Data de aprova??o retirada da vers?o impressa do trabalho. / Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2017-08-30T18:13:36Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) gelson_cerqueira_oliveira_junior.pdf: 2578577 bytes, checksum: 83cb8ab9378ea856fed151a0f1c1992d (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2017-08-30T18:51:12Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) gelson_cerqueira_oliveira_junior.pdf: 2578577 bytes, checksum: 83cb8ab9378ea856fed151a0f1c1992d (MD5) / Made available in DSpace on 2017-08-30T18:51:12Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) gelson_cerqueira_oliveira_junior.pdf: 2578577 bytes, checksum: 83cb8ab9378ea856fed151a0f1c1992d (MD5) Previous issue date: 2015 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / Neste trabalho s?lica gel foi preparada a partir de areia de constru??o e carbonato de s?dio, apresentando uma ?rea de superf?cie de 378,68 m2/g, e volume de poro de 1,59x10-2 cm3/g. A fim de preparar diferentes catalisadores a base do mesmo material uma al?quota foi previamente aquecida a 400? C e outra a 700? C, as quais foram denominadas S400 e S700 que ap?s tratamento com H2SO4, deram origem a dois diferentes catalisadores, chamados de C400 e C700. Os catalisadores apresentaram volume total dos mesoporos de 0,23 cm3/g (C400) e 0,20 cm3/g (C700) e ?rea superficial de 31,06 m2/g (C400) e 23,10 m2/g (C700). Pela primeira vez foi utilizado ?cido de Bronsted imobilizado em s?lica para a convers?o de OGR em biodiesel. Ambos C400 e C700 apresentaram alta atividade na convers?o do ?leo e gordura residuais altamente ?cidos (13,7 mg de KOH) e com teor de ?gua de 0,58%, a biodiesel (?steres met?licos de ?cido graxo) em aproximadamente 99,4 %. As rea??es foram repetidas 4 vezes antes do catalisador perder sua atividade catal?tica. / Disserta??o (Mestrado) ? Programa de P?s-gradua??o em Biocombust?veis, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2015. / In this work, silica gel was prepared from building sand and sodium carbonate, having a surface area of 378.68 m2/g and pore volume of 1,59x10-2 cm3/g. In order to prepare different catalysts the basis of the same material aliquot was preheated to 400? C and another at 700? C, which were referred to as S400 and S700 which upon treatment with H2SO4, gave rise to two different catalysts, called C400 and C700. The catalysts showed total volume of mesopores of 0.23 cm3/g (C400) and 0.20 cm3/g (C700) and surface area of 31.06 m2/g (C400) and 23.10 m2/g (C700). For the first time was used Bronsted acid immobilized on silica OGR for conversion into biodiesel. Both C400 and C700 showed high activity in the oil conversion and highly acidic waste fat (13.7 mg of KOH) and 0.58% water content, biodiesel (fatty acid methyl esters) by approximately 99.4% . Reactions were repeated four times before the catalyst to lose its catalytic activity.

?rea de concentra??o: Ci?ncias Fisiol?gicas. / Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2017-10-26T18:38:02Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) vanessa_kelly_silva_lage.pdf: 1557890 bytes, checksum: f19cfa3f49dfb4300750d35b50ea527f (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2017-11-08T14:15:37Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) vanessa_kelly_silva_lage.pdf: 1557890 bytes, checksum: f19cfa3f49dfb4300750d35b50ea527f (MD5) / Made available in DSpace on 2017-11-08T14:15:37Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) vanessa_kelly_silva_lage.pdf: 1557890 bytes, checksum: f19cfa3f49dfb4300750d35b50ea527f (MD5) Previous issue date: 2017 / A Doen?a Pulmonar Obstrutiva Cr?nica (DPOC) ? caracterizada por uma obstru??o cr?nica persistente ao fluxo a?reo. Estudos que avaliaram o uso da vibra??o de corpo inteiro (VCI) em pacientes com DPOC demonstraram melhora em par?metros cl?nico-funcionais, contudo, o conhecimento a respeito do efeito agudo da VCI na DPOC ainda ? escasso O estudo teve como objetivo, caracterizar a intensidade do exerc?cio em diferentes frequ?ncias de VCI e dos tipos de agachamento (est?tico ou din?mico) durante uma sess?o de exerc?cio, bem como, avaliar o efeito agudo do exerc?cio sobre as respostas cardiorrespirat?rias e inflamat?rias na DPOC.Os volunt?rios da pesquisa foram pareados quanto ao sexo, idade, IMC e foram divididos em 2 grupos, sendo eles: grupo controle (GC, n=13), composto por sujeitos sem DPOC e grupo DPOC (DPOC, n=13). A familiariza??o e aplica??o do Teste de Caminhada de 6 minutos foram realizadas em 1 dia, ap?s 1 semana, a caracteriza??o com o exerc?cio de VCI foi realizada em 4 dias com um intervalo de 48 horas entre as sess?es. O agachamento est?tico foi realizado nas frequ?ncias 30, 35 e 40 Hz e o agachamento din?mico na frequ?ncia 35 Hz. Os dois grupos passaram pelas mesmas condi??es experimentais. Foram mensurados os par?metros cardiorrespirat?rios durante todos os dias de exerc?cio e os par?metros inflamat?rios foram avaliados durante o exerc?cio est?tico na frequ?ncia de 35 Hz atrav?s da concentra??o plasm?tica da adiponectina, resistina, IL-6, IL-8, IL-10, BDNF e receptores sol?veis de TNF (STNFR-1 e STNFR-2). Os resultados demonstraram que o agachamento est?tico promoveu maior varia??o (39,2%) na FC quando comparado ao din?mico. A an?lise nas 3 frequ?ncias de VCI demonstraram comportamento semelhante entre os grupos com aumentos significativos do VO2 (GC: 27,4 a 40% e DPOC: 21,5 a 28,5%) e da FC (GC: 10,2 a 12,5% e DPOC: 4,3 a 12,7%). Foram encontradas