Με την εργασία έγινε μελέτη του σηματοδοτικού μονοπατιού Sonic Hedgehog σε 96 περιστατικά καρκίνου πνεύμονα με τη μέθοδο της ανοσοϊστοχημείας. Επίσης μελετήσαμε την πιθανή συμμετοχή του μεταγραφικού παράγοντα FoxM1 στο καρκίνωμα του πνεύμονα και την πιθανή συσχέτισή του με το μονπάτι του Hedgehog. Έγινε μελέτη της έκφρασης των μορίων Shh, Ptch1, Smo, Gli1, Gli2 και FoxM1. Τα αποτελέσματα αποκάλυψαν μια έντονη έκφραση των μορίων του μονοπατιού και αυξημένα ποσοστά ενεργοποίησής του. Επίσης βρέθηκε στατιστικά σημαντική συσχέτιση με τα πλακώδη καρκινώματα και με τα χαμηλού grade καρκινώματα. Ανάλογη σημαντική συσχέτιση βρέθηκε και με το φύλο,συχνότερα ενεργοποιημένο μονοπάτι στους άντρες. Ακόμα ανιχνεύτηκε μια συσχέτιση της έκφρασης του FoxM1 με το ενεργοποιημένο μονοπάτι. / The hedgehog (HH)-signaling pathway is implicated in developmental processes and its aberrant activation in adult tissues has been associated with malignancy. The aim of this study was to determine the expression pattern of HH-signaling molecules in lung carcinomas, as well as the involvement of the transcription factor FOXM1, that controls cell proliferation, in this process. Paraffin-embedded tissue sections of 96 lung cancer cases and adjacent non-neoplastic lung parenchyma were immunohistochemically analyzed with anti-SHH, anti-Patched1 (PTCH1), anti-Smoothened (SMO), anti-GLI1, anti-GLI2 and anti-FOXM1 antibodies. Correlations of HH molecules with clinicopathological parameters and FOXM1 expression were evaluated. All the HH-signaling molecules examined were overexpressed in lung cancer compared with the adjacent non-neoplastic lung parenchyma. HH pathway activity and expression of PTCH1 and SMO were significantly higher in squamous cell carcinomas compared to other histological types. Activation of HH pathway and PTCH1 expression were correlated with tumor grade being higher in low grade tumors. There was a significant correlation of lymph node metastases with expression of SMO in all histological types and with the gender higher in men. Overexpression of FOXM1 in lung cancer was also significantly correlated with PTCH1, SMO and GLI1 expression. In conclusion, HH-signaling pathway is activated in lung cancer and correlates with histological type, prognostic parameters of the tumors as well as with the increased expression of FOXM1.

No description available.

Chez les animaux à vision binoculaire, la vision tridimensionnelle permet la perception de la profondeur grâce à l'intégration de l'information visuelle en provenance des deux yeux. La première étape de cette intégration est rendue possible anatomiquement par la ségrégation des axones controlatéraux et ipsilatéraux des cellules ganglionnaires de la rétine (CGR) au niveau du chiasma optique. Les axones controlatéraux croisent la ligne médiane au chiasma en route du nerf optique vers le cerveau. À l’inverse, les axones ipsilatéraux s'écartent du chiasma et continuent dans le tractus optique ipsilatéral, en évitant la ligne médiane vers leurs cibles cérébrales. Les mécanismes moléculaires à la base de ce phénomène ne sont pas complètement compris. Les études présentées dans cette thèse montrent que Boc, le récepteur de Sonic Hedgehog (Shh) dans le guidage axonal, est enrichi dans les CGRs ipsilatérales de la rétine en développement. La présence de Shh sur la ligne médiane, et le mode d'expression complémentaire du récepteur nous ont conduit à émettre l'hypothèse que Shh pourrait repousser les axones ipsilatéraux au niveau du chiasma en activant le récepteur Boc. Conformément à cette hypothèse, nous avons constaté que seulement les CGR exprimant Boc se rétractent in vitro en réponse à Shh et que cette réponse est perdue dans les CGR mutantes pour Boc. In vivo, nous démontrons que Boc est