The Global Positioning System (GPS) has been widely used for precise positioning applications throughout the world. However, there are still some limiting factors that affect the performance of satellite-based positioning techniques, including the ionosphere. The GPS Network-RTK (NRTK) concept has been developed in an attempt to remove the ionospheric bias from user observations within the network. This technique involves the establishment of a series of GNSS reference stations, spread over a wide geographical region. Real time data from each reference station is collected and transferred to a computing facility where the various spatial and temporal errors affecting the GNSS satellite observations are estimated. These corrections are then transmitted to users observations in the field. As part of a Victorian state government initiative to implement a cm-level real time positioning service state-wide, GPSnet is undergoing extensive infrastructure upgrades to meet high user demand. Due to the sparse (+100km) configuration of GPSnet's reference stations, the precise modelling of Victoria's ionosphere will play a key role in providing this service. This thesis aims is to develop a temporal model for the ionospheric bias within a Victorian NRTK scenario. This research has analysed the temporal variability of the ionosphere over Victoria. It is important to quantify the variability of the ionosphere as it is essential that NRTK corrections are delivered sufficiently often with a small enough latency so that they adequately model variations in the ionospheric bias. This will promote the efficient transmission of correctional data to the rover whilst still achieving cm-level accuracy. Temporal analysis of the ionosphere revealed that, during stable ionospheric conditions, Victoria's double differenced ionospheric (DDI) bias remains correlated to within +5cm out to approximately two minutes over baselines of approximately 100km. However, the data revealed that during more disturbed ionospheric conditions this may decrease to one minute. As a preliminary investigation, four global empirical ionospheric models were tested to assess their ability to estimate the DDI bias. Further, three temporal predictive modelling schemes were tested to assess their suitability for providing ionospheric corrections in a NRTK environment. The analysis took place over four seasonal periods during the previous solar maximum in 2001 and 2002. It was found that due to the global nature of their coefficients, the four global empirical models were unable to provide ionospheric corrections to a level sufficient for precise ambiguity resolution within a NRTK environment. Three temporal ionospheric predictive schemes were developed and tested. These included a moving average model, a linear model and an ARIMA (Auto-Regressive Integrated Moving Average) time series analysis. The moving average and ARIMA approaches gave similar performance and out-performed the linear modelling scheme. Both of these approaches were able to predict the DDI to +5cm within a 99% confidence interval, out to an average of approximately two minutes, on average 90% of the time when compared to the actual decorrelation rates of the ionosphere. These results suggest that the moving average scheme, could enhance the implementation of next generation NRTK systems by predicting the DDI bias to latencies that would enable cm-level positioning.

<p>Vid användning av nätverks-RTK behöver driftcentralen kommunicera med användarens GNSS-mottagare på ett effektivt sätt oberoende av fabrikat. Av den anledningen finns ett standardiserat format för överföring av data som är utvecklat av RTCM (The Radio Technical Commission for Maritime Services). 2006 publicerades version 3.1 som stödjer utsändning av s.k. nätverksmeddelande som innebär att komprimerade observationsdata skickas till mottagaren för beräkning av korrektioner. För att bestämma GNSS-mottagarens position används i dagsläget till största delen VRS-tekniken (Virtual Reference Station). Denna teknik används bland annat av SWEPOS som driver en nätverks-RTK-tjänst i Sverige. VRS-tekniken kräver att mottagarens position ska skickas till driftcentralen, där huvuddelen av beräkningarna sker. Nätverksmeddelande har inte funnits i tidigare versioner av RTCM-standarden, men införandet av dem innebär bland annat att korrektioner kan skickas med envägskommunikation och att större delen av beräkningarna kan göras i mottagaren.</p><p>Syftet med studien är att göra jämförelser mellan VRS och RTCM 3.1 nätverksmeddelande, med avseende på bland annat mätkvalitet och initialiseringstider. I studien ingick även att undersöka behovet av nätverksmeddelande och hur tekniken fungerar under förflyttning. I studien användes GNSS-mottagare från Leica och Trimble för att göra upprepade mätningar med dels VRS och dels RTCM 3.1 nätverksmeddelande med s.k. automatisk respektive statisk konfiguration. Statisk konfiguration användes i två olika nät, ett där SWEPOS-stationen Gävle och ett där SWEPOS-stationen Leksand användes som s.k. masterstation. Totalt 1200 mätningar utfördes på tre väl inmätta punkter under 12 dagar. Vid varje mätning registrerades tiden till fixlösning och mätt position. Resultaten bearbetades därefter och analyserades med statistiska metoder.