altas concentra??es basais das adipocinas e IL-8 e baixos valores de IL-10 no grupo DPOC. Ap?s a VCI foi observado aumento das concentra??es de IL-10 (40,6%) no grupo DPOC alcan?ando valores semelhante a concentra??o basal do GC. Em conclus?o, o presente estudo traz subs?dios para a elabora??o de protocolos de treinamento com a VCI, uma vez que o exerc?cio foi caracterizado como de baixa intensidade (<2 METs) nas frequ?ncias avaliadas, sendo aplic?vel e seguro na DPOC. Adicionalmente, a VCI parece modular as concentra??es de IL-10 na popula??o de DPOC avaliada. / Disserta??o (Mestrado) ? Programa Multic?ntrico de P?s-gradua??o em Ci?ncias Fisiol?gicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2017. / Chronic Obstructive Pulmonary Disease (COPD) is characterized by chronic persistent airflow obstruction. Studies evaluating the use of whole body vibration (WBV) in patients with COPD have shown improvement in clinical-functional parameters, however, knowledge about the acute effect of WBV in COPD is still scarce. The objective of this study was to characterize the intensity (static or dynamic) during an exercise session, as well as to evaluate the acute effect of exercise on cardiorespiratory and inflammatory responses in COPD. The study volunteers were matched for gender, age, BMI and were divided into 2 groups: control group (GC, n = 13), composed of subjects without COPD and COPD group (COPD, n = 13). Familiarization with WBV exercise and the application of the 6-minute Walk Test were performed in one day, after 1 week, the characterization of the WBV exercise was performed in 4 days with a 48-hour interval between sessions. Static squatting was performed at frequencies 30, 35 and 40 Hz and dynamic squatting at 35 Hz frequency. Both groups underwent the same experimental conditions. Cardiorespiratory parameters were measured during all exercise days and inflammatory parameters were evaluated during static exercise at the 35 Hz frequency through the plasma concentration of adiponectin, resistin, IL-6, IL-8, IL-10, BDNF and soluble TNF receptors (STNFR-1 and STNFR-2). The results showed that static squatting promoted greater variation (39.2%) in HR when compared to dynamic. The analysis of 3 frequencies of WBV showed similar results between the groups with significant increases in VO2 (GC: 27.4 to 40% and COPD: 21.5 to 28.5%) and HR (CG: 10.2 a 12.5% e COPD: 4.3 a 12.7%). Baseline concentrations of adipokines and IL-8 showed higher values, in the other hand low IL-10 values were found in the COPD group. After WBV, an increase in IL-10 concentrations (40.6%) was observed in the COPD group reaching values similar to basal GC concentration. In conclusion, the present study provides subsidies for the elaboration of training protocols with WBV, since exercise was characterized as low intensity (<2 METs) in the frequencies evaluated, being applicable and safe in COPD. In addition, VCI appears to modulate IL-10 concentrations in the COPD population evaluated.

Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2018-03-20T18:00:43Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) namibia_rizzari_leite.pdf: 3000386 bytes, checksum: 4ad82a1678a4c363522c1631a2cdead0 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2018-03-29T14:18:22Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) namibia_rizzari_leite.pdf: 3000386 bytes, checksum: 4ad82a1678a4c363522c1631a2cdead0 (MD5) / Made available in DSpace on 2018-03-29T14:18:22Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) namibia_rizzari_leite.pdf: 3000386 bytes, checksum: 4ad82a1678a4c363522c1631a2cdead0 (MD5) Previous issue date: 2017 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (Capes) / Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais (FAPEMIG) / Esta pesquisa foi realizada com o objetivo de avaliar o efeito da intera??o gen?tipo x n?veis de lisina digest?vel das dietas sobre caracter?sticas morfom?tricas e de desempenho de til?pias do Nilo, variedade GIFT, em fase de crescimento. O experimento foi constitu?do de duas fases, sendo que na primeira as til?pias foram alimentadas dos 90 aos 150 dias de idade com dietas contendo percentuais de lisina iguais a 1,43, 1,53, 1,63, 1,73 e 1,83 e na segunda fase, dos 151 aos 255 dias, os percentuais de lisina das dietas foram iguais a 1,28, 1,38, 1,48, 1,58 e 1,68. As til?pias foram pesadas dos 90 aos 255 dias de idade com intervalos de aproximadamente 30 dias, foram calculados o ganho de peso total e o ganho de peso di?rio e, posteriormente, as idades foram ajustadas para 90 e 150 dias na primeira fase, e 185, 220 e 255 dias na segunda fase. As medidas de altura, largura, comprimento de cabe?a, comprimento padr?o e comprimento total das til?pias foram coletadas aos 150 dias de idade. A partir desses dados, foram calculadas as rela??es cabe?a/comprimento padr?o, comprimento padr?o/comprimento total e largura/altura. Modelos de regress?o aleat?ria, por meio do modelo animal uni caracter?stica, foram utilizados para avaliar a sensibilidades dos valores gen?ticos aos n?veis de lisina digest?vel das dietas, plotando-se as normas de rea??o de 25 peixes amostrados aleatoriamente para as diferentes caracter?sticas para demonstrar o padr?o de comportamento dos valores gen?ticos das caracter?sticas ao longo do gradiente ambiental. Foram testados modelos com homogeneidade (1 classe) e heterogeneidade de vari?ncia residual (2, 3 e 4 classes). Modelos com heterogeneidade de vari?ncia residual foram mais