requis pour la ségrégation normale des axones ipsilatéraux au niveau du chiasma optique et, inversement, que l'expression ectopique de Boc dans les CGR contralatérales empêche leurs axones de traverser le chiasma optique. Dans l’ensemble, ces résultats suggèrent que Shh repousse les axones ipsilatéraux au niveau du chiasma optique par son récepteur Boc. Cette première partie de notre travail identifie un nouveau couple ligand-récepteur requis pour la ségrégation des axones au niveau du chiasma optique. Une interaction moléculaire impliquée dans cette ségrégation implique l’éphrine-B2 et ses récepteurs EphB (EphB1). Dans la deuxième partie de notre travail, nous montrons, in vivo, en utilisant des souris doubles et quadruples mutantes pour les récepteurs Boc, EphB1 ou les trois récepteurs EphB, que l’abrogation des deux voies de signalisation Shh et éphrine-B2 conduit à l'absence de projections ipsilatérales. Ceci indique que les deux signalisations agissent de façon indépendante dans des voies parallèles. De manière intéressante, ces souris mutantes ont été utilisées comme modèle génétique pour démontrer des défauts dans la perception de la profondeur de champs chez des animaux dépourvus de projections visuelles ipsilatérales. Ainsi, les travaux présentés dans cette thèse démontrent pour la première fois que la formation des projections rétiniennes ipsilatérales est essentielle à l’établissement de la vision binoculaire et dépend des voies induites par les récepteurs d’éphrine-B2 et Shh. / In animals with binocular vision, three dimensional vision allows perception of depth through the integration of visual information from both eyes. The first step of this integration is possible anatomically with the segregation of contralateral and ipsilateral axons at the optic chiasm. Contralateral axons cross the chiasm midline as they progress from the optic nerve to the optic tract. In contrast, ipsilateral axons deviate from the chiasm and continue in the ipsilateral optic tract. The molecular mechanism underlying this phenomenon is not completely understood. The studies presented in this thesis show that the Sonic Hedgehog (Shh) receptor Boc is enriched in ipsilateral RGCs of the developing retina. Together with the presence of Shh at the midline, this complementary expression pattern led us to hypothesize that Shh might repel ipsilateral RGC axons at the chiasm. Consistent with this hypothesis, we found that only Boc positive RGC axons retract in vitro in response to Shh and that this response is lost in Boc mutant RGCs. In vivo, we show that Boc is required for the normal segregation of ipsilateral axons at the optic chiasm and, conversely, that Boc expression in contralateral RGCs prevents their axons from crossing the optic chiasm. Taken together, these results suggest that Shh repels ipsilateral RGC axons at the optic chiasm via its receptor Boc. This first part of this thesis identifies a novel receptor required for the segregation of axons at the optic chiasm. The other couple ligand-receptor involved in this segregation is the Ephrin-B2/EphB signalling. In the second part of this thesis, I show that in vivo, the abrogation of both signalling pathways using quadruple knockout mice of the receptor Boc and three EphB receptors led to the absence of ipsilateral projections, indicating that Shh and ephrinB2 signalling act independently in two parallel pathways. More importantly, these animals, used as a new genetic model to perform visual tests, had a diminished ability to perceive depth. Thus, this thesis demonstrates for the first time that the establishment of ipsilateral retinal projections, essential for accurate binocular vision and perception of depth, is made possible by the combination of EphB and Shh signalling.

