Highland of Bohemia and Moravia is one of oldest areas of our country. Historical sources show evidence of plentiful silver-ore deposits already since middle of 13th century. There were silver streaks appurtenant to Jihlava´s mineral district in the close environ of Jihlava town. This mineral district extends to regions Brtnicko, Stonařovsko and Třešťsko. Silver streak leaded to Třešťsko (towards Salavice, Jezdovice and periphery of Třešť town to be specific) from former mineral district of Rantířovsko. The mediaeval mining was almost forgotten nowadays and mining pieces were cancelled and buried. Some of extant relicts could remind us this Gothic time if they were not instantly land-filled and aligned. I concern myself with natural characteristics of the determinate district in the first part of my graduation thesis. Content of the second part of my graduation thesis is the proposal of nature trail in the mineral district of Jihlava - part ?Jezdovice u Třeště? ? itself. First of all I focus on the history of nature trails, on its types and segmentation. I addict myself to the trail proposal itself and its marking and design in the second chapter. The trail is focused on the mining history and geological attractions in the first place. The nature trail has sight-seeing character and thanks to its easy low-end terrain is easily accessed for all visitors. So, it is destined for the general public. The part of appendixes contains photo-documentation of interesting locations on the trail, pictures of samples mined here already in the Gothic time and other appendixes as maps, plans, charts etc.

abstract: Cancer is the second leading cause of death in the United States and novel methods of treating advanced malignancies are of high importance. Of these deaths, prostate cancer and breast cancer are the second most fatal carcinomas in men and women respectively, while pancreatic cancer is the fourth most fatal in both men and women. Developing new drugs for the treatment of cancer is both a slow and expensive process. It is estimated that it takes an average of 15 years and an expense of $800 million to bring a single new drug to the market. However, it is also estimated that nearly 40% of that cost could be avoided by finding alternative uses for drugs that have already been approved by the Food and Drug Administration (FDA). The research presented in this document describes the testing, identification, and mechanistic evaluation of novel methods for treating many human carcinomas using drugs previously approved by the FDA. A tissue culture plate-based screening of FDA approved drugs will identify compounds that can be used in combination with the protein TRAIL to induce apoptosis selectively in cancer cells. Identified leads will next be optimized using high-throughput microfluidic devices to determine the most effective treatment conditions. Finally, a rigorous mechanistic analysis will be conducted to understand how the FDA-approved drug mitoxantrone, sensitizes cancer cells to TRAIL-mediated apoptosis. / Dissertation/Thesis / Ph.D. Chemical Engineering 2013

