Univ., Diss.--Basel, 2002.

This thesis presents how to establish a theoretical model to predict risk of thermal cracking in young concrete when cast on ground or an arbitrary construction. The crack risk in young concrete is determined in two steps: 1) calculation of temperature distribution within newly cast concrete and adjacent structure; 2) calculation of stresses caused by thermal and moisture (due to self-desiccation, if drying shrinkage not included) changes in the analyzed structure. If the stress reaches the tensile strength of the young concrete, one or several cracks will occur. The main focus of this work is how to establish a theoretical model denoted Equivalent Restraint Method model, ERM, and the correlation between ERM models and empirical experiences. A key factor in these kind of calculations is how to model the restraint from any adjacent construction part or adjoining restraining block of any type. The building of a road tunnel and a railway tunnel has been studied to collect temperature measurements and crack patterns from the first object, and temperature and thermal dilation measurements from the second object, respectively. These measurements and observed cracks were compared to the theoretical calculations to determine the level of agreement between empirical and theoretical results. Furthermore, this work describes how to obtain a set of fully tested material parameters at CompLAB (test laboratory at Luleå University of Technology, LTU) suitable to be incorporated into the calculation software used. It is of great importance that the obtained material parameters describe the thermal and mechanical properties of the young concrete accurately, in order to perform reliable crack risk calculations.  Therefore, analysis was performed that show how a variation in the evaluated laboratory tests will affect the obtained parameters and what effects it has on calculated thermal stresses.

No description available.

Made available in DSpace on 2014-12-17T15:37:20Z (GMT). No. of bitstreams: 1 AlineLD_DISSERT.pdf: 1012769 bytes, checksum: dbe4a7a77cff780cc71b4acb54601b4b (MD5) Previous issue date: 2014-04-11 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The physiologist H. Selye defined stress as the nonspecific response of the body to any factors that endanger homeostasis (balance of internal environment) of the individual. These factors, agents stressors, are able to activate the Hypothalamic-Pituitary-Adrenal (HPA) axis, thus resulting in the physiological responses to stress by the release of glucocorticoids that leads to psychophysiological changes, including effects on cognitive functions such as learning and memory. When this axis is acutely stimulated occurs a repertoire of behavioral and physiological changes can be adaptive to the individual. Notwithstanding, when the HPA axis is chronically stimulated, changes may favor the development of, such as anxiety disorders. Some drugs used in the clinic for the treatment of anxiety disorders these can exert effects on cognitive function, on the HPA axis and on the anxiety. In this context, the aim of our study was to investigate the effects of administration i.p. acute of diazepam (DZP, 2 mg/kg), buspirone (BUS, 3 mg/kg), mirtazapine (MIR, 10 mg/kg) and fluoxetine (FLU, 10 mg/kg) in male mice submitted to acute restraint stress, and evaluated using plus-maze discriminative avoidance task (PMDAT), which simultaneously evaluates parameters such as learning, memory and anxiety. Our results demonstrated that (1) the administration of DZP and BUS, but not FLU, promoted anxiolytic effects in animals; (2) administration mirtazapine caused sedative effect to animals; (3) in the training session, the animals treated with BUS, MIR and FLU learned the task, on the other hand DZP group showed impairment in learning; (4) in the test session, animals treated with DZP, BUS, and MIR showed deficits in relation to discrimination between the enclosed arms, aversive versus non-aversive arm, demonstrating an impairment in memory, however, animals treated with FLU showed no interference in the retrieval of this memory; (5) acute stress did not interfere in locomotor activity, anxiety, or