El documento digital no refiere asesor / Publicación a texto completo no autorizada por el autor / Determina el nivel del desempeño analítico mediante la Sigmametría en el Laboratorio de Bioquímica del Hospital Nacional Daniel A. Carrión, Lima 2015. Material y Métodos: Es un estudio descriptivo y transversal cuya muestra lo constituyen las 13 pruebas bioquímicas más frecuentemente solicitadas según el Reporte Estadístico Mensual 2014. Se usó un Suero Control de Tercera Opinión (de 2 niveles de concentración: Normal y Patológico) al cual se le midieron los 13 analitos mediante 15 corridas por cada uno. Primero se determinó la precisión y la veracidad, luego el Error Total y finalmente el Sigma para cada analito. El Desempeño Analítico se evaluó mediante el nivel Sigma obtenido para cada analito, dichos niveles son: Inaceptable (<(2σ), Marginal (3σ), Bueno (4σ), Excelente (5σ) y Óptimo (6σ). Resultados: Los analitos con Sigmametría “Optima” fueron el Ácido Úrico, Albumina, Bilirrubina Total, Creatinina, Proteína Total y Triglicéridos; “Bueno” para Transaminasa Glutámico-Oxalacético, “Marginal” para Lactato Deshidrogenasa, “Pobre” para Bilirrubina Directa y Urea; “Inaceptable” para Colesterol Total, Glucosa y Transaminasa Glutámico-Pirúvica. Conclusión: El presente estudio permitió al Laboratorista conocer el desempeño analítico real, y al Clínico, saber el grado de Error Total con que se emiten los resultados por parte del Laboratorio de Bioquímica del Hospital. / Trabajo académico

O tema deste trabalho é a metodologia Seis Sigma. O objetivo principal é apresentar e desenvolver uma metodologia para aplicação do Seis Sigma e desenvolver estudo aplicado. Inicialmente, é realizada uma revisão bibliográfica, enfocando os temas qualidade, satisfação do cliente e Seis Sigma. Na seqüência, é apresentada uma proposta de modelo para a aplicação do Seis Sigma em processos industriais. O modelo proposto aborda a estrutura para aplicação do Seis Sigma, os treinamentos e as principais atividades e ferramentas do ciclo DMAIC (Define, Measure, Analyse, Improve e Control). O modelo proposto é aplicado através de uma série de projetos. Um desses projetos é descrito detalhadamente, ilustrando o modelo proposto. Os resultados apresentados na aplicação do Seis Sigma são amplamente positivos. Os resultados obtidos abrangem melhorias radicais de qualidade, produtividade e custos. As atividades e ferramentas que apresentaram melhores resultados são destacadas. Apesar do Seis Sigma estar associado à aplicação intensiva de estatística, verifica-se que, de um modo geral, o Seis Sigma pode ser aplicado de um modo mais simplificado. / The subject of this work is the Six Sigma methodology. The main purpose is to present and develop a methodology for Six Sigma application, illustrating through a case study. First, a literature review, focusing on the items quality, customer satisfaction and Six Sigma methodology, is carried out. Next, a model proposed for Six Sigma application in industrial processes is presented. The proposed model deals with the structure for Six Sigma application, the training of the people involved and the main activities and tools of the DMAIC cycle (Define, Measure, Analysis, Improve, Control). The proposed model is applied to many projects. One of these projects is described in detail, illustrating the proposed model. The results achieved with Six Sigma are very positive. The results include breakthrough improvements in quality, productivity and costs. The activities and tools that show best results are emphasized. Despite the association of Six Sigma with intensive statistical application, it is possible to verify that this methodology can be applied in a more simplified way.