adequados para avalia??o gen?tica da maioria das caracter?sticas das til?pias na primeira fase e modelos com homogeneidade de vari?ncia residual para a maioria das caracter?sticas de desempenho das til?pias avaliadas na segunda fase. Os valores gen?ticos das til?pias, em ambas as fases, variaram entre os n?veis de lisina estudados para a maioria das caracter?sticas, indicando a presen?a de intera??o gen?tipo x ambiente. No geral, as herdabilidades e vari?ncias gen?ticas aditivas variaram de baixas a altas magnitudes. As correla??es de Spearman, assim como as normas de rea??o, indicaram reordenamento dos valores gen?ticos ao longo do gradiente ambiental, sugerindo a presen?a de intera??o gen?tipo x ambiente. A sele??o para desempenho e medidas morfom?tricas de til?pias GIFT deve ser realizada no n?vel de lisina da dieta com a qual as til?pias ser?o alimentadas. / Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Zootecnia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2017. / This research was carried out with the objective of evaluating the effect of genotype x levels of digestible lysine of the diets on morphometric and performance characteristics of Nile tilapia, GIFT variety, in the growing phase. The experiment consisted of two phases, and in the first the tilapia were fed from 90 to 150 days of age diets containing lysine percentages equal to 1.43, 1.53, 1.63, 1.73 and 1.83. In the second phase, from 151 to 255 days, the lysine percentages of the diets were 1.28, 1.38, 1.48, 1.58 and 1.68. Tilapia were weighed from 90 to 255 days of age at intervals of approximately 30 days. Total weight gain and daily weight gain were calculated and, subsequently, were adjusted for 90 and 150 days in the first phase, and 185 , 220 and 255 days in the second phase. The measurements of height, width, head length, standard length and total length of tilapias were collected at 150 days of age. From these data, the head / standard length ratios, standard length / total length and width / height ratios were calculated. Single trait random regression modes were used in the analyses and the reaction norm plots of 25 randomly sampled fishes were used to demonstrate the sensitivity of breeding values to dietary digestible lysine level. Models with homogeneity (1 class) and heterogeneity of residual variance (2, 3 and 4 classes) were tested. Models considering heterogeneity of residual variance were more adequate for genetic evaluation of most of the characteristics of tilapia in the first phase and models considering homogeneity of residual variance for most of the performance characteristics of tilapia evaluated in the second phase. The breeding values of tilapia, in both phases, varied among the lysine levels studied for most of the traits, indicating the presence of genotype x environment interaction. In general, heritabilities and additive genetic variances varied from low to high magnitude. Spearman correlations, as well as the reaction norms, suggested rearrangement of breeding values along the environmental gradient, again indicating the presence of genotype x environment interaction. The selection for performance and morphometric traits of tilapia GIFT strain should be performed at the lysine level of the diet with which the tilapia will be fed.

Made available in DSpace on 2014-12-17T13:53:34Z (GMT). No. of bitstreams: 1 ElidaRMS_DISSERT.pdf: 2121129 bytes, checksum: a588269dcbb9d940a7267a0f2c55eb74 (MD5) Previous issue date: 2012-09-14 / Based on the definitions of Public Communication, Political Marketing, Public Interest Information and Communication as a Tool of Governance, the study notes the use of the news section of the websites of the City Christmas and Mossoro, Rio Grande do Norte, in regard to strengthening citizenship and encouraging participatory management, from the characterization of materials like pieces of Political Marketing and Public Communication. Data collection in qualitative research was conducted from August to September 2011 and content analysis showed that the appropriation of public property for personal use is a reality, despite legal requirements to the detriment of strategic communication and governance for results from the dissemination of information of public interest and the establishment of a communication channel between State Government and Society. Elements of this study suggest the need for further research to deepen the discussion / Baseado nas defini??es de Comunica??o P?blica, Marketing Pol?tico, Informa??o de Interesse P?blico e na Comunica??o como Ferramenta de Governan?a, o estudo observa o uso da se??o de not?cias dos sites das Prefeituras de Natal e Mossor?, no Rio Grande do Norte, no tocante ao fortalecimento da cidadania e incentivo ? gest?o participativa, a partir da caracteriza??o das mat?rias como pe?as de Marketing Pol?tico e Comunica??o P?blica. A coleta de dados da pesquisa qualitativa foi realizada de agosto a setembro de 2011 e a an?lise do conte?do demonstrou que a apropria??o da coisa p?blica para uso pessoal ? uma realidade, apesar das exig?ncias legais, em detrimento de a??es estrat?gicas de comunica??o e de governan?a para resultados, a partir da difus?o de informa??es de interesse p?blico e do estabelecimento do canal de comunica??o entre Estado, Governo e Sociedade. Elementos deste estudo sugerem a necessidade de novas pesquisas para aprofundar a discuss?o

