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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 41 to 44 of 44 (0.028 seconds)Spelling suggestions: "subject:"cooled""
| 41 |
Méthodes d'analyse statistique pour données répétées dans les essais cliniques : intérêts et applications au paludisme / Statistical method for analysis of recurrent events in clinical trials : interest and applications to malaria dataSagara, Issaka 17 December 2014 (has links)
De nombreuses études cliniques ou interventions de lutte ont été faites ou sont en cours en Afrique pour la lutte contre le fléau du paludisme. En zone d'endémie, le paludisme est une maladie récurrente. La revue de littérature indique une application limitée des outils statistiques appropriés existants pour l'analyse des données récurrentes de paludisme. Nous avons mis en oeuvre des méthodes statistiques appropriées pour l'analyse des données répétées d'essais thérapeutiques de paludisme. Nous avons également étudié les mesures répétées d'hémoglobine lors du suivi de traitements antipaludiques en vue d'évaluer la tolérance ou sécurité des médicaments en regroupant les données de 13 essais cliniques.Pour l'analyse du nombre d'épisodes de paludisme, la régression binomiale négative a été mise en oeuvre. Pour modéliser la récurrence des épisodes de paludisme, quatre modèles ont été utilisés : i) Les équations d'estimation généralisées (GEE) utilisant la distribution de Poisson; et trois modèles qui sont une extension du modèle Cox: ii) le modèle de processus de comptage d'Andersen-Gill (AG-CP), iii) le modèle de processus de comptage de Prentice-Williams-Peterson (PWP-CP); et iv) le modèle de Fragilité partagée de distribution gamma. Pour l'analyse de sécurité, c'est-à-dire l'évaluation de l'impact de traitements antipaludiques sur le taux d'hémoglobine ou la survenue de l'anémie, les modèles linéaires et latents généralisés mixtes (« GLLAMM : generalized linear and latent mixed models ») ont été mis en oeuvre. Les perspectives sont l'élaboration de guides de bonnes pratiques de préparation et d'analyse ainsi que la création d'un entrepôt des données de paludisme. / Numerous clinical studies or control interventions were done or are ongoing in Africa for malaria control. For an efficient control of this disease, the strategies should be closer to the reality of the field and the data should be analyzed appropriately. In endemic areas, malaria is a recurrent disease. Repeated malaria episodes are common in African. However, the literature review indicates a limited application of appropriate statistical tools for the analysis of recurrent malaria data. We implemented appropriate statistical methods for the analysis of these data We have also studied the repeated measurements of hemoglobin during malaria treatments follow-up in order to assess the safety of the study drugs by pooling data from 13 clinical trials.For the analysis of the number of malaria episodes, the negative binomial regression has been implemented. To model the recurrence of malaria episodes, four models were used: i) the generalized estimating equations (GEE) using the Poisson distribution; and three models that are an extension of the Cox model: ii) Andersen-Gill counting process (AG-CP), iii) Prentice-Williams-Peterson counting process (PWP-CP); and (iv) the shared gamma frailty model. For the safety analysis, i.e. the assessment of the impact of malaria treatment on hemoglobin levels or the onset of anemia, the generalized linear and latent mixed models (GLLAMM) has been implemented. We have shown how to properly apply the existing statistical tools in the analysis of these data. The prospects of this work remain in the development of guides on good practices on the methodology of the preparation and analysis and storage network for malaria data.
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| 42 |
Faith-based organizations in multilateral humanitarian aid : A closer look at Country-Based Pooled FundsÖberg, Jakob January 2023 (has links)
Religion has played a central part in human history and is still a foundation in many societies. Faith-based organizations are in some countries the largest providers of social services and were pioneers in the humanitarian aid sector. There is in academia a growing interest in faith-based organizations and a perception that they have an advantage over their secular counterparts. This study has identified those established theories and provided a comprehensive overview of the research field. It has been argued that faith-based organizations for one should be more cost-effective than their secular counterparts. The faith of their staff members is a significant part of their motivation. They, therefore, accept lower salaries or volunteer to a higher degree. It has also been argued that projects implemented by faith-based organizations could be more rooted in local communities due to a long history of cooperation and collaboration. The claims have been mostly theoretical or supported by qualitative studies. This study contributed to filling the quantitative research gap by analyzing key differences between projects implemented by faith-based and secular organizations that were financed by the United Nations Country-Based Pooled Funds. The data selection provided a scenario where the institutional pressure from strict processes, monitoring, and evaluation theoretically minimizes differences between implementers and therefore tested the study’s hypotheses in a least-likely scenario. The analysis found that there was no significant difference between how many beneficiaries the projects reached. Faith-based organizations did however implement projects that with 95 % certainty costed between 2.20 to 7.87 % less compared to their secular counterparts. Their projects with 95 % certainty also had a four percent higher direct-to-total project cost ratio. This provides support for the theoretical claims and contributed to building a foundation for future research in this emerging field. The study surprisingly also found a significant and large difference in project cost between national and international implementers. Projects implemented by national organizations with 95 % certainty cost between 27.98 and 31.50 % less than projects implemented by international organizations. They with 95 % certainty also had a six percent higher direct-to-total project cost ratio. It was not in the scope of this paper to determine what these results depended on but they give further fuel to the current localization debate in both academia and public administration.
