La periodontitis es una enfermedad infecciosa de naturaleza inflamatoria, que involucra una respuesta inmune del hospedero y que se caracteriza por la destrucción de los tejidos de inserción del diente. Numerosos estudios han determinado que el infiltrado inflamatorio de la enfermedad se caracteriza por un predominio de células de la línea linfocitaria, principalmente linfocitos T. En otras enfermedades de naturaleza inflamatorio-destructivas, como la artritis reumatoide, se ha evidenciado un rol central de los linfocitos T en el perfil de citoquinas relacionado con la destrucción de los tejidos articulares y se ha propuesto que IL-17 regularía la diferenciación y activación de las células clásticas responsables de la destrucción del cartílago y hueso articular. Con el objeto de estudiar si existe asociación entre IL-17 y periodontitis, se determinaron los niveles de IL-17 en 16 individuos con periodontitis crónica y en 8 individuos periodontalmente sanos tanto en muestras biológicas de fluido gingival crevicular (FGC) como en los sobrenadantes de células mononucleares extraídas de biopsias de tejido gingival (CMG). Las muestras de FGC y los sobrenadantes de cultivos celulares de CMG fueron analizadas para determinar la presencia y síntesis de IL-17 mediante ELISA. En el FGC y los sobrenadantes de cultivo de CMG de individuos con periodontitis crónica se observó una presencia y síntesis significativamente mayor de IL-17 en comparación a individuos periodontalmente sanos. De estos resultados se puede concluir que IL-17 se encuentra sobreexpresada en individuos con peridontitis crónica y contribuiría a explicar, por lo menos en parte, los fenómenos etiopatogénicos involucrados en la destrucción del tejido óseo alveolar ocurrido en la periodontitis.

Magister Scientiae - MSc / Patients who are in end-stage renal disease (ESRD) experience a significantly increased rate of atherosclerotic complications. Inflammation plays a central role in the pathogenesis of these complications. The major acute phase protein, C-reactive protein (CRP) has been found to predict all-cause and cardiovascular mortality in ESRD patients. Many patients in ESRD experience elevated CRP levels without an overt infection. Periodontal diseases in the general population have been associated with both an increased prevalence of atherosclerotic complications and an elevation in serum CRP values. The aim of this present study was to investigate whether periodontal disease is associated with increased systemic inflammation reflected by CRP values, in patients with ESRD on maintenance haemodialysis (HD) or perioneal dialysis (PD). / South Africa