learning on the learning task, but induced impairment in retrieval memory, and the group treated with FLU did not demonstrated this deficit of memory . These results suggest that acute administration of drugs with anxiolytic and antidepressant activity does not interfere with the learning process this aversive task, but impair its retrieval, as well as the acute restraint stress. However, the antidepressant fluoxetine was able to reverse memory deficits promoted by acute stress, which may suggest that modulation, even acutely serotonergic neurotransmission, by selectively inhibiting the reuptake of this neurotransmitter, interferes on the process of retrieval of an aversive memory / O fisiologista H. Selye definiu estresse como a resposta n?o espec?fica do organismo a quaisquer fatores que coloquem em risco a homeostase (equil?brio do meio interno) do indiv?duo. Esses fatores, os agentes estressores, s?o capazes de ativar o eixo Hipot?lamo-Hip?fise-Adrenal (HPA), resultando assim na resposta fisiol?gica ao estresse. Quando esse eixo ? agudamente estimulado, ocorre um repert?rio de mudan?as comportamentais e fisiol?gicas adaptativas ao indiv?duo. Por outro lado, quando o eixo HPA ? cronicamente estimulado, podem ocorrer modifica??es psicofisiol?gicas prejudiciais ao indiv?duo, entre elas, efeitos sobre as fun??es cognitivas, como na aprendizagem e na mem?ria, al?m do desenvolvimento de patologias, como os transtornos de ansiedade. Alguns f?rmacos utilizados na cl?nica para o tratamento de transtornos de ansiedade podem exercer efeitos sobre fun??es cognitivas, sobre o eixo HPA e sobre a ansiedade. Neste contexto, o objetivo de nosso estudo foi verificar os efeitos da administra??o aguda de quatro f?rmacos, o diazepam (DZP, 2 mg/Kg), a buspirona (BUS, 3 mg/Kg), a mirtazapina (MIR, 10 mg/Kg) e a fluoxetina (FLU, 10 mg/Kg) em camundongos machos submetidos ao estresse agudo por conten??o, utilizando a tarefa de esquiva discriminativa em labirinto em cruz elevado, que avalia simultaneamente par?metros de aprendizagem, mem?ria e ansiedade. Nossos resultados demonstraram que (1) a administra??o do DZP e da BUS promoveu efeitos ansiol?ticos nos animais, mas n?o a FLU; (2) a MIR causou efeito sedativo aos animais; (3) durante a sess?o de treino, os animais tratados com BUS, MIR e FLU aprenderam a tarefa, por outro lado o grupo DZP demonstrou preju?zo na aprendizagem; (4) na sess?o teste, animais tratados com DZP, BUS, e MIR mostraram d?ficit na discrimina??o entre os bra?os fechados, aversivo versus n?o aversivo, demonstrando um preju?zo na mem?ria, entretanto, animais que receberam FLU n?o mostraram interfer?ncia na evoca??o dessa mem?ria; (5) o estresse agudo n?o interfere na aprendizagem da tarefa, mas induz preju?zo na evoca??o da mem?ria, sendo este preju?zo revertido apenas para o grupo tratado como FLU. Esses resultados sugerem que a administra??o aguda de f?rmacos com atividade ansiol?tica e antidepressiva n?o interferem no processo de aprendizagem desta tarefa aversiva, mas prejudicam sua evoca??o, bem como o estresse agudo de conten??o. Contudo, o antidepressivo fluoxetina foi capaz de reverter o d?ficit de mem?ria promovido pelo estresse agudo, o que pode sugerir que a modula??o, mesmo que agudamente da neurotransmiss?o serotonin?rgica, por inibidores seletivos da recepta??o desse neurotransmissor, interfere no processo de consolida??o de uma mem?ria aversiva

Neste trabalho estudam-se os efeitos dependentes do tempo em vigas de concreto pré-moldado, protendidas ou não, com concretagem posterior formando um conjunto de seção composta com lajes alveolares, usual em pavimentos de edifícios, e ocasionando um estabelecimento da continuidade com ligação semi-rígida. Os esforços de restrição causados pelos efeitos de retração e fluência dos diversos concretos envolvidos e possível relaxação das cordoalhas de protensão nos extremos dessas vigas acarretam uma redistribuição de esforços função do tempo, causando deslocamentos axiais e rotações no elemento. Esta análise é feita utilizando a programação em elementos finitos CONS, própria para análise não-linear de estruturas em concreto construídas evolutivamente, aplicada a modelos