The purpose of this action research is to discover how self-evaluation training affects students’ knowledge and understanding about their writing and needs for improvement. In this study of 46 fifth and sixth graders, students underwent a four-stage self-evaluation training process. This involved students in defining criteria for their stories, teaching them how to apply the criteria using a variety of samples, giving students feedback about their self-evaluations, and developing action plans The study showed that after the self-evaluation process was set into place, students had an increased awareness of what made a good fictional writing piece. The self-evaluation process helped students become more aware of writing practices and of themselves as a writer. The study also found that the self-evaluation process set clear guidelines for students, focused student attention on important writing criteria, and opened up the conversation between students and teachers about evaluation, goal setting and the writing process.

The purpose of this action research is to discover how self-evaluation training affects students’ knowledge and understanding about their writing and needs for improvement. In this study of 46 fifth and sixth graders, students underwent a four-stage self-evaluation training process. This involved students in defining criteria for their stories, teaching them how to apply the criteria using a variety of samples, giving students feedback about their self-evaluations, and developing action plans The study showed that after the self-evaluation process was set into place, students had an increased awareness of what made a good fictional writing piece. The self-evaluation process helped students become more aware of writing practices and of themselves as a writer. The study also found that the self-evaluation process set clear guidelines for students, focused student attention on important writing criteria, and opened up the conversation between students and teachers about evaluation, goal setting and the writing process.

Students with emotional and behavioral disorders (E/BD) have academic deficits that affect their success in school; however, few researchers have investigated what strategies work best for this population, especially in the area of writing. One promising intervention to support the writing skills of students with and at-risk for E/BD is self-regulated strategy development (SRSD). SRSD is a six-stage, explicit strategy instruction model that includes procedures for goal setting, self-monitoring, self-instruction, and self-reinforcement and can be generalized to a variety of writing tasks. The purpose of this study was to determine the effects of an SRSD persuasive writing intervention on the writing achievement of 44 students in a residential school. Results of a piecewise hierarchical linear modeling growth curve analysis suggest statistically significant gains were made over the course of the intervention in writing (quality, correct word sequences, and essay elements) and academic engagement. Effects also generalized to writing achievement measures. In addition, teachers implemented the intervention with high fidelity, and both students and teachers rated the intervention as socially acceptable, with higher ratings postintervention.

Bakgrund: I Sverige ska de statligt ägda bolagen från och med den första januari 2008, upprätta en hållbarhetsredovisning. Motsvarande skyldighet finns inte för icke-reglerade bolag, dessa kan dock frivilligt välja att presentera hållbarhetsinformation. Institutionell teori menar att organisationer inom en institution efterliknar varandra som ett reslutat av samhällets påtryckningar. Regeringens riktlinjer gällande en obligatorisk hållbarhetsredovisning för statliga bolag skulle på så sätt kunna resultera i en indirekt reglering av de icke-reglerade företagen. De undersökta bolagen i denna studie är det statliga bolaget Vattenfall AB samt de icke-reglerade bolagen E.ON Sverige AB, Tekniska Verken i Linköping AB och Mälarenergi AB. Syfte: Syftet med uppsatsen är att undersöka huruvida de fyra undersökningsföretagen kan ha påverkats av Regeringens riktlinjer för en obligatorisk hållbarhetsredovisning för statliga bolag. Avsikten är även att utifrån de tre icke-reglerade bolagen synliggöra situationer där riktlinjerna indirekt skulle kunna påverka. Metod: Uppsatsen är en kvalitativ tvärsnittsstudie av de fyra bolagen. En litteraturstudie av företagens hållbarhetsredovisningar och kvalitativa semistrukturerade intervjuer har genomförts. Slutsats: Vattenfall har genom en tvingande isomorfi blivit direkt reglerade då de valt att samtycka till Regeringens riktlinjer. Uppsatsens insamlade empiri indikerar att det finns två eventuella situationer där Regeringens riktlinjer indirekt skulle kunna påverka de icke-reglerade bolagens hållbarhetsredovisningar; (1) genom en ökad mediebelysning av publicering av Regeringens riktlinjer och (2) genom benchmarking gentemot andra företag. / Background: In Sweden the state-owned companies are as of January 1st 2008 directly bounded to establish a sustainability report. There is no equivalent legislation available for the non-regulated companies, they may however voluntarily choose to present sustainability information. Institutional theory argues that organizations within an institution resemble each other as a result of the society’s social pressure. The Government’s guidelines regarding a mandatory sustainability report for state-owned companies could result in an indirect regulation of the non-regulated companies. The companies featured in this study is the state-owned company Vattenfall AB and the three non-regulated companies E.ON Sverige AB, Tekniska Verken i Linköping AB and Mälarenergi AB. Purpose: The aim of this paper is to examine whether there is a possibility that the four chosen companies can have been affected by the Government’s guidelines. The purpose is also to highlight possible situations where the guidelines indirect could affect the non-regulated companies.Method: This essay is a qualitative cross-sectional study of the four companies. A literature review of the companies’ sustainability reports and qualitative semi-structured interviews has been conducted. Results: Vattenfall has through a coercive isomorphism become directly regulated, because they have chosen to acquiescence to the Governments guidelines. The study’s empirical data indicates two possible situations where the guidelines could indirect affect the non-regulated companies; (1) through increased media attention of the publication of the Guidelines and (2) through impact through benchmarking.