Made available in DSpace on 2014-12-17T13:56:56Z (GMT). No. of bitstreams: 1 PatriciaVT_capa_ate_cap1_.pdf: 2021691 bytes, checksum: 8f29e932ee450f2f59d070013ff553ae (MD5) Previous issue date: 2007-02-28 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The present research concerns about outdoor s thermal comfort conditions in hot-humid climate cities, understanding that life quality is a result of the urban object s type built for the human being in an environment with specific climate and morphological characteristics. It is presented as object of study the correlation between the neighborhood Renascen?a II s microclimate in S?o Luis /MA-Brazil, hot-humid climate city, and its urban morphological changes. As well as the thermal comfort s satisfaction level of its outdoor users. The research has as general goal to diagnosis the way these transformations caused by the urbanization influence the Renascen?a II s microclimate, identifying critical spots of the studied area, in order to contribute with land use recommendations based on bioclimatic architecture concepts and supply bases to urban design decisions adequate to the S?o Luis climate. It is presented as theoretical bases the urban climate, its concepts and elements. After that, the thermal comfort conditioners and its prediction models of thermal comfort sensation in outdoor are presented. The predictive models are presented along with bioclimatic assessment methods. Finally the use of bioclimatic assessment as an effective tool to identify places that need changes or preservation in order to seek environment quality. The applied methodology was based on the studies of Katzschner (1997), complemented by Oliveira s (1988) and Bustos Romero s (2001) studies that suggest an analysis and evaluation of maps of topography, buildings floors, land use, green areas and land covering, in order to overlap their characteristics and identify climate variable s measurements points; then a quantitative analysis of the climate variables (air temperature and humidity, wind speed and direction) of the chosen points takes place. It was perceived that Renaissance II has no permanence areas as squares or parks, its outdoor has little vegetation and presets high land impermeability and built density levels. The majority of the people interviewed said that was comfortable in a range of air temperature between 27,28?C and 30,71?C. The elaboration of a neighborhood master plan is important, which defines strategies for improvement of the life quality of its inhabitants / O presente trabalho parte das preocupa??es com as condi??es de conforto t?rmico dos espa?os externos em cidades de clima quente-?mido, entendendo que a qualidade de vida neste ambiente ? fruto do tipo de objeto urbano constru?do para a viv?ncia humana em um meio ambiente com clima e caracter?sticas morfol?gicas espec?ficas. Apresenta-se como objeto de estudo a correla??o entre o microclima do Bairro do Renascen?a II em S?o Luis/MA, cidade de clima quente ?mido frente ?s mudan?as nas caracter?sticas morfol?gicas urbana e o ?ndice de satisfa??o de conforto t?rmico dos usu?rios dos espa?os externos do bairro em quest?o. Tem como objetivo geral diagnosticar a maneira como as transforma??es ocasionadas pela urbaniza??o influenciam o microclima do Renascen?a II, identificando ?reas cr?ticas da ?rea estudada, a fim de contribuir com recomenda??es de uso e ocupa??o do solo baseadas em conceitos de arquitetura bioclim?tica e fornecer subs?dios a futuras decis?es projetuais urbanas adequadas ao clima quente e ?mido de S?o Luis-MA. Apresenta-se como fundamenta??o te?rica o clima urbano, seus conceitos, elementos formadores e condicionantes. Em seguida, os condicionantes do conforto t?rmico e seus modelos de predi??o de sensa??o de conforto t?rmico em espa?os externos. Foram levantados os modelos preditivos de conforto e estresse t?rmico como ferramenta junto ? an?lise bioclim?tica. E finalmente a utiliza??o da an?lise bioclim?tica no diagn?stico do conforto t?rmico de ?reas urbanas, com sua efic?cia na identifica??o de locais que necessitam de mudan?as quanto ao conforto ambiental, merecendo aten??o ou at? prote??o; e suas estrat?gias na busca por cidades mais adequadas ao seu meio natural, resultando no urbanismo bioclim?tico. A metodologia aplicada baseou-se nos estudos de Katzschner (1997), complementados por Oliveira (1988) e Bustos Romero (2001) que sugerem uma an?lise e avalia??o de mapas de topografia, altura das edifica??es, uso do solo, ?reas verdes e tipo de cobertura do solo, para superposi??o e identifica??o de pontos para medi??o; a partir da? uma an?lise quantitativa com aferi??o das vari?veis ambientais (temperatura e umidade do ar, a velocidade e a dire??o dos ventos) nos pontos escolhidos. Percebeu-se que o bairro do Renascen?a II n?o possui ?reas de perman?ncia como pra?as e parques, as suas ?reas externas possuem pouca arboriza??o e apresenta alto ?ndice de impermeabilidade e alta densidade construtiva. A maioria dos entrevistados disse estar confort?vel em uma faixa de temperatura do ar entre 27,28? e 30,71?C. ? importante a elabora??o de um plano diretor para o bairro, definindo de estrat?gias para melhoria da qualidade de vida de seus habitantes

