The thesis titled Evaluation design therapy of neurogenic disorders of language in clinical speech therapy aims to find out what effect the speech reeducation to improve communication skills in people with acquired neurogenic communication disorders speech. Next, determine whether therapy plays a role during client environment, if the success rate of therapy affected patient's condition and the extent to which the clients are motivated to therapy. The theoretical part summarizes the findings from the literature on neurogenic communication disorders, aphasia and dysarthria. Each chapter is devoted to the terminological definition and definition, etiology, symptoms (for aphasia), classification, diagnostics and therapy. The practical part deals with the research survey. There are set targets mentioned methodology, research sample characteristics and place of the investigation. Following processing of four case studies. Which describes the therapy sessions and individual work with clients. KEYWORDS Neurogenic speech disorders, aphasia, dysarthria, logopedic therapy

Mirror neurons are very specific nerve cells that are both motor and sensory in nature. Mirror neurons are a relatively new discovery first identified by a team of neurophysiologists at the University of Parma. These neurons were first observed in primates, and then later in humans in several regions of the cerebral cortex. A large amount of research on mirror neurons have shown that they play an important role in imitation, language acquisition and empathy. The theoretical part of this work summarizes what is currently known about mirror neurons. It emphasizes the relationship between mirror neurons, autism, empathy, and its training. This theoretical framework is followed by pilot research, which consists of two components: the quantitative part consisted of a questionnaire survey to ascertain the level of empathy of the participants using the Index of Interpersonal Reactivity. The participants were the parents of autistic children who were compared with a control group. A statistically significant difference in empathy levels between the two groups was not observed but there was a tendency for higher scoring in some questionnaire scales in experimental group The second part of this work is an analysis of observations of the interactions between parents and autistic children. Additionally, two...

Aim. The aim of the present work is to examine and compare brain abnormalities found on magnetic resonance imaging (MRI) in children diagnosed with autism spectrum disorders (ASD) and in children without this diagnosis. In terms of psychopathology, the aim is to evaluate a possible relationship between the MRI findings and the severity of autistic symptomatology. Methods. The research study is based on a retrospective analysis of a sample of patients who attended a diagnostic examination focused on ASD and at the same time underwent brain MRI at the Department of Child Psychiatry of the Second Faculty of Medicine at Charles University and University Hospital Motol between the years 1998 and 2015. For clinical diagnosis of ASD, the International Classification of Diseases, 10th revision (ICD-10), was used. Between 1998 and 1999, the assessment of patients was supported by the Childhood Autism Rating Scale. Starting in 2000, the third version of the Autism Diagnostic Interview - Revised was used for assessments; and from 2012 onwards, the Autism Diagnostic Observation Schedule - Generic was added to the diagnostic procedures. From 1998 to 2015, a total of 489 children were diagnosed with pervasive developmental disorder (404 boys, 85 girls). The mean age in the group was 8.0 ± 4.2 years (range...

The diploma thesis deals with problems of identification and specification of insurmountable impairments with a focus on moisture. The aim of my work is generally explain what the fault and failure, what is their cause, and the overall approach in this area. Next determine the difference between removable and irremovable defect. Part of this work is a chapter devoted to surveys of buildings, which are an integral part in detecting defects, failures and their root structures. Another section is devoted to the main subject of work - moisture, approach this issue and the problems caused by moisture in the structure. At the end of this chapter is about ways of reducing the moisture in structures. The last section is on the case (the object affected moisture) approach procedure for identifying and assessing these impairments in practice.

Title: Specifics of swimming teaching children with autism spectrum disorder. Objectives: Application of the structured learning by the concept of common preparatory and basic swimming lessons for children with autism spectrum disorder. Presentation and evaluation of nine case studies and subsequent implementation of policy for teaching swimming to children with autism spectrum disorder. Methods: Analysis of specialized literature, case studies, surveys, interviews, scaling observation and statistics method. Results of the work: Methods of the structured learning support and facilitate the implementation of standard swimming lessons for children with autism spectrum disorder. The case studies confirm the effectiveness of our taught realized swimming lessons. The principles for swimming education of children with autism spectrum disorder are designed based on the above-mentioned examples of swimming lessons. Keywords: Autism Spectrum Disorders, structured teaching swimming lessons

ABSTRACT Title: Laterality influence on the violinists locomotor system disorders Objectives: The main object of this work is to find relation between laterality (dominance, preferences body) and forced left-sided activities - playing the violin, and to authenticate if the forced lateral activity indicate greater effect on musculosceletal disorders in the nondominant laterality. Methods: Questionnaire includes questionnaire part, preference task and performance task, it's anonymous. Probands are students of music conservatory and professionals violinist of chambre and symphony orchestra. The final number of probands who have involved the questionnaire is 110 (66 womens and 44 mens). Results: The hypothesis hasn't been confirmed. Results showed better subjective evaluation of potential musculoskeletal disorders by probands left-handers Keywords: playing the violin, laterality, dominance, musculoskeletal disorders