Bandgap reference circuits are used in a host of analog, digital, and mixed-signal systems to establish an accurate voltage standard for the entire IC. The accuracy of the bandgap reference voltage under steady-state (dc) and transient (ac) conditions is critical to obtain high system performance. In this work, the impact of process, power-supply, load, and temperature variations and package stresses on the dc and ac accuracy of bandgap reference circuits has been analyzed. Based on this analysis, the a bandgap reference that 1. has high dc accuracy despite process and temperature variations and package stresses, without resorting to expensive trimming or noisy switching schemes, 2. has high dc and ac accuracy despite power-supply variations, without using large off-chip capacitors that increase bill-of-material costs, 3. has high dc and ac accuracy despite load variations, without resorting to error-inducing buffers, 4. is capable of producing a sub-bandgap reference voltage with a low power-supply, to enable it to operate in modern, battery-operated portable applications, 5. utilizes a standard CMOS process, to lower manufacturing costs, and 6. is integrated, to consume less board space has been proposed. The functionality of critical components of the system has been verified through prototypes after which the performance of the complete system has been evaluated by integrating all the individual components on an IC. The proposed CMOS bandgap reference can withstand 5mA of load variations while generating a reference voltage of 890mV that is accurate with respect to temperature to the first order. It exhibits a trimless, dc 3-sigma accuracy performance of 0.84% over a temperature range of -40°C to 125°C and has a worst case ac power-supply ripple rejection (PSRR) performance of 30dB up to 50MHz using 60pF of on-chip capacitance. All the proposed techniques lead to the development of a CMOS bandgap reference that meets the low-cost, high-accuracy demands of state-of-the-art System-on-Chip environments.

English Language Learners (ELLs) are a growing population within the U.S. school system. In the secondary grades, this diverse group requires instruction to improve not only English language proficiency but also utilization of the academic language register, especially in writing tasks. The present study focused on ELLs in middle school. The aim was to explore the effects of enhanced Self–Regulated Strategy Development (SRSD) writing instruction on the use of complex language, particularly elaborated noun phrases (ENPs) when SRSD was combined with linguistic instruction on increased sentence complexity. As a part of a larger study exploring critical literacy and the persuasive writing instruction of Spanish–English speaking students, this repeated measures design detailed the effects of two six–week instructional periods aimed at teaching 19 ELLs methods for organizing, planning, and constructing persuasive texts (the macr–-structure level), as well as ways of incorporating academic language forms and functions in their writing (the micro–structure level). Within the critical literacy project that involved topics and themes related to immigration, the 19 students produced three texts in English (pre–, mid–, and post–instruction essays). These texts were analyzed for ENP frequency and complexity. Three case studies were also chosen to highlight the variation in ENP outcomes and to discuss additional aspects of persuasive writing at both the macr–- and micro–structure levels. Statistical analysis of group use of ENPs revealed no significant increase in frequency or complexity across essays as simple pre–noun modifications were produced in amounts greater than all other ENP type across all essays. The three case studies revealed that frequency of ENP use generally corresponded to strength of abilities at either the macro–structure level, such as inclusion of more persuasive elements, or the micro–structure level as indicated by increased text length and variety of vocabulary. One implication of these outcomes indicates the need for more in–depth emphasis on the coordination of both the macro– and micro–structure levels in writing instruction studies with ELLs. Other implications pertain to further analysis of classification approaches for designating ENP complexity, and how enhanced understanding of ENP production signals aspects of the academic language register.

Activation of the MAPK cascade during mitosis is critical for spindle assembly and normal mitotic progression. The underlying regulatory mechanisms that control activation of the MEK/MAPK cascade during mitosis are poorly understood. The goal of my dissertation research is to identify the MEK kinase responsible for activation of the MAPK cascade during mitosis and to elucidate the biochemical mechanisms that regulate its activity. In the described herein work I purified and characterized the MEK kinase activity present in M-phase arrested Xenopus egg extracts. I demonstrate that B-Raf is the critical MEK kinase required for activation of the MAPK pathway at mitosis. Consistent with this, I show that B-Raf is activated in an M-phase dependent manner. Further, I provide data linking Cdk1/cyclin B to mitotic activation of B-Raf. Cdk1/cyclin B associates with and phosphorylates B-Raf in M-phase arrested extracts and directly targets Xenopus B-Raf in vitro at a conserved Ser-144 residue. Phosphorylation at Ser-144 is critical for M-phase dependent activation of B-Raf and for B-Raf's ability to trigger activation of the MAPK cascade at mitosis. Finally, I demonstrate that mitotic B-Raf undergoes feedback phosphorylation by MAPK at its conserved C-terminal SPKTP motif. Mutation of both phosphorylation sites within the SPKTP sequence to alanines increases activity of mitotic B-Raf. Further, inhibition or over-activation of MAPK during mitosis enhances or diminishes B-Raf activity, respectively. These results indicate that MAPK-mediated feedback phosphorylation negatively regulates B-Raf activity. Additionally, I show that active mitotic B-Raf exists in large multi-protein complex(s). By utilizing a proteomics approach I identify a set of proteins, which potentially associate with B-Raf at M-phase. Future studies are necessary to elucidate the involvement of these proteins in regulating B-Raf mitotic functions. In summary, my dissertation studies demonstrate that B-Raf activates MAPK signaling at mitosis and undergoes an M-phase dependent regulation. I propose that B-Raf has important functions at mitosis that contributes to its overall role in promoting cell proliferation.