</p><p>Resultaten visade bland annat att initialiseringstiden för nätverksmeddelande är något längre än för VRS och att det inte finns någon större skillnad i kvalitetstalen mellan VRS och nätverksmeddelande. Inte heller mellan det automatiska nätet och de statiska näten finns någon större skillnad. 95:e percentilens avvikelser var i plan 25 mm och i höjd 45 mm. De enda resultaten som skiljde sig nämnvärt från övriga var mätningarna med Leica i det statiska nätet med Leksand som masterstation, där Leica hade problem med att få fixlösning.</p> / <p>When using network RTK the control centre needs to communicate with the user's GNSS receivers in an efficient manner regardless of the brand of equipment. For this reason, a standardized format for transmission of data has been developed by RTCM (the Radio Technical Commission for Maritime Services). In 2006 the version 3.1 was released which supports broadcasting of network RTK messages which means that the compressed observation data are sent to the rover for calculation of corrections. Today the most used concept to determine the position of the rover is VRS (Virtual Reference Station). SWEPOS, which provides a network RTK service in Sweden, is based on the VRS concept. The concept requires that the position of the rover should be sent to the control centre, where most of the calculations are made. Network RTK messages have not been found in earlier versions of the RTCM standard, but their introduction means that corrections can be sent with one-way communication and that most of the calculations can be made in the rover.</p><p>The purpose of the study is to make comparisons between the VRS and RTCM 3.1 network RTK messages regarding the measurement quality and the time for initialization. The study also included to examine the need for network RTK messages and how the technology works while continuously moving the rover. The study used GNSS receivers from Leica and Trimble to make repeated measurements with VRS and with RTCM 3.1 with automatic and static configurations. Static configuration was used in two different networks, one in which the SWEPOS station Gävle and one in which the SWEPOS station Leksand was used as master station. Totally 1200 measurements were carried out on three known points in 12 days. At each measurement the time for initialization and the measured position was registered. The results were then processed and analysed using statistical methods.</p><p>The results showed that the times for initialization regarding network RTK messages are slightly longer than for VRS and that there is no obvious difference in quality between the VRS and network RTK messages. The difference between the automatic network and the static network is not noticeable either. 95th percentile discrepancies were 25 mm horizontally and 45 mm vertically. The only results that clearly differed from the rest of the measurements were those with Leica in the static network with Leksand as master station, where Leica had problems to resolve the ambiguities.</p>

Vid användning av nätverks-RTK behöver driftcentralen kommunicera med användarens GNSS-mottagare på ett effektivt sätt oberoende av fabrikat. Av den anledningen finns ett standardiserat format för överföring av data som är utvecklat av RTCM (The Radio Technical Commission for Maritime Services). 2006 publicerades version 3.1 som stödjer utsändning av s.k. nätverksmeddelande som innebär att komprimerade observationsdata skickas till mottagaren för beräkning av korrektioner. För att bestämma GNSS-mottagarens position används i dagsläget till största delen VRS-tekniken (Virtual Reference Station). Denna teknik används bland annat av SWEPOS som driver en nätverks-RTK-tjänst i Sverige. VRS-tekniken kräver att mottagarens position ska skickas till driftcentralen, där huvuddelen av beräkningarna sker. Nätverksmeddelande har inte funnits i tidigare versioner av RTCM-standarden, men införandet av dem innebär bland annat att korrektioner kan skickas med envägskommunikation och att större delen av beräkningarna kan göras i mottagaren. Syftet med studien är att göra jämförelser mellan VRS och RTCM 3.1 nätverksmeddelande, med avseende på bland annat mätkvalitet och initialiseringstider. I studien ingick även att undersöka behovet av nätverksmeddelande och hur tekniken fungerar under förflyttning. I studien användes GNSS-mottagare från Leica och Trimble för att göra upprepade mätningar med dels VRS och dels RTCM 3.1 nätverksmeddelande med s.k. automatisk respektive statisk konfiguration. Statisk konfiguration användes i två olika nät, ett där SWEPOS-stationen Gävle och ett där SWEPOS-stationen Leksand användes som s.k. masterstation. Totalt 1200 mätningar utfördes på tre väl inmätta punkter under 12 dagar. Vid varje mätning registrerades tiden till fixlösning och mätt position. Resultaten bearbetades därefter och analyserades med statistiska metoder. Resultaten visade bland annat att initialiseringstiden för nätverksmeddelande är något längre än för VRS och att det inte finns någon större skillnad i kvalitetstalen mellan VRS och nätverksmeddelande. Inte heller mellan det automatiska nätet och de statiska näten finns någon större skillnad. 