Resumo A nicotina é um alcalóide encontrado em cigarros de tabaco sendo um dos maiores responsáveis pelo vício e por problemas associados ao tabagismo. Com relação ao vício, que é um fenômeno comportamental complexo, ressaltamos a ação da nicotina como um potente agente viciante que altera não só mecanismos celulares como também comportamentais e de aprendizagem. O trabalho para a reversão do vício a drogas como a nicotina é bastante difícil de modo que intervenções alternativas, como o exercício físico, são práticas que têm estado cada vez mais em evidência. Após tratarmos cronicamente ou não ratos com nicotina durante 60 dias e submetê-los ou não a atividade física espontânea por 7 semanas, verificamos que nem o tratamento crônico com a droga e nem a atividade física alteraram parâmetros como o peso e a pressão arterial média dos ratos bem como a marcação para o RNAm da enzima tirosina hidroxilase na Área Tegmental Ventral e da glutaminase no Córtex Pré-Frontal. Porém, verificamos alterações na frequência cardíaca e na ansiedade dos ratos, além do RNAm da glutaminase e do fator neurotrófico derivado do cérebro em áreas hipocampais, sugerindo que ambos o treinamento físico espontâneo e o tratamento crônico com nicotina podem alterar o comportamento, a ansiedade e a memória dos ratos utilizados. / Resumo A nicotina é um alcalóide encontrado em cigarros de tabaco sendo um dos maiores responsáveis pelo vício e por problemas associados ao tabagismo. Com relação ao vício, que é um fenômeno comportamental complexo, ressaltamos a ação da nicotina como um potente agente viciante que altera não só mecanismos celulares como também comportamentais e de aprendizagem. O trabalho para a reversão do vício a drogas como a nicotina é bastante difícil de modo que intervenções alternativas, como o exercício físico, são práticas que têm estado cada vez mais em evidência. Após tratarmos cronicamente ou não ratos com nicotina durante 60 dias e submetê-los ou não a atividade física espontânea por 7 semanas, verificamos que nem o tratamento crônico com a droga e nem a atividade física alteraram parâmetros como o peso e a pressão arterial média dos ratos bem como a marcação para o RNAm da enzima tirosina hidroxilase na Área Tegmental Ventral e da glutaminase no Córtex Pré-Frontal. Porém, verificamos alterações na frequência cardíaca e na ansiedade dos ratos, além do RNAm da glutaminase e do fator neurotrófico derivado do cérebro em áreas hipocampais, sugerindo que ambos o treinamento físico espontâneo e o tratamento crônico com nicotina podem alterar o comportamento, a ansiedade e a memória dos ratos utilizados.

Diss. (sammanfattning) Linköping : Univ., 2003. / Härtill 4 uppsatser.

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2006. / Härtill 4 uppsatser.

