Made available in DSpace on 2016-12-23T14:00:37Z (GMT). No. of bitstreams: 1 Oldair Luiz Goncalves.pdf: 966844 bytes, checksum: dfff481b4e04c97921352cfb29baa59c (MD5) Previous issue date: 2011-05-27 / In the context of Environmental Regulation and Sustainable Development this dissertation has as focus the economic study of the potential and limitations of PSA projects, as instruments for promotion of sustainable development in the state of Espírito Santo. It systematizes concepts of growth, economic and sustainable development, environmental regulation, public assets, externalities and theoretic solution proposals. Systematize technical and historical data aiming at identifying the water s role on sustainable development and, finally, synthesizes and analyses the structure and operationalization of the Project "ProdutorES de Água do Espírito Santo", pointing out conclusions as follows: although still very limited in it s capacity and area of coverage, this program has important potential as an instruments sustainable development promotion in the state of Espírito Santo / No contexto do tema Regulação Ambiental e Desenvolvimento Sustentável esta dissertação tem como objeto o estudo econômico das potencialidades e limitações de projetos de PSA e mais especificamente do Projeto Produtor ES de Água, como instrumento de promoção do desenvolvimento Sustentável no Estado do Espírito Santo. Sistematiza conceitos de crescimento, desenvolvimento econômico e desenvolvimento sustentável, de regulação ambiental, bens públicos, bens comuns, externalidades e propostas teóricas de solução destas. Sistematiza informações técnicas e históricas objetivando a identificação dos papéis da água no desenvolvimento e finalmente sintetiza e analisa a estrutura e a operacionalização do Projeto Produtor ES de Água no Espírito Santo apontando para as conclusões de que embora ainda muito limitado em seu escopo e área de abrangência este programa tem importante potencial como instrumento de promoção do desenvolvimento sustentável no Estado

Nous proposons, dans cette thèse, d'utiliser les techniques de modélisation en pharmacométrie selon l'approche de population afin de décrire les cinétiques de plusieurs marqueurs tumoraux sériques, et d'analyser leurs potentielles applications. Dans un premier temps, nous avons construit un modèle reliant les cinétiques de taille tumorale et de CA-125 dans le cancer de l'ovaire. Nous avons ensuite évalué son application pour : i) la prévision de la réponse tumorale au niveau individuel ; ii) la prédiction précoce de la survie au niveau d'une population dans le développement du médicament. Dans un second temps, nous avons réalisé un travail plus méthodologique sur la modélisation des cinétiques conjointes de PSA et d'un nouveau marqueur, le nombre de cellules tumorales circulantes (CTCs), dans le cancer de la prostate. Un modèle atypique combinant plusieurs innovations en pharmacométrie a été développé. En perspective, un lien va être établi avec la survie. En conclusion, la modélisation mathématique est un outil efficace pour l'évaluation précoce de l'efficacité des traitements / Our thesis project aimed at building mathematical models, using population approach, for different serum tumor markers, in order to describe their kinetics and to assess their potential applications. In a first intent, we built a semi-mechanistic model linking tumor size changes and CA-125 kinetics induced by chemotherapy in ovarian cancer patients. This model allowed assessment of CA-125 as: i) a biomarker for tumor size dynamics and treatment efficacy for clinical purposes; ii) an early predictor of clinical benefit during drug development. Then, we realized a more fundamental work by developing a semi-mechanistic model for characterizing the relationships between PSA kinetics and circulating tumor cell count dynamics during treatment in metastatic prostate cancer patients. This is an atypical model combining several advanced features in pharmacometrics. We have planned to assess a link with survival. In conclusion, mathematical modeling could be an efficient tool for the early prediction of treatment efficacy

