My doctoral work aims to construct a theoretical and intellectual framework to understand a set of remarkable developments concerning the Italian discourse on architecture from the early 1950s to the mid 1970s. This was when the term Rationalism and its theoretical body of work acquired renewed prestige replacing the ephemeral aesthetic of the modernist movement with a grounded discourse based on a deep understanding of the city as background of all architectural artifacts. The main hypothesis of my research is that this return to a rational methodology characterized by a deep understanding of architecture's internal building logic and identifiable in the work and ideas expressed in the International section of the XV Triennale Exhibition of 1973 had a significant and lasting impact on the thinking and formation of architecture culture in Italy and worldwide. This dissertation will thus attempt to construct a matrix of historical and methodological associations and demonstrations that validate and legitimize that rational methodology through a close examination of the work and key concepts of Tendenza, a group of architects in the Italy of the 1960s, pointing out their importance in preparing the ground for the International section of the XV Triennale Exhibition of 1973, which represented a major point of arrival and a point of departure for architecture culture in Italy and worldwide.

<p>For the moduli stack $\mathcal{M}_{g,n/\mathbb{F}_p}$ of smooth curves of type $(g,n)$ over Spec $\mathbb{F}_p$ with the function field $K$, we show that if $g\geq3$, then the only $K$-rational points of the generic curve over $K$ are its $n$ tautological points. Furthermore, we show that if $g\geq 3$ and $n=0$, then Grothendieck's Section Conjecture holds for the generic curve over $K$. A primary tool used in this thesis is the theory of weighted completion developed by Richard Hain and Makoto Matsumoto.</p> / Dissertation

A connection is established between uniform rational approximation, and approximation in the mean by polynomials on compact nowhere dense subsets of the complex plane C. Peak points for R(X) and bounded point evaluations for Hp(X, dA), 1 ≤ p < ∞, play a fundamental role.

Cryptosystems are used to provide security in communications and data transmissions. Stream ciphers are private key systems that are often used to transform large volumn data. In order to have security, key streams used in stream ciphers must be fully analyzed so that they do not contain specific patterns, statistical infomation and structures with which attackers are able to quickly recover the entire key streams and then break down the systems. Based on different schemes to generate sequences and different ways to represent them, there are a variety of stream cipher analyses. The most important one is the linear analysis based on linear feedback shift registers (LFSRs) which have been extensively studied since the 1960's. Every sequence over a finite field has a well defined linear complexity. If a sequence has small linear complexity, it can be efficiently recoverd by Berlekamp-Messay algorithm. Therefore, key streams must have large linear complexities. A lot of work have been done to generate and analyze sequences that have large linear complexities. In the early 1990's, Klapper and Goresky discovered feedback with carry shift registers over Z/(p) (p-FCSRS), p is prime. Based on p-FCSRs, they developed a stream cipher analysis that has similar properties to linear analysis. For instance, every sequence over Z/(p) has a well defined p-adic complexity and key streams of small p-adic complexity are not secure for use in stream ciphers. This disstation focuses on stream cipher analysis based on feedback with carry shift registers. The first objective is to develop a stream cipher analysis based on feedback with carry shift registers over Z/(N) (N-FCSRs), N is any integer greater than 1, not necessary prime. The core of the analysis is a new rational approximation algorithm that can be used to efficiently compute rational representations of eventually periodic N-adic sequences. This algorithm is different from that used in $p$-adic sequence analysis which was given by Klapper and Goresky. Their algorithm is a modification of De Weger's rational approximation algorithm. The second objective is to generalize feedback with carry shift register architecture to more general algebraic settings which are called algebraic feedback shift registers (AFSRs). By using algebraic operations and structures on certain rings, we are able to not only construct feedback with carry shift registers, but also develop rational approximation algorithms which create new analyses of stream ciphers. The cryptographic implication of the current work is that any sequences used in stream ciphers must have large N-adic complexities and large AFSR-based complexities as well as large linear complexities.