As a result of the interactive nature of modern programming languages the perception has developed that proper planning of a solution, reasoned action during the process of problem solving and evaluation of the solution have become less important during computer programming. Learn often rely on the programming language to help them solve a problem, without themselves planning the solution beforehand and then using a computer language to implement the solution. This approach usually leads to using bad programming techniques, resulting in unstructured programmes or rendering the learner unable to solve the problem. The importance of continuous reflection by learners while doing a programming activity has been advocated for quite some time... / Thesis (M.Ed.)--North-West University, Potchefstroom Campus, 2006.

<p><font size="3" face="Arial"><font size="3" face="Arial"> <p align="left">In this study, I will look at the common law principle of offset to see whether it can be applied to employers making deductions against employees for loss or damage. Notice is a quantifiable amount and is a legal debt / therefore. it should be able to be applied as an offset. Two subsections deal with deductions / after looking carefully at the wording of theses subsections I will try to determine whether the one is alternate to the other, or whether the narrow interpretation that the Department of Labour gives to the statute is accurate. A narrow interpretation of the law states that the employee must sign an acknowledgement of debt. However, employees often refuse to sign an acknowledgement of debt, thereby frustrating the law. Could this possibly have been the intentions of the drafters? Surely not, yet the Department of Labour, by having a narrow interpretation of the law, see it as such and as a result the employer is left out of pocket. In this mini-thesis, I will look at the way the law should be interpreted and the way it should be applied in practice.</p> <p>&nbsp / </p> </font></font></p>

<p>\abstract</p><p>Transcription and translation describe the flow of genetic information from DNA to mRNA to protein. Recent studies show that at a single cell level, these processes are stochastic, which results in the variation of the number of mRNA and proteins even under identical environmental conditions. Because the number of mRNA and protein in each single cell are actually very small, these variations can be crucial for cellular function in diverse contexts, such as development, stress response, immunological and nervous system function. Most studies examine the origin and effects of stochastic gene expression using computer simulations. My goal is to develop a theoretical framework to study activity-dependent gene expression using simplified models that capture essential features. </p><p>I have examined the dynamics of stochastic gene regulation in three contexts. First, I examine how fluctuations in promoter accessibility lead to "bursty" transcription, during which genes are turned "on" or "off" stochastically. I describe a mathematical formalism to represent bursty gene expression in a coarse-grained manner as a Markov process and derive a master equation for the time evolution of the probability distribution of the number of mRNA molecules. This allows us to examine how transcript number responds to time varying stimuli. This model forms a basic building block for understanding the signal transmission and noise of the transcription process to time varying inputs as would be sensed by cells in dynamic environments. In addition to synthesis, gene expression is subject to additional modes of regulation. One such mechanism that controls transcript numbers is by microRNAs (miRNAs), which pair with target mRNAs to repress protein production following transcription. Although hundreds of miRNAs have been identified in mammalian genomes, the function of miRNA-based repression in the context of gene regulation networks still remains unclear. I explore the functional roles of feedback regulation by miRNAs and show that protein fluctuations strongly depend on the mode of miRNA-mediated repression. I discuss the functional implications of protein fluctuations arising from miRNA-mediated repression on gene regulatory networks. Finally, I examine the impact of fluctuations on alternative splicing, which is a major source for proteomic complexity in higher eukaryotes. Although the proteins regulating alternative splicing have been extensively studied, little is known about how noise arising from the stochastic nature of alternative splicing contributes to the entire gene expression process. I explore the functional roles and noise properties of alternative splicing, focusing on the case of exon skipping and intron retention. I show that while the overall counts of the mRNAs of the two isoforms are independent and Poisson distributed, diffusion and binding of the splicing factors contributes to the variance in the abundance of the isoforms. </p><p>Noise in gene expression may be of particular relevance in the nervous system. Environmental stimuli drive the rapid remodeling of neural circuitry in part by inducing the activation of genes to make proteins that modify neuronal excitability and connectivity, ultimately influencing higher order brain function. Finally, I examine the implications of our studies for activity dependent gene expression in the nervous system.</p> / Dissertation