The aim of this diploma thesis is to design and implement a web application focused on rephotography management. Analyze existing solutions, create list of features and simple graphical user interface. It also includes a design of API structure to communicate with the mobile application. Essential application requirements include adding photos on a map and combining different photos in a photo editor with enhanced auto-alignment features.

The goal of this thesis was to design two complex scenarios with focus on different kinds of transmission in packet-switched networks. First scenario is about ARQ (Automatic Repeat Request) protocols. It consists of introduction to Stop-and-Wait, Go Back N and Selective Repeat protocols and their comparison. Second scenario compares unicast, multicast, broadcast and anycast transmission methods. Both scenarios use applications which can simulate particular methods or protocols. These applications along with virtual environments are used for demonstration of characteristics of these methods/protocols.

The diploma thesis aimed at the study of the topic of communication protocols and several transmission modes, as well as ARQ (Automatic Repeat Request) mechanisms. Subsequently, the task was to design and describe individual scenarios for their simulation. As a part of solving the mentioned task, it was necessary to create an application that allows the emulation of the behaviour of communication protocols without the need for a transmission in the real network a nd the requirements for the edition of the source code. The application was created in the Microsoft Visual Studio 2017 development environment using the C# programming language and .NET framework and it consists of a library and a graphical interface. The output of the solution is the application of a mode simulator of the data transmission in the network with two scenarios with the prepared input situations in the frame of graphical environment together with instructions, additional tasks and sample solutions. The program allows the simulation of the behaviour of communication protocols between the client and the server without the need for a transmission in a real network. In conclusion, the simulator of data transfer was created in the form of the desktop application which contains two scenarios. The first scenario is used to simulate ARQ mechanisms and the second one is active in the simulation of commutation of messages, circuits, packets or cells.

(in English) The aim of this work is to perform an in-depth analysis of the workplace of the children's crisis line - Linka bezpečí, focusing on the work of consultants with repeat callers of this line. The chosen subject was processed by a quantitative method (finding the number of calls with long-term clients on the crisis line during the six-month period, the duration of these calls, the topics that repeat callers bring to the calls on the line, etc.) and the qualitative method - organization a focus group with Linka bezpečí line's staff to find out their potential to work with long-term clients. The main result of the thesis is a summary of the findings, which make the work with the long-term calling clients easy for the workers and which, on the contrary, make it difficult, along with practical tips for practice.

Repeat sprint ability has been investigated thoroughly, however optimal training methodology to improve RSA remains elusive. Both kinetic and physiological viewpoints have been used to scrutinize aspects of RSA including, initial sprint performance (anaerobic power), maximal cardiorespiratory fitness (VO2max), lactate threshold, anaerobic capacity (mean power), muscle activation (EMG), and local muscle oxygenation kinetics. To our knowledge no study has utilized maximal strength levels as a separate factor among a homogenous group of cardiorespiratory fitness individuals (as determined by peak VO2 during RSA). The purpose of this study was to better understand the relationship between maximal strength, muscular characteristics, and cycling RSA- respective to muscle oxygenation responses. Fifteen participants completed fifteen 10-second maximal effort sprints on a cycle ergometer interspersed with 30-seconds passive recovery. Respiratory, muscle oxygenation, and kinetic responses were monitored continuously and evaluated relationships with maximal strength and muscular architecture as determined by isometric mid-thigh pull and ultrasonography respectively. A series of 2 x 15 mixed design, group x time, ANOVA’s were used to evaluate the effects of group and or sprint on muscle oxygenation kinetics. Strong individuals were found to have significantly greater levels of muscle oxygenation usage, recovery and the respective rates; p = 0.01, p = 0.02, p

