Submitted by Emanuel Varela Cardoso (emanuel.varela@ufcg.edu.br) on 2018-08-07T17:53:40Z No. of bitstreams: 1 CLÁUDIA FREIRE – TESE (PPGCS) 2016.pdf: 4241734 bytes, checksum: 4f09dc8165032d263c166a224fbd5d68 (MD5) / Made available in DSpace on 2018-08-07T17:53:40Z (GMT). No. of bitstreams: 1 CLÁUDIA FREIRE – TESE (PPGCS) 2016.pdf: 4241734 bytes, checksum: 4f09dc8165032d263c166a224fbd5d68 (MD5) Previous issue date: 2016-09-27 / A pesquisa desenvolvida teve como objetivo analisar trajetórias de empresários formais e atuantes no Polo de Confecções de Pernambuco, para apreender em suas narrativas a formação e reprodução de configurações locais do trabalho. A análise foi estruturada numa abordagem qualitativa, usando a pesquisa de campo como meio de intervenção no local, através de entrevistas semiestruturadas com 11 empresários formalizados, durante dez/2014 a nov/2015. Após a realização das entrevistas, se estruturou uma interpret ação das configurações locais do trabalho e das formas de produção em três momentos. O primeiro, corresponde ao início das trajetórias, apresenta os elementos e valores estruturais que alicerçaram a produção de confecções no Polo. O segundo, corresponde às narrativas de como se passou da condição de trabalhador à condição de empresário, expondo as estratégias dos empresários para montar sua estrutura produtiva, a partir de condições precárias de vida, e os usos que fizeram dos vários tipos de trabalho existentes, para dar continuidade à produção e consolidar seus negócios. A terceira, corresponde à caracterização da organização atual do trabalho nas fábricas, expõe como as fábricas foram modernizadas em termos físicos e tecnológicos e que o principal tipo de trabalho utilizado é o assalariado, submetido ao controle e à disciplina da gestão racional. Contudo, a modernidade das fábricas esbarra nas tradições lo cais, compondo um mix de características que agregam costumes locais, a fábrica limpa e moderna e uma mão de obra multifuncional e semianalfabeta. Tudo isso, faz do trabalho no Po lo de Confecções um desafio à compreensão do trabalho enquanto principal elemento da co nstituição socioeconômica local. / This search was developed with goal for analyze trajectories of formal and active entrepreneurs in the Clothing Pole of Pernambuco to learn in their narratives training and breeding sites job settings. The analysis it was structured in qualitative approach, using field research as an intervention form in place, through semi-structured interviews with eleven formalized entrepreneurs, during December 2014 to November 2015. After the interviews, it was built an interpretation of the local settings of work and production in three moments. The first moment, corresponds to the beginning of the trajectories, presents the elements and structural values that underpinned the garment production in Pole. The second, corresponds to the narrative of how if went to worker condition for entrepreneur status, exposing the strategies of entrepreneurs to set up their production structure, due to poor living conditions, and the uses made of the various existing types of work, to continue the production and consolidate their businesses. The third corresponds to the characterization of the current organization of work in the factories, i t exposes how the factories were upgraded in physical and technological terms, and that the main type of labor applied is the employed, subject to the control and discipline of rational management. However, the modernity of factories comes up against in the local traditions and inheritance of unskilled labor and semi-illiterate, composing a mix of features that aggregate the current organization of work in local traditions, the factory clean and modern up until multifunctional work and semi-literate. All this, makes thework in the Clothing Pole a challenge to the understanding of the work as the main element of the local socioeconomic constitution.