Accurate determination of the pressure losses at the bit is very important for drilling practices in petroleum industry. In the literature, there are several studies on determination of the pressure losses. Major focus is concentrated on single phase drilling fluids, which is far from accurate estimation of pressure losses for multiphase fluids, i.e., fluids including a liquid and a gas phase, at the bit. Some of these models are valid for multiphase fluids, however, they are either valid for very high gas flow rates, or developed using very strong assumptions. This study presents a mathematical model for calculating bit hydraulics for gasified drilling fluids. The theory, which is valid for both sonic (critical) and subsonic (sub-critical) regimes, is based on the solution of the general energy equation for compressible fluid flow. The model is sensitive to changes in internal energy, temperature and compressibility. In addition, the model uses &ldquo / mixture sound velocity&rdquo / approach. A computer program is developed based on the proposed mathematical model. The program calculates pressure drop through a nozzle in subsonic flow region, and suggest flow rate if the calculated pressure drop values is in the sonic flow pressure ranges. The program has been run at reasonable field data. The results of the models have been compared with the results of existing models in the literature. The results show that the pressure losses through the bit can be estimated with a variation less than 9%. Also, it has been observed that bottom hole pressure, velocity of the liquid phase and nozzle size have a strong influence on bit pressure drop.

Os Mbyá-Guarani são um subgrupo indígena de fala Guarani, pertencente à família lingüística Tupi-Guarani. Estima-se que cerca de 5.000 pessoas da etnia Mbyá vivam entre o Sul e o Sudeste brasileiro. As crianças indígenas Mbyá-Guarani e as performances musicais e lúdicas que as envolvem cotidianamente são o tema central desta tese desenvolvida a partir de uma etnografia norteada pela Etnomusicologia, em uma aldeia Mbyá-Guarani, no estado do Rio Grande do Sul, Brasil. Neste estudo reflito sobre o protagonismo das crianças Mbyá como agentes sociais co-responsáveis pela construção do modo de ser Mbyá-Guarani e problematizo o estudo da música nos moldes ocidentais, no sentido de descrever etnograficamente categorias êmicas Mbyá relacionadas ao âmbito sonoro, cuja centralidade na sociocosmologia Mbyá indico pelo termo "cosmo-sônico". A partir da análise músico-performática, textual e músicoestrutural de três âmbitos de performance musical de que as crianças participam - as apresentações dos mboraí (cantos sagrados) pelos grupos de cantos e danças tradicionais Guarani, as gravações dos mboraí em diversos CDs e as performances cotidianas dos kyringüé mboraí (cantos das crianças) -, apresento os significados que os Mbyá compartilham e negociam sobre estas performances, sobre ser criança e sobre sua musicalidade. A análise destes cenários indica seu vínculo a uma outra esfera performático-musical, às rezas xamânicas, assim como aos processos de construção da pessoa, da etnia e do território. Interpretei que a agentividade (agency) entre as kyringüé se expressa, por um lado, no âmbito ontológico. A concepção de uma criança é vista como um sinal de satisfação das divindades na relação com os humanos e ao mesmo tempo propulsora desta relação; os adultos, ao se tornarem mais alegres e sábios no convívio com as crianças, ganham força para criar cantos e cantar, no caminho de se tornarem mais próximos às divindades. Por outro, no âmbito da cosmo-sônica Mbyá, a performance cantada das crianças, variavelmente conforme o âmbito de performance musical em que se realiza, desencadeia emoções nos humanos, colaborando na constituição de caminhos de comunicação destes com as divindades e na perpetuação da vida na Terra; media a relação dos Mbyá com os não-indígenas; faz circular capacidades e notícias entre os Mbyá de diferentes aldeias; ou ainda media as relações afetivas, de cuidado e de diálogo das kyringüé entre si e com seus afins adultos. / The Mbyá-Guarani are an indigenous subgroup of Guarani speech that belongs to the Tupi-Guarani linguistic family. It is estimated that nearly 5.000 people of the Mbyá ethnical group live between the South and South-east Brazil. The Mbyá-Guarani indigenous children and the music and play performances that involve them in their daily life are the central theme of this work, developed from one oriented by a ethnomusicological ethnography, in a Mbyá-Guarani