95:e percentilens avvikelser var i plan 25 mm och i höjd 45 mm. De enda resultaten som skiljde sig nämnvärt från övriga var mätningarna med Leica i det statiska nätet med Leksand som masterstation, där Leica hade problem med att få fixlösning. / When using network RTK the control centre needs to communicate with the user's GNSS receivers in an efficient manner regardless of the brand of equipment. For this reason, a standardized format for transmission of data has been developed by RTCM (the Radio Technical Commission for Maritime Services). In 2006 the version 3.1 was released which supports broadcasting of network RTK messages which means that the compressed observation data are sent to the rover for calculation of corrections. Today the most used concept to determine the position of the rover is VRS (Virtual Reference Station). SWEPOS, which provides a network RTK service in Sweden, is based on the VRS concept. The concept requires that the position of the rover should be sent to the control centre, where most of the calculations are made. Network RTK messages have not been found in earlier versions of the RTCM standard, but their introduction means that corrections can be sent with one-way communication and that most of the calculations can be made in the rover. The purpose of the study is to make comparisons between the VRS and RTCM 3.1 network RTK messages regarding the measurement quality and the time for initialization. The study also included to examine the need for network RTK messages and how the technology works while continuously moving the rover. The study used GNSS receivers from Leica and Trimble to make repeated measurements with VRS and with RTCM 3.1 with automatic and static configurations. Static configuration was used in two different networks, one in which the SWEPOS station Gävle and one in which the SWEPOS station Leksand was used as master station. Totally 1200 measurements were carried out on three known points in 12 days. At each measurement the time for initialization and the measured position was registered. The results were then processed and analysed using statistical methods. The results showed that the times for initialization regarding network RTK messages are slightly longer than for VRS and that there is no obvious difference in quality between the VRS and network RTK messages. The difference between the automatic network and the static network is not noticeable either. 95th percentile discrepancies were 25 mm horizontally and 45 mm vertically. The only results that clearly differed from the rest of the measurements were those with Leica in the static network with Leksand as master station, where Leica had problems to resolve the ambiguities.

Mutation and over-expression of Receptor Tyrosine Kinases (RTKs) or the proteins they regulate serve as oncogenic drivers in diverse cancers. RTKs catalyze the transfer of phosphate from ATP to the hydroxyl group on tyrosine. The proximal stretch of amino acids including this post translational modification is then able to be recognized by SH2 and PTB domains. Chapter 1 details our work to better understand RTK signaling and its link to oncogenesis using protein microarrays to systematically and quantitatively measure interactions between virtually every SH2 or PTB domain encoded in the human genome and all known sites of tyrosine phosphorylation on 40 out of the 53 Receptor Tyrosine Kinases. Chapter 2 expands upon this work to study the next layer of binding among SH2 and PTB domain-containing adaptor proteins themselves. We found that adaptor proteins, like RTKs, have many high affinity bindings sites for other adaptor proteins. In addition, proteins driving oncogenesis, including both receptors and adaptor proteins, tend to be highly interconnected via a network of SH2 and PTB domain-mediated interactions. Our results suggest that network topological properties such as connectivity can be used to prioritize new drug targets in these well-studied signaling networks. Despite the extensive work presented here on experimentally determining interactions, we nevertheless are unable to keep up with the discovery of new sites of tyrosine phosphorylation by high throughput mass spectrometry as well as their mutation in cancer discovered by next generation tumor sequencing approaches. Chapter 3 introduces work in progress to build a unified predictive model of SH2 domain interactions via integration of diverse data sets of binding as well as crystal structures of domain-peptide interactions. This model will enable researchers discovering new phosphorylation events or mutations to be able to predict potential interaction partners and thereby elucidate novel functional mechanisms. / Chemistry and Chemical Biology