Made available in DSpace on 2014-12-17T14:09:12Z (GMT). No. of bitstreams: 1 FilipeOQ_TESE.pdf: 3544001 bytes, checksum: a41be36b03f0fc409d26c8565085c60f (MD5) Previous issue date: 2010-02-25 / In the artificial lift method by Electrical Submersible Pump (ESP), the energy is transmitted for the well?s deep through a flat electric handle, where it is converted into mechanical energy through an engine of sub-surface, which is connected to a centrifugal pump. This transmits energy to the fluid under the pressure form, bringing it to the surface In this method the subsurface equipment is basically divided into: pump, seal and motor. The main function of the seal is the protect the motor, avoiding the motor?s oil be contaminated by oil production and the consequent burning of it. Over time, the seal will be wearing and initiates a contamination of motor oil, causing it to lose its insulating characteristics. This work presents a design of a magnetic sensor capable of detecting contamination of insulating oil used in the artificial lift method of oil-type Electrical Submersible Pump (ESP). The objective of this sensor is to generate alarm signal just the moment when the contamination in the isolated oil is present, enabling the implementation of a predictive maintenance. The prototype was designed to work in harsh conditions to reach a depth of 2000m and temperatures up to 150?C. It was used a simulator software to defined the mechanical and electromagnetic variables. Results of field experiments were performed to validate the prototype. The final results performed in an ESP system with a 62HP motor showed a good reliability and fast response of the prototype. / No m?todo de eleva??o artificial de petr?leo por Bombeio Centr?fugo Submerso (BCS) a energia el?trica ? transmitida para o fundo do po?o atrav?s de um cabo, onde ? transformada em energia mec?nica por um motor de sub-superf?cie, o qual est? conectado a uma bomba centr?fuga, que transmite a energia para o fluido sob a forma de press?o, elevando-o para a superf?cie. Neste m?todo, os equipamentos de sub-superf?cie subdividem-se basicamente em: bomba, selo e motor. A principal fun??o do selo ? a prote??o do motor, evitando a contamina??o do ?leo do motor pelo ?leo de produ??o e a conseq?ente queima do mesmo. Com o tempo, o selo vai desgastando-se e come?a haver uma contamina??o do ?leo do motor, fazendo com que o mesmo perca a sua caracter?stica isolante. Este trabalho apresenta um projeto de um sensor magn?tico capaz de detectar a contamina??o do ?leo isolante utilizado no m?todo de eleva??o artificial de petr?leo do tipo (BCS). O objetivo deste sensor ? gerar um sinal de alarme apenas no momento em que a contamina??o do ?leo isolante estiver presente, possibilitando ? execu??o de uma manuten??o preditiva. O prot?tipo foi projetado para trabalhar em condi??es operacionais severas, podendo alcan?ar uma profundidade de 2000m e temperaturas at? 150?C. Foi utilizado um software simulador para definir as vari?veis mec?nicas e eletromagn?ticas. Experimentos de campo foram realizados para validar o prot?tipo. Os resultados finais realizados em um sistema BCS com um motor de 62HP mostrou uma boa confiabilidade e resposta r?pida do prot?tipo.

Made available in DSpace on 2014-12-17T14:09:16Z (GMT). No. of bitstreams: 1 JardelDC_TESE_Parcial.pdf: 1739659 bytes, checksum: 19974b9395e0d9fcb23b07c3997dab2f (MD5) Previous issue date: 2012-07-30 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The resistance of aluminum and their alloys, to the corrosion phenomenon, in aqueous solutions, is a result of the oxide layer formed. However, the corrosion process in the aluminum alloy is associated with the presence a second phase of particles or the presence of chloride ions which promote the disruption of the oxide layer located producing the corrosion process. On the other hand, the term water produced is used to describe the water after the separation of the oil and gas in API separators. The volumes of produced water arrive around 5 more times to the volume of oil produced. The greatest feature of the water is the presence of numerous pollutants. Due to the increased volume of waste around the world in the current decade, the outcome and the effect of the discharge of produced water on the environment has recently become an important issue of environmental concern where numerous treatments are aimed at reducing these contaminants before disposal. Then, this study aims to investigate the electrochemical corrosion behavior of aluminum alloy 6060 in presence of water produced and the influence of organic components as well as chloride ions, by using the electrochemical techniques of linear polarization. The modification of the passive layer and the likely breakpoints were observed by atomic force microscopy (AFM). In the pit formation potential around -0.4 to -0.8 V/EAg/AgCl was observed that the diffusion of chloride ions occurs via the layer formed with the probable formation of pits. Whereas, at temperatures above 65 ?C, it was observed that the range of potential for thepit formation was -0.4 to -0.5 V/EAg/AgCl. In all reactions, the concentration of Al(OH)3 in the form of a gel was observed / A resistencia do aluminio e suas ligas a corros?o em meio aquoso ? resultado da camada de oxido formada. Entretanto, o processo corrosivo nas ligas de alum?nio esta associado a presen?a de part?culas de segunda fase ou a presen?a de ions cloreto que promovem a ruptura da camada de ?xido produzindo o processo corrosivo localizado. Por outro lado, o termo ?gua produzida ? usado para descrever a ?gua ap?s a sua separa??o do ?leo e g?s nos separadores API. Os volumes de ?gua produzida chegam em m?dia de 5 vezes o volume do ?leo produzido. A maior caracter?stica dessa ?gua ? a presen?a de in?meros contaminantes. Devido ao aumento do volume dos res?duos