Sverige har bidragit med trupp till internationella insatser sedan 1950-talet. Detta har gjorts med bidrag från framför allt markstridskrafter men även med luftstridskrafter. Det dröjer fram till 2006 innan beslut tas om en marin internationell insats i form av korvettförband som bidrag till FN-insatsen UNIFIL i Libanon. Denna insats har fram till idag följts av fyra marina insatser, en förlängning av UNIFIL i Libanon 2007 och tre insatser i Somalia under åren 2009-2013. Beslutet om den marina insatsen i Libanon är för marinen banbrytande. Syftet med uppsatsen är att ge en ökad förståelse och insikt kring bakgrund och orsaker till beslutet. Bakomliggande orsaker till beslut om insats kan förklaras med hjälp av olika teorier och förklaringsmodeller. Denna uppsats använder sig av den amerikanske forskaren Graham Allissons modeller framtagna i boken ”Essence of decision: Explaining the Cuban Missile Crisis”. Två av tre modeller används för att anlysera beslutet, the Rational Actor och Organizational Behavior. Resultatet av analysen visar att det fanns en politisk enighet och uttalad målsättning att Sverige skulle bidra till en fredlig lösning i konflikten. Vidare framkommer att det vid tillfället för beslutet fanns få alternativ till det marina korvettförbandet, framför allt beroende på ekonomiska och personella förutsättningar i Försvarsmakten. Allisons modeller har fungerat som analysverktyg för att ge en ökad förståelse och insikt kring bakgrund och orsaker till beslutet. Modellerna ses som kompletterande till varandra då de belyser och framhäver olika aspekter och orsaker till det valda alternativet.

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Prescribing of drugs is an integral component of health care. In ideal situations drug prescribing constitute safe, effective, and inexpensive treatment alternatives for many conditions. However, poor and inappropriate prescribing is associated with illness and increased costs that can have an important impact at population level. Therefore, evaluation of the quality of drug prescribing is an important part of the process to improve quality in health care delivery. "Drug Utilisation 90%" (DU90) is an innovative approach to assess drug prescribing. Using this approach the drugs that represent 90% of the drug prescription/sales volume are identified. The rationale behind the development of DU90 rests on an assumption that a low number of products prescribed is associated with more rational prescribing practices. Furthermore, the approach can be used to asses what proportion of the drugs that represent 90% of the volume is made up by drugs recommended by local drug committees. In this essay, a feasibility study of DU90 is presented. Furthermore, the usefulness of DU90 as an indicator for quality assessment is discussed. It is concluded that DU90 does not directly reflect the quality of prescribing but it seems to be an useful tool in the quality assessment process through indicating areas that need to be analysed in more depth. The approach can be used for exploring drug prescribing data in a rapid, effective and inexpensive way / Läkemedelsförskrivningen är en viktig komponent inom sjukvården. Använd på rätt sätt är den en relativt säker, effektiv och mindre kostsam form av behandling jämförd med andra terapeutiska åtgärder. Utvärderingen av kvaliteten på läkemedelsförskrivningen är en viktig insats eftersom dålig läkemedelsförskrivning kan leda till onödig sjuklighet för patienten och ökade kostnader för samhället. Drug Utilisation 90 % (DU90) är en ny metod för utvärderingen av läkemedelsförskrivningen. Med hjälp av denna metod identifieras de läkemedel som utgör 90 % av förskrivnings/försäljningsvolymen. Konceptet har utvecklats baserat på antagandet att användning av få produkter är associerat med en mer rationell läkemedelsförskrivning. Baserad på DU90 kan även följsamheten till listan på rekommenderade läkemedel som utfärdas periodvis av Läkemedelskommittéerna, utvärderas inom 90 % av förskrivnings-/försäljningsvolymen. I denna uppsats presenteras en pilotstudie av användbarheten av DU90. Vidare diskuteras DU90 som indikator för kvalitetsutvärdering. Sammanfattningsvis dras slutsatsen att DU90 inte direkt reflekterar kvaliteten på läkemedelsförskrivningen men verkar vara ett användbart verktyg eftersom det kan ge värdefull indikation på terapiområden som behöver vidare analys. DU90 förefaller vara ett snabbt, effektivt och billigt instrument för utvärdering av förskrivningsdata. / <p>ISBN 91-7997-105-9</p>