representativos. O programa CONS apresentou bastante precisão na avaliação dos efeitos do tempo respaldado por estudos experimentais. Com base no estudo de dois modelos representativos de concreto pré-moldado foi observado que: a) os momentos de restrição acarretaram modificações sensíveis na região da ligação influenciando na fissuração da peça e no valor final de momento fletor, com alterações de até 80% para a viga de concreto armado, e inversão do sinal para a viga de concreto protendido; b) em comparação com as demais, as deformações axiais tiveram uma maior influência dos efeitos do tempo chegando a acréscimos posteriores à imposição do último carregamento de até 90% para a viga de concreto protendido; c) a retração diferencial entre concretos de idades distintas originou tensões de tração consideráveis em especial na região da interface. / In this research, time-dependent effects in precast concrete beams, prestressed or not, with posterior concreting resulting in a structure of a composite cross section with hollow core slabs, usual in buildings floors, and made continuous with semi-rigid connection are studied. The restraint stresses caused by the effects of the shrinkage and creep of the various concretes involved and possible relaxation of the prestressed tendons in the extremities of these beams imply in a rearrangement of time-dependent stresses, leading to axial deflection and rotations in the element. This analysis is made using the finite element based program CONS for non-linear analysis of progressively assembled concrete structures, applied in representative samples. CONS presented great accuracy in the evaluation of time effects supported by experimental studies. Based on a study of two precast concrete structures examples, it was observed that: a) the restraint stresses lead to sensible modifications in the connection, influencing on the cracking of the piece and in the final bending moment with changes of 80% for the reinforced concrete sample, and sign inversion for the prestressed one; b) In comparison among the others, the axial deformation had a greater influence in time effects in the samples analyzed, with increases after the last load of 90% in the prestressed example; c) the differential shrinkage between concretes of different ages has generated great tensile stresses, specially on the interface.

RESUMO FORTALEZA, E. A. T. Função da neurotransmissão noradrenérgica do núcleo medial da amígdala na modulação do sistema cardiovascular em ratos. 2013. 153p. Tese (Doutorado) Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 2013. O núcleo medial da amígdala (NMA) está envolvido no controle de uma variedade de processos fisiológicos e comportamentais, dentre eles, a regulação do sistema cardiovascular durante situações aversivas. Além disso, existem evidências indicando a presença de receptores noradrenérgicos no NMA e que os níveis de noradrenalina (NA) no NMA aumentam quando animais são submetidos ao modelo de estresse por restrição (ER). Portanto, o presente estudo foi dividido em duas partes: 1) avaliamos os efeitos da microinjeção local de NA no NMA de ratos, bem como os receptores locais e os mecanismos periféricos envolvidos na sua mediação e 2) investigamos o papel desempenhado pela neurotransmissão noradrenérgica do NMA sobre as respostas cardiovasculares causadas pelo ER. A primeira parte dos nossos resultados indicou que doses crescentes de NA (3, 9, 27 ou 45nmol/100nL) microinjetadas no NMA causavam respostas pressoras e bradicardicas de maneira dose-dependente em ratos não anestesiados. Os efeitos da NA no NMA foram abolidos pelo pré-tratamento local com antagonista de receptores 2-adrenérgicos (RX821002, 10 nmol/100nL), porém não foram alterados pelo pré-tratamento com antagonista de receptores 1adrenérgicos (WB4101, 10 nmol/100nL). A magnitude da resposta pressora à NA no NMA foi aumentada pelo pré-tratamento intravenoso (i.v.) com o bloqueador ganglionar pentolínio (5mg/kg) e foi significativamente reduzida pelo pré-tratamento i.v. com antagonista dos receptores vasopressinérgicos do tipo V1 dTyr(CH2)5(Me)AVP (50 g/Kg) sugerindo que o mecanismo periférico envolvido nestas respostas