Frisörers arbete med preparat som påverkar hårets kemiska uppbyggnad ökar och därmed även felbehandlingar på salonger. Detta skapar frågor kring från gymnasieutbildningen nyexaminerade frisörers kunskaper kring hur frisörers arbetsmaterial, det vill säga kunden, fungerar i samverkan med den kemiska behandling som utförs. Forskning kring hår finns då produktionen av produkter är enorm, men frågan är om frisörerna som användare av produkterna sitter på kunskapen kring håret och om de använder den kunskapen när de arbetar med kunden. Fokus som använts i studien är grundade på tre områden. Dessa presenteras som: Kund som helhet eller bara hår? Undervisningens styrkor och svagheter samt Yrkesutövandets förutsättningar. Resultaten visar respondenters erfarenheter i arbetets fokusområden utifrån utbildningens inriktning. De påvisar skillnader i sin uppfattning kring förutsättningarna för kemiska behandlingar av kundens hår som skiljer sig beroende på vilken skola de gått på, men påvisar även skillnader efter hur praktikplatsers förhållningssätt kring hårets beskaffenhet. Upplevelser i undervisningen påvisar vad de anser vara bra respektive dålig lärostil. Utöver det är framtidstron för ett arbete i yrket inte glasklar. Diskussionen sker utifrån respondenternas syn på fokusområdena vägt mot branschens och skolans perspektiv. / The use of chemical substances that negatively affect the biological composition of hair has increased, leading to more mistreatments in salons and hair studios. This has, consequently, led to questions arising from educators within the field regarding the knowledge levels of newly-trained hairdressers/stylists relative to the potential reactions of customers’ hair and the increasing use of preparative substances. Research and development conducted in the general field of hair-care is plentiful due to the huge level of production within the industry. Questions remain unanswered, however, in terms of whether those using the products within the profession have the relevant knowledge and/or if this knowledge is applied practically. The focus of this study is threefold: The customer; a whole (an entirety) or just hair The strengths and weaknesses of teaching within this field The pre-requisites for practicing the profession  Results indicate respondents’ experiences in the relevant areas dependent upon educational focus points. Furthermore, results show disparities in the understanding of pre-requisites concerning the chemical treatment of customer’s hair dependent on the school attended. A differentiation can also be seen practically, dependent on the variety of approaches and attitudes towards hair within salons offering practical placements. Experiences within the processes of learning show views of what are considered good or bad teaching styles. Belief in the employment potential within the industry is a debatable issue. The discussion has a comparative format; results herein are placed in contrast to the industry and in relation to the perspective of the school/educational institutions.

Our aim with this essay is to examine if social work in the care of elderly tends to be salutogenetic or patogenetic oriented. A salutogenetic oriented activity means that the social workers focuses on the elderly peoples individual possibilities, and collaborate with the receiver of care in order to offer him or her aid and resources for meaningful living conditions. A patogenetic oriented activity on the other hand means that the social workers focuses on the elderly peoples most primary needs, their illnesses and to introduce adequate treatment. We also examine if social workers in the care of elderly tend to prefer male or female characteristic features in the receivers of care. Finally we wanted to find out if there were any gender distinctions, if the appraisal of aid were more affected by a male or female receiver of care. We also considered that gender might not have any affect on their appraisal at all. Our theoretical framework is mainly based on three already existing theories. These gave us a general list of salutogenetic/patogenetic statements and typical male/female characteristic features. Because of time shortage the material includes only one empirical method, which is a questionnaire to the employees in the care of the elderly. The method of analysis is mostly quantitative, but since the questionnaire also contained some opened questions, our study is partly qualitative. A total of 101 persons participated in our questionnaire poll. The results of our study brought about unexpected results. To our surprise, the social workers in the care of elderly tend to prefer male characteristic features in the receivers of care. We also found that what requires of a good apraisal of aid is a salutogenetic perspective, but that the social workers thought it was difficult to apply in practice.