em todo o mundo na d?cada atual, o desfecho e do efeito da descarga de ?gua produzida sobre o meio ambiente tem recentemente tornar-se uma quest?o importante de preocupa??o ambiental onde in?meros tratamentos s?o destinados a redu??o destes contaminantes antes do descarte. Ent?o, o presente estudo visa investigar o comportamento eletroquimico de corros?o da liga de aluminio 6060 em presen?a de ?gua produzida e a influencia dos componentes organicos assim como dos ions cloreto, atrav?s do uso das tecnicas eletroqu?micas de polariza??o linear. A modifica??o da camada passiva e os prov?veis pontos de ruptura foram observados por microscopia de for?a atomica (AFM). No potencial de forma??o de pit de -0,4 a -0,8 V/EAg/AgCl observa-se que ocorre a difus?o dos ?ons cloreto pela camada formada com prov?vel forma??o de pites. Entretanto, em temperaturas superiores a 65?C observou-se que a faixa de potencial de forma??o de pit foi de -0,4 a -0,5V/ EAg/AgCl. Em todas as rea??es observou-se o aumento na concentra??o de Al(OH)3 sob a forma de um gel / 2020-01-01

Made available in DSpace on 2014-12-17T14:13:58Z (GMT). No. of bitstreams: 1 IramiAF.pdf: 656108 bytes, checksum: 1ac30916d2a3afe1a1b29b6e3fa7c51f (MD5) Previous issue date: 2007-08-15 / The biliopancretic diversion with duodenal switch is one of the mixing techniques used in the treatment of morbid obesity. The duodenal switch reduces the stomach capacity and leaves only 50-100 cm of small intestine for nutrition and absorption. The surgery produces hormonal, structural and biochemical changes, which can influence on the result of scintigraphic examinations in operated patients. With the objective of evaluate the postoperative biodistribution of sodium pertechnetate (Na99mTcO4) in brain, thyroid, heart, lung, liver, spleen, kidney, stomach, duodenum, pancreas, small intestine, bladder, muscle and bone of Wistar rats. The rats were randomly allocated into 3 groups of 7 rats each: the duodenal switch group (DS), the control group (C) and the sham group (S). They were operated under anesthesia and aseptic technique. In the tenth postoperative day, 0.1mL of sodium pertechnetate was injected via orbital plexus. After 30 min the animals were killed with overdose of anesthetic and samples of liver, spleen, pancreas, stomach, duodenum, small intestine, thyroid, lung, heart, kidney, bladder, muscle, bone and brain were harvested, washed with saline and weighed. The detention of radioactivity was made using the automatic Gamma Counter Wizard, PerkinElmer and the percentage of activity per gram of tissue (%ATI/g) was calculated. There was no early or late mortality in either rats groups. The values of percent radioactivity per gram of tissue (%ATI/g), showed no significant difference in liver, stomach, small bowel, duodenum, kidney, heart, bladder, bone and brain, when compared the DS rats with sham and controls rats. A postoperative significant increase in mean %ATI/g levels was observed in spleen, pancreas and muscle in group DS rats, as compared to group S and C rats (p<0.05). In the lung there was an increase and in thyroid a decrease in mean %ATI/g of DS rats, when compared to sham rats (p>0.05). In conclusion, the biliopancreatic diversion with duodenal switch in rats modified the biodistribution of sodium pertechnetate in thyroid, lung, pancreas, spleen and muscle. The study had the participation of the departments and laboratories researches, as Nucleus of Experimental Surgery, Department of Surgery, Laboratory of Radiobiology, Department of Pathology and Service of Nuclear Medicine, certifying the character of a multidisciplinary research / A cirurgia do desvio biliopancre?tico ? uma das t?cnicas mistas utilizada no tratamento da obesidade m?rbida. O Switch duodenal reduz o est?mago a ? de sua capacidade e deixa apenas 50-100 cm de intestino delgado para nutri??o e absor??o. Isso leva a altera??es estruturais, hormonais e bioqu?micas que podem influenciar no resultado de exames cintilogr?ficos de pacientes operados. Com o objetivo de avaliar a biodistribui??o p?s-operat?ria do pertecnetato de s?dio (Na99mTcO4) em ?rg?os de diversos sistemas como c?rebro, tire?ide, cora??o, pulm?o, f?gado, ba?o, rim, est?mago, duodeno, p?ncreas, intestino delgado, bexiga, m?sculo e f?mur de ratos Wistar submetidos ? t?cnica do switch duodenal, foram utilizados ratos com 3 meses de idade alocados aleatoriamente em: grupo tratado, submetido ? cirurgia de desvio biliopancre?tico, t?cnica do switch duodenal (SD), o grupo controle (C) e o grupo submetido a uma simula??o de cirurgia, denominado sham (S). No d?cimo dia de p?s-operat?rio, 0,1 mL do pertecnetato de s?dio (Na99mTcO4) foi injetado via plexo orbital (IV). Decorridos trinta minutos da administra??o do radiof?rmaco, os animais foram sacrificados e submetidos a toracolaparotomia mediana para retirada do f?gado, ba?o, p?ncreas, est?mago, duodeno, intestino delgado, tire?ide, pulm?o, cora??o, rim, bexiga, m?sculo, f?mur e c?rebro. A detec??o da radioatividade foi feita com Contador Gama (Wizard, PerkinElmer USA), autom?tico. Calculou-se em seguida o percentual de atividade por grama de tecido (%ATI/g) do pertecnetato de s?dio (Na99m TcO4) em cada ?rg?o. Os valores da biodistribui??o do pertecnetato no ba?o, p?ncreas e m?sculo nos animais do grupo switch tiveram uma diferen?a significativamente maior do que os dos grupos C e S (p<0,05). Na tire?ide dos animais do grupo SD o pertecnetato teve menor capta??o em rela??o aos demais