Pseudozyma (Candida) antarctica lipase B (PalB) was expressed in Escherichia coli facilitating protein engineering. The lack of glycosylation was evaluated for a deeper understanding of the difficulties in expressing PalB in E. coli. Different systems were tested: periplasmic expression in Rosetta (DE3), cytosolic expression in Rosetta-gami 2(DE3), Origami 2(DE3), and coexpression of groES and groEL. Periplasmic expression resulted 5.2 mg/L active PalB at 16 °C in shake flasks. This expression level was improved by using the EnBase technology, enabling fed-batch cultivation in 24-deep well scale. The feed rate was titrated with the addition of α-amylase, which slowly releases glucose as energy source. Different media were evaluated where the EnBase mineral salt medium resulted in 7.0 mg/L of active PalB. Protein secreted directly into the media was obtained using the constitutive glyceraldehyde-3-phosphate dehydrogenase (GAP) promoter for screening and production of PalB in P. pastoris. A protease sensitive fusion protein CBM-PalB (cellulose-binding module) was used as a model system. When optimised, the expression system resulted in 46 mg/L lipase in 72 hours in shake flask, 37 mg/L lipase in 28 hours in 96-deep-well plate format, and 2.9 g PalB per 10 L bioreactor cultivation. The E. coli expression system was used to express a small focused library of PalB variants, designed to prevent water from entering the active site through a hypothesised tunnel. Screening of the library was performed with a developed assay, allowing for simultaneous detection of both transacylation and hydrolytic activity. From the library a mutant S47L, in which the inner part of the tunnel was blocked, was found to catalyse transacylation of vinyl butyrate in 20 mM butanol 14 times faster than hydrolysis. Water tunnels, assisting water in reaching the active sites, were furthermore found by molecular modelling in many hydrolases. Molecular modelling showed a specific water tunnel in PalB. This was supported by experimental data, where the double mutant Q46A S47L catalysed transacylation faster than hydrolysis compared to the wild type PalB. / <p>QC 20100818</p>

Increased possibilitiesof choosing one’s school of preference hasbeen raised as a key factor in many countries to promote equal opportunitiesand higher quality of education. This has been endorsed by policymakers whoassume that students make well-informed rational choices and that students only stress academic quality whendeciding which school to attend. If this is true, it will benefit schools ofhigh academic quality, rendering improved school quality overall. To date,little research has examined the validity of these assumptions despite theprofound effects they have had for changing the school systems in manycountries. This study employs an experimental approach to investigate therelative importance of attributes in school choice. Specifically the study isbased on experimental data from 587 prospective high school students inHalmstad, Sweden. The purpose is to contrast the principal school qualityattributes behind the policy change (academic reputation and programfeasibility), with the presence of friends and geographical attributes such asdistance, location and accessibility, while controlling for individualcharacteristics. The results are disturbing as they reveal flaws in theassumptions that motivated the school choice policy reform. The study presents evidence of differencesin preferences and that grades are the most important background characteristic for this difference. The study also shows that all studentsare not rational to the same extent as theory predicts. Hence theSwedish school reforms have been based on a slightly biased theory. Finally, the study indicates that differentgeographic contexts (e.g. where the studentslive) affect students' preferences.

This thesis explores and implements techniques for frequency domain modelling and time domain simulation of overhead transmission lines. The popular Vector Fitting algorithm is employed to approximate the frequency domain model using rational functions, and the recursive convolution technique is applied to the rational approximation to generate a time domain form. The frequency domain model is translated into the time domain using delay extraction, modal decomposition, passivity enforcement, and rational approximation. Several approaches to each of these procedures are investigated. The thesis also discusses several choices for the integration method used within the recursive convolution procedure. In order to make the transmission line modeller and simulator easy to use, a Java-based library and partial graphical interface were developed. Specifically, the goal was to develop a platform-independent program that can run either stand-alone or as an applet inside a web page.