CD28 co-stimulation is required for the generation of naturally occurring regulatory T cells (nTregs) in the thymus through Lck-signaling. However, high level of CD28 suppresses the generation of induced Tregs (iTregs) from naïve CD4 T cells, although underlying mechanism(s) has not been defined. Here we investigated the role of CD28-mediated signaling pathways in the suppression of Treg generation. We used a series of transgenic (Tg) mice on CD28-deficient background that bears WT CD28 or mutated CD28 in its cytosolic tail incapable of binding to Lck, PI3K or Itk. Regardless of exogenous IL-2, strong CD28 costimulation suppressed iTreg generation through Lck signaling. Using a GVHD model to test the role of CD28-mediated iTreg suppression in T cell pathogenicity in vivo, we found that CD28-Lck T cells induced significantly less GVHD than T cells from CD28-WT mice. Furthermore, we found that the recipients of T cells from CD28-Lck mice generated significantly more iTregs than those with T cells from CD28-WT, which contribute to reduced graft-versus-host disease (GVHD) development in recipients of CD28-Lck T cells. These results indicate that CD28 costimulation can negatively regulate Treg generation and may provide an avenue for control of T-cell immunity or tolerance by regulating Tregs using the CD28 signal as a target. We went a step forward and investigated the therapeutic potential of antigen-specific iTregs in the prevention of GVHD. Donor hematopoietic stem cells and mature T cells are transplanted into a lymphopenic host to potentially cure many cancers and hematopoietic diseases like leukemia in bone marrow transplantation (BMT) or hematopoietic stem cell transplantation (HCT), but the frequent development of GVHD is the main drawback of this treatment. nTregs suppress the development of GVHD and may spare graft-versus-tumor effect. However, nTregs are a minor (~5%) subpopulation of CD4 helper T cells in healthy individuals, and using in vitro expanded nTregs is a common strategy to test their therapeutic potential in BMT. The concern of in vitro expanded nTregs may include their stability of Foxp3 (master regulatory gene for the development and function of regulatory T cell) expression and suppressive function, survival in vivo, and the non-selective suppression of the pre-activated nTregs. Antigen-specific activation of the regulatory T cells is important for optimal function. In this study, we used an alternative strategy to generate antigen-specific, iTregs and assessed their suppressive potential by comparing their effectiveness in preventing GVHD with polyclonal iTregs. We found that antigen-specific iTregs prevented GVHD lethality in recipients that expressed the target antigen, but were not protective of recipients who did not express the target antigen. Furthermore, antigen-specific iTregs were significantly more efficient than those polyclonal Tregs in the prevention of GVHD. These results reveal the therapeutic potential of antigen-specific iTregs to prevent GVHD efficiently and selectively, and provide the rationale to use antigen-specific iTregs in clinical HCT.

This paper offers an empirical analysis of net job creation patterns at the firm level for the Austrian economy between 1993 and 2013 focusing on the impact of firm size and age. We propose a new estimation strategy based on a two-part model. This allows to identify the structural parameters of interest and to decompose behavioral differences between exiting and surviving firms. Our findings suggest that conditional on survival, young Austrian firms experience the largest net job creation rates. Differences in firm size are not able to explain variation in net job creation rates among the group of continuing enterprises. Job destruction induced by market exit, however, is largest among the young and small firms with this effect being even more pronounced during the times of the Great Recession. In order to formulate sensible policy recommendations, a separate treatment of continuing versus exiting firms as proposed by the new two-part model estimation approach seems crucial.(authors' abstract) / Series: Department of Economics Working Paper Series