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| 43 |
Legal and regulatory aspects of mobile financial servicesPerlman, Leon Joseph 11 1900 (has links)
The thesis deals with the emergence of bank and non-bank entities that provide a range of unique
transaction-based payment services broadly called Mobile Financial Services (MFS) to unbanked,
underserved and underbanked persons via mobile phones.
Models of MFS from Mobile Network Operators (MNOs), banks, combinations of MNOs and banks, and
independent Mobile Financial Services Providers are covered. Provision by non-banks of ‘bank-type’
services via mobile phones has been termed ‘transformational banking’ versus the ‘additive banking’
services from banks. All involve the concept of ‘branchless banking’ whereby ‘cash-in/cash out’ services
are provided through ‘agents.’
Funds for MFS payments may available through a Stored Value Product (SVP), particularly through a
Stored Value Account SVP variant offered by MNOs where value is stored as a redeemable fiat- or mobile
‘airtime’-based Store of Value.
The competitive, legal, technical and regulatory nature of non-bank versus bank MFS models is discussed,
in particular the impact of banking, payments, money laundering, telecommunications, e-commerce and
consumer protection laws. Whether funding mechanisms for SVPs may amount to deposit-taking such that
entities could be engaged in the ‘business of banking’ is discussed. The continued use of ‘deposit’ as the
traditional trigger for the ‘business of banking’ is investigated, alongside whether transaction and paymentcentric
MFS rises to the ‘business of banking.’
An extensive evaluation of ‘money’ based on the Orthodox and Claim School economic theories is
undertaken in relation to SVPs used in MFS, their legal associations and import, and whether they may be
deemed ‘money’ in law.
Consumer protection for MFS and payments generally through current statute, contract, and payment law
and common law condictiones are found to be wanting. Possible regulatory arbitrage in relation to MFS in
South African law is discussed.
The legal and regulatory regimes in the European Union, Kenya and the United States of America are
compared with South Africa. The need for a coordinated payments-specific law that has consumer
protections, enables proportional risk-based licensing of new non-bank providers of MFS, and allows for a
regulator for retail payments is recommended. The use of trust companies and trust accounts is
recommended for protection of user funds.
| vi / Public, Constitutional and International Law / LLD
|
| 44 |
Legal and regulatory aspects of mobile financial servicesPerlman, Leon Joseph 11 1900 (has links)
The thesis deals with the emergence of bank and non-bank entities that provide a range of unique
transaction-based payment services broadly called Mobile Financial Services (MFS) to unbanked,
underserved and underbanked persons via mobile phones.
Models of MFS from Mobile Network Operators (MNOs), banks, combinations of MNOs and banks, and
independent Mobile Financial Services Providers are covered. Provision by non-banks of ‘bank-type’
services via mobile phones has been termed ‘transformational banking’ versus the ‘additive banking’
services from banks. All involve the concept of ‘branchless banking’ whereby ‘cash-in/cash out’ services
are provided through ‘agents.’
Funds for MFS payments may available through a Stored Value Product (SVP), particularly through a
Stored Value Account SVP variant offered by MNOs where value is stored as a redeemable fiat- or mobile
‘airtime’-based Store of Value.
The competitive, legal, technical and regulatory nature of non-bank versus bank MFS models is discussed,
in particular the impact of banking, payments, money laundering, telecommunications, e-commerce and
consumer protection laws. Whether funding mechanisms for SVPs may amount to deposit-taking such that
entities could be engaged in the ‘business of banking’ is discussed. The continued use of ‘deposit’ as the
traditional trigger for the ‘business of banking’ is investigated, alongside whether transaction and paymentcentric
MFS rises to the ‘business of banking.’
An extensive evaluation of ‘money’ based on the Orthodox and Claim School economic theories is
undertaken in relation to SVPs used in MFS, their legal associations and import, and whether they may be
deemed ‘money’ in law.
Consumer protection for MFS and payments generally through current statute, contract, and payment law
and common law condictiones are found to be wanting. Possible regulatory arbitrage in relation to MFS in
South African law is discussed.
The legal and regulatory regimes in the European Union, Kenya and the United States of America are
compared with South Africa. The need for a coordinated payments-specific law that has consumer
protections, enables proportional risk-based licensing of new non-bank providers of MFS, and allows for a
regulator for retail payments is recommended. The use of trust companies and trust accounts is
recommended for protection of user funds.
| vi / Public, Constitutional and International Law / LL. D.
|
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