Submitted by Renata Lopes (renatasil82@gmail.com) on 2017-03-07T12:02:26Z No. of bitstreams: 1 danielepiresmagalhaesespiritosanto.pdf: 19885258 bytes, checksum: cc404305a80b23fea7d1a26415bf75bf (MD5) / Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-03-07T15:03:55Z (GMT) No. of bitstreams: 1 danielepiresmagalhaesespiritosanto.pdf: 19885258 bytes, checksum: cc404305a80b23fea7d1a26415bf75bf (MD5) / Made available in DSpace on 2017-03-07T15:03:55Z (GMT). No. of bitstreams: 1 danielepiresmagalhaesespiritosanto.pdf: 19885258 bytes, checksum: cc404305a80b23fea7d1a26415bf75bf (MD5) Previous issue date: 2014-08-29 / CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / A arritmia ventricular maligna é uma das principais causas de morte no mundo. Muitas vezes o início de um episódio de arritmia está associado a uma excitação inoportuna no coração, também denominada extra-sístole, ou Potencial de Ação Espontâneo (PAE). O surgimento de PAEs pode estar relacionado a mudanças estruturais ou moleculares nos canais iônicos e a alterações no ciclo de cálcio intracelular. Anormalidades no ciclo de cálcio podem gerar transientes de cálcio espontâneos (TCEs) e estes podem desencadear Potenciais de Ação Espontâneos (PAEs). Estudos experimentais mostram que o surgimento de TCEs é mais frequente sob a estimulação β-Adrenérgica. Em experimentos recentes, notou-se que a presença de episódios de TCEs em cardiomiócitos saudáveis não desencadeia a geração de PAEs. Em contrapartida, em camundongos com a mutação de super expressão da bomba NCX (NaCa), PAEs foram observados em miócitos isolados e foram relacionados a episódios de TCEs. O principal objetivo deste trabalho foi a simulação da formação de PAEs utilizando modelos computacionais desenvolvidos para cardiomiócitos do ventrículo esquerdo de camundongos. Em particular os modelos computacionais foram capazes de reproduzir os cenários experimentais descritos acima, relacionando a geração de PAEs com a estimulação β-Adrenérgica e alterações de canais iônicos como a mutação NCX. Dessa forma, as simulações computacionais apresentadas neste trabalho permitem uma melhor compreensão dos complexos fenômenos associados a arritmias cardíacas. / Malignant ventricular arrhythmias are the major cause of death around the world. The beginning of an episode of arrhythmia is often associated with ectopic beats in the heart, also called extrasystole, or Spontaneous Action Potential (SAP). The development of SAP may be related to structural or molecular changes in ion channels and changes in intracellular calcium cycle. Abnormalities in calcium cycle can result in Spontaneous Calcium Transientes (SCT) and these can trigger SAP. Experimental studies show that the development of SCT is more common under β1-adrenergic stimulation. However, we found, in recent experiments, that the presence of episodes of SCT in healthy cardiomyocytes does not trigger the development of SAP. On the other hand, on mice presenting mutation of overexpression of NCX (NaCa) pump, SAP were observed in isolated cardiomyocytes and were related to episodes of SCT. Thus, we aimed, in this study, to simulate development of SAP using computational models developed for cardiomyocytes of left ventricle of mice. The computational models were able to reproduce the experimental scenarios described above, relating the development of SAP to the β-adrenergic stimulation and to the changes of ion channels as the NCX mutation. Therefore, the computational simulations showed in this work allow the best comprehension of the complex phenomena associated with cardiac arrhythmia.

Bakgrund: I Sverige slutar ungefär 12-13 % av alla kända graviditeter med missfall. De flesta sker innan graviditetsvecka 13 och räknas därmed som tidiga. Många kvinnor upplever att vårdpersonalen inte ger dem det stöd de behöver. Detta kan bero på bristfällig kunskap om den känslomässiga processen vid tidiga missfall. Syfte: Syftet med denna litteraturstudie var att beskriva kvinnors upplevelser i samband med tidiga missfall. Metod: I litteraturstudien har 10 kvalitativa empiriska studier sammanställts och analyserats utifrån Fribergs analysmetod, inspirerad av beskrivande syntes. Artikelsökning utfördes i databaserna Cinahl, Pubmed och SweMed+. Resultat: Upplevelserna vid tidiga missfall innefattar psykiska, existentiella och sociala aspekter samt omvårdnadsrelaterade upplevelser. Missfallet upplevs ofta som en oväntad förlust vilket kan medföra reaktioner som sorg, ifrågasättande av den egna identiteten och skuldkänslor. Många kvinnor känner sig missförstådda av sina anhöriga och att vårdpersonalen inte uppmärksammar deras känslor, upplevelser och behov. Slutsats: Litteraturstudiens resultat visar att kvinnor vill bli bemötta med respekt och förståelse vid tidiga missfall. För att förbättra omvårdnaden av dessa kvinnor krävs personcentrerad omvårdnad som uppmärksammar deras individuella behov, utbildning bland vårdpersonalen samt ytterligare forskning inom området. / Background: About 12-13 % of all recognised pregnancies in Sweden end in a miscarriage. The majority of these occur before gestational week 13 and are therefore classified as early. Many women experience inadequate support from the nursing staff. This could be related to a limited knowledge about the emotional process subsequent to early miscarriages. Aim: The aim of this study was to describe women’s experiences associated with early miscarriages. Methods: In this literature study 10 empirical studies were compiled and analysed with Friberg’s method of analysis, inspired by descriptive synthesis. Article search was performed in the Cinahl, PubMed and SweMed+ databases. Results: The experiences of early miscarriages include psychological, existential and social aspects and experiences connected to nursing care. The miscarriage is often perceived as an unexpected bereavement that can bring about reactions such as grief, questioning of one’s identity and guilt. Many women feel misunderstood by their friends and families and that the nursing staff does not recognize their feelings, experiences and needs. Conclusion: The result of the literature study shows that women want to be met with respect and understanding during the time of early miscarriage. Person centred care that recognise the women’s individual needs, education among the staff and further research in this area is needed to improve the nursing care of these women.