L'exigence principale du cycle cellulaire est une coordination étroite entre l'achèvement du processus de réplication et l'entrée des cellules en mitose, afin de maintenir l'intégrité génétique, l'identité et à la survie cellulaire. Toutes les cellules somatiques exécutent de manière reproductible une phase G2 intermédiaire, d'une durée constante pendant les divisions cellulaires successives au sein d'un type cellulaire donné. Cependant, les mécanismes moléculaires qui contrôlent précisément sa durée au cours d'un cycle cellulaire non perturbé, restent mal caractérisés. La kinase Cycline B1-Cdk1, facteur universel permettant l'entrée en mitose, est sous le contrôle, chez les mammifères, d'un ensemble de régulateurs directs, les kinases inhibitrices Wee1 et Myt1 et les phosphatases activatrices Cdc25A, B et C. Son activation soudaine, en fin de phase G2, révèle qu'une modification rapide de l'équilibre entre ses régulateurs opposés prend place par des mécanismes moléculaires qui restent à élucider. Dans ce cadre, j'ai étudié le rôle potentiel de la kinase Polo-like kinase 1 (Plk1) pour l'initiation de l'activation de Cycline B1-Cdk1. Bien que les rôles de Plk1 au cours de la mitose soient bien caractérisés, sa contribution dans la régulation de l'entrée des cellules en mitose reste controversée. Au niveau moléculaire, Plk1 phosphoryle au moins in vitro, plusieurs régulateurs de Cycline B1-Cdk1, tels que Cdc25B & C, et Wee1 et Myt1. Cependant, il reste largement inconnu si ces événements de phosphorylation se produisent in vivo et s'ils contribuent de manière significative au processus de l'activation de Cycline B1-Cdk1 permettant l'entrée en mitose. / A main requirement of the cell cycle is a tight coordination between the completion of the replication process and entry into mitosis in order to maintain genetic integrity and the identity and survival of cell progeny. All somatic cells reproducibly execute an intermediate G2 phase of constant duration during successive cell divisions in a given cell type. However the molecular mechanisms controlling precisely its duration during unperturbed cell cycle remains poorly characterized. In this context, the main objective of my PhD project was to decipher signaling pathways controlling entry into mitosis during normal cell cycles as well as their spatiotemporal regulation. CyclinB1-Cdk1, the universal master mitotic driver, is under the control of direct inhibitors (Wee1 and Myt1) and activators (Cdc25A, B and C). Previously, it was determined that CyclinB1-Cdk1 is suddenly activated in very late G2 phase, suggesting that a rapid modification in the equilibrium between its opposite regulators is reproducibly taking place in late G2 by poorly elucidated mechanisms. During my PhD, I investigated the potential role of Polo-like kinase 1 (Plk1) in the initial activation of CyclinB1-Cdk1. Even though its roles during mitosis are well characterized, its contribution for the regulation of entry into mitosis remains controversial. At the molecular level, Plk1 was shown to phosphorylate at least in vitro, several regulators of CyclinB1-Cdk1 including Cdc25B&C, and Wee1 and Myt1. However, it remains largely unknown if these phosphorylation events are taking place in vivo and whether they significantly contribute to the activation process of CyclinB1-Cdk1 leading to mitotic entry.

This study aims to analyze the current condition of the Local Productive Arrangement of the furniture sector in the city of Rio Verde (GO). The methodology used in this research is bibliographical, documentary and field, with a qualitative approach. The study was conducted in two stages; primarily a document search which analyzed documents of the Associação dos Fabricantes de Móveis de Rio Verde (AFAMORV), when it was revealed the origin of the project which resulted in APL, and then came the field research as a tool which had a semi structured interview script.The data collected in documentary research were presented in order to show the current condition of the Local Productive Arrangement, and the interviews were analyzed through categorization by content analysis. The president and the fifteen members of the furniture center of the Associação dos Fabricantes de Móveis de Rio Verde (AFAMORV) were interviewed. The study is justified by checking the variables that guide, through literature, the composition of the APL and the union of the companies, which will realize the form of associations, and competitive advantages. The study also highlights the potential of the city of Rio Verde (GO) in the furniture sector, and encourages future studies to promote growth and development of the Region. The results show that daily practice of business owners do not follow the history of APL, because the lack of support from the State and the City makes the development of the Local Productive Arrangement harder. For there to be integration between theory and practice it is possible that with a larger time-management dialogue with more excellence among management and business occurs. / Este estudo tem por objetivo analisar a atual condição do Arranjo Produtivo Local do setor moveleiro da cidade de Rio Verde (GO). A metodologia empregada nesta pesquisa é bibliográfica, documental e de campo,com abordagem qualitativa. O estudo foi realizado em duas etapas; primeiramente ocorreu uma investigação documental em que se analisaram documentos da Associação dos Fabricantes de Móveis (AFAMORV), identificando a origem do projeto que resultou em APL, e na segunda etapa, foi realizada à pesquisa de campo que teve como instrumento um roteiro de entrevista semiestruturado. Os dados coletados na pesquisa documental foram aprestados de forma a evidenciar a atual condição do Arranjo Produtivo Local, e as entrevistas foram analisadas por meio de categorização, por análise de conteúdo. Foram entrevistados o presidente e os 15associados do polo moveleiro da Associação dos Fabricantes de Móveis de Rio Verde (AFAMORV).O estudo se justifica por verificar, por meio da literatura, as variáveis que norteiam a composição do APL e a união das empresas, que passam a perceber a forma do associativismo, e as vantagens competitivas. O estudo destaca, também, potencialidades da cidade de Rio Verde (GO) no setor moveleiro, e incentiva estudos futuros para promoção de políticas de crescimento e desenvolvimento da Região. Os resultados obtidos demonstram que a prática cotidiana dos empresários não segue o histórico do APL, visto que a falta de apoio por parte do Estado e do Município dificulta o desenvolvimento do Arranjo Produtivo Local. Para que haja a integração entre teoria e prática é possível que com um tempo maior de gestão ocorra um diálogo com mais excelência entre gestão e empresários.