Le développement de nouveaux adsorbants écologiques et efficaces pour la séparation du CO2 nécessite un lien quantitatif entre les propriétés des adsorbants et ses propriétés d'adsorption. Dans ce travail, nous développons une méthodologie qui prend en compte explicitement les propriétés des adsorbants, tels que le diamètre de pore, la densité, la forme de pore et la composition chimique. L'objectif est d'établir des corrélations quantitatives entre les paramètres mentionnés ci-dessus et les forces qui gouvernent la physisorption dans les milieux poreux, c'est à dire les interactions van der Waals et les interactions électrostatiques. Ainsi, les propriétés optimales des adsorbants pour la séparation du CO2 sont identifiées. En parallèle à ces études théoriques, une série d'adsorbants potentiellement intéressants pour la séparation du CO2 par PSA ont été testées expérimentalement. Une étude systématique de l'influence du centre métallique sur les séparations de mélanges CO2/CH4 et CO2/CH4/CO a été réalisée sur MOFs présentant sites coordinativement insaturés. Dans le cas des zéolithes, l'effet de la composition chimie (rapport Si / Al) sur les propriétés de séparation a été étudiés. Les capacités cycliques et des sélectivités ont été déterminées par des expériences de perçage. Les matériaux présentant un bon compromis entre la sélectivité et la capacité de travailler dans les conditions typiques de PSA ont été identifiés. Finalement, une comparaison entre la prédiction du modèle d'adsorption et les expériences a été faite / The design of new environmentally friendly and efficient adsorbents for CO2 separation requires a quantitative link between the adsorbent properties and adsorption capabilities. In this work we develop a methodology, which explicitly takes into account the adsorbent properties, such as the pore diameter, density, pore shape and chemical composition. The objective is to establish quantitative correlations between the above-mentioned parameters and the forces that govern physisorption in porous media, i.e. van der Waals forces and electrostatic interactions. Thus, the optimal properties of the adsorbent for CO2 separation are identified. In parallel to these theoretical studies, a series of potentially interesting adsorbents for CO2 separation by PSA were tested experimentally. A systematic study of the influence of the metal center on the separations of CO2/CH4 and CO2/CH4/CO mixtures was carried out on MOFs presenting coordinatively unsaturated sites. In the case of zeolites, the effect of the framework composition (Si/Al ratio) on the separation properties was studied. The cyclic capacities and selectivities were determined by breakthrough experiments. Materials presenting a good compromise between selectivity and working capacity under typical PSA conditions were identified. Finally, a comparison between the prediction of the adsorption model and the breakthrough experiments is carried out

[pt] Este estudo foi desenvolvido com o objetivo de avaliar o Programa Subsidio de Alimentos (PSA) em Moçambique, especialmente em Cahora Bassa (Tete) com o intuito de compreender as repercussões do programa nas condições de vida das famílias de acordo com suas próprias visões. De maneira específica, buscámos conhecer o perfil dos beneficiários; apresentar suas principais carências; o conhecimento das titulares acerca do programa, as principais repercussões em suas condições de vida; analisar os significados que atribuem ao PSA e verificar se o PSA estaria contribuindo para a utilização de serviços sociais, como o acesso à alimentação e saúde. A pesquisa procurou fazer um levantamento bibliográfico sobre as políticas socais em Moçambique, relacionados à pesquisa. Também foi realizada a pesquisa de campo desenvolvida por meio de 30 (trinta) entrevistas em profundidade, sendo vinte e cinco com beneficiários do PSA e cinco com gestores do programa, a partir de um roteiro previamente elaborado. A pesquisa indicou que a população reconhece o PSA como uma ajuda que contribui de forma significativa no orçamento familiar, promove a manutenção ou uma maior variedade na alimentação ou mesmo o acesso a bens de consumo, mesmo considerando problemas em sua execução ligada ao baixo valor do benefício que varia de acordo com a renda familiar per capita e com a estrutura familiar, e mais cautelosos em relação às críticas. Por outro lado, os gestores indicam que predomina a aprovação e a percepção de que o PSA tem efeitos e resultados positivos uma vez que permite a ruptura com o ciclo vicioso da pobreza, e a saída permanente dos beneficiários dessa situação em Moçambique. Porém, sendo financiamento externo o principal instrumento de realização do PSA, o programa enfrenta limitações para se efetivação e expansão devido à escassez de recursos financeiros do governo os quais apontam o impacto da insegurança alimentar nas estruturas familiares, cuja expressão mais severa é a fome. / [en] This study was developed to evaluate the Benefit Food Program (PSA) in Mozambique, especially in Cahora Bassa (Tete) in order to understand the program s impact on the living conditions of families according to their own views. Specifically, we sought to know the profile of the beneficiaries; present their main needs; the knowledge of the owners about the program, the main impact on their living conditions; analyze the meanings they attach to PSA and verify that the PSA would be contributing to the use of social services, such as access to food and health. The research sought to review the literature on socais policies in Mozambique, related to the research. It was also carried out field research developed through thirty (30) indepth interviews, twenty-five with PSA beneficiaries and five program managers, from a previously prepared script. Research has indicated that the population recognizes the PSA as an aid that contributes significantly to the family budget, promotes maintenance or a greater variety in food or access to consumer goods, even considering problems in implementation connected to the low value of benefit varies according to family income and family structure, and more cautious with regard to criticism. On the other hand, managers indicate that dominates the approval and the perception that the PSA has effects and positive results since it allows to break the vicious cycle of poverty, and the permanent departure of the beneficiaries of this situation in Mozambique. However, with external funding the main instrument for implementing the PSA, the program has limitations to effective and expansion due to lack of government funds which point the impact of food insecurity in family structures, the most severe expression is hunger.

