abstract: Vitamin C is a micronutrient with many important physiological roles. It can