Submitted by Jakeline Ortega (jakortega@unoeste.br) on 2017-06-26T18:01:30Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Claudio Braz de Figueiredo.pdf: 526247 bytes, checksum: ac58547efa4bf056d40aa6ecac0b5d11 (MD5) / Made available in DSpace on 2017-06-26T18:01:30Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Claudio Braz de Figueiredo.pdf: 526247 bytes, checksum: ac58547efa4bf056d40aa6ecac0b5d11 (MD5) Previous issue date: 2017-05-08 / The present dissertation was developed in the Masters in Education of Unoeste, in the Area of concentration: Educational Institution and Educator Training. Research Line: Training and Pedagogical Practice of the Teaching Profession. The research investigated the management of a face-to-face support center of a private distance learning institution in the interior of the state of São Paulo. A qualitative approach was adopted, developing as a case study. Participants included: a polo manager, a polo coordinator, three tutors and fifteen students from the final stages of the courses, five of each of the courses: Pedagogy, Administration and Logistics. The data collection was performed through semi-structured interviews. The data were organized and interpreted using the technique of content analysis. The results indicated that the adopted management is characterized as centralizing, in which decisions are taken without the dialogue with the poles, this implies in damages to the use of available technological resources and pedagogical support and makes difficult the work of the tutor face-to-face. It is hoped that the results of this research may contribute to further research on Distance Education management, mainly in the context of the face-to-face support poles. / A presente dissertação foi desenvolvida no Mestrado em Educação da Unoeste, na Área de concentração: Instituição Educacional e Formação do Educador. Linha de pesquisa: Formação e Prática Pedagógica do Profissional Docente. A pesquisa investigou a gestão de um polo de apoio presencial de uma instituição privada de ensino superior a distância, do interior do estado de São Paulo. Adotou-se uma abordagem de natureza qualitativa, desenvolvendo-se como um estudo de caso. Como participantes da pesquisa contou-se com: um gestor de polo, um coordenador de polo, três tutores e quinze alunos das etapas finais dos cursos, sendo cinco de cada um dos cursos: Pedagogia, Administração e de Logística. A recolha de dados foi realizada por meio de entrevistas semiestruturadas. Os dados foram organizados e interpretados recorrendo-se à técnica de análise de conteúdo. Os resultados alcançados indicaram que a gestão adotada caracteriza-se como centralizadora, em que as decisões são tomadas sem o diálogo com os polos, isso implica em prejuízos à utilização dos recursos tecnológicos e de apoio pedagógico disponíveis e dificulta o trabalho do tutor presencial. Espera-se que os resultados desta pesquisa possam contribuir para novas investigações acerca de gestão da Educação a Distância, principalmente, no contexto dos polos de apoio presencial.

