This thesis addresses the development of materials, technologies and circuits applied for the fabrication of a new class of microelectronic devices that are relying on a three-dimensional shape variation namely shapeable microelectronics. Shapeable microelectronics has a far-reachable future in foreseeable applications that are dealing with arbitrarily shaped geometries, revolutionizing the field of neuronal implants and interfaces, mechanical prosthetics and regenerative medicine in general. Shapeable microelectronics can deterministically interface and stimulate delicate biological tissue mechanically or electrically. Applied in flexible and printable devices shapeable microelectronics can provide novel functionalities with unmatched mechanical and electrical performance. For the purpose of shapeable microelectronics, novel materials based on metallic multilayers, photopatternable organic and metal-organic polymers were synthesized. Achieved polymeric platform, being mechanically adaptable, provides possibility of a gentle automatic attachment and subsequent release of active micro-scale devices. Equipped with integrated electronic the platform provides an interface to the neural tissue, confining neural fibers and, if necessary, guiding the regeneration of the tissue with a minimal impact. The self-assembly capability of the platform enables the high yield manufacture of three-dimensionally shaped devices that are relying on geometry/stress dependent physical effects that are evolving in magnetic materials including magentostriction and shape anisotropy. Developed arrays of giant magnetoimpedance sensors and cuff implants provide a possibility to address physiological processes locally or distantly via magnetic and electric fields that are generated deep inside the organism, providing unique real time health monitoring capabilities. Fabricated on a large scale shapeable magnetosensory systems and nanostructured materials demonstrate outstanding mechanical and electrical performance. The novel, shapeable form of electronics can revolutionize the field of mechanical prosthetics, wearable devices, medical aids and commercial devices by adding novel sensory functionalities, increasing their capabilities, reducing size and power consumption.