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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 10 of 10 (0.08 seconds)| 1 |
Sex Differences in the Effect of Prenatal and Perinatal Fluoxetine Exposure on Adult Aggression and Avoidance in the Syrian HamsterSlaby, Ryan J 07 May 2016 (has links)
Anti-depressants are commonly used to treat major depression and post-traumatic stress disorder. 17% of women experience major depression during pregnancy, where up to 10% of pregnant women use antidepressants. 20% these women use Prozac (fluoxetine) to treat major depressive symptoms, which crosses the placental barrier and is present in breast milk. Little is known about how exposure to developmental fluoxetine affects adulthood behaviors such as agonistic and submissive behaviors, especially in females. Furthermore, the effects of developmental fluoxetine exposure on aggression and avoidance in Syrian hamsters have not been studied. Therefore, we explored how prenatal and perinatal exposure to fluoxetine affects adulthood aggression and avoidance in male and female Syrian hamsters. Dams were given fluoxetine via drinking water 7 days prior impregnation. Fluoxetine administration continue until offspring reached postnatal day (PD) 12. The offspring were weaned and group-housed at PD 25 and single-housed at PD 60. Animals were handled one week prior to behavioral testing. The following week, animals were tested for aggression in a neutral arena with a non-aggressive stimulus hamster of the same sex. Another group of hamsters were tested for avoidance behavior in a neutral arena 24 hours after social defeat. Duration of aggression and avoidance were quantified. There was no main effect of sex or drug nor was there an interaction. Therefore, we reject our hypothesis of prenatal and perinatal exposure to fluoxetine will affect aggression and avoidance in male and female Syrian hamsters. These findings may be due to a ceiling effect in Syrian hamsters, where the subtle effects of developmental fluoxetine exposure were not observable.
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Genetics of Circadian Rhythms and SleepLee, Yin Yeng January 2022 (has links)
No description available.
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The Effects of Infection with Adenoviruses on the Chromosomes of Human Cells and Syrian Hamster CellsCooper, John Ernest Keith 10 1900 (has links)
No abstract provided. / Thesis / Doctor of Philosophy (PhD) / Scope and contents: Seven adenoviruses, including oncogenic and nononcogenic serotypes from human and simian hosts, were utilized to investigate their effects upon the chromosomes of human and Syrian hamster cells. Human cells support adenovirus multiplication while hamster cells do not support replication of infectious adenovirus. The chromosome damage induced by adenoviruses in abortive infection of hamster cells was compared with respect to the effect of virus dose upon the incidence and the types of chromosome aberrations. The effect of different adenoviruses upon the amount and types of chromosome damage was also examined. The effect of adenovirus infection upon DNA synthesis of human and hamster cells was examined, and the relevance of adenovirus-induced chromosome aberrations to the etiology of human cancers is discussed.
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The Effects of Testicular Nerve Transection and Epididymal White Adipose Tissue Lipectomy on Spermatogenesis in Syrian HamsterSpence, Jeremiah E 30 July 2008 (has links)
Previous investigators demonstrated that epididymal white adipose tissue (EWAT) lipectomy suppressed spermatogenesis and caused atrophy of the seminiferous tubules. EWAT lipectomy, however, may disrupt testicular innervation, which reportedly compromises testicular function. To resolve this confound and better clarify the role of EWAT in spermatogenesis, three experimental groups of hamsters were created in which: i.) the superior and inferior spermatic nerves were transected (SSNx) at the testicular level, ii.) EWAT was extirpated (EWATx), and iii.) testicular nerves and EWAT were left intact (SHAM controls). It was hypothesized that transection of the superior and inferior spermatic nerves would disrupt normal spermatogenesis. The findings indicate a significant reduction in spermatogenic activity and marked seminal tubule atrophy within the EWATx testis, as compared to the SSNx and controls testes, which did not differ significantly from each other. From these data, it is concluded that EWAT, and not testicular innervation, is central to normal spermatogenesis.