L’objectif de cette thèse est de proposer une nouvelle lecture du Devisement du Monde – connu également sous le titre du Livre des Merveilles, La Description du Monde ou Il Milione – axée sur le regard que porte Marco Polo sur ses contemporains de l’autre bout du monde et la réception qui lui est réservée. Parti dans le contexte des croisades qui réduit l’opposition Orient/Occident à la dualité sarrasin/chrétien, le jeune Marco Polo se retrouve, au travers de ses voyages et à la cour de Kubilai Khan, dans une problématique beaucoup plus vaste, où pratiques et croyances multiples s’inscrivent dans des courants philosophiques jusqu’alors peu connus en Occident. « L’observateur des religions », comme le nomme Philippe Ménard, semble être véritablement fasciné par cette diversité culturelle et religieuse qu’il relève durant son séjour dans l’empire mongol. Tant de nouveautés sont difficiles à assimiler et surtout à rapporter. Nous nous intéressons à la forme que prennent ces descriptions à l’intérieur d’un récit aux versions et traductions multiples, dans un contexte historique et littéraire marqué par les guerres de religion et de pouvoir. Dans la poursuite des travaux de C. Dutschke et de C. Gadrat sur la réception, ce travail de recherche s’appuie sur l’étude diachronique de dix manuscrits et de six éditions du Devisement du monde datant de la première moitié du XIVe siècle jusqu’à la fin du XIXe siècle. Nous envisageons cette réception du texte, non pas sous l’angle de l’usage du récit polien par d’autres auteurs ou au regard de sa diffusion, mais à partir du texte lui-même, du paratexte ainsi que des enluminures et des illustrations. Ces éléments renseignent sur la manière dont le texte est reçu au cours des siècles, et sont porteurs des attentes du public potentiel qui évoluent elles-mêmes avec le temps. La numérisation systématique des versions/traductions retenues, ainsi que l’usage d’outils d’analyse de données textuelles permettent de concilier une lecture attentive du texte et une analyse quantitative au-delà de l’approche linéaire traditionnelle. / The main goal of this dissertation is to propose a new reading and approach of Marco Polo’s Travels, also known as the Devisement du monde, the Description of the World or Il Milione. This study is based both on Marco Polo’s description of people living on the other side of the world and on the critical reception of his book. When Marco Polo left Venice, the prevailing opposition between West and East was mainly grounded in the duality opposing Christians and Saracens. However, through his travels and during his stay at Kubilai Khan’s Mongol court, the young man embraced more complex issues relating to religious beliefs and practices related to philosophical movements barely known in the Western world.“The observer of religions”, as historian P. Ménard calls him, seems to be fascinated by the cultural and religious diversity he encounters during his stay in the Mongol empire. So, many differences with his own culture were difficult to absorb and to report. In this study, we particularly focus on the many versions and translations of these descriptions, written in a context of political and religious turmoil. Following the works of C. Dutschke and C. Gadrat on the reception theory applied to the Travels, this diachronic research is founded on ten manuscripts and six editions dating from the early 14th century until the late 19th century. The impact of Marco Polo’s account is not studied here through the circulation of his Travels or according to the number of authors mentioning it in their own writings, but is rather established in relation to the text itself, along with the paratext, miniatures and illustrations. All these elements provide valuable information concerning its reception through ages, and about the expectations of the potential audience, which also evolved over time. All the versions and translations of our corpus have been digitized, and thanks to text analysis tools, we were able to reconcile close reading and data processing while analyzing the text.

The aim of this work is to study the development of balance between the factographic and belletristic components in travel literature during the medieval era in Italy. The basis for the analysis are following works: Historia Mongolorum by Giovanni da Pian del Carpine, Il Milione by Marco Polo and Diversae Historiae by Odorico da Pordenone, namely the excerpts from the chosen texts. This work is divided into five chapters. The second chapter is a short introduction to the whole work. In the third chapter is presented Giovanni da Pian del Carpine, his life and historical context, followed by a study of the extent of author's presence in the text composed according to a clear given conditions. The fourth chapter is dedicated to Marco Polo, his life, work and short analysis of author's presence in a text written without any formulated task. In the fifth chapter is presented Odorico da Pordenone, his life and historical context. Afterwards the extent of author's presence in a text is studied on an example of text with a relatively clearly formulated given conditions. The sixth and last chapter is a recapitulation. It contains confrontation and comparison of the gathered information and points out differences and similarities.

No description available.