Thesis (MTech(Engineering))--Cape Peninsula University of Technology, 2011 / Reliable analytical results represent the pinnacle assessment of the quality of an analytical laboratory. Variability associated with the analytical method, or process known as selenium analysis which is being used at Western Cape Provincial Veterinary Laboratory (WC PVL), presents a critical quality problem. This is due to the narrow margin of safety between toxic and deficient doses for animal health. In addition, control features of this selenium process, were found to be limited. Limited control features represent ‘process waste’. To overcome the adverse impact of variation and limited control, steps towards process improvement present the best solution.The primary research objective of the research study is: “To establish an alternative accurate and safer digestion procedure within the ‘selenium analysis process, in order to attain quality improvement of the process”.The scientific method was employed to accomplish the research objective. The research design and methodology selected was based on the scientific PDCA cycle, and is known as Lean Six Sigma. A research hypothesis was set as H0 : Variation in process, time and control procedures have a direct impact on the disparity in selenium testing results. Research was able to test the hypothesis using scientific methodology which was empirical, inductive and deductive, systematic, relied on data and was fact based.Implementation of an alternative, more reliable and safer selenium analysis process is believed to result in reduced risks associated to the digestion procedure, while optimising selenium yield and ultimately translating into improved quality in terms of accuracy and precision, thus confidence in results.

Made available in DSpace on 2014-06-11T19:30:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-06-20Bitstream added on 2014-06-13T20:39:46Z : No. of bitstreams: 1 fernandes_st_me_guara.pdf: 826161 bytes, checksum: 1d2c98dc42fcc4f9ab290957112eccca (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Este trabalho apresenta a aplicação do Lean Six Sigma em um estudo de caso na indústria metalúrgica. O Six Sigma e o Lean Manufacturing são dois processos de melhoria utilizados por diversas empresas. Atualmente, a integração destes processos é um desafio para estas empresas, que buscam uma maneira mais eficiente de reduzir seus desperdícios e se adaptarem às necessidades de seus mercados consumidores. O trabalho teve como finalidade demonstrar a aplicabilidade do Lean Six Sigma em um problema logístico real de transporte de produtos entre as unidades de uma indústria metalúrgica. As etapas usadas para a solução do problema seguem o ciclo DMAIC – Definir, Medir, Analisar, Melhorar e Controlar. A dissertação apresenta detalhadamente a abordagem integrada dos processos de melhoria Lean Manufacturing e Six Sigma, seus conjuntos de ferramentas, bem como os resultados obtidos no estudo de caso. / This work presents the application of Lean Six Sigma in a case study of the metallurgic industry. The Six Sigma and the Lean Manufacturing are two processes of improvement used by many enterprises. Currently the integration of these processes is a challenge for these companies, which search a way more efficient to reduce their wastes and to adapt to the needs of their markets. The work had as purpose to demonstrate the applicability of the Lean Six Sigma in a real logistical problem of the transportation of goods among units of the metallurgic industry. The stages used for the solution of the problem follow the DMAIC cycle – Define, Measure, Analyze, Improve and Control. The dissertation presents in details the integrated approach of the improvement processes Lean Manufacturing and Six Sigma, their tools set, as well the results obtained in the case study.

abstract: Nineteenth-century French organ builder Aristide Cavaillé-Coll and organist-composer César Franck established a foundation for the revival of organ music in France. Following the French Revolution, organ culture had degenerated because of the instrument's association with the church. Beginning with his instrument at St. Dénis, Cavaillé-Coll created a new symphonic organ that made it possible for composers to write organ music in the new Romantic aesthetic. In 1859, Franck received a new Cavaillé-Coll organ at the Parisian church where he served as organist, Sainte-Clotilde. He began experimenting with the innovations of this instrument: an expressive division, mechanical assists, new types of tone color, and an expanded pedal division. From about 1860, Franck began composing his first pieces for the Cavaillé-Coll organ; these were published in 1868 as the Six Pièces. With these compositions, Franck led the way in adapting the resources of the French symphonic organ to Romantic music. In this paper, I provide an analysis of the structure of each of the Six Pièces as a foundation for exploring ways in which Franck exploited the new features of his Cavaillé-Coll organ. I have made sound recordings to demonstrate specific examples of how the music fits the organ. Thanks to Cavaillé-Coll's innovations in organ building, Franck was able to write large-scale, multi-thematic works with the sonorous resources necessary to render them convincingly. The Six Pièces reveal a strong creative exchange between organist and organ builder, and they portend many of the subsequent developments of the French symphonic organ school. / Dissertation/Thesis / D.M.A. Music 2012