cardiovasculares é a liberação de vasopressina na circulação sanguínea. Como estruturas finais participando das respostas cardiovasculares desencadeadas pela microinjeção de NA no NMA, foi observado o possível envolvimento dos núcleos paraventricular (NPV) e supra-óptico (NSO) do hipotálamo, que sintetizam vasopressina. O bloqueio de sinapses, tanto no NPV quanto no NSO, com cloreto de cobalto (CoCl2, 1mM/100nL), reduziu as respostas cardiovasculares desencadeadas pela microinjeção de NA no NMA, sugerindo que ambos os núcleos são responsáveis pela liberação de vasopressina em resposta à NA no NMA. Na segunda parte deste estudo, os resultados mostraram que a microinjeção bilateral de WB4101, antagonista seletivo dos receptores 1- adrenérgicos (10, 15 e 20nmol/100nL) no NMA 10 min antes do ER, reduziu a resposta taquicárdica evocada pelo ER, de maneira dose-dependente. Em contraste, a microinjeção bilateral de RX821002, antagonista seletivo dos receptores 2- adrenérgicos (10, 15 e 20nmol/100nL) no NMA 10 min antes do ER, aumentou a resposta taquicárdica evocada pelo ER de maneira dose-dependente. Ambos os tratamentos não causaram alterações na resposta pressora observada nos animais submetidos ao ER. Estes resultados sugerem que receptores 1- e 2-adrenérgicos no NMA desempenham papel facilitatório e inibitório, respectivamente, na resposta taquicárdica durante o ER. Além disso, a microinjeção bilateral de propranolol, antagonista não seletivo dos receptores -adrenérgicos (10, 15 e 20nmol/100nL), no MNA 10 min antes do ER, causou aumento na resposta taquicárdica apenas quando os animais foram pré-tratados com a dose de 15 nmol, sem efeito significativo sobre a resposta pressora observada durante o ER. Este resultado indica que receptores -adrenérgicos no NMA desempenham um papel inibitório sobre a frequência cardíaca durante o ER. Uma vez que foi observada a participação dos receptores - adrenérgicos, realizamos o pré-tratamento com os antagonistas seletivos dos receptores 1- e 2- adrenérgicos, CGP 20712 e ICI 118,551, respectivamente. A microinjeção bilateral de ICI 118,551 (10, 15 e 20nmol/100nL) no NMA aumentou as respostas taquicárdicas ao ER após a microinjeção das doses de 15 e 20 nmol. Esse efeito foi semelhante ao observado após o tratamento prévio com propranolol, na dose de 15 nmol, sem efeito significativo sobre a resposta da pressora durante o ER. Porém, o pré-tratamento com o CGP 20712 (10, 15 e 20 nmol/100 nL) causou um efeito oposto sobre a resposta taquicárdica evocada pelo ER, ocorrendo uma redução da resposta taquicárdica que foi observada apenas após a dose de 20 nmol no NMA, sem efeito significativo sobre a resposta pressora evocada pelo ER. Esses resultados sugerem que os receptores 2-adrenérgicos desempenham influência inibitória sobre a resposta taquicárdica, ao passo que, os receptores 1-adrenérgicos desempenham influência facilitatória na resposta taquicárdica evocada pelo ER. / ABSTRACT FORTALEZA, E. A. T. Noradrenergic neurotransmission function of the medial nucleus of the amygdala in the modulation of the cardiovascular system in rats. 2013. 153p. Thesis (Doctoral) School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 2013. The medial amygdaloid nucleus (MeA) regulates a variety of physiological and behavioral processes, as well as regulation of the cardiovascular system during aversive situations. Moreover, there is evidence indicating that noradrenergic receptors are present into the MeA and that the levels of noradrenaline (NA) in this nucleus increases when animals are submitted to acute restraint model. Therefore, this study was divided into two parts: 1) we tested the effects of local NA microinjection into the MeA on cardiovascular responses in unaesthetized rats. Moreover, we describe the type of adrenoceptors activated and the peripheral mechanisms involved in the cardiovascular responses and 2) we investigated the involvement of MeA adrenoceptors in the modulation of cardiovascular responses that are observed during acute restraint. The first part of our results indicated that increasing doses of NA (3, 9, 27 or 45 nmol/ 100nL) microinjected into the MeA of unanesthetized rats caused dose-related