There is some evidence from scholarship that politeness norms in China are diversified. I maintain that a study aiming to provide systematic evidence of this would require an approach to politeness phenomena that is able to address such diversity. Drawing upon the insights of recent scholarship on the distinction between the modernist and postmodernist approaches to politeness, I survey relevant literature. I show that many current works on politeness argue that the modernist approach (Lakoff 1973/1975, Brown and Levinson 1987[1978], Leech 1983) generally tends to assume that society is relatively homogeneous with regard to politeness norms. By contrast, I demonstrate that the postmodernist approach to politeness (e.g. Eelen 2001, Mills 2003, Watts 2003) foregrounds the heterogeneity of society and the rich variability of politeness norms within a given culture. I argue that, by using a postmodernist approach to politeness, it is possible to show evidence of differences between groups of the Chinese in their politeness behaviour and the informing norms of politeness. I then explore this issue in depth by focusing on compliments and compliment responses (CRs). I show that studies on these speech acts in Chinese have to date tended to adopt a modernist approach to politeness and often assume a compliment and a CR to be easily identifiable. Moreover, I show that they do not address the heterogeneity of Chinese society and generally assume interactants to be homogeneous in terms of politeness norms that inform compliment and CR behaviours. On this basis, I raise the questions as to whether, by adopting a postmodernist rather than modernist approach, there is empirical evidence that politeness norms informing compliments and CRs vary among the Chinese, and whether these norms correlate with generation. v To this end, by audio-recording both spontaneous naturally occurring conversations and follow-up interviews, I construct a corpus of compliments and CRs generated by two generations of the Chinese brought up before and after the launch of China's reform. Quantitative and qualitative analyses of these data show that there is variation in compliment and CR behaviours in Chinese and the informing politeness norms. Furthermore, the result shows that this variation is correlated with generation. I then show how, by using a research methodology which emphasizes the interactants' perceptions obtained through follow-up interviews, my study brings to light problems with previous studies on compliments and CRs which hitherto are not addressed. By showing evidence that compliments and CRs are not as easy to identify as many previous researchers have indicated. I argue that my emic approach to data analysis provides a useful perspective on the complexity of intention in studies on speech acts and perhaps beyond. My study, therefore, makes an interesting contribution to the debate over this notion central to politeness research. Moreover, I argue my methodology which is able to categorize and analyze data according to participants' self-reported perceptions allows me to draw out differences in the two generations' compliment and CR behaviours and the informing politeness norms.

The purpose of this essay called is to examine how preschool teachers understand planned and spontaneous physical activities in preschool. We also search to elucidate if there is some difference between a preschool with a pedagogical orientation based on outdoor physical activities and a traditional preschool in which outdoor physical activities are not a part of their pedagogical orientation. We want even to examine how teachers understand their own role in children's physical development. The study draws on a phenomenographic approach and we apply a qualitative method to collect our data. The data is mainly based on interviews with preschool teachers from preschools with the two forms of pedagogical orientation that we mentioned earlier. We interviewed a total of six preschool teachers, three from each preschool. The results of the study showed that the informants from both preschools understand planned physical activities as an activity that is initiated and organised by the teachers. On the contrary they understand spontaneous physical activities as an activity initiated by the children, often in the form of games. Another important result is that the informants in our study agree in that spontaneous physical activities are given quite more time in the preschool’s everyday than planned activities. Finally, the study shows that the informants in the study feel confident as leaders in physical activities, regardless of the preschools pedagogical orientation. It is rather a question of education and personal interests than pedagogical focus.