Despite the plethora of SLA research conducted on the acquisition of the definite marker in noun phrase configurations in L2 Arabic and English (e.g., Sarko, 2007; Master, 1997; Collier, 1987; Anderson, 1984; Kharma, 1981), there is as yet no definitive description of how noun phrases are acquired and why errors persist after advanced stages in L2 learning. Results, as shown by Butler (2002), are inconclusive, and the primary causes of difficulties in the acquisition of the definite marker in noun phrase configurations remain unclear. Recently, the internal syntax-semantics interface (Cuza & Frank, 2011; Montrul, 2010; Tsimpli & Sorace, 2006; Sorace, 2003, 2004) and the specificity-definiteness distinction (Ionin, 2003; Ionin et al., 2004; Ionin et al., 2008) have been considered as appropriate frameworks for exploring the acquisition of noun phrases and other structural features. The structure of noun phrase configurations in Arabic and English offers a complex interface between form and meaning for L2 learners with multiple cases of matches and mismatches between specificity and definiteness. In this three-article dissertation project, two of which were conducted in a bidirectional methodological framework with L1 Arabic-L2 English and L1 English-L2 Arabic learners, I explored the acquisition of three cases of noun phrase configurations. In the first study, I investigated the acquisition of plural noun phrase configurations that carry generic and specific readings at the initial state of L2 learning. Using three data collection instruments: written translation; error detection and correction; and forced choice elicitation, I tested the predictions made by the Interface Hypothesis (IH) and the Full Transfer (FT) Hypothesis. Results showed that L2 learners in both directions tend to transfer noun phrase configurations from L1 into L2, a result that I took to support the FT hypothesis. In addition, it took L1 English-L2 Arabic learners two years of instruction to recover from this L1 effect. The second study aimed at confirming the result of the first study, but in the acquisition of the definite marker in generic singular noun phrase configurations in the L1 English-L2 Arabic direction. The behavior of generic singular noun phrases in L2 Arabic offers a good testing ground since it has numerous similarities and differences with English. Two conditions were established: a matching condition and a mismatching condition. Both conditions were tested in the L1 English-L2 Arabic direction. Results showed a similar pattern to the one recorded in the first study. Typological proximity and distance were found to be important determiners of language acquisition of the in/definiteness configurations of singular noun phrases. In the third study, I shifted to the exploration of a more complex type of noun phrases; namely the definite Iḍāfah construction in Modern Standard Arabic (MSA) and its equivalent noun phrase configurations in English in the two directions. I started with a common difference between MSA and English. Whereas in MSA there is a canonical configuration in terms of head-complement ordering and head-complement definiteness, English is tolerant of more than one permissible configuration. I operationalized the acquisition of these noun phrases in terms of head-complement ordering and head-complement definiteness. Results showed a clear effect of L1 transfer in both directions; knowledge of L1 noun phrase configurations acts as the initial step in L2 learning. I concluded that both communities of L2 learners face problems that vary according to the L1 noun phrase configuration at hand. However, in the L1 English-L2 Arabic direction, learners reached a satisfactory level of performance in the Iḍāfah construction after two years of instruction. I approached this finding as a result of intensive Focus-on-Form Episodes (Loewn, 2005) that the Iḍāfah construction receives in MSA instruction. At the conclusion of this research project I highlighted some implications for the second language acquisition and teaching of noun phrases. The overall results were couched in a broader perspective that characterizes the initial state of L2 learning of noun phrases in + article and – article languages, the effects of typological proximity and distance, and the effects of Instructed SLA. For the pedagogical implications, I called for the integration of the semantics of the definite marker while presenting noun phrases in textbooks. I also recommended the use of explicit instruction and structured-input activities (VanPatten, 2004; Marsden & Chen, 2011) as effective pedagogical tools that foster form-meaning mapping in the acquisition of L2 Arabic and English noun phrases.