pressor and bradycardiac responses. The cardiovascular effects of NA were abolished by MeA local pretreatment with 10 nmol/ 100nL of the specific 2-adrenoceptor antagonist RX821002, but were not affected by local pretreatment with 10 nmol/100nL of the specific 1-adrenoceptor antagonist WB4101. The magnitude of pressor response evoked by NA microinjected into the MeA was potentiated by intravenous pretreatment with the ganglion blocker pentolinium (5 mg/kg, i.v.) and blocked by intravenous pretreatment with the selective V1 vasopressin antagonist dTyr (CH2)5(Me) AVP (50 g/Kg, i.v.). Our results suggest that microinjection of NA into the MeA of unanesthetized rats activates local 2- adrenoceptors, evoking pressor and bradycardiac responses, which are mediated by vasopressin release in the blood circulation. The vasopressin is synthesized by magnocellular cells of paraventricular (PVN) and supraoptic nucleus (SON) of the hypothalamus. Thus, it was investigated the role of these hypothalamic nucleus on the cardiovascular pathway activated by the microinjection of NA into the MeA. Pressor and bradycardiac responses to NA (27nmol/100nL) were blocked when cobalt chloride (CoCl2, 1mM/100nL) was microinjected into the PVN or SON, thus indicating that both hypothalamic nucleus are responsible for the mediation of the cardiovascular responses evoked by NA microinjection into the MeA. Our results suggest that pressor and bradycardic responses caused by NA microinjection into the MeA are mediated by magnocellular neurons in the PVN and SON. In the second part of this study Male Wistar rats received bilateral microinjections of the selective 1-adrenoceptor antagonist WB4101 (10, 15, and 20 nmoL/100nL) or the selective 2-adrenoceptor antagonist RX821002 (10, 15, and 20 nmoL/nL) into the MeA, 10 min before the exposure to acute restraint. The injection of WB4101 into the MeA reduced the restraint-evoked tachycardia. In contrast, the injection of RX821002 increased the tachycardia. Both drugs had no effect on the BP increase observed during the acute restraint. Our findings indicate that 1 and 2-adrenoceptors in the MeA play different roles in the modulation of the HR increase evoked by restraint stress in rats. Results suggest that 1-adrenoceptors and 2-adrenoceptors respectively mediate the MeA facilitatory and inhibitory influences on restraint-related HR responses. Moreover, we investigated the involvement of -adrenoceptors in the MeA in cardiovascular responses evoked in rats submitted to an acute restraint stress. We first pretreated Wistar rats with the nonselective -adrenoceptor antagonist propranolol, microinjected bilaterally into the MeA (10, 15, and 20 nmol/100nL) 10 min before exposure to acute restraint. The pretreatment with propranolol did not affect the BP increase evoked by restraint. However, it increased the tachycardiac response caused by acute restraint when animals were pretreated with a dose of 15 nmol, without a significant effect on the BP response. This result indicates that -adrenoceptors in the MeA have an inhibitory influence on restraintevoked HR changes. Pretreatment with the selective 2- adrenoceptor antagonist ICI 118,551 (10, 15, and 20 nmol/100 nL) significantly increased the restraint evoked tachycardiac response after the doses of 15 and 20 nmol, an effect that was similar to that observed after the pretreatment with propranolol at the dose of 15 nmol, without a significant effect on the BP response. Pretreatment of the MeA with the selective 1-adrenoceptor antagonist CGP 20712 (10, 15, and 20 nmol/100nL) caused an opposite effect on the HR response, and a significant decrease in the restraint-evoked tachycardia was observed only after the dose of 20nmol, without a significant effect on the BP response. Because propranolol is an equipotent antagonist of both 1 and 2-adrenoceptors, and opposite effects were observed after the treatment with the higher doses of the selective antagonists ICI 118,551 and CGP 20712, the narrow window in the dose-response to propranolol could be explained by a functional antagonism resulting from the simultaneous inhibition of 1 and 2-adrenoceptors by the treatment with propranolol.