This study's main purpose is to examine the space children's spontaneous imaging gets in a preschool. I have chosen to focus on two preschool teachers views on their own approach to children's spontaneous imaging and what space they find that it gets in preschool. I have also investigated how this is documented in preschool. As a theoretical approach I adopt Lev S Vygotsky's socio-cultural theories of learning and development. In my essay, I also describe previous studies on children's imaging. I have collected the material through qualitative methods such as interviews of two preschool teachers and through six days of observation divided on two of the preschool departments. The result shows that preschool teachers adult-driven approach characterizes the creative climate of the nursery, which is not particularly allowing in practice, but allowing in theory and preschool teachers thoughts. The preschool teachers approach is significant for how well the child's spontaneous creation capability will be developed or inhibited. Children can come to have a view of his own creation as something insignificant and without meaning if it never followed up in the form of pedagogical documentation or attention. The results also show that children's spontaneous imaging don´t get space in the form of schedule, this is because preschool teachers have a view on the activity as a pastime rather than an educational activity with a clear goal or purpose.

published_or_final_version / Speech and Hearing Sciences / Master / Master of Science in Audiology

Oral narrative ability has received increasing attention over the past three decades, and the importance of children's oral narrative skills to academic achievement has been well established. Children with reading disabilities are known to demonstrate difficulties in the ability to produce and comprehend oral narratives (Roth & Spekman, 1986; Snyder & Downey, 1991). However, the nature of the relationship between oral narrative ability and reading comprehension performance in children with reading disability is not clear. The experiments reported in this thesis aim to address this issue. The following questions are asked: 1) Do deficits in oral narrative ability contribute to reading comprehension difficulties? and 2) What is the likely direction of the relationship between aspects of oral narrative ability and reading comprehension performance in children with reading disabilities? Fourteen children (aged between 6;4 and 7;8 at the initial assessment) with mixed reading disability (MRD: i.e., children who demonstrate both word recognition and listening comprehension deficits) participated in the study. Their oral narrative skills were compared to those of their chronological age-matched peers with typical development (TD) and their reading-age-matched peers with typical development (RMTD). The study consisted of three phases: 1) A longitudinal phase in which the children's oral narrative performance was assessed on three occasions over a two-year period; 2) An intervention phase (using a nonequivalent pretest-posttest control group design) in which 10 children participated in an oral narrative intervention program that focused on enhancing children's story structure knowledge; and 3) A follow-up assessment phase conducted eight months post-intervention. Oral narratives were elicited in a personal narrative context and in a story retelling context. Oral narrative production ability was analysed at macrostructure (story quality) and microstructure (morpho-syntax and vocabulary) levels. Oral narrative comprehension was assessed in a fictional story context through questions relating to story structure elements. Reading comprehension performance was assessed using a standardised test of reading ability. The results from the longitudinal study showed that the children with MRD demonstrated inferior oral narrative production and oral narrative comprehension performance compared to their peers with typical reading development at each assessment occasion. When comparing the poor readers' performance to the RMTD group at the third assessment trial, the results suggested that the children with MRD demonstrated a specific deficit in oral narrative comprehension. In contrast, a pattern of delay was observed on the microstructure measures of oral narrative performance. The results from the intervention indicated significant treatment effects with large effect sizes for oral narrative comprehension performance. Despite this improvement in oral narrative comprehension, there was little change in oral narrative production ability, and transfer to reading comprehension was not evident. Although the follow-up assessment indicated sustained improvement in oral narrative comprehension for the children with MRD, accelerated reading comprehension progress was not evident. The findings from the longitudinal case study highlighted the benefits of oral narrative intervention for a child considered at high risk of continuing academic difficulties. This thesis provides evidence of the persistent oral narrative difficulties in children with MRD. The findings also provide support for the importance of narrative structure knowledge to these poor readers' oral narrative comprehension performance. The results demonstrate that oral narrative comprehension ability explains only a small amount of the variance in reading comprehension performance. Rather, the persistent word recognition difficulties of the children with MRD exert the biggest influence on their reading comprehension performance. These results are discussed in terms of current models of reading and language development. Implications for clinical practice are also addressed.