El objetivo de este trabajo es analizar desde la mayor cantidad de aspectos posibles la técnica RTK, para luego obtener las respectivas conclusiones. Para cumplir con el objetivo propuesto se debió contar con una red de puntos con coordenadas geodésicas conocidas, la cual sirvió de base para las pruebas y mediciones que se hicieron con los equipos RTK. Por otro lado, se conformó una red de puntos con coordenadas geodésicas y planas locales con el fin de probar las funciones de replanteo con las que cuenta el equipo RTK y de comparar resultados de esta técnica con los de un levantamiento Stop and Go y con los de una Estación Total. Otro punto de importancia para la concreción del trabajo fue la zona elegida para llevar a cabo la experiencia, la cual debió guardar características variadas para analizar el comportamiento de las comunicaciones entre los receptores. Con el objeto de analizar las precisiones, el alcance, el comportamiento de la comunicación radial ante diversos terrenos y de comparar la técnica RTK con el método Estático, se diseñó una red de puntos en la zona de Punta Lara y Diagonal 74 que se midió en forma estática y con abundantes vectores redundantes. Posteriormente se realizó un ajuste de la red para darle mayor calidad a la posición de los puntos que la componían. Con esta red se podrá establecer la precisión real que pueden proporcionar los equipos RTK y además determinar si la misma es dependiente de la distancia entre la base y el móvil, o si depende en mayor medida de otros factores. Con el fin de efectuar comparaciones de resultados, el procesamiento de vectores y el ajuste de red se hicieron con programas de dos empresas: GPSurvey y TRIMNET, de la firma TRIMBLE (con la que se hicieron todas las mediciones) y GPPS y FILLNET, de la firma ASHTECH. A su vez, con cada programa se hicieron dos ajustes diferentes; uno con los vectores independientes de cada sesión solamente y otro con vectores dependientes. Esta segunda prueba también se hizo para encontrar diferencias entre ajustes. Con el objeto de dejar en claro algunos conceptos básicos de la medición con equipos GPS (Sistema de Posicionamiento Global), sistema en el que se apoyan los equipos RTK, se hará una breve descripción del mismo y se definirán conceptos propios y relacionados al mismo; aunque es necesario aclarar que este sistema de medición utiliza una gran cantidad de algoritmos que le dan cierta complejidad. / Trabajo final de carrera de la Facultad de Ingeniería (UNLP). Grado alcanzado: Ingeniero Agrimensor. Director de trabajo: Ricardo Soto; co-director de trabajo: Roberto Aldasoro.

An introduction, background and research progress in the areas of antifolates, receptor tyrosine kinase (RTK) inhbitors and antimitotic agents has been discussed. &lt;br&gt;Thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFTase) are important folate dependent enzymes that are targets for cancer chemotherapy and the treatment of infectious diseases. Classical antifolates, in most cases, are substrates for folypoly-g-glutamate synthase (FPGS) and rely on folate transporter systems to enter cells. As a part of this study, twenty-eight compounds were designed on the basis of existing clinically active compounds and crystal structures, synthesized and evaluated as single and/or muliple targeted classical and nonclassical antifolates to decrease toxicity and improve the activity and selectivity of existing therapeutic agents. In addition, these structures provides an extension to the structure activity relationship in the antifolate area. &lt;br&gt;RTK inhibitors and antimitotic agents are important antitumor agents and are extensively used in the clinic for the treament of various types of cancers. Pgp overexpression is one of the common reasons for drug resistance to existing antitumor agents and consequently the reason for some chemotherapeutic failures. A furo[2,3-d]pyrimidine compound was discovered to have dual RTK inhibitory activity along with antimitotic activity that circumvent pgp over expression. Antimitotic activity via the binding at the colchicine site is one of the mechanisms of action. Molecular modelling and biological evaluation suggest the importance of conformational restriction for activity. Fifty-seven furo[2,3-d]pyrimidines and six thieno[2,3-d]pyrimidines were designed on the basis of crustal structures and synthesized as potential RTK inhibitors with antimitotic antitumor activity. Four pyrrolo[2,3-d]pyrimidines were designed and synthesized as antimitotic anticancer agents that also reverse pgp action. / Mylan School of Pharmacy and the Graduate School of Pharmaceutical Sciences / Medicinal Chemistry / PhD / Dissertation

Real-Time Kinematic (RTK) positioning is a technique used to provide precise positioning services at centimetre accuracy level in the context of Global Navigation Satellite Systems (GNSS). While a Network-based RTK (N-RTK) system involves multiple continuously operating reference stations (CORS), the simplest form of a NRTK system is a single-base RTK. In Australia there are several NRTK services operating in different states and over 1000 single-base RTK systems to support precise positioning applications for surveying, mining, agriculture, and civil construction in regional areas. Additionally, future generation GNSS constellations, including modernised GPS, Galileo, GLONASS, and Compass, with multiple frequencies have been either developed or will become fully operational in the next decade. A trend of future development of RTK