Apoptoseresistenz ist einer der Gründe für ein Versagen von Chemotherapie bei vielen Krebserkrankungen, darunter das Burkitt Lymphom. Um die molekularen Mechanismen der Apoptoseresistenz aufzuklären, wurde die Apoptoseinduktion in 15 Burkitt-Lymphom-Zelllinien nach Behandlung mit den Spindelgiften Taxol (Paclitaxel), Nocodazol und Vincristin untersucht. Interessanterweise entwickelten Zellen, die sich als resistent gegenüber Taxol- und Nocodazol-induzierter Apoptose erwiesen, nach Behandlung eine Polyploidie (>4N DNA), was eine inverse Relation von Apoptose und Polyploidie aufzeigt. In den sensitiven Zelllinien war die Taxol- und Nocodazol-induzierte Apoptose von Caspase-Aktivierung, Bid-Spaltung und Herunterregulation von Mcl-1 begleitet. Im Gegensatz zu den sensitiven Zelllinien wiesen die meisten apoptoseresistenten Zellen einen Verlust von Bax und Bak auf und waren durch einen anhaltenden mitotischen Arrest mit Auftreten eines >4N DNA-Gehalts nach Behandlung charakterisiert. Um weitere Einblicke in den Mechanismus der Spindelgift-induzierten Apoptose zu erhalten, wurde die Rolle der mitotische Kinase PLK1 (polo-like kinase) näher untersucht. Eine dominant-negative PLK1-Mutante induziert Apoptose. Allerdings zeigte eine zusätzliche Behandlung mit Spindelgiften keinen synergistischen Effekt, was darauf schließen lässt, dass sowohl Inhibierung von PLK1 als auch Mikrotubuli-destabilisierende Agenzien den gleichen Stress-Signalweg aktivieren. Andererseits unterstützte Überexpression von Wildtyp-PLK1 in Taxol behandelten Zellen die Zellzyklus-Progression. Dies deutet auf eine Verbindung zwischen Zelltodresistenz und genetischer Instabilität (Aneuplodie) hin. Inhibition von Apoptose in sensitiven Zelllinien durch Caspase-Inhibierung förderte Polypoidie, welche die inverse Relation bestätigte. Medikamente, welche die Caspase-Aktivierung unabhängig von Bax und Bak induzieren, könnten eine weitere Möglichkeit zur Behandlung von resistenten Burkitt-Lymphomen darstellen. / Apoptosis resistance is the major cause of chemotherapy failure in most kinds of cancers, including Burkitt lymphomas (BL). To elucidate molecular mechanisms regulating the development of apoptosis resistance, a panel of 15 BL cell lines was investigated for apoptosis induction upon treatment with microtubule inhibitors taxol, nocodazole and vincristine. Significant differences were observed in the extent of apoptosis induction among BL cell lines examined. Interestingly, cell lines exhibiting resistance to taxol- or nocodazole-induced apoptosis, showed development of polyploidy (>4N) and vice versa, displaying an inverse relationship between apoptosis and polyploidy induction. Further, in sensitive cell lines taxol-induced apoptosis was accompanied by caspase activation, Bid cleavage and Mcl-1 down-regulation. In contrast, most apoptosis resistant cell lines exhibited a loss of Bax and Bak expression and showed prolonged mitotic arrest with >4N DNA content upon treatment. To gain mechanistic insights into microtubule inhibitor-induced cell death, the role of the mitotic kinase PLK1 was addressed. Dominant negative PLK1 mutant induced apoptosis, however, failed to show synergism in induction of apoptosis in combination with microtubule inhibitors. This indicates that PLK1 inhibition and spindle toxins might trigger a similar mitotic stress pathway. Conversely, overexpression of wildtype PLK1 promoted cell cycle progression in cells treated with taxol. Remarkably, inhibition of apoptosis in sensitive cell lines by caspase inhibition promoted polyploidy confirming the inverse relationship between apoptosis and polyploidization. Considering targets to induce Bax/Bak independent caspase activation would be of great importance to avoid undesirable events leading to chromosomal imbalances in treating resistant cancers.