L'étage Valanginien est caractérisé dans le registre sédimentaire par une excursion positive des isotopes du carbone (amplitude 1,5-2‰), appelée " Episode Weissert ". Cet événement coïncide avec des changements paléoenvironnementaux et paléoclimatiques majeurs. La formation de la province volcanique ignée du Paraná-Etendeka a été proposée comme principal facteur forçant contrôlant ces changements. Cependant, de récentes études démontrent que l'Episode Weissert précède systématiquement l'activité volcanique. Ainsi, les facteurs déclenchant qui contrôlent ces changements sont encore source de débat. Dans cette étude des analyses cyclostratigraphique, biostratigraphique, minéralogique et géochimique ont été réalisés sur des sites de moyennes et hautes latitudes (coupes d'Orpierre et de La Charce/Arnayon dans le Bassin Vocontien, site 765C dans la plaine abyssale Argo) dans le but (i) d'explorer la dynamique des changements paléoenvironnementaux à l'échelle locale versus globale et (ii) de discuter des possibles facteurs forçant contrôlant l'épisode Weissert. Les processus diagénétiques et sédimentologiques locaux, qui pouvaient modifier le signal paléoclimatique, ont été discuté avant des interprétations paléoenvironnementales. La calibration astronomique de l'épisode Weissert, réalisée sur la coupe d'Orpierre, a permis pour la première fois le calcul de flux détritiques et de nutriments dans le Bassin Vocontien. Ces résultats indiquent de rapides changements climatiques aux moyennes latitudes, marqués par des conditions plus humides pendant l'Episode Weissert et des conditions plus sèches au Valanginien supérieur. En parallèle de nouvelles données géochimiques et minéralogiques, réalisés sur le site ODP 765C, ont été intégrées à une compilation globale de données géochimique et minéralogique sur 23 coupes répartie dans cinq grands environnements. Trois ceintures climatiques latitudinales majeures ont été identifié durant le Valanginien : (i) une ceinture aride dans l'océan proto Nord Atlantique (~15-17°N), (ii) une ceinture climatique subtropical dans la marge NW téthysienne (~25-30°N), et (iii) une ceinture climatique chaude et tempéré aux sites de hautes latitudes (~53°S et ~40 à ~70°N). Il apparaît que durant cette période, des facteurs orbitaux et tectoniques peuvent avoir contrôlé la distribution de ces ceintures et les principaux changements durant l'Episode Weissert.

Ultraviolet-visible spectra are presented for a polycrystalline sample of chlorine clathrate hydrate and two single crystal samples of bromine clathrate hydrate. The data shows that the UV-visible spectroscopy is a sensitive probe for studying the interactions between the halogen guest molecule and the host water lattice. The spectrum for chlorine hydrate shows a surprisingly strong temperature dependence. The spectra reported for bromine clathrate hydrate single crystals reinforce our previous conclusion that there is a stable cubic type II structure as well as the tetragonal structure. There is also a metastable cubic type I structure. The new results are discussed in the context of previous results, resonance Raman spectroscopy, and how the molecules fit into the host cages.

Phase transitions and other intrinsic properties (shape, size, architecture) of molecularly structured aerosol particles are important for understanding their role in planetary atmospheres and for technical applications. By combining bath gas cooling with time resolved mid-infrared spectroscopy and modeling, information is obtained on dynamic processes and intrinsic properties of fluoroform and ethane aerosol particles. The distinct infrared spectral features of fluoroform aerosol particles make it a particularly suitable model system. Homogeneous crystallization rates of the sub-micron sized aerosol particles are determined (JV = 10⁸ - 10¹⁰ cm-³s-¹ or JS = 10³ – 10⁵ cm-²s-¹ at a temperature of T = 78 K), and the controversial question regarding volume versus surface nucleation in freezing aerosols is addressed. It is demonstrated that current state of the art measurements of droplet ensembles cannot distinguish between the two mechanisms due to inherent experimental uncertainties. The evolution of particle shape from spherical supercooled droplets to cube-like crystalline particles and eventually to elongated crystalline particles is recorded and analyzed in detail with the help of vibrational exciton model calculations. Phase behaviour of pure ethane aerosols and ethane aerosols formed in the presence of other ice nuclei under conditions mimicking Titan’s atmosphere provide evidence for the formation of supercooled liquid ethane aerosol droplets, which subsequently crystallize. The observed homogeneous freezing rates (JV = 10⁷ – 10⁹ cm-³s-¹) imply that supercooled ethane could play a similar role in ethane rich regions of Titan’s atmosphere as supercooled water does in the Earth’s atmosphere.