Prostatacancer är den vanligaste cancerformen hos män. Prostatan tillhör de manliga reproduktionsorganen och producerar bland annat prostataspecifikt antigen (PSA) som kan påvisas i blodet. Förhöjda värden av PSA kan bero på prostatacancer. Transrektalt ultraljuds (TRULS)-ledda systematiska biopsier används i högre frekvens än magnetkamera med riktad biopsi. Röntgensjuksköterskans möte med dessa patienter är före, under och efter bildtagningen med magnetkameran. Syftet var att göra en översikt av den diagnostiska träffsäkerheten för TRULS-ledda systematiska biopsier och magnetresonans (MR)-undersökning med riktade biopsier vid misstanke om prostatacancer. Metoden bestod av en litteraturöversikt med systematisk ansats. Inkluderingskriterier var vetenskapliga artiklar skrivna mellan 2015–2020. Artiklarna skulle vara peer-reviewed och etiskt granskade. Databasen Medline användes till sökningen. Kvalitetsgranskning gjordes med granskningsprotokoll hämtade från Avdelningen för omvårdnad på Hälsohögskolan. I resultatet inkluderades 15 artiklar som visade att skillnaden i den diagnostiska träffsäkerheten för prostatacancer hos män inte var stor mellan metoderna. Däremot hittade MR-undersökning med riktade biopsier större andel kliniskt signifikanta cancrar och mindre del insignifikanta cancrar än vad TRULS-ledda systematiska biopsier gjorde. MR-undersökning med riktad biopsi är en bra metod för att öka träffsäkerheten att hitta kliniskt signifikant cancer. Dock går det inte utesluta TRULS-ledda systematiska biopsier då kontraindikationer och missade cancrar på MR-undersökning med riktade biopsier förkommer. / Prostate cancer is the most common cancer in men. The prostate belongs to the male reproductive organs and produces, among other things, prostate-specific antigen (PSA) that can be detected in the blood. Elevated levels of PSA may be due to prostate cancer. Transrectally ultrasound (TRULS)-guided systemic biopsies are used at higher frequency than magnetic cameras with directed biopsy. The X-ray nurse's meeting with these patients is before, during and after the imaging with the magnetic camera. The aim was to make an overview of the diagnostic accuracy of TRULS guided systematic biopsies and MRI with targeted biopsies on suspicion of prostate cancer. The method consisted of a literature review with systematic approach. Inclusion criteria were scientific articles written between 2015-2020. The articles would be peer-reviewed and ethically approved. The Medline database was used for the search. Quality review was done with review protocols obtained from the Department of Nursing at the School of Health. The result included 15 articles showing that there was no big difference in the diagnostic accuracy of prostate cancer in men between the methods. In contrast, MRI with targeted biopsies found a greater proportion of clinically significant cancers and a smaller proportion of insignificant cancers than TRULS guided systematic biopsies did. MRI with targeted biopsy is a good method for increasing the accuracy of finding clinically significant cancer. However, TRULS guided systematic biopsies cannot be ruled out as contraindications and missed cancers on MRI with targeted biopsies occur.

Die wachsende Weltbevölkerung und die stetigen Entwicklungen in der Industrie benötigen einerseits immer größere Mengen an Grundchemikalien und führen andererseits zu einem ständig steigenden Energiebedarf. Die Dissertation behandelt daher die Themen Zeolithe und Kathodenmaterialien, welche zwei aktuelle Forschungsschwerpunkte der chemischen Industrie darstellen. Der Fokus der Arbeit lag in der Steuerung der Partikelgröße durch die hydrothermale und mikrowellenunterstützte Kristallisation.