O tema deste trabalho é a metodologia Seis Sigma. O objetivo principal é apresentar e desenvolver uma metodologia para aplicação do Seis Sigma e desenvolver estudo aplicado. Inicialmente, é realizada uma revisão bibliográfica, enfocando os temas qualidade, satisfação do cliente e Seis Sigma. Na seqüência, é apresentada uma proposta de modelo para a aplicação do Seis Sigma em processos industriais. O modelo proposto aborda a estrutura para aplicação do Seis Sigma, os treinamentos e as principais atividades e ferramentas do ciclo DMAIC (Define, Measure, Analyse, Improve e Control). O modelo proposto é aplicado através de uma série de projetos. Um desses projetos é descrito detalhadamente, ilustrando o modelo proposto. Os resultados apresentados na aplicação do Seis Sigma são amplamente positivos. Os resultados obtidos abrangem melhorias radicais de qualidade, produtividade e custos. As atividades e ferramentas que apresentaram melhores resultados são destacadas. Apesar do Seis Sigma estar associado à aplicação intensiva de estatística, verifica-se que, de um modo geral, o Seis Sigma pode ser aplicado de um modo mais simplificado. / The subject of this work is the Six Sigma methodology. The main purpose is to present and develop a methodology for Six Sigma application, illustrating through a case study. First, a literature review, focusing on the items quality, customer satisfaction and Six Sigma methodology, is carried out. Next, a model proposed for Six Sigma application in industrial processes is presented. The proposed model deals with the structure for Six Sigma application, the training of the people involved and the main activities and tools of the DMAIC cycle (Define, Measure, Analysis, Improve, Control). The proposed model is applied to many projects. One of these projects is described in detail, illustrating the proposed model. The results achieved with Six Sigma are very positive. The results include breakthrough improvements in quality, productivity and costs. The activities and tools that show best results are emphasized. Despite the association of Six Sigma with intensive statistical application, it is possible to verify that this methodology can be applied in a more simplified way.

Este presente trabalho visa avaliar a aplicação da metodologia Design for Six Sigma (DFSS) ao processo de desenvolvimento de veículos (PDV) visando atingir níveis de qualidade Seis Sigma quando do início do processo de fabricação. Na verdade, quando se fala em fabricar produtos que já nasçam com níveis de qualidade Seis Sigma, não significa que seja mandatório que se obtenha a honrosa relação de 3,4 defeitos por milhão de oportunidades, mas sim que proporcionem resultados positivos em relação à melhoria da qualidade, otimização de custos, redução do tempo de desenvolvimento, vislumbrando o mais importante de todos os aspectos: o total entusiasmo do cliente. Para tanto, quando se fala da aplicação do DFSS no âmbito do desenvolvimento de veículos, o panorama deste contexto torna-se relativamente mais amplo e complexo, face ao nível de desenvolvimento tecnológico deste setor. O assunto é introduzido descrevendo-se o processo de desenvolvimento de veículos em sua abordagem atualmente difundida, alicerçada por um processo bem definido e estruturado, para se poder introduzir o DFSS neste processo. Antes, porém, introduz-se toda a metodologia referente ao Seis Sigma, por ser o fundamento base para a criação do DFSS. Por fim, a colocação de um estudo de caso procura relatar a aplicação da metodologia DFSS aplicada especificamente para a GM, procurando relatar a estratégia da aplicação, bem como seus principais ganhos alcançados. / This present work aims to evaluate the application of the Design for Six Sigma (DFSS) methodology to the vehicle development process (VDP) seeking to reach Six Sigma quality levels when the beginning of the production process. Actually, when it is spoken in manufacturing products that are already born with Six Sigma quality levels, it doesn\'t mean that it is mandatory that must be obtained the honorable relationship of 3,4 defects per millions of opportunities, but that provide positive results in relation to the quality improvement, costs optimization, reduction of the development timing, glimpsing the most important of all of the aspects: the customer\'s total enthusiasm. For that, when it is spoken about the application of DFSS in the extent of the vehicles development, the scenery of this context becomes relatively wider and complex, face at the level of technological development of this section. The subject is introduced being described the vehicles development process in its approach currently spread, found by a very defined and structured process, to allow introducing DFSS in this process. Before, however, the whole methodology regarding Six Sigma is introduced, for being the foundation base for the creation of DFSS. Finally, the placement of a case study tries to demonstrate the application of the DFSS methodology applied specifically for GM, trying to report the strategy of the application, as well as their main reached benefits.

