successors, e.g. Ps.-Leosthenes (FGrH 105 F 6 = MP3 2496). It shows that Ps.-Aeschines owes a great deal to the culture of rhetoric and highlights his significance in the Nachleben of Attic oratory. As for the other letters, this thesis argues that they deserve some space in our accounts of the history of exilic, periegetic, and epinician literatures for contextualising a wide range of preexisting literary forms such as the Homeric Odyssey (Ep. 1) and Pindar’s victory odes (Ep. 4). As contingent by-products of the ‘Demosthenic’ counterparts, however, they seem to allow no confident judgement about generic consciousness, esp. the very notion of ‘novel’, and need to be approached as antedating the Imperial exponents. Contrary to the communis opinio, therefore, I attempt to move the date of composition forward to the late Hellenistic period, in which there was already ample encouragement for a sophist, as well as for his students, to write pseudonymous letters. The ‘traitors’ blacklist’ (Ep. 12.8–9) and the term for the Rhodian family of Diagoreans (Ep. 4.4) entertain this possibility inasmuch as both show marked affinities with the Hellenistic sources. Last but not least, the two coexisting, radically opposed interpretations of one’s civic orientation in exile will help us tackle the stability and change in the political cultures of the post-Classical era. My conclusion is that these letters hold a unique position as very early – and very illuminating – examples of how different literary, political trends were interwoven to make, and to remould, a Classic. It is hoped that this study may have done something to reappraise Ps.-Aeschines, who is, in all likelihood, a pre-sophisticated forerunner at a crossroads in the history of Greek literature.

O objetivo deste trabalho é apresentar uma tradução e um comentário textual à 13ª Olímpica de Píndaro, com base nas mais recentes edições e trabalhos críticos acerca do poeta e do gênero desse poema, o epinício. Também foi composto um ensaio interpretativo que tenta abarcar os temas mais importantes da ode e relacioná-los com o todo da obra de Píndaro. As imagens do poema desenvolvem a contraposição entre medida e excesso, representada tanto nas referências mitológicas (Têmis e as Horas contra a Soberba e Insolência; Belerofonte encilhando Pégaso) quanto nas reflexões da primeira pessoa (que não deve exceder-se no elogio para não errar o alvo, assim como um arqueiro disparando suas flechas; nem deve tentar relatar todas as vitórias da família, pois são tão numerosas quanto os grãos de areia etc.). Em anexo, há a tradução dos escólios relativos a essa ode para permitir a consulta direta a essa fonte, que não se acha traduzida. / The objective of this study is to present a translation and a textual commentary of Pindar\'s Olympian 13, based on the most recent editions and critical works about the poet and the genre of this poem, the epinician. An interpretative essay was composed in order to cover the most important themes of this ode and articulate them with Pindar\'s other works. The poetical imagens of the poem develop the central theme, the opposition between measure and excess, represented by the mithological references (Themis and the Hours against the Excess and the Satiety; Bellerophon taming Pegasus etc.) and by the first-person\'s reflections on the laudatory art (the first-person should not exceed in praise in order to not miss the target, as an archer with his arrows; nor should try to enumerate all the victories of this family, for they are greater than the grains of sand from the sea). There is a translation of the scholia to this ode attached, allowing direct consultation, once there is no other version of this text.

No description available.

In this thesis, the dynamics of an isolated cavitation bubble submerged in a steady flow is studied numerically. A Lagrangian-Eulerian approach is considered, in which properties of the fluid are computed first by means of Eulerian methods (in this study the commercial CFD software Ansys Fluent 19 was used) and the trajectory of the bubble is then computed in a Lagrangian fashion, i.e. the bubble is considered as a small particle moving relative to the fluid, due to the effect of several forces depending on fluid's pressure field, fluid's velocity field and bubble's radius. Bubble's radius dynamics, modeled by Rayleigh-Plesset equation, has a big influence on its kinetics, so a special attention is given to it. Two study cases are considered. The first one, motivated by acoustic cavitation is concerned with the response of the bubble's radius in a static flow under the influence of an oscillatory pressure field, the second one studies the trajectory of the bubble submerged in a fluid passing by a Venturi tube and a sharp-edged orifice plate.

This thesis presents a solver to handle constrained-state-space ODEs. This solver locates the points where any of the states go outside of the constraining set, and then, transfers the control from the continuous time ODE to the function governing the behavior of the system on the boundaries of the constrained set. The main contribution of this solver is found simulating complex right-hand-sided ODEs for long periods of time. / Master of Science

Basotho family odes (diboko) form part of oral literature, and refer to names of families, clans or totems. They constitute poetic compositions conveying information about clans' historical origin, philosophy and ancestors. The performance of this oral art form makes use of formulaic techniques such as linking, parallelism, alliteration, etc., which are commonly used in praise poetry. As basis to the content of these oral art forms, the genealogies of the various Basotho clans are discussed to show the reflection of the progenitor names in the clan praises. The functions of family odes are of educational, social and religious nature. Other functions include their use in compositions of other genres, such as, praise poems, mine workers' chants, traditional doctors' falls (mawa) and songs. The recitation of this oral art form is characterised by the instability of the texts, which takes the form of extensions, additions, truncations, improvisations and genre transitions. / African Languages / M.A. (African Languages)