Orientadores: Antonio Celso Fonseca de Arruda, Paulo Roberto Gardel Kurka / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica / Made available in DSpace on 2018-08-14T02:53:31Z (GMT). No. of bitstreams: 1 Jorge_AlexandreFonseca_M.pdf: 2455128 bytes, checksum: 714a30d7c2214aa6edc9a048f74aa56d (MD5) Previous issue date: 2006 / Resumo: Um dispositivo de retenção infantil, a ser certificado pela norma NBR14400, tem como um dos principais requisitos atingir determinados níveis de performance em ensaios de impacto. Durante seu desenvolvimento, o dispositivo deve ser submetido a esse teste várias vezes, até ser aprovado, o que envolve altos custos. Este estudo propõe um teste de impacto simplificado, não para substituir o teste de certificação, mas na condição de teste de desenvolvimento preliminar e eliminatório. O principal equipamento envolvido, neste estudo, é o boneco de testes, que possui simplificações tanto na parte biomecânica quanto na parte de instrumentação. Como vantagem, quando comparado ao boneco instrumentado completo, seu custo é significativamente menor. Neste trabalho são apresentadas as condições de contorno envolvidas no projeto, na construção e no uso desse boneco. Adicionalmente, são reportados os resultados comparativos dos ensaios de impacto entre o boneco construído e o instrumentado completo Hybrid III. Tais resultados validam a proposta do projeto / Abstract: A child restraint system, to be certified to NBR 14400 standard, has as one of its main requirements, to reach specific performance levels under impact tests. During its development, the device has to undergo several times such tests, which are expensive, until approval. This study proposes a simplified impact test, not to replace the certification test, but as a preliminary and eliminatory test. The main equipment involved in this study is the test dummy, which has simplifications both on biomechanical and instrumentation aspects. As an advantage, when compared to a complete instrumented dummy, it has a considerably lower cost. In this work, the guiding conditions involved in the project, construction and use of that dummy are presented. Also, the results of comparative impact testes between the projected dummy and the complete instrumented dummy Hybrid III are reported. Such results validate the proposal of the project / Mestrado / Mestre em Engenharia Mecânica

En France, en 2015 les motocyclistes représentent 43% des blessés graves victimes d'accidents de la circulation routière. Au même moment, même si les accidents de chocs de motocyclistes contre les dispositifs de retenue routiers ne représentent en moyenne que 10% des accidents de la circulation routière, les motocyclistes présentent un risque de décès 30 à 80 fois supérieur au risque de décès des usagers de véhicules impliqués dans le même type d'accidents.Pour renforcer la sécurité des motocyclistes, les dispositifs de retenue pour automobiles (dispositifs traditionnels) sont équipés à leur partie inférieure d'écran de protection motards. Les écrans motards ont pour but d'amortir de manière progressive les chocs des motocyclistes en les empêchant dans le même temps de passer à travers la partie inférieure des dispositifs de retenue pour automobiles, de percuter un poteau et d'être sévèrement blessés. Les écrans motards doivent subir des essais de chocs normatifs et répondre à certaines exigences afin de pouvoir être installés sur le bord des routes européennes et de garantir surtout la sécurité des motards. Cependant, il n'existe que des procédures normatives pour tester ces dispositifs, la procédure LIER dans le contexte Français et la procédure normative EN 1317-8 dans le contexte Européen. Afin d'évaluer ces deux procédures normatives et de proposer de nouvelles dispositions pouvant servir de procédure normative plus avancée sur le protocole d'essais d'évaluation de performances d'écrans motards, des simulations numériques ont été réalisées. Un modèle numérique complet de dispositif de retenue routier équipé d'écran motard en acier a été développé et corrélé sur un essai de choc réel sur un dispositif de même type. Une fois corrélé,le modèle a été utilisé afin d'évaluer l'influence des conditions d'essais et des caractéristiques mécaniques matériaux de l'écran sur les performances de l'écran motard. Enfin, une nouvelle démarche d'évaluation de performances d'écran de protection motard a été mise en place / In France, in 2015,motorcyclists represent 43% of seriously injured accident victims in road traffic. At the same time, even though