systems is to make use of various isolated operating network and single-base RTK systems and multiple GNSS constellations for extended service coverage and improved performance. Several computational challenges have been identified for future NRTK services including: • Multiple GNSS constellations and multiple frequencies • Large scale, wide area NRTK services with a network of networks • Complex computation algorithms and processes • Greater part of positioning processes shifting from user end to network centre with the ability to cope with hundreds of simultaneous users’ requests (reverse RTK) There are two major requirements for NRTK data processing based on the four challenges faced by future NRTK systems, expandable computing power and scalable data sharing/transferring capability. This research explores new approaches to address these future NRTK challenges and requirements using the Grid Computing facility, in particular for large data processing burdens and complex computation algorithms. A Grid Computing based NRTK framework is proposed in this research, which is a layered framework consisting of: 1) Client layer with the form of Grid portal; 2) Service layer; 3) Execution layer. The user’s request is passed through these layers, and scheduled to different Grid nodes in the network infrastructure. A proof-of-concept demonstration for the proposed framework is performed in a five-node Grid environment at QUT and also Grid Australia. The Networked Transport of RTCM via Internet Protocol (Ntrip) open source software is adopted to download real-time RTCM data from multiple reference stations through the Internet, followed by job scheduling and simplified RTK computing. The system performance has been analysed and the results have preliminarily demonstrated the concepts and functionality of the new NRTK framework based on Grid Computing, whilst some aspects of the performance of the system are yet to be improved in future work.

Made available in DSpace on 2014-06-11T19:22:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-05-28Bitstream added on 2014-06-13T20:28:45Z : No. of bitstreams: 1 barbosa_em_me_prud.pdf: 6325120 bytes, checksum: 83ca12d41a1c8b2c08c84707b01d7e4c (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Os avanços tecnológicos nos métodos de posicionamento têm possibilitado o desenvolvimento de metodologias que viabilizam a sua utilização pelo usuário numa diversidade de aplicações. Um dos métodos de posicionamento GNSS (Global Navigation Satellite System) de grande destaque é o RTK (Real Time Kinematic) utilizando o conceito de rede de estações. Esse método utiliza a infra-estrutura de uma rede de estações de referência, para disponibilizar correções ao usuário. O conceito clássico do RTK tem como princípio básico a alta correlação dos erros provocados pela ionosfera, troposfera e órbita dos satélites na estação de referência e em uma estação próxima de interesse. No entanto, com o afastamento entre o usuário e a estação base, a eficiência do método é degradada, pois a correlação dos erros é reduzida. Mas, quando se utiliza uma rede de estações de referência, pode-se realizar a modelagem dos erros na área de abrangência da rede. Esta concepção é denominada de RTK em Rede. No que concerne a rede de estações de referência GNSS, utilizou-se a rede estabelecida no oeste do estado de São Paulo (rede GNSS-SP). O software adotado para realizar o processamento em rede foi o GPSNet na versão 2.73. Outra questão levantada foi com relação aos padrões disponíveis para a transmissão dos dados ao usuário, tais como o RTCM e CMR, mostrando as evoluções e aplicações. A questão do enlace de comunicação (link) também foi abordada, mostrando os principais tipos disponíveis, mas com ênfase na telefonia móvel que foi utilizada para transmitir os dados via internet. Foram conduzidos vários experimentos... / Technological advances in positioning methods have enabled the development of methodologies that allow its use in a great variety of applications. One method of GNSS (Global Navigation Satellite System) positioning of high performance is the RTK (Real Time Kinematic) network. This method uses the infrastructure of a network of reference stations. The original concept of RTK is the high correlation of the errors caused by ionosphere, troposphere and satellite orbit at a reference station and at a nearby station of interest. However, increasing the distance between the user and the base station, the efficiency of the method is degraded, because the error correlation is reduced. But when using a network of reference stations, a better error modeling in the area of the network is possible. This concept is the so called Network RTK. Regarding the network of GNSS reference stations, in this work the established network in the western state of São Paulo (GNSS network-SP) was used. The software adopted to perform the tests in the network was that GPSNet, version 2.73. Another issue raised during the investigation was related to the available standards for transmitting data to the user, such as CMR and RTCM. The developments and applications were presented. The issue of communication link (link) has been addressed, showing the main available types, but with emphasis on mobile phone that was the technology used to transmit data via the Internet. Several experiments were conducted in different locations to examine the integrity, availability and accuracy for RTK positioning and RTK network. The experiments performed with RTK and RTK network (using the concept of VRS (Virtual Reference Station)) showed some problems, probably related to the density of the network. Among them the accuracy, the initialization time span more than expected or even... (Complete abstract click electronic access below)