Title: Management of sporting event - 6 Nations Objectives: Target of the thesis is brought and defines problems with organization sport action 6 Nations. Whole organization will be describe and next will be analyzed the problems, with which the organizers had the opportunity to meet. With help of selected theoretic method will be on the conception of the project the next year show, how prevent and eliminate the arising situation so as the negative repercussion was least. The most important chapter is propagation of the action and options, that this part was the best result. Methods: With help of descriptive case study and date analysis of case study will be description organization of whole action that will be analyzed. On a questionnaire and discussion will be shown problems with propagation and will be devise the methods of propagation so as the propagations was the most intensive and reach target groups. In conclusion is done generalization the obtained results and setting assumptions to successful organization of sport enterprise. Results: Have been identified deficiencies in quality of propagation that wasn't focused on ideal target groups and thus not be met, which was set before the event. The main purpose was expand the water polo between people and get to water polo another young active...

A presente tese é uma pesquisa composta de duas partes. A primeira e principal é constituída do ensaio em economia aplicada denominado “Emprego e investimentos no Polo Naval de Rio Grande”. O estudo analisa a atividade econômica e o emprego no setor naval dos municípios do Polo Naval de Rio Grande, correspondente aos investimentos de produção nos estaleiros, e estima seus efeitos sobre o emprego agregado desses municípios. Documenta diversas características e fatos do emprego naquele setor e procede a uma investigação minuciosa da sua sazonalidade. Importantes correlações deste com o de outros setores selecionados também foram identificadas. Na análise do impacto sobre o emprego agregado, utiliza-se uma especificação diferenciada do modelo diff-in-diff e estima-se um efeito médio ponderado significativo, heterogêneo no tempo e entre os municípios. Já a segunda parte da tese, complementar à primeira, é composta de dois ensaios: um em teoria econômica e outro em economia aplicada. Ambos estão relacionados ao conceito e medida de credibilidade. Em economia monetária o termo credibilidade tem sido interpretado com distintos significados e predicados. Como consequência, as confusões e perda de eficiência acabam retardando o avanço teórico e empírico de questões importantes. O ensaio “Credibilidade: o conceito” busca organizar a interpretação e a medida de credibilidade, principalmente no contexto monetário. Nele propõe-se um conceito abrangente, baseado na linguagem natural e que aninha diversas interpretações, formalizando-o matematicamente na estrutura da Teoria da Probabilidade, na qual também construi-se a medida. No outro ensaio, denominado “Credibilidade: aplicação empírica”, realiza-se uma aplicação do conceito e da medida de credibilidade construídos no anterior. Utilizando dados de um survey de expectativas de inflação (pontuais e probabilísticas) para a economia dos Estados Unidos, estima-se diversas credibilidades para variados horizontes temporais e focos. Emprega-se métodos não-paramétricos para as estimações (spline e kernel), com especificações adaptadas à particularidade dos dados. / The present thesis is a research composed of two parts. The first and main consists of the essay in applied economy called “Emprego e investimentos no Polo Naval de Rio Grande”. The study analyzes the employment in the naval sector of the Rio Grande Naval Pole municipalities, correspondent to the production investments in the shipyards, and estimates their effects on the aggregate employment of these municipalities. It documents various characteristics and facts of employment in that sector and proceeds to a thorough investigation of its seasonality. Moreover, important correlations between this and other selected sectors were identified. In the analysis of impact on aggregate employment we used a differentiated specification of the model diff-in-diff, and estimated a weighted average effect, which is heterogeneous in time and between municipalities. Now, the second part of the thesis, complementary to the first one, is composed of two essays: one in economic theory and the other in applied economics. Both are related to the concept and measure of credibility. In monetary economics the term credibility has been interpreted with different meanings and predicates. Consequently, the confusions and loss of efficiency slow down the theoretical and empirical advancement of important issues. The essay “Credibilidade: o conceito” seeks to organize the interpretation and measurement of credibility, especially in the monetary context. In that essay are proposed a comprehensive concept, based on natural language and that nestles diverse interpretations, formalizing it mathematically in the framework of Probability Theory, in which the measure was also constructed. In the other essay, called “Credibilidade: aplicação empírica”, we apply the concept and measure of credibility built in the previous one. Using data from a survey of inflation expectations (both point and probabilistic) for the US economy, we estimate various credibilities for various time horizons and focus. We use non-parametric methods (spline and kernel) to estimate, with specifications adapted to the particularity of the data.