Orientador: Antônio Wilson Sallum / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-27T11:01:24Z (GMT). No. of bitstreams: 1 Cirino_CamilaCamarinhadaSilva_D.pdf: 1496366 bytes, checksum: 8799d632fc19f56ec6fedacdf4d723e6 (MD5) Previous issue date: 2015 / Resumo: O presente estudo teve o objetivo de avaliar clínica e microbiologicamente o efeito das terapias periodontais cirúrgica e não cirúrgica em um período de 12 meses no tratamento da periodontite agressiva generalizada (PAG). Quinze pacientes diagnosticados com PAG foram incluídos neste estudo com desenho experimental de boca dividida. Os quadrantes superiores foram submetidos ao tratamento, e foram alocados em dois grupos: Grupo TNC (terapia não-cirúrgica) ¿ debridamento ultrassônico associado a raspagem manual; e Grupo TC (terapia cirúrgico) ¿ acesso cirúrgico para debridamento ultrassônico associado a raspagem manual. No baseline, e aos 3, 6 e 12 meses pós terapia, foram avaliados os seguintes parâmetros clínicos: índice de placa (IP), índice de sangramento à sondagem (ISS), profundidade de sondagem (PS), nível de inserção clínica (NIC) e posição da margem gengival (PMG). Nos mesmos períodos foram determinados os níveis de concentração de Porphyromonas gingivalis (Pg) e Aggregatibacter actinomycetemcomitans (Aa) no biofilme subgengival. Os resultados indicaram que a TC foi capaz de promover maior redução de PS quando comparada à TNC, em bolsas profundas, aos 12 meses (5,9±1,2 mm e 4,8±0,6 mm, TNC e TC respectivamente, p < 0,05), e também em dentes posteriores aos 6 meses de acompanhamento (4,8±0,8 mm e 4,1±1,3 mm, TCN e TC, respectivamente, p < 0,05). Além disso, foi observada maior recessão gengival em dentes posteriores do grupo TC, aos 6 meses, comparados ao baseline (-0,2±0,2mm e -0,7±1,2 mm, TCN e TC, respectivamente, p < 0,05). A avaliação microbiológica não demonstrou diferença estatística nos níveis de Aa e Pg para ambos os grupos em todos os períodos de acompanhamento. Pode-se concluir que, apesar de ambas a terapias não terem sido capazes de reduzir os níveis de Aa e Pg, clinicamente a terapia cirúrgica promoveu maior redução de PS em bolsas profundas e dentes posteriores / Abstract: The present study aimed to evaluate clinically and microbiologically the effects of surgical and non- surgical periodontal therapy in a 12-month period in the treatment of generalized aggressive periodontitis (GAgP). Fifteen patients with GAgP were included in this randomized controlled clinical study with experimental split-mouth design. Superior quadrants were treated, and allocated into two groups: Non-Surgical Therapy Group (NST) - ultrasonic debridement associated with manual scaling, and Surgical Therapy Group (ST) - access to surgical ultrasonic debridement associated with scaling manual. At baseline and at 3, 6 and 12 months after treatment, the following clinical parameters were assessed: plaque index (PI), bleeding on probing index (BoP), probing depth (PD), clinical attachment level (CAL) and gingival margin position (GMP). In same periods were determined the concentrations of Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans (Aa) in subgingival biofilm. The results showed that ST was able to promote further PS reduction compared to the NST, in deep pockets, at 12 months (5.9 ± 1.2 mm and 4.8 ± 0.6 mm, NST and ST respectively, p < 0.05) and also in posterior teeth at 6 months follow-up (4.8 ± 0.8 mm and 4.1 ± 1.3 mm, NST and ST, respectively, p < 0.05). In addition, it was observed higher gingival recession in posterior teeth of ST group at 6th month, comparing to baseline (-0.2 ± 0.2 and -0.7 ± 1.2 mm, NST and ST, respectively, p < 0.05). The microbiological evaluation showed no statistical difference in the levels of Aa and Pg for both groups at all follow-up periods. It can be concluded that, althought both therapy failed do reduce the levels of Aa and Pg, clinically the surgical therapy promoted more PD reduction in deep pockets and posterior teeth / Doutorado / Periodontia / Doutora em Clínica Odontológica