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Le RFRP-3 et l’axe gonadotrope du hamster syrien : effets genre-dépendants et modes d’action / The effect of RFRP-3 on the gonadotrophic axis of the Syrian hamster : sex-dependent differences and modes of actionAncel, Caroline 15 May 2013 (has links)
Le peptide RFRP-3 joue un rôle dans la régulation de l’axe hypothalamo-hypophyso-gonadotrope des mammifères. Le but de cette étude était de déterminer l’implication du RFRP-3 dans la régulation de l’axe reproducteur du hamster Syrien. Nos résultats montrent que le RFRP-3 stimule l’axe gonadotrope chez le hamster Syrien mâle, tandis qu’il a des effets variables chez la femelle. En effet, chez la femelle le peptide inhibe l’axe reproducteur lorsqu’il est administré au moment du pic pré-ovulatoire de LH le jour du proestrus, et n’a pas d’effet pendant le diestrus. Nous avons poursuivi notre étude par la caractérisation des sites d’action du RFRP-3 chez le hamster Syrien, en démontrant que l’effet du peptide sur l’axe gonadotrope est médié directement ou indirectement par les neurones à GnRH. De plus, nous avons écarté l’hypothèse d’un effet hypophysiotrope du peptide chez cette espèce. Pour conclure, les résultats présentés soulèvent de nombreuses questions quant aux effets espèce- et genre-dépendants du RFRP-3 sur l’axe gonadotrope du mammifère. / RFRP-3 has been shown to play a role in the regulation of the mammalian hypothalamic-pituitary-gonadal axis. The aim of this work was to determine the involvement of RFRP-3 in the regulation of the Syrian hamster reproductive axis. We report unprecedented results indicating that RFRP-3 stimulates the male Syrian hamster gonadotrophic axis, whereas it has variable effects in female Syrian hamsters. Indeed, in females the peptide inhibits the reproductive axis at the time of the LH surge on the day of proestrus, and has no effect during diestrus. We went on to characterize RFRP-3 sites of action in the Syrian hamster brain, and show that the effect of the peptide on the gonadotrophic axis is mediated directly or indirectly via GnRH neurons. Moreover, we clearly rule out the possibility of a hypophysiotrophic effect of RFRP-3 in this species. Taken together, the present data raise interesting questions regarding species- and sex-dependent effects of RFRP-3 on the mammalian gonadotrophic axis.
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Estrous Cyclicity Modulates Circadian Rhythms In Female Syrian HamstersHerrman, Erin Rae 01 December 2008 (has links)
No description available.
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Interactions between Exercise, Aging and Ethanol and the Mammalian Circadian Timing SystemHammer, Steven Berlin 20 July 2009 (has links)
No description available.
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Assessment of the Integrative Roles of the Intergeniculate Leaflet in Circadian Timing and Reward PathwaysGuinn, Jessie, Jr. 01 November 2011 (has links)
No description available.
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The Effects of Testicular Nerve Transection and Epididymal White Adipose Tissue Lipectomy on Spermatogenesis in Syrian HamsterSpence, Jeremiah E. 30 July 2008 (has links)
Previous investigators demonstrated that epididymal white adipose tissue (EWAT) lipectomy suppressed spermatogenesis and caused atrophy of the seminiferous tubules. EWAT lipectomy, however, may disrupt testicular innervation, which reportedly compromises testicular function. To resolve this confound and better clarify the role of EWAT in spermatogenesis, three experimental groups of hamsters were created in which: i.) the superior and inferior spermatic nerves were transected (SSNx) at the testicular level, ii.) EWAT was extirpated (EWATx), and iii.) testicular nerves and EWAT were left intact (SHAM controls). It was hypothesized that transection of the superior and inferior spermatic nerves would disrupt normal spermatogenesis. The findings indicate a significant reduction in spermatogenic activity and marked seminal tubule atrophy within the EWATx testis, as compared to the SSNx and controls testes, which did not differ significantly from each other. From these data, it is concluded that EWAT, and not testicular innervation, is central to normal spermatogenesis.
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The Ability of Hamsters (Mesocricetus auratus) to Use the Binaural Phase Cue to Localize SoundCumming, John Freeman, IV 04 September 2019 (has links)
No description available.
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