grupos, sendo estatisticamente significante quando comparada ao grupo S (p<0,05). A biodistribui??o pulmonar nos animais do grupo SD s? foi significativamente maior quando comparada a do grupo S (p<0,05). N?o houve diferen?a significante, para os demais ?rg?os. Em conclus?o, a t?cnica do desvio biliopancre?tico com switch duodenal alterou a biodistribui??o p?s-operat?ria do Na99mTcO4 em ?rg?os como tire?ide, pulm?o, ba?o, p?ncreas e m?sculo de ratos operados, devido a prov?veis altera??es metab?licas e estruturais causadas por t?cnica cir?rgica mutilante. O trabalho teve um car?ter multidisciplinar com a participa??o de pesquisadores de diferentes departamentos e laborat?rios, como N?cleo de Cirurgia Experimental, Departamento de Cirurgia, Laborat?rio de Radiobiologia e o Servi?o de Medicina Nuclear da Liga Norte-Riograndense contra o C?ncer, atestando o car?ter multidisciplinar da pesquisa

Made available in DSpace on 2014-12-17T14:16:27Z (GMT). No. of bitstreams: 1 AliceRO_DISSERT.pdf: 2104659 bytes, checksum: 208850f5293dd4764037ec4c490d3636 (MD5) Previous issue date: 2011-12-19 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Methotrexate (MTX) is a drug used in the chemotherapy of some kind of cancers, autoimmune diseases and non inflammatory resistant to corticosteroids uveits. However, the rapid plasmatic elimination limits its therapeutic success, which leads to administration of high doses to maintain the therapeutic levels in the target tissues, occurring potential side effects. The aim of this study was to obtain spray dried biodegradable poly-lactic acid co-glycolic acid (PLGA) microparticles containing MTX. Thus, suitable amounts of MTX and PLGA were dissolved in appropriate solvent system to obtain solutions at different ratios drug/polymer (10, 20, 30 and 50% m/m). The physicochemical characterizing included the quantitative analysis of the drug using a validate UV-VIS spectrophotometry method, scanning electron microscopy (SEM), infrared spectrophotometry (IR), thermal analyses and X-ray diffraction analysis. The in vitro release studies were carried out in a thermostatized phosphate buffer pH 7.4 (0.05 M KH2PO4) medium at 37?C ? 0.2 ?C. The in vitro release date was subjected to different kinetics release models. The MTX-loaded PLGA microparticles showed a spherical shape with smooth surface and high level of entrapped drug. The encapsulation efficiency was greater then 80%. IR spectroscopy showed that there was no chemical bond between the compounds, suggesting just the possible occurrence of hydrogen bound interactions. The thermal analyses and X-ray diffraction analysis shown that MTX is homogeneously dispersed inside polymeric matrix, with a prevalent amorphous state or in a stable molecular dispersion. The in vitro release studies confirmed the sustained release for distinct MTX-loaded PLGA microparticles. The involved drug release mechanism was non Fickian diffusion, which was confirmed by Kornmeyer-Peppas kinetic model. The experimental results demonstrated that the MTX-loaded PLGA microparticles were successfully obtained by spray drying and its potential as prolonged drug release system. / O metotrexato (MTX) ? um f?rmaco utilizado na quimioterapia de alguns tipos de c?ncer, doen?as autoimunes e uve?tes n?o inflamat?rias resistentes aos corticoster?ides. No entanto, sua r?pida elimina??o plasm?tica limita o sucesso terap?utico, levando ? necessidade de altas doses para manuten??o da concentra??o efetiva no tecido alvo, ocasionando o potencial surgimento de rea??es adversas. O objetivo principal desse estudo foi obter um sistema microparticulado biodegrad?vel ? base de ?cido poli (?cido l?tico-co-?cido glic?lico) (PLGA) por spray drying para libera??o prolongada do MTX. Para isso, quantidades distintas de MTX e PLGA foram dissolvidas em sistema solvente adequado para obter solu??es com diferentes propor??es de f?rmaco em rela??o ao pol?mero (10, 20, 30 e 50% m/m). A caracteriza??o f?sicoqu?mica incluiu an?lise quantitativa do f?rmaco incorporado na matriz polim?rica por espectrofotometria UV-VIS em 303nm previamente validada, microscopia eletr?nica de varredura (MEV), espectrofotometria de infravermelho (IV), an?lises t?rmicas e difra??o de raios-X (DRX). O perfil de libera??o in vitro do f?rmaco nas micropart?culas foi realizado em tamp?o fosfato (0.05 M KH2PO4) em banho termostatizado 37 ?C ? 0.2 ?C. Os dados obtidos do estudo de libera??o in vitro foram submetidos a diferentes modelos cin?ticos de libera??o. As micropart?culas de PLGA contendo o MTX apresentaram a forma esf?rica, uniforme, com superf?cie aparentemente lisa. O n?vel de efici?ncia de encapsula??o foi superior a 80%. A espectroscopia na regi?o do infravermelho demonstrou que n?o ocorreu liga??o qu?mica entre os componentes dos sistemas, no entanto foi observado forte intera??o entre o MTX e PLGA indicando prov?vel ocorr?ncia de pontes de hidrog?nio. An?lise XII t?rmica e DRX demonstraram que o MTX est? distribu?do na matriz polim?rica com a preval?ncia do estado amorfo ou em dispers?o molecular. O estudo de libera??o in vitro confirmou o perfil de libera??o prolongada para as diferentes micropart?culas. O mecanismo de libera??o envolvido foi por difus?o n?o Fickiana, ao qual foi determinado a partir do modelo cin?tico de Kornmeyer- Peppas. Os resultados experimentais demonstraram o sucesso na obten??o das micropart?culas de PLGA contendo o MTX por spray drying e seu potencial como sistema de libera??o prolongada do f?rmaco.