Receptor tyrosine kinase (RTK) inhibitors are emerging as an effective therapeutic option for treatment of breast cancer patients overexpressing particular RTKs. However, more patients may benefit from an inhibitor targeting a common effector protein downstream several RTKs. The presented studies herein identify c-Jun N-Terminal Kinase 2 (JNK2), a kinase downstream multiple RTKs, as a novel target to effectively inhibit Phosphatidylinositol 3-kinase/AKT activation and metastasis. Knockdown of JNK2 in the highly metastatic 4T1.2 mammary cancer cells significantly decreased growth factor induced invasion in Boyden chambers, orthotopic tumor growth, and metastatic lesions in lungs and bone. Intra-cardiac introduction of cancer cells is utilized to specifically study the later steps in the metastatic cascade including travel of disseminated cancer cells to a secondary location. Thus, earlier steps such as the process of acquiring a malignant phenotype leading to escape from the primary tumor are bypassed. Survival was prolonged in mice receiving intra-cardiac injection of cells deficient of JNK2 either in the host or in the tumor cells, suggesting a potential role for JNK2 as a therapeutic target for advanced stage breast cancer patients. Using siRNA and inhibitors against Src and PI3K, we determined that JNK2 activity is dependent on Src and PI3K, positioning JNK2 downstream of two critical factors involved in tumor progression. Microarray analysis of JNK2 deficient tumors revealed that JNK2 positively regulates the adaptor protein Grb2 associated binding protein 2 (Gab2). Knockdown of Gab2 in 4T1.2 cells resulted in decreased tumor growth and a trend for decreased lung metastasis. In vitro, stimulation of 4T1.2 shJNK2 or 4T1.2 shGab2 cells with HGF, heregulin, or insulin resulted in impaired AKT activation, suggesting involvement of Gab2 and JNK2 in multiple RTK signaling pathways. Understanding of the intricate mechanisms involved in RTK signal transduction can contribute to drug design geared towards more effective targets, namely JNK2. The secondary goal of this research was to decipher the individual roles of JNK2 and JNK1 in metastatic breast cancer. Survival was significantly shortened in mice injected intra-cardiac with 4T1.2 shJNK1 cells. In congruence, serum Cathepsin K levels were increased and bone lesions observed were higher in mice injected with shJNK1 expressing tumor cells compared to mice injected with control cells. In sharp contrast, jnk1-/- mice displayed dramatically increased survival and fewer bone lesions upon intra-cardiac injections of 4T1.2 cells. Collectively, these data suggest cell and isoform specific roles for JNKs. / text

Este trabalho procurou por evidências das ocupações sambaquieiras para fora dos sambaquis, buscando eventos de ocupação relativos aos concheiros, mas externo a eles em áreas de alta dinâmica sedimentar. Para tanto se consorciou o radar de penetração de solo (GPR) ao sistema de navegação global por satélite (GNSS), funcionando em modo cinemático de tempo real (RTK), em um esforço de sensoriamento remoto em meio a um campo de dunas no Município de Jaguaruna, no litoral de Santa Catarina. Conseguimos, através do sensoriamento, realizar prospecções arqueológicas e encontrar estruturas marginais aos concheiros, previstas em estudos anteriores que apontavam a remobilização de material processados em outras áreas para dentro dos sambaquis. Encontramos, mapeamos, escavamos, descrevemos e amostramos essas estruturas peri-sambaquieiras no entorno do Sambaqui da Figueirinha II de forma a apresentarmos um panorama da distribuição espacial e temporal destas estruturas. / The work presented here searched for evidences of mound builder\'s occupation outside the shell mounds itself, in search of events related to the shell mounds, but external to it in a very dynamic area. We have integrated the GPR and GNSS-RTK technologies in order to take the archaeological research regarding the shell mound cultures outside the mounds, by remote sensing areas in which extensive sand dunes are found in search of evidence regarding the mound builder\'s settlement in the areas surrounding the mounds, which the existence was predicted in previous studies. In this sense, we integrate the technologies and carried out the sensing of the Figueirinha Region in Santa Catarina State. We have found, mapped, excavated, described and sampled the extra-mounds archaeological occurrences surrounding the Figueirinha II shell mound, in order to presenting an overview of the spatial and chronological distributions of such structures.