The IKEA customers are looking for new solutions to mount products in their homes and IKEA has embraced the request for this type of applications in bathroom environments as it is of the largest challenges for the customer. Double sided tape has been identified as a possible solution, hence why this project was put together. The research aims to give the reader a deeper understanding regarding double sided tape and the influences of external variables such as material, substrate and surface tension to mention a few. Extensive tests have been carried out where samples from double sided tape suppliers are examined. The test that was developed and carried out in this project aimed to include some of IKEA´s most commonly used materials together with common substrates in bathroom environments. The test data was compiled and the outcome was used to give recommendations to IKEA regarding future product development when using double sided tape and also recommend suitable tape suppliers for continued cooperation.

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

La migration cellulaire est un processus complexe. Lors du développement, elle permet aux cellules de rejoindre leur destination finale, puis à l'âge adulte elle intervient dans de nombreux processus tels la réponse immunitaire ou le développement de pathologies.La migration est modulée par l'action de molécules d'adhérence. Nous nous sommes intéressés à la molécule NCAM (Neural Cellular Adhesion Molecule) dont les effets sont modulés par l'acide polysalique (PSA). Lors de précédentes études, il a été montré que le peptide mimétique de PSA-NCAM, PR-21 stimulait la migration issus de la zone sous-ventriculaire (SVZ).Nous avons synthétisés des analogues non-peptidiques de PR-21 en nous appuyant sur des analogies structurales. ces analogues ont été testés dans divers modèles de migration cellulaire : explants de SVZ et cellules C6 sur-exprimant PSA. Nous avons mis en évidence la présence de fonctions structurales clés dans la modulation de la migration cellulaire. / Cell migration is a complex process. During development, it contributes to cell reaching their final target. during adulthood, cell migration is involved in immune response or pathological processes.Migration is modulated by adhesion molecules. We concentrated on the Neural Cellular Adhesion Molecule (NCAM) which action is regulated by the post traductional addition of polysialic acid (PSA). PR-21 is a mimetic peptide of PSA-NCAM. In previous studies, PR-21 has been shown to stimulate in the migration of meuroblasts from sub-ventricular zone (SVZ) to the olfactory bulb.We designed non-peptidic analogues of PR-21 on the basis of structural analogies. these analogues were tested on various cell migration models : SVZ explants and C6 over-expressing PSA. We then established the need of key structural functions to modulate cell migration.

The purpose of this study was to examine whether or not Public Service Announcements (PSAs) were an effective tool at modifying young adults’ perception of the r-word (the word “retard” or “retarded”). The PSAs included in this study were part of the Special Olympics’ “Spread the Word to End the Word” campaign. This study examined the efficacy of these PSAs by comparing three groups’ perception of the r-word: experimental group 1 who watched a PSA titled “It’s Not Acceptable” (PSA 1 group), experimental group 2 who watched a PSA titled “We Need a New R-word” (PSA 2 group), and a third control group who watched no PSA. The purpose of the control group was to gain a baseline of how today’s young adults perceived the r-word with no influence from PSAs. Six hundred and seventy-five participants were randomly assigned to one of the three groups. The two experimental groups watched their respective PSAs and completed the survey materials comprised of a consent form, their affective and cognitive responses to the PSA, their ratings of the r-word and their demographic information. The control group watched no PSA but completed the survey materials comprised of a consent form, their ratings of the r-word and their demographic information. This study then examined what the differences were between the three groups’ perception of the r-word. It was hypothesized that PSA 1 group would have a more negative perception of the r-word than PSA 2 group and the control group, due to PSA 1’s framing the r-word as similar to other minority slurs, and using affect to facilitate message acceptance. The PSA 1 group participants thought more about the argument within their PSA, and rated higher affective responses to their PSA, when compared to the PSA 2 group; however, PSA 1 group did not have a more negative perception of the r-word than the other two groups. Results found that the PSA 2 group perceived the r-word as significantly less respectful than the participants in the control group. These findings are discussed in terms of message design for future PSAs regarding the r-word