Diese Studie sollte die Überlebensrate parodontal schwer vorgeschädigter parodontaler Taschen prüfen. Untersucht wurde anhand von Patienten aus dem Studentenkurs der Parodontologie in Würzburg, die eine nicht-chirurgische Parodontitistherapie nach dem Würzburger Behandlungskonzept erhielten. Ausgewählt wurden alle Patienten, die zum Zeitpunkt ihrer Initialtherapie parodontale Taschen mit einer Sondierungstiefe von 8 mm oder mehr aufwiesen. Nach diesem Kriterium ergab die Ermittlung ganzer Behandlungsjahrgänge 179 Patienten mit dem durchschnittlichen Alter von ca. 57 Jahren, die sich in den Jahren 2008, 2009, 2011 und 2012 erstmals aufgrund von Parodontitis behandeln ließen. Alle untersuchten Patienten durchliefen das Standardprocedere der Initialtherapie und einer Reevaluation. Die meisten Patienten nahmen an dem für gewöhnlich bis zu zwei Mal jährlich stattfindenden Recallterminen mehr oder weniger regelmäßig teil, was die Alltagsrealität in den deutschen Zahnarztpraxen wiederspiegelt. Die Untersuchung beinhaltet insgesamt 627 Zähne mit 1331 parodontalen Taschen. Ihre Auswertung erfolgte durch die Kaplan-Meier-Schätzung. Diese ist eine Überlebenszeitanalyse, die die Wahrscheinlichkeit für das Eintreffen eines oder mehrerer vorausgewählter Ereignisse berechnet. Diese Ereignisse wurden in dieser Untersuchung durch die für die parodontale Stabilität wichtigen Sondierungstiefen (5 mm und weniger, 5-8 mm und 8mm und größer) definiert. Der Vorteil dieser Auswertungsmethode besteht darin, dass alle Patienten bis zum Zeitpunkt ihrer letzten Behandlung in die Untersuchung einbezogen werden und dass die Zielereignisse variabel definiert werden können. In der Hauptanalyse der 179 Patienten beschrieb die Überlebenskurve der Kaplan-Meier-Schätzung den positiven Effekt des Behandlungskonzeptes. Nach drei Jahren lag die Wahrscheinlichkeit bei 65,7 % für das Erreichen von Sondierungstiefen 5 mm oder weniger, was den Bereich der parodontalen Stabilität darstellt. Selbst unter der am meisten pessimistischen Annahme erreichten nach drei Jahren knapp ein Drittel aller Patienten den Bereich der parodontalen Stabilität. / This study was designed to examine the survival rate of periodontally heavily damaged periodontal pockets. The examination was based on patients from the periodontology student course in Würzburg, who received non-surgical periodontitis therapy according to the Würzburg treatment concept.

Objectives: Systemic lupus erythematosus is a systemic, long-term autoimmune condition that has chronic inflammatory effects in connective tissue throughout the body. There are numerous studies that have examined the association between systemic lupus erythematosus and chronic periodontitis, with varying conclusions. The purpose of this cross-sectional study is to evaluate and compare the risk for periodontitis in patients with SLE to patients without SLE. Materials and Methods: Medical and dental records were retrospectively reviewed for patients that had been admitted to the Temple University School of Dentistry from 2010 to 2018. A roster of 22 SLE positive patients were generated from the Temple University patient database and matched to a control population of 22 patients without SLE. Periodontal probing depths were then documented and used to evaluate periodontal statuses in both test and control groups. Sites with probing depths ³5mm were considered to be at increased risk for periodontal breakdown. Prevalence was defined as the percentage of individuals having at least one site with a ³5mm probing depth, and extent was defined as the average percentage of sites with increased periodontitis risk. The number of missing teeth in patients from each group were also recorded as a secondary outcome. Results: The prevalence of ³5mm probing depths in SLE and control groups was 50% (10/20) and 40.9% (9/22), respectively. Calculations of relative risk (1.22) and odds ratio (1.44) were not statistically significant between the two populations (p&gt;0.05). The extent of ≥5mm probing depths was 1.5% in SLE patients and 3.7% in healthy patients, which was also not significant between groups (p&gt;0.05). SLE patients were missing an average of 9.6 teeth per individual compared to 3.8 in healthy patients (p&lt;0.05). Conclusions: The results of the present study indicate that patients with SLE do not have an increased risk for periodontitis when compared to patients without SLE. Risk analysis on the prevalence and the extent of deeper probing depths were not statistically different between SLE and control groups. Further studies with a larger sample size and elimination of unseen confounders are needed in order to validate our results. An interesting observation was the finding that SLE patients have a significantly greater number of missing teeth. The exact mechanism through which SLE patients experience periodontal breakdown and increased tooth loss is an avenue that warrants future research. / Oral Biology

Thesis (M.S.)--University of Michigan, 1987.

Thesis (Ph. D.)--University of Washington, 1996. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Washington, 1996. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Nebraska Medical Center, 1999. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (M.S.)--University of Michigan, 1987.