Plus de 80 000 libérations des prisons de France ont été enregistrées chaque année au cours de la dernière décennie. La question du devenir pénal des sortants de prison s’impose dans une réflexion générale sur la récidive et la réinsertion sociale. Un échantillon de la population carcérale a été constituée à partir d’un terrain professionnel afin d’étudier les parcours et les profils sociaux des sortants. Cette recherche, dans une approche quantitative et qualitative, tente de dégager les déterminants sociaux les plus prédictifs de l’évolution du parcours post-carcéral.L’analyse des effets des fins de peines aménagées, et plus généralement les parcours de vie, permet d’isoler un certain nombre de facteurs qui marquent, en tendance, la poursuite d’un parcours pénal. La nature et la qualité du lien social qui caractérise l’individu avant l’incarcération, déterminent la poursuite d’un parcours pénal ou son interruption. Se trouve également réaffirmée la plus forte répression de l’illégalisme populaire (vol, violence, infraction au code de la route), délinquance touchée le plus largement par la récidive, et caractéristique des couches sociales les plus pauvres. / More than 80 000 inmates have been released from French prisons in the last ten years. Questions about these releasees had to be studied from the point of view of recidivism and social reintegration. A sample of the French inmate population has been built, from a professional field, to study the social profiles and courses of the released inmates. This study tries, by quantitative and qualitative approach, to find the most predictive social determinants of the individual post-custodial journey.Analysing the results of sentence adjustments, and more generally life courses, made it possible to isolate a number of factors that can predict the pursuit (or not) of a criminal route.The nature and the quality of the integration into the social fabric before custody, defines the continuation or interruption of a criminal life.The strongest repression of the most common offences (theft, violence, reckless driving) is also confirmed by the study as well as the fact that the segment of the population most affected by repeat offenses are the poorest classes.

Les intoxications médicamenteuses volontaires répétées (IMVr) constituent un problème de santé publique croissant, mais sous-évalué et traité comme une conduite suicidaire, alors qu’elles appartiendraient au registre des addictions. Notre travail abonde dans ce sens en montrant que les suicides alcoolisés se font principalement par IMV et correspondent au deliberate self-harm syndrom ; les suicidants récidivants se distinguent par un névrosisme et un attachement anxieux typiques des addictions ; les IMVr même suicidaires témoignent d’une relation addictive aux médicaments ; le facteur le plus prédictif d’IMV serait de l’avoir envisagée. Conceptualisé de façon translationnelle et argumenté par une approche pharmacologique, nous proposons un modèle dimensionnel des conduites suicidaires, intégré au continuum des addictions, confirmant l’hypothèse initiale et l’intérêt d’un raisonnement transnosographique diagnostique et thérapeutique dans le champ des pathologies mentales. / Repeated Self-poisoning (RSP) constitute an under evaluated but growing public health problem, treated as a suicidal rather than an addictive behavior. Our work brings arguments by showing that suicides involving alcohol are mainly by self-poisoning and correspond to deliberate self-harm syndrome; repeat suicide attempters are identified by a neuroticism and anxious attachment typically found in addicts; even suicidal RSP shows addictive behavior involving medicines; the best predictor of self-poisoning is having thought about it. Conceptualized through a translational approach and supported by pharmacological arguments, we propose a multidimensional model of suicidal behaviors, that could integrate the continuum of addictive behaviors. This confirms the initial hypothesis and the viability of a transnosographic concept for diagnosis and treatment of mental illnesses.