Memoria para optar al título de Ingeniero en Alimentos / El chocolate es considerado uno de los productos más importantes dentro del negocio de confitería. Las pérdidas de materias primas durante el 2008 en la fábrica de chocolates alcanzaron los $ 784 millones de pesos y el 25% se concentró en la etapa de fabricación de chocolates. Se utilizó la metodología DMAIC (Definir, medir, analizar, implementar y controlar) para reducir las pérdidas y mejorar los procesos involucrados en las etapas de fabricación de chocolate, a nivel de ingeniería, producción y calidad. Siguiendo la metodología DMAIC se creó un equipo multidisciplinario de trabajo. Se identificaron las causas potenciales de pérdidas en cada etapa del proceso de fabricación, se priorizaron y se asignaron responsables para su implementación. La capacidad del proceso se midió mediante el uso de herramientas estadísticas, obteniendo un sigma inicial de 1,83, y luego de implementar las mejoras el sigma final fue de 3,87. Se crearon planillas para mantener bajo control las mejoras implementadas. Con el uso de la metodología DMAIC implementada, las pérdidas disminuyeron en el proceso de 207,6 kg por día promedio, a 137,3 kg por día promedio, esto significará un ahorro de $ 22 millones de pesos anuales. / The chocolate is considered one of the most important products in the confectionery business. The raw material losses during 2008 in the Manufacture chocolate business reached $ 784 million (chilean pesos) and 25% was focused on the stage of manufacture chocolate. It was used the DMAIC (Define, measure, analyze, implement and control) methodology to reduce losses and improve the processes involved in the stages of chocolate manufacture at the level of engineering, production and quality. Following the DMAIC methodology was created by a multidisciplinary team work. The potential causes of losses was identified at each stage of the manufacturing process, and assigned responsibility people was prioritized for its implementation. The process capability was measured by using statistical tools, obtaining an initial sigma of 1,83, and then implement the improvements was the final sigma 3,87. Spreadsheet were created to keep control of the improvements implemented. Using the DMAIC methodology implemented, the losses in the process decreased from 207,6 kg per day average to 137,3 kg per day average, this will mean was saving of $ 22 million (chilean pesos) per year.

Economic development in any country or area depends heavily on the performance of the construction industry. This is because the subsequent development of infrastructure increases economic activity, living standards, direct foreign investments, and business opportunities. The construction industry in Pakistan also plays a significant role in its economic activity, and the government’s focus towards increasing infrastructure development provides the construction industry with growth prospects. It is observed that quality management practices in the Pakistan construction industry are highly inadequate to enhance quality. The construction industry there is highly challenged with inadequate delays in projects and project quality. The need for the implementation of Six Sigma in the construction industry in Pakistan is underestimated. The structured questionnaire has been developed to collect data from a sample size of 100 managers from 100 construction companies in Pakistan. Current study determines the current trends, the extent of implementation, prior knowledge and related training required in the implementation of Six Sigma.

D.Phil. (Engineering Management) / Process improvement is essential for an organisation to remain competitive in the global market. Regardless of the type of products or service being rendered, such improvement is essential for remaining profitable and staying at the top of one’s industry market. The Lean Six Sigma (LSS) methodology is a preferred methodology for continuously improving business processes, thereby improving profitability and increasing market share. Higher education institutions are increasingly being placed under pressure to improve throughput and to ensure that that their institutions are sustainable. This focus on higher education inefficiencies has resulted in institutions looking for new ways to improve processes which will lead to increases in throughput. In this study, a LSS framework has been developed and applied for improving engineering education processes...