village, in the state of Rio Grande do Sul, Brazil. In this study I reflect about the role of Mbyá children as social agents, co-responsible for the construction of the way of being Mbyá-Guarani, and I consider the problem of the study of the music in the western ways, in the sense of to describe ethnographically emics Mbyá categories related to the sound ambit, which centrality in the Mbyá socio-cosmology I refer by the term "cosmo-sonic". Beginning from performing-musical, textual and structural-musical analysis of three ambits of music performance in which participate the children - presentations of the mboraí (sacred songs) by the Guarani groups of traditional songs and dances, the records in CD of mboraí, and the daily performances of kyringüé mboraí (children's songs), I present the meaning that the Mbyá share and negotiate about these performances, about being a child and about their musicality. The analysis of these settings points to their vinculum to another performing-musical context, of the shamanic prayers, so as to the construction of the person, the ethnical group and the territory. I interpreted that the agency between the kyringüé expresses itself, by one side, in the ontological domain. The conception of a child is seen as a sign of satisfaction of the divinities in face of the human beings and, at the same time, as stimulating to this relationship; so that the adults, becoming more happy and wise in the life sharing with the children, gain force to create songs and to sing, in the way to become more close to the divinities. On the other side, in the ambit of Mbyá cosmo-sonic, the singing performance of children, variously, in accord of the domain of musical performance in which it happens, it provokes emotions in the humans, collaborating to the constitution of ways of communication between humans and divinities and to the perpetuation of life on Earth; makes the mediation between the Mbyá with the not-indigenous people; makes circulate capacities and news between the Mbyá of different villages; or still mediates de affective relations, the care, and the dialog of the children to each other and to the related adults.

The purpose of this research is to understand the senses of the sound practice called “música propia” (own music) in the ontology of Misak amerindian collective, that inhabits the southwest of Colombia, through an ethnography. The central concerns were triggered during a dialogic relationship in a participant observation that was modulated by the visual and auditory perceptions. These are the main two points: what do the Misaks call “música propia”, and what do they mean with the frequent claim that “música propia” differs from the "chirimía". The latter consists of a type of musical ensemble that has been associated with festive and catholic practices which manifests itself in different variations, common near the Misak territory and in other regions of the country. The sonority of the “música propia” comes from the mixing of two flutes timbres and two or more drums, whose sounds refer to the presence of non-human alterities performed in public and ritualized events within what Misaks call the “Ciclo de Vida” (Life Cycle). Drawing from performance studies, and on the discussion of epistemologies of sound in ethnomusicology and anthropology of music (Seeger, Feld, Bastos), I propose that the idea of cosmo-sonic (Stein) is a possibility to understand the música propia. Sonoro-performatic categories, socio-cosmological conceptions and the ideal principles of being Misak are all articulated within the Misak’s cosmo-sonic. In this sense, the Misak cosmo-sonic is a sonic ontology that enters cosmopolitical scene when disputing with other worlds its existence. One of these worlds is in the process of patrimonialization of the type of ensemble of “chirimía caucana” that is underway and intendes to include in it the música propia. Here I interpret this attempt of patrimonialization as a state’s mechanism of simplification supported by global policies that tries to incorporate the música propia within a standardized logics. It is a hegemonic form of the ontology of modernity that is not detached from the coloniality of power, and which is revealed in the effects of the interactions of subjects. Faced with this process, some Misak musicians have reacted and, based on the field of cosmopolitics, these reactions are taken in here as an indicator of an ontological conflict. / El objetivo de esta investigación es, mediante una etnografía, comprender los sentidos de la práctica sonora de