Indiana University-Purdue University Indianapolis (IUPUI) / SETMAR is a chimeric protein that originates from the fusion of a SET domain to the mariner Hsmar1 transposase. This fusion event occurred approximately 50 million years ago, after the split of an anthropoid primate ancestor from the prosimians. Thus, SETMAR is only expressed in anthropoid primates, such as humans, apes, and New World monkeys. Evolutionary sequence analyses have revealed that the DNA-binding domain, one of the two functional domains in the Hsmar1 transposase, has been subjected to a strong purifying selection. Consistent with these analyses, SETMAR retains robust binding specificity to its ancestral terminal inverted repeat (TIR) DNA. In the human genome, this TIR sequence is dispersed in over 1500 perfect or nearly perfect sites. Given that many DNA-binding domains of transcriptional regulators are derived from transposases, we hypothesized that SETMAR may play a role in gene regulation. In this thesis, we determined the crystal structures of the DNA-binding domain bound to both its ancestral TIR DNA and a variant TIR DNA sequence at 2.37 and 3.07 Å, respectively. Overall, the DNA-binding domain contains two helix-turn-helix (HTH) motifs linked by two AT-hook motifs and dimerizes through its HTH1 motif. In both complexes, minor groove interactions with the AT-hook motifs are similar, and major groove interactions with HTH1 involve a single residue. However, four residues from HTH2 participate in nucleobase-specific interactions with the TIR and only two with the variant DNA sequence. Despite these differences in nucleobase-specific interactions, the DNA-binding affinities of SETMAR to TIR or variant TIR differ by less than two-fold. From cell-based studies, we found that SETMAR represses firefly luciferase gene expression while the DNA-binding deficient mutant does not. A chromatin immunoprecipitation assay further confirms that SETMAR binds the TIR sequence in cells. Collectively, our studies suggest that SETMAR functions in gene regulation.

Subconcussive (SC) impacts have become a growing concern within the neuroscience community regarding the immediate and long-lasting effects of sports-related injuries. While a single low-level impact, i.e., a subconcussion, may not cause cerebral perturbations, it has been increasingly recognized that repeated SC exposure can induce deleterious effects. Therefore, determining the lower limits of systematic perturbation resulting from multiple SC impacts is of critical importance in expanding our understanding of cerebral vulnerability and recovery. Currently, there is a lack of correlation between a mild traumatic brain injury (mTBI) and repeated SC impacts with respect to injury biomechanics. Moreover, the cumulative threshold for repetitive low-level impacts is currently undefined. Thus, this research was designed to determine the pathophysiological differences between a single impact of an mTBI and repeated SC impacts with a subdivided cumulative kinetic energy of the single mTBI impact. In order to address this gap in knowledge, the present investigation employed a surgery-free, closed-head, weight drop injury device capable of producing repeatable, head impacts within a rat model. General locomotion and anxiety-like behavior were assessed using an Open Field Test and motor coordination dysfunction was measured using the rotarod assay. Neuroinflammation was measured using immunohistochemical assessment of astrogliosis (GFAP) and microgliosis (Iba-1) within the hippocampus. Additionally, immunohistochemical assessment of neuronal loss (NeuN) was measured within the hippocampus. To investigate the tolerance and the persistence of cerebral vulnerability following a single mTBI and repeated subconcussive impacts, measurement outcomes were assessed over two-time points (3- and 7-days) post final impact. Although injury groups were not statistically different from their associated sham groups with respect to behavioral outcomes; on average, RSC injury rats displayed a significant increase in anxious-like behavior after 7-days of recovery compared to the single mTBI group. From an inflammatory perspective, both mTBI and RSC injury groups led to extensive microgliosis in the gray matter following 3-days post-impact. Overall, this work’s findings do not provide evidence in support of the notion that repeated subconcussive impacts do result in behavioral disturbances and neuroinflammation, that do not manifest following a single mTBI of the same energy input.

Interferometry and coherent change detection (CCD) utilize phase differences between complex SAR images to find terrain height and to detect small changes between images, respectively. A new method for improving interferometry and CCD using multiple sub-apertures is proposed. Using backprojection processing, multiple sub-aperture images are created for a pair of flights. An interferogram and coherence map is made from each sub-aperture. For CCD, each sub-aperture coherence map offers an independent estimate of the coherence over the same area. By combining coherence maps, low coherence areas associated with residual motion errors are reduced, shadowed areas are minimized, and the overall coherence of stationary objects between images is increased. For interferometry, combining independent estimates of a scene's height offers a more accurate height estimate. For repeat-pass interferometry, multiple apertures are shown to increase the coverage of valid height estimates. The benefits of multi-aperture interferometry and CCD are shown using examples with real data.