Com a iminência da construção de mais um trecho do Rodoanel Mário Covas, seu Trecho Norte, tem fechamento um ciclo longo de acumulação de capital na metrópole paulista, de mais de 150 anos, caracterizado pela expansão metropolitana (desigual e combinada) impulsionada pela especulação imobiliária baseada na verticalização do centro expandido e na horizontalização da cidade via loteamentos periféricos. Nesse um século e meio, seu motor foi à crescente financeirização do espaço urbano, tendo como principal conseqüência terrível, a produção de um ambiente construído agressor para sua própria população metropolitana. Como num roteiro de Tarantino, esse presente denota uma sarcástica imagem: hoje, as deseconomias metropolitanas, como as enchentes, o congestionamento e a poluição, tomam o lugar que um dia foi da garoa, de Adoniran Barbosa e dos bairros tradicionais de imigrantes, na produção da identidade paulistana. O novo ciclo de acumulação de capital em gestação não tem como objetivo resgatar essas memórias paulistanas. Ironicamente, esse novo modelo, baseado na suburbanização de alto padrão e no congelamento/urbanização das áreas de loteamento periférico precário e irregular, tem como objetivo construir uma plataforma logística metropolitana apropriada para o que Karl Manheim e tantos outros chamam de fuga do urbano. Pois, o que está em questão é a clara mudança de um padrão de urbanização brasileira (subdesenvolvimento de tipo cepalino) para o do tipo estadunidense, caracterizado por highways que ligam os luxuosos subúrbios ajardinados e as grandes aglomerações médias e populares aos centros degradados das cidades. O presente estudo tem por objetivo, apresentar três dinâmicas espaciais urbanas provisórias dessa fuga do urbano, vetorizadas por três grupos de capital urbano (proprietários da terra/intermediadores financeiros; empresas de construção/incorporação; grupos sociais em geral). A exposição da investigação parte do método dialético e da idéia de espaço geográfico composto por forma, função, estrutura e processo. / With the imminent construction of a Rodoanel Mario Covas, its your Trecho Norte thern section, is closing a long cycle of capital accumulation of more than 150 years, characterized by metropolitan expansion (uneven and combined) driven by speculation based on the vertical expanded center and flattening the town allotments via peripherals. In a century and a half, its engine was the growing financial character of urban space, with the primary tremendous consequence, the production of a built environment aggressor for its own metropolitan population. Like a Tarantino script, the most appropriate image is less promising and more disgustingly sarcastic: today, diseconomies metropolitan areas, such as flooding, congestion and pollution, take the place that was once the garoa of Adoniran Barbosa and the traditional neighborhoods of immigrants in the production of identity in São Paulo. The new cycle of capital accumulation in pregnancy is not meant to recover these memories from São Paulo. Ironically, this new model, based on the suburbanization of high standard and the freeze / urbanizing areas of poor and irregular peripheral housing estate, is to build a logistics hub for the metropolitan appropriate that Karl Manheim and many others call urban trail. For what is at issue is the clear shift from a pattern of urbanization in Brazil (underdevelopment CEPAL type) for the U.S. type, characterized by highways that link the luxurious surroundings and landscaped large clumps and popular medium degraded the centers of cities. This study aims to submit three spatial dynamics of urban temporary escape from the urban, vectorized by three groups of urban capital (owners of the land / financial intermediaries, companies of construction / incorporation; social groups in general). Exposure of the research part of the dialectical method and the idea of geographic space composed of form, function, structure and process.