This thesis examined the relationships of the conceptions of sport ability, achievement goals, and intrinsic motivation in Physical Education. Studies 1 and 2 investigated the psychometric properties of the Conceptions of the Nature of Athletic Ability Questionnaire (CNAAQ), a measure of sport ability beliefs. Results showed that the revised version of the scale possesses sound psychometric properties in assessing sport ability beliefs among children and youth. In addition, the relationships between ability beliefs, goal orientations, perceived competence, and behavioural indicators (intentions and amotivation) were also examined in the first two studies. An incremental belief predicted task orientation, whereas an entity belief predicted ego orientation. Intentions to be physically active were predicted by goal orientations indirectly through perceived competence, and directly by task orientation. In addition, amotivation was predicted directly and indirectly by ability beliefs and directly by achievement goals. Specifically, entity beliefs directly predicted amotivation, task orientation negatively predicted amotivation. Study 3 examined the interrelationships between ability beliefs, achievement goals, perceived competence, behavioural regulation, and arnotivation using cluster analysis. Five distinct clusters were identified based on these motivational constructs and these profiles were found to be related to perceived physical self-worth and levels of sport participation. Study 4 experimentally manipulated sport ability beliefs and examined their causal influence on achievement goals and motivation patterns when faced with failure. The causal link between ability beliefs and goals was supported. Ability attributions for failure were stronger for entity theorists compared to incremental theorists. However, hypotheses predicting differences on effort attributions, affective reactions, and behavioural markers were not supported. Study 5 examined the effects of goal involvement on enjoyment and intrinsic motivation under positive feedback. The results suggested that task-involved and ego-involved participants did not differ in self-reported enjoyment and free-choice behaviour measure. However, the free-choice behaviour of the ego-involved participants may not be fully intrinsically motivated. In addition, autonomous communication increased the positive effects of task and ego involvement on intrinsic motivation and enjoyment, whereas controlling communication had an undermining effect. Overall, results show that high incremental beliefs and high task orientation facilitate adaptive motivational patterns. Autonomy-supportive contexts also enhanced students' task motivation compared to controlling contexts.

The Fas pathway is critical for the maintenance of normal T cell homeostasis. Humans and mice with defects in this pathway exhibit the accumulation of large numbers of peripheral lymphocytes and lupus-like autoimmunity. A major feature of these organisms is the accumulation of non-NK TCRαβ+CD4-CD8- “double negative” (DN) T cells. While regulatory T cells (Tregs) with the DN phenotype have been extensively characterized in Fas-sufficient mice and humans, limited data exist on the role of DN T cells as Tregs in Fas-deficient animals. In fact, most of the literature suggests that the DN T cells accumulating in Fas-deficiency states are pathogenic, contributing to secondary lymph node enlargement and autoimmune disease. In this body of work, data are presented that illustrate that Fas-deficient lymphoproliferative (LPR) DN T cells can act as Tregs in an interferon γ (IFNγ)- and Fas ligand (FasL)-dependent fashion toward Fas-sufficient T cells. LPR DN T cells needed to be able to secrete and respond to IFNγ in order to upregulate surface FasL, in order to ameliorate GVHD mediated by CD4+ T cells in vivo and to suppress the proliferation of and kill activated CD4+ T cells in vitro. FcRγ, a key molecule involved in innate immune responses, can substitute for CD3ζ in the T cell receptor (TCR) of mouse and human T cells in certain circumstances; in doing so, it is essential for the regulatory function of TCR transgenic DN Tregs. FcRγ-deficient LPR mice were found to have exacerbated T cell accumulation and early mortality. We show that while FcRγ expression was required for LPR DN T cells to regulate CD4+ and CD8+ T cells responding to alloantigens in vitro and in vivo, it does not control autologous lymphoproliferation in LPR mice by supporting the function of a regulatory cell, nor does it affect the rate of proliferation of LPR T cells in vivo. Instead, FcRγ-expressing LPR CD4+, CD8+ and DN T cells were found to be undergoing apoptosis at a high rate in vivo, and in contrast to their FcRγ-deficient counterparts, FcRγ+ LPR DN T cells were capable of undergoing TCR restimulation-induced cell death (RICD). The data presented in this thesis therefore show that LPR DN T cells can exhibit IFNγ-, FasL- and FcRγ-dependent regulatory function, and also illustrate a previously unknown function for FcRγ in controlling the expansion of Fas-deficient T cells. The implications of these data for autoimmune lymphoproliferative syndromes, and normal T cell homeostasis, are discussed.