motorcyclists impact crashes against the road restraint systems represent on average 10% of accidents in road traffic, motorcyclists present a risk of death from30 to 80 times upper than the risk of death for users of vehicles involved in the same type of accidents. To enhance the safety of motorcyclists, Vehicle Restraints Systems (VRS) arefitted to the lower part of restraint systems for motorcyclists. Motorcyclist’s Restraint Systems (MRS) are designed to absorb shocks gradually and to preventmotorcyclists to pass through the lower part of VRS, to hit a post and be severely injured. Before being installed on the roadsides, MRS have to be crash-tested according to standards in order to evaluate their safety and ensure motorcyclists safety. However, there are only normative procedures to testMRS, the LIER procedurein the French context and the procedure EN1317-8 in the European context. To assess both normative procedures and propose new provisions which can be used as normative procedure more advanced on the protocol of MRS performances evaluation tests, numerical simulations were performed. A numerical model of MRS was developed and correlated on one real impact test on other device of same type. Once correlated, the model was used to conduct a parametric study on the test conditions and thematerialsmechanical properties of the MRS. Finally, a new demarche of MRS performances evaluation was developed

Plus d'un million de personnes meurent dans des accidents sur les routes du monde et beaucoup de millions sont gravement blessés chaque année. Selon les études, ‘Run-Off-Road accidents (ROR)’, c'est-à-dire que le véhicule a au moins une collision avec des équipements routiers, représentent environ 10% des accidents routières, mais 45% de tous les accidents mortels sont des ROR. Les dispositifs de retenue des véhicules (DDR) sont les infrastructures installées sur la route pour fournir un niveau de confinement du véhicule ‘hors de contrôle’. La barrière de sécurité routière est un DDR continu installé à côté ou sur la réserve centrale d'une route pour empêcher les véhicules errants de s'écraser sur les obstacles routiers et de les conserver en toute sécurité. Les résultats statistique montrent que l'existence des barrières peut réduire les morts jusqu'à un facteur de 4 par rapport aux collisions contre d'autres obstacles routiers. Les performances de sauvetage d'un DDR dépendent de la conception de l'appareil. Des normes telles que EN1317 ont normalisé les conditions des essais de chocs sous lesquelles une conception de DDR doit être testée et ont défini les critères pour l'évaluation des performances d'une conception. En fait, un DDR ne puisse pas vraiment être optimisé: il existe des critères multiples pour l'évaluation de la performance d'un DDR et tous les critères ne peuvent pas être optimisés en même temps; les conditions de travail d’un DDR, c'est-à-dire les conditions d'impact d’un DDR avec un véhicule errant, sont nombreuses; les facteurs incertains du DDR peuvent dégrader les performances d'une conception. La thèse vise à définir une approche qui peut servir : l'analyse de sensibilité (AS) et la conception robuste du DDR ; enrichissement des normes existantes dans la conception du DDR. Le cas d'une barrière de sécurité routière est spécifié dans l'étude : une barrière a été testée expérimentalement, le programme Ls-Dyna est utilisé pour la simulation de choc de l'appareil ; en tenant compte des propriétés du modèle de choc, les efficacités de différentes méthodes de l’AS ont été étudiées ; les influences des facteurs critiques dont les incertitudes contribuent le plus à l'instabilité de la barrière ont été quantifiées avec les approches d’AS sélectionnées ; compte tenu des incertitudes des facteurs critiques, l’optimisation robuste de multi-objectif de la barrière est réalisée ; des simulations d'impact de la barrière optimisée ont été effectuées sous des conditions d'impact différentes pour évaluer ses performances dans les véritables accidents. Les approches présentées dans l'article peuvent être utiles pour la conception d'autres DDR ou plus largement d'autres systèmes d'ingénierie complexes. On peut espérer que l'analyse de robustesse et l'analyse de la généralisation (c'est-à-dire l'évaluation de la performance du DDR sous différentes conditions d'impact) du DDR pourraient enrichir les normes de la conception des DDR / More than 1 million people die in crashes on the world’s roads and many millions are seriously injured each year. According to the studies: Run-Off-Road accidents (ROR), i.e. the vehicle run-off the road into the roadside and has at least one collision with either roadside equipment or the roadside itself, “represent about 10% of the total road accidents, while 45% of all fatal accidents are ROR”. Vehicle Restraint Systems (VRS) are the infrastructures installed on the road to provide a level of containment for an errant vehicle. Safety barrier is “continuous VRS installed alongside, or on the central reserve, of a road to prevent errant vehicles from crashing on roadside obstacles, and to retain them safely”. Statistic results show that “the existence of protective barriers on road can reduce fatalities up to a factor of 4 when compared to collisions against other road obstacles.” The life-saving performances of a VRS depend on the design of the device. Standards such as EN1317 normalized the impact conditions under which a design of VRS must be tested by crash tests, and defined the criteria for performance evaluation of a design. While a VRS cannot really be optimized: Multi-criteria exist for performance evaluation of a VRS and all the criteria cannot be optimized in the same time; the impact conditions of the VRS with the errant vehicle are numerous; uncertain factors of the VRS may degrade the performances of a design. The thesis aims to define an approach that can serve: sensitivity analysis (SA) and robust design of the VRS; Enrichment for the existing standards in the design of VRS. The case of a safety barrier is specified in the study: a safety barrier has been test experimentally, the program Ls-Dyna was used for crash simulation of the device; considering properties of the crash model, efficiencies of different SA methods were studied and influences of the critical factors whose uncertainties contribute the most to the instability of the barrier were quantified with the selected SA approaches; considering the uncertainties of the critical factors, Multi-Objective robust optimization of the tested barrier were realized; under different impact conditions, crash simulations of the optimized barrier were carried out to evaluate its performances in the real crash accidents. The approaches presented in the article can be useful for the design of other VRS or more broadly, other complex engineering systems. Hopefully, the robustness analysis and generalization analysis (i.e. performance evaluation of the VRS under different impact conditions) of the safety barrier could enrich the standards for the design of VRS

Orientador: Antonio Celso Fonseca de Arruda / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecânica / Made available in DSpace on 2018-08-26T12:30:34Z (GMT). No. of bitstreams: 1 Souza_VictorCesarde_M.pdf: 2933493 bytes, checksum: ad3ab87009ea90dcb39a5fd7757c4c9a (MD5) Previous issue date: 2015 / Resumo: Projeto, construção e avaliação de desempenho de simulador de testes de impacto de dispositivos de retenção infantis. A solução construtiva objetivou simular uma colisão automobilística e utiliza manequins representativos de crianças para fins de efeito demonstrativo e de convencimento sobre a necessidade de se reter crianças em veículos automotores. Trata-se de um trenó, guiado, que se desloca sobre trilhos sendo tracionado por cabo de aço e, capaz de, sem dano permanente, colidir contra uma barreira de impacto deformável. O equipamento foi concebido para fácil instalação em locais públicos e utiliza motor de indução para tracionar o cabo de aço e sistemas de automatização de aferição da velocidade, de aceleração e parada do motor. A instrumentação eletrônica utilizada na montagem do simulador permite avaliação do desempenho do equipamento para velocidades de até 20 Km/h / Abstract: Design, construction and evaluation of impact tests simulator performance of child restraint systems. The constructive solution aimed to simulate an automobile collision and uses dummies representing children for the purposes of demonstration effect and conviction about the need to retain children in motor vehicles. This is a sled, guided, moving on rails being pulled by steel cable and capable of, without permanent damage, crash into a deformable barrier impact. The equipment is designed for easy installation in public places and induction motor uses to pull the cable and speed measurement automation systems, acceleration and engine stop. The electronic instrumentation used in the simulator assembly allows assessment of equipment performance for speeds up to 20 km / h / Mestrado / Materiais e Processos de Fabricação / Mestre em Engenharia Mecânica