O Transtorno Depressivo Maior (TDM) está entre as síndromes psiquiátricas que mais atingem a população em geral. A prevalência da depressão durante a vida é de 7 a 12% para homens e 20 a 25% para mulheres, independente de raça, educação, estado civil ou renda. Entre os idosos a prevalência é de aproximadamente 5%. Além do tratamento medicamentoso, as psicoterapias têm um papel importante durante a fase aguda e na fase de remissão. A Arteterapia é uma abordagem terapêutica primordialmente não verbal, e tem sido utilizada em diversos contextos, mas há carência de estudos quantitativos que comprovem sua eficácia. O objetivo deste trabalho foi avaliar a eficácia da Arteterapia para uma população de mulheres idosas com diagnóstico de TDM, segundo o DSM - 5 = Manual de Diagnóstico e Estatística dos Transtornos Mentais - 5º versão, medicadas. Participaram do estudo 66 idosas com diagnóstico de TDM em tratamento medicamentoso, sem mudança medicamentosa durante o estudo e intactas no ponto de vista da cognição. Essas idosas foram alocadas aleatoriamente em dois grupos: 33 constituíram o Grupo Experimental (GE), que constou de 20 oficinas de Arteterapia com duração de noventa minutos, semanalmente, e 33 participaram do Grupo Controle (GC) o qual não recebeu nenhuma intervenção. Ambos os grupos foram avaliados com as mesmas escalas no início e após 20 semanas. Foram utilizadas as seguintes escalas para avaliar aspectos cognitivos - Mini exame do Estado Mental (MEEM), o Teste do Desenho do Relógio (TDR), o teste de Fluência Verbal - categoria animal (FV), e o teste Trilhas A. Para a avaliação Visuoconstrutiva foi utilizada a Figura complexa de Rey - cópia e evocação. Para avaliar aspectos psiquiátricos foram utilizadas a Geriatric Depression Scale (GDS), a Escala de Beck para Depressão (BDI) e a Escala de Beck para Ansiedade (BAI). Para avaliar qualidade de vida - Functional Assessment Staging Test (FAST). No final do estudo 31 idosas completaram todas as oficinas do GE e 25 idosas do GC retornaram para as avaliações finais, apesar de todas terem sido contatadas. O GC diminuiu na GDS 0,6 ± 2,3 pontos, enquanto o GE diminuiu 3,2 ± 3,4 pontos, e esta diferença entre os grupos foi significante (p = 0,007). Na escala BDI, o GC diminuiu 1,6 ± 4,9 pontos e o GE diminuiu 8,6 ± 12,8 pontos (p = 0,025). Na escala BAI, o GC diminuiu 2,9 ± 1,4 pontos e o GE diminuiu 8,9 ± 14,5 pontos (p = 0,032). Não foram encontradas diferenças nas demais escalas. Assim, houve diferença entre os grupos Controle e Experimental após as 20 semanas nos aspectos psiquiátricos de depressão e ansiedade. Não foram observadas mudanças na cognição. Desta forma, intervenções como a deste estudo parecem auxiliar no tratamento de sintomas depressivos e ansiosos de idosas com TDM / Major Depressive Disorder (MDD) is, among the psychiatric syndromes, that most affect the general population. The prevalence of depression during life is 7 to 12% for men and 20 to 25% for women, regardless of race, education, marital status or income. Among the elderly, the prevalence is approximately 5%. In addition to drug treatment, psychotherapies have an important role during the acute phase and in the remission phase. Art Therapy is a therapeutic approach primarily nonverbal, and has been used in several contexts, but there is a lack of quantitative studies that prove its efficacy. The objective of this study was to evaluate the efficacy of Art therapy for a population of elderly women diagnosed with MDD, according to the Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM - 5). A total of 66 elderly women with a diagnosis of MDD were enrolled in the drug treatment, without drug change during the study and intact from the point of view of cognition. These elderly women were randomly allocated into two groups: 33 were the Experimental Group (EG), which consisted of 20 Art therapy workshops lasting 90 minutes, weekly, and 33 participated in the Control Group (CG), which received no intervention. Both groups were evaluated with the same scales at baseline and after 20 weeks. The following scales were used to evaluate cognitive aspects - Mini Mental State Examination (MMSE), Clock Drawing Test, Verbal Fluency Test - Animal Category (VF), and Trail A. To evaluate psychiatric aspects, the Geriatric Depression Scale (GDS), the Beck Depression Scale (BDI) and the Beck Anxiety Scale (BAI) were used. For the Visuoconstructive evaluation, Rey\'s Complex Figure and Delayed Recall was used. And to evaluate quality of life - Functional Assessment Staging Test (FAST). At the end of the study, 31 elderly women completed all EG workshops and 25 elderly women of CG returned to the final evaluations, although all were contacted. The CG decreased in the GDS 0.6 ± 2.3 points, while the EG decreased by 3.2 ± 3.4 points, and this difference between the groups was significant (p = 0.007). On the BDI scale, the CG decreased by 1.6 ± 4.9 points and the EG decreased by 8.6 ± 12.8 points (p = 0.025). On the BAI scale, the CG decreased by 2.9 ± 1.4 points and the EG decreased by 8.9 ± 14.5 points (p = 0.032). No differences were found in the other scales. Thus, there was difference between the Control and Experimental groups after the 20 weeks in the psychiatric depression and anxiety aspects. No changes in cognition were observed. Thus, interventions such as this study seem to aid in the treatment of depressive and anxious symptoms of elderly patients with TDM

The aim of the diploma thesis is to monitor and analyze cyclotourism in the selected region of the Czech Republic. The thesis focuses on The Elbe Trail and its economic benefits for the selected area, which is the Ústi region. The theoretical part of the thesis introduces the basic terms related to the cyclotourism, funding and organization of cyclotourism in the Czech Republic. The practical part analyzes the Elbe Trail as a tourist product and then evaluates the economic benefits of the Elbe Trail.