Congenital disorders of glycosylation (CDG) represent a rapidly growing group of rare inherited metabolic diseases with estimated prevalence as high as 1:20 000, which are caused by genetic defects that impair the process of glycosylation, i.e. the enzymatic addition of a specific saccharide structure onto a protein or lipid backbone. Due to non-specificity and variability of clinical symptoms in the patients, the medical diagnosis of CDG remains extremely challenging and significantly relies on accurate biochemical and genetic analyses. The overall goal of the present dissertation thesis was to study CDG at the biochemical and molecular genetic level in the context of the Czech and Slovak Republic, which involved three specific aims: A.) to introduce and optimize laboratory screening methods for CDG detection in a group of clinically suspected patients, B.) to determine the corresponding genetic defect in the positive patients selected via CDG screening and to study the pathobiochemical aspects of specific CDG types at the cellular level, and C.) to analyze glycosylation disturbances of non- CDG etiology. Contributions of this work include optimization of isoelectric focusing of apolipoprotein C-III (ApoC-III) as a screening method for O-glycosylation abnormalities, as well as the description of...

Dolichol is a membrane lipid, which carries monnosaccharides and glycans for N-linked protein glycosylation and glycosylphosphatidylinositol-anchor biosynthesis occuring in endoplasmic reticulum. Its structure is composed of isoprenoid units. Dolichol is present in all tissues and in most of the membrane organelles of eukaryotic cells. Recently some types of congenital disorders of glycosylation have been described as a consequence of dolichol biosynthesis and metabolism defects, which are not detectable by standard methods. The aim of this diploma thesis was to analyze dolichol content in urine and in different tissues from patients with deficiency in dolichol biosynthesis by mass spectrometry and to study the impact of these defects on energetic metabolism. Biological material for this study consisted of urine samples from 76 controls with age ranging from 1 months to 81 years, 6 patients with congenital disorders of glycosylation and 43 patients with suspicion of congenital disorder of glycosylation; samples of frontal cortex, liver, muscle and heart tissues from 2 patients with mutation in NUS1 gene and controls. Urine samples were stored at -20 řC and tissue homogenates were stored in -80 řC until analysis. Lipid fraction after extraction was separated by liquid chromatography. Dolichols were...

2 ABSTRACT In the Alternative DSM-5 Model for Personality Disorders (AMPD), the diagnosis of specific personality disorders is obtained through an evaluation of the level of impairment in personality functioning and an assessment of dimensional personality traits associated in 25 "lower order" facets and 5 "higher order" domains. The Personality Inventory for DSM-5 (PID-5) was developed for examination of personality traits within this system. This Ph.D. thesis covers five relevant publications regarding AMPD, particularly PID-5. First, the authors introduce the theoretical background of the PID-5. Attention is paid on its ease of use, data interpretation and use of these data for treatment planning in different clinical settings. Two empirical studies test PID-5 psychometric properties (internal consistency, validity, discrimination capacity and unidimensional structure) in the sample of community volunteers (n=351) and a clinical sample of psychiatric patients (n=143). PID-5 was administered individually and in a group setting using pen-paper method and online data collection. 33 respondents completed the inventory twice to check test-retest reliability. Authors presumed, evidence will be found to support internal consistency and convergent validity of the PID-5 personality trait domains, as well as their...

Title: Effect of rehabilitation intervention on soft tissue of shoulder joint in handball players Objectives: The aim of the thesis is to explore the benefits of 10-session conservative therapy in handball players diagnosed with throwing shoulder. The chosen therapy should eliminate the players' difficulties as much as possible and allow them to once again fully engage in the activity. Methods: Experiment-based qualitative research with randomized control study was conducted. The objective was to assess the findings of four probands - players of a major-league team - diagnosed with shoulder joint soft tissue injury caused by playing handball. Two women and two men between the ages of 19 and 30 took part in the research. The subjects were divided into two groups. The first group, a man and a woman, took part in 10 therapeutic sessions, whereas the other did not receive any kind of treatment and served as a reference group. Both initial and final kinesiologic examinations were carried out at the beginning and the end of the therapy, consisting of anamnesis, physical inspection, palpation, anthropometric and goniometric measuring, examination of muscle, muscle shortening, joint movement and movement stereotype. Measured data was analysed and evaluated. Results: After ten successive therapeutic...