Made available in DSpace on 2014-12-17T14:16:28Z (GMT). No. of bitstreams: 1 CarolinaMC_DISSERT.pdf: 2312881 bytes, checksum: 468e37b11a049ed173243a8574567f3c (MD5) Previous issue date: 2012-02-10 / All medicine, whether allopathic or homeopathic, must go through strict quality control, which must ratify their characteristics throughout the period of validity. During the time of preparation and storage, solutions of the drugs are in permanent contact with packaging materials that can release undesirable substances to the solution. Several factors may influence the release of packing materials, and factorial design (FD) is a useful tool for analyzing the phenomenon. The aim of this study was the determination of quality parameters for Homeopathic solid (globules) and liquid (drops) dosage forms. It was carried out analysis in homeopathic globules for weight variation, mechanical strength, and moisture content uniformity. For liquid preparations, standard solutions were prepared from natural rubber bulbs, which were subjected to exhaustive extraction with two ethanol solutions (30 and 70%) in the ultrasonic bath for 20 minutes at 25?C and 50?C in three successive cycles. Studies of transfer have been made within five days, by spectrophotometric analysis in the UV region at 312 nm with &#955;m?x and 323 nm for samples in 70% ethanol and 30% respectively. PH values were analyzed. We also conducted two FD studies, where the first, the three-level variables were solvent (chloroform, ethanol and nhexane), sample mass (30, 60 and 90mg), particle size (large disk, small disk and powder sample). In the second study, the solvent level variables were different ethanolic degrees (EtOH 30%, 70% and pure). The percentage of lending in the solutions was 5.5%, 12.4%, 24.2% and 41% of the total estimated in the reference solution. The values of rate constants of transfer were determined in the order of 0.0134 days-1 and 0.0232 days-1 in absorbance values, the solutions in ethanol at 30% and 70% respectively. These results suggest that the speed of transfer of materials from rubber is affected both by the nature of the vehicle as by the temperature / Todo medicamento, quer seja alop?tico ou homeop?tico, deve passar por rigoroso controle de qualidade, o qual deve ratificar as suas caracter?sticas ao longo de todo o per?odo de validade. Durante o tempo de preparo e armazenamento, as solu??es dos medicamentos est?o em contato permanente com os materiais de embalagem que podem liberar subst?ncias indesej?veis para a solu??o. V?rios fatores podem influenciar a libera??o de materiais da embalagem, e planejamento fatorial (PF) ? uma ferramenta ?til para analisar o fen?meno. O objetivo deste trabalho foi a determina??o de par?metros de qualidade para Formas Farmac?uticas Homeop?ticas s?lidas (gl?bulos) e liquidas (gotas). Foi efetuada a avalia??o dos gl?obulos homeop?ticos no que diz respeito ? sua varia??o de peso, testes de resist?ncia mec?nica, uniformidade de conte?do e umidade. Para as prepara??es liquidas, preparamos solu??es de refer?ncia a partir de bulbos de borracha natural, os quais foram submetidos ? extra??o exaustiva com duas solu??es de etanol (30 e 70%), em banho de ultrassom durante 20 minutos a 25?C e 50?C, em tr?s ciclos sucessivos de 24 horas. Os estudos de ced?ncia foram efetuados num tempo de cinco dias, atrav?s de an?lise espectrofotom?trica na regi?o UV com &#955;m?x em 312 nm e 323 nm para as amostras em etanol a 70% e 30%, respectivamente. Foram verificados valores de pH. Foram tamb?m realizados dois estudos de PF, onde no primeiro, as tr?s vari?veis de n?vel foram solvente (clorof?rmio, etanol e n-hexano), massa de amostra (30, 60 e 90mg), a forma de amostra (grande disco, disco pequeno, a amostra em p?). No segundo estudo, as vari?veis de n?vel solvente foram gradua??es etan?licas diferentes (EtOH 30%, 70% e puro). O percentual de ced?ncia nas solu??es foi de 5,5%, 12,4%, 24,2% e 41% do total estimado na solu??o de refer?ncia. Os valores das constantes de velocidade de ced?ncia foram determinados na ordem de 0,0134 dia-1 e 0,0232 dia-1, em valores de absorb?ncia, nas solu??es em etanol a 30% e 70%, respectivamente. Esses resultados sugerem que a velocidade de ced?ncia de materiais a partir da borracha ? afetada tanto pela natureza do ve?culo como pela temperatura