It has long been demonstrated that increased appreciation of place initiates stewardship and responsible management of the land. Interpretative design possesses the potential to generate this stewardship through recovering the connections between place and the people that inhabit it. It is essential that interpretation be integrated into the everyday landscape to deepen one's respect of the past and one's commitment to its future. This vision of an interpretive trail in Mission, British Columbia, explores techniques of illuminating place history to inspire and challenge cognitive participation with the landscape. The format of this project begins with a discussion of the values and limits of interpretative methods. Secondly, the study area is introduced through site reconnaissance with special emphasis on historical morphology and social history. Next, interpretive design strategies are explored in conjunction with significant landscape precedents, culminating in a design approach for an interpretive trail on Mission Flats. Six nodes along the trail serve as keystones for this approach, with individual nodes revealing historical processes, both natural and cultural, through design. Akin to Mission Flats, every place is intimately bound to the people and events that have shaped it. Illumination of this connection is the goal of interpretive design. The planning and design phases of development are incomplete without the inclusion of this holistic vision of place. It is therefore imperative that we further explore interpretive design, so that it may be integrated into the oft-impersonal contemporary landscape, for the generation of authentic place identity. / Applied Science, Faculty of / Architecture and Landscape Architecture (SALA), School of / Graduate

The aim of this thesis is to evaluate beer tourism potential of Jihočeský kraj. The first part of this thesis deals with the characteristics of gastronomy and beer tourism. The first chapter also presents successful foreign projects of gastronomy tourism. The second chapter presents tourism infrastructure and beer industry in Jihočeský kraj. In this chapter there are described and evaluated breweries in the region. The third chapter identifies possible reasons for Jihočeské pivní stezky project failure. Last chapter suggests beer cycle trails and beer packages on the ground of previous chapters.

No description available.

The Irish Hills Natural Reserve Conservation Plan is a unique component of the Cityof San Luis Obispo’s green belt that provides a number of hiking and mountain bikingtrails within a short distance from the downtown core as well as ensures that valuablehabitat be preserved into the future. As the subject of my thesis project, IHNR presented the opportunity to pursue an aspect of city planning that can often be over-looked and, conservation planning. Conservation planning is an important element of the planning profession in that it incorporates such elements into the future growth of cities. With proper planning it is possible to foresee future development patterns and thus be able to designate and protect high value natural resource areas as open space, in order to preserve and protect their resources. In addition to setting the guidelines for preserving and protecting the natural resources and important habitats of Irish Hills, the conservation plan has a secondary effect of ensuring the future health of the surrounding habitats.

Many downtowns in North America have been severed from the rest of the city and from the contextual relationship to their surroundings. Sundered from their context, the ecological characteristics of a site are frequently taken for granted, and the disengagement of its public spaces erodes the downtown's character as well as the urban fabric. Downtown Clearwater has lost the vitality and vibrancy that once characterized it as a lively district. Because of recent developments in the downtown area, public spaces have been lost between parking lots, high rises and a small number of sporadic residential pockets. Some of the most important streets fail to create connections for the pedestrians to the surrounding public spaces and areas of interest; as a result some local businesses have dried up, affecting Downtown Clearwater's economy and its community. There is also a disconnection of the downtown with its context and it is evident that some of the major ecological and environmental characteristics of the site have been ignored through its development. This thesis studies how the ecological characteristics of a site can be integrated into the core of its design and experience. The Thesis proposes to revitalize Downtown Clearwater with a new system of green corridors that will promote activity and circulation. The corridors will define a new invigorating framework of points of interest supported by surrounding land uses. The main objectives of the project are to create a new urban destination, enhance the pedestrian experience, reconnect public spaces, cleanup water runoff and organize circulation of bicycles and pedestrians.The thesis emphasizes the design and development of a specific node and section of the green corridor system to explain the design.