la “música propia” en la ontología del colectivo amerindio misak, que habita en el sudoeste de Colombia. Las inquietudes centrales fueron provocadas durante la relación dialógica en la observación participante, modulada por lo visual y lo auditivo, concretándose en las dos siguientes: qué es lo que los misak llaman música propia y a qué se refiere el frecuente esclarecimiento de que la música propia se diferencia de la “chirimía”. Esta última consiste en un tipo de conjunto musical que ha estado relacionado con prácticas festivas y católicas, y que se manifiesta en diferentes variaciones, comunes en las proximidades del territorio misak y en otras regiones del país. La sonoridad de la música propia surge del trenzado tímbrico de dos flautas y dos o más tambores, cuyos sonidos remiten a la presencia de alteridades no humanas performadas en eventos públicos y ritualizados dentro de lo que los misak llaman el Ciclo de Vida. Basado en los estudios de performance, y en la discusión sobre epistemologías sonoras en la etnomusicología y en la antropología de la música (Seeger, Feld, Bastos) planteo que la idea de cosmosónica (Stein) es una posibilidad de entender la música propia. En la cosmosónica misak se articulan categorías sonoro-performáticas, las concepciones sociocosmológicas y los principios ideales del ser misak. En este sentido, la cosmosónica misak es una ontología sonora que entra en escena cosmopolítica (De la Cadena, Blaser) al disputar con otros mundos su existencia. Uno de estos mundos es el proceso de patrimonialización del conjunto de chirimía caucana que está en curso y pretende incluir en él a la música propia. Aquí interpreto esta tentativa de patrimonialización como un mecanismo de simplificación del estado apoyado en políticas globales, que intenta incorporar a la música propia dentro de unas lógicas estandarizadas. Se trata de una forma hegemónica de la ontología de la modernidad que no se desliga de la colonialidad del poder, y que se revela en los efectos de las interacciones de los sujetos. Frente a este proceso, las reacciones por parte de algunos músicos misak se revelan en el campo de la cosmopolítica como un conflicto ontológico.

Os Mbyá-Guarani são um subgrupo indígena de fala Guarani, pertencente à família lingüística Tupi-Guarani. Estima-se que cerca de 5.000 pessoas da etnia Mbyá vivam entre o Sul e o Sudeste brasileiro. As crianças indígenas Mbyá-Guarani e as performances musicais e lúdicas que as envolvem cotidianamente são o tema central desta tese desenvolvida a partir de uma etnografia norteada pela Etnomusicologia, em uma aldeia Mbyá-Guarani, no estado do Rio Grande do Sul, Brasil. Neste estudo reflito sobre o protagonismo das crianças Mbyá como agentes sociais co-responsáveis pela construção do modo de ser Mbyá-Guarani e problematizo o estudo da música nos moldes ocidentais, no sentido de descrever etnograficamente categorias êmicas Mbyá relacionadas ao âmbito sonoro, cuja centralidade na sociocosmologia Mbyá indico pelo termo "cosmo-sônico". A partir da análise músico-performática, textual e músicoestrutural de três âmbitos de performance musical de que as crianças participam - as apresentações dos mboraí (cantos sagrados) pelos grupos de cantos e danças tradicionais Guarani, as gravações dos mboraí em diversos CDs e as performances cotidianas dos kyringüé mboraí (cantos das crianças) -, apresento os significados que os Mbyá compartilham e negociam sobre estas performances, sobre ser criança e sobre sua musicalidade. A análise destes cenários indica seu vínculo a uma outra esfera performático-musical, às rezas xamânicas, assim como aos processos de construção da pessoa, da etnia e do território. Interpretei que a agentividade (agency) entre as kyringüé se expressa, por um lado, no âmbito ontológico. A concepção de uma criança é vista como um sinal de satisfação das divindades na relação com os humanos e ao mesmo tempo propulsora desta relação; os adultos, ao se tornarem mais alegres e sábios no convívio com as crianças, ganham força para criar cantos e cantar, no caminho de se tornarem mais próximos às divindades. Por outro, no âmbito da cosmo-sônica Mbyá, a performance cantada das crianças, variavelmente conforme o âmbito de performance musical em que se realiza, desencadeia emoções nos humanos, colaborando na constituição de caminhos de comunicação destes com as divindades e na perpetuação da vida na Terra; media a relação dos Mbyá com os não-indígenas; faz circular capacidades e notícias entre os Mbyá de diferentes aldeias; ou ainda media as relações afetivas, de cuidado e de diálogo das kyringüé entre si e com seus afins adultos. / The Mbyá-Guarani are an indigenous subgroup of Guarani speech that belongs to the Tupi-Guarani linguistic family. It is estimated that nearly 5.000 people of the Mbyá ethnical group live between the South and South-east Brazil. The Mbyá-Guarani indigenous children and the music and play performances that involve them in their daily life are the central theme of this work, developed from one oriented by a ethnomusicological ethnography, in a Mbyá-Guarani village, in the state of Rio Grande do Sul, Brazil. In this study I reflect about the role of Mbyá children as social agents, co-responsible for the construction of the way of being Mbyá-Guarani, and I consider the problem of the study of the music in the western ways, in the sense of to describe ethnographically emics Mbyá categories related to the sound ambit, which centrality in the Mbyá socio-cosmology I refer by the term "cosmo-sonic". Beginning from performing-musical, textual and structural-musical analysis of three ambits of music performance in which participate the children - presentations of the mboraí (sacred songs) by the Guarani groups of traditional songs and dances, the records in CD of mboraí, and the daily performances of kyringüé mboraí (children's songs), I present the meaning that the Mbyá share and negotiate about these performances, about being a child and about their musicality. The analysis of these settings points to their vinculum to another performing-musical context, of the shamanic prayers, so as to the construction of the person, the ethnical group and the territory. I interpreted that the agency between the kyringüé expresses itself, by one side, in the ontological domain. The conception of a child is seen as a sign of satisfaction of the divinities in face of the human beings and, at the same time, as stimulating to this relationship; so that the adults, becoming more happy and wise in the life sharing with the children, gain force to create songs and to sing, in the way to become more close to the divinities. On the other side, in the ambit of Mbyá cosmo-sonic, the singing performance of children, variously, in accord of the domain of musical performance in which it happens, it provokes emotions in the humans, collaborating to the constitution of ways of communication between humans and divinities and to the perpetuation of life on Earth; makes the mediation between the Mbyá with the not-indigenous people; makes circulate capacities and news between the Mbyá of different villages; or still mediates de affective relations, the care, and the dialog of the children to each other and to the related adults.

The purpose of this research is to understand the senses of the sound practice called “música propia” (own music) in the ontology of Misak amerindian collective, that inhabits the southwest of Colombia, through an ethnography. The central concerns were triggered during a dialogic relationship in a participant observation that was modulated by the visual and auditory perceptions. These are the main two points: what do the Misaks call “música propia”, and what do they mean with the frequent claim that “música propia” differs from the "chirimía". The latter consists of a type of musical ensemble that has been associated with festive and catholic practices which manifests itself in different variations, common near the Misak territory and in other regions of the country. The sonority of the “música propia” comes from the mixing of two flutes timbres and two or more drums, whose sounds refer to the presence of non-human alterities performed in public and ritualized events within what Misaks call the “Ciclo de Vida” (Life Cycle). Drawing from performance studies, and on the discussion of epistemologies of sound in ethnomusicology and anthropology of music (Seeger, Feld, Bastos), I propose that the idea of cosmo-sonic (Stein) is a possibility to understand the música propia. Sonoro-performatic categories, socio-cosmological conceptions and the ideal principles of being Misak are all articulated within the Misak’s cosmo-sonic. In this sense, the Misak cosmo-sonic is a sonic ontology that enters cosmopolitical scene when disputing with other worlds its existence. One of these worlds is in the process of patrimonialization of the type of ensemble of “chirimía caucana” that is underway and intendes to include in it the música propia. Here I interpret this attempt of patrimonialization as a state’s mechanism of simplification supported by global policies that tries to incorporate the música propia within a standardized logics. It is a hegemonic form of the ontology of modernity that is not detached from the coloniality of power, and which is revealed in the effects of the interactions of subjects. Faced with this process, some Misak musicians have reacted and, based on the field of cosmopolitics, these reactions are taken in here as an indicator of an ontological conflict. / El objetivo de esta investigación es, mediante una etnografía, comprender los sentidos de la práctica sonora de la “música propia” en la ontología del colectivo amerindio misak, que habita en el sudoeste de Colombia. Las inquietudes centrales fueron provocadas durante la relación dialógica en la observación participante, modulada por lo visual y lo auditivo, concretándose en las dos siguientes: qué es lo que los misak llaman música propia y a qué se refiere el frecuente esclarecimiento de que la música propia se diferencia de la “chirimía”. Esta última consiste en un tipo de conjunto musical que ha estado relacionado con prácticas festivas y católicas, y que se manifiesta en diferentes variaciones, comunes en las proximidades del territorio misak y en otras regiones del país. La sonoridad de la música propia surge del trenzado tímbrico de dos flautas y dos o más tambores, cuyos sonidos remiten a la presencia de alteridades no humanas performadas en eventos públicos y ritualizados dentro de lo que los misak llaman el Ciclo de Vida. Basado en los estudios de performance, y en la discusión sobre epistemologías sonoras en la etnomusicología y en la antropología de la música (Seeger, Feld, Bastos) planteo que la idea de cosmosónica (Stein) es una posibilidad de entender la música propia. En la cosmosónica misak se articulan categorías sonoro-performáticas, las concepciones sociocosmológicas y los principios ideales del ser misak. En este sentido, la cosmosónica misak es una ontología sonora que entra en escena cosmopolítica (De la Cadena, Blaser) al disputar con otros mundos su existencia. Uno de estos mundos es el proceso de patrimonialización del conjunto de chirimía caucana que está en curso y pretende incluir en él a la música propia. Aquí interpreto esta tentativa de patrimonialización como un mecanismo de simplificación del estado apoyado en políticas globales, que intenta incorporar a la música propia dentro de unas lógicas estandarizadas. Se trata de una forma hegemónica de la ontología de la modernidad que no se desliga de la colonialidad del poder, y que se revela en los efectos de las interacciones de los sujetos. Frente a este proceso, las reacciones por parte de algunos músicos misak se revelan en el campo de la cosmopolítica como un conflicto ontológico.

El mundo sonoro de los mbyà-guaraní es una dimensión clave de su existencia, así como lo son los niños, quienes a través de su presencia y sus mboraí (cantos y danzas), ocupan un lugar central en el porãoguatá (caminar sagrado guaraní, hacia la perfección). en este artículo se describen datos etnográficos acerca de los procesos y tratamientos corporales y de las teorías de las prácticas visuales y sonoro-performáticas presentes en la forma de ser / vivir mbyà, sobre la base de una investigación entomusicológica entre colectivos mbyà en el sur de Brasil. A partir de estas descripciones se propone la interpretación de un dominio «cosmo-sónico» de la ontología y de la epistemología de este pueblo amerindio, es decir, que la construcción de la persona mbyà y la construcción del conocimiento están estrechamente vinculados con procesos sonoros, así como con performances imagéticas, cinéticas y materiales que fortalecen la escucha y la resonancia del ser. / The mbyà-Guarani sound world is an important dimension of theirexistence as well as their children are, through their presence and their songs, which occupy a central place in the oguatá porã (Guarani sacred walk towards perfection). In this paper, I present ethnographic data on body processes and treatments as well as theories of visual and sound-performative practices that are part of the mbyà way of being / living. the paper is, based on an ethnomusicological research among mbyà groups in southern Brazil. From ethnographic descriptions an interpretation is built: a «cosmo-sonic» domain of ontology and epistemology of this Amerindian people, that is to say, that the construction of the mbyà person— and the construction of knowledge are closely linked with sound processes, as well as to imagery, kinetic and material performances, that strengthen the listening and the resonance of the being.

Os Mbyá-Guarani são um subgrupo indígena de fala Guarani, pertencente à família lingüística Tupi-Guarani. Estima-se que cerca de 5.000 pessoas da etnia Mbyá vivam entre o Sul e o Sudeste brasileiro. As crianças indígenas Mbyá-Guarani e as performances musicais e lúdicas que as envolvem cotidianamente são o tema central desta tese desenvolvida a partir de uma etnografia norteada pela Etnomusicologia, em uma aldeia Mbyá-Guarani, no estado do Rio Grande do Sul, Brasil. Neste estudo reflito sobre o protagonismo das crianças Mbyá como agentes sociais co-responsáveis pela construção do modo de ser Mbyá-Guarani e problematizo o estudo da música nos moldes ocidentais, no sentido de descrever etnograficamente categorias êmicas Mbyá relacionadas ao âmbito sonoro, cuja centralidade na sociocosmologia Mbyá indico pelo termo "cosmo-sônico". A partir da análise músico-performática, textual e músicoestrutural de três âmbitos de performance musical de que as crianças participam - as apresentações dos mboraí (cantos sagrados) pelos grupos de cantos e danças tradicionais Guarani, as gravações dos mboraí em diversos CDs e as performances cotidianas dos kyringüé mboraí (cantos das crianças) -, apresento os significados que os Mbyá compartilham e negociam sobre estas performances, sobre ser criança e sobre sua musicalidade. A análise destes cenários indica seu vínculo a uma outra esfera performático-musical, às rezas xamânicas, assim como aos processos de construção da pessoa, da etnia e do território. Interpretei que a agentividade (agency) entre as kyringüé se expressa, por um lado, no âmbito ontológico. A concepção de uma criança é vista como um sinal de satisfação das divindades na relação com os humanos e ao mesmo tempo propulsora desta relação; os adultos, ao se tornarem mais alegres e sábios no convívio com as crianças, ganham força para criar cantos e cantar, no caminho de se tornarem mais próximos às divindades. Por outro, no âmbito da cosmo-sônica Mbyá, a performance cantada das crianças, variavelmente conforme o âmbito de performance musical em que se realiza, desencadeia emoções nos humanos, colaborando na constituição de caminhos de comunicação destes com as divindades e na perpetuação da vida na Terra; media a relação dos Mbyá com os não-indígenas; faz circular capacidades e notícias entre os Mbyá de diferentes aldeias; ou ainda media as relações afetivas, de cuidado e de diálogo das kyringüé entre si e com seus afins adultos. / The Mbyá-Guarani are an indigenous subgroup of Guarani speech that belongs to the Tupi-Guarani linguistic family. It is estimated that nearly 5.000 people of the Mbyá ethnical group live between the South and South-east Brazil. The Mbyá-Guarani indigenous children and the music and play performances that involve them in their daily life are the central theme of this work, developed from one oriented by a ethnomusicological ethnography, in a Mbyá-Guarani village, in the state of Rio Grande do Sul, Brazil. In this study I reflect about the role of Mbyá children as social agents, co-responsible for the construction of the way of being Mbyá-Guarani, and I consider the problem of the study of the music in the western ways, in the sense of to describe ethnographically emics Mbyá categories related to the sound ambit, which centrality in the Mbyá socio-cosmology I refer by the term "cosmo-sonic". Beginning from performing-musical, textual and structural-musical analysis of three ambits of music performance in which participate the children - presentations of the mboraí (sacred songs) by the Guarani groups of traditional songs and dances, the records in CD of mboraí, and the daily performances of kyringüé mboraí (children's songs), I present the meaning that the Mbyá share and negotiate about these performances, about being a child and about their musicality. The analysis of these settings points to their vinculum to another performing-musical context, of the shamanic prayers, so as to the construction of the person, the ethnical group and the territory. I interpreted that the agency between the kyringüé expresses itself, by one side, in the ontological domain. The conception of a child is seen as a sign of satisfaction of the divinities in face of the human beings and, at the same time, as stimulating to this relationship; so that the adults, becoming more happy and wise in the life sharing with the children, gain force to create songs and to sing, in the way to become more close to the divinities. On the other side, in the ambit of Mbyá cosmo-sonic, the singing performance of children, variously, in accord of the domain of musical performance in which it happens, it provokes emotions in the humans, collaborating to the constitution of ways of communication between humans and divinities and to the perpetuation of life on Earth; makes the mediation between the Mbyá with the not-indigenous people; makes circulate capacities and news between the Mbyá of different villages; or still mediates de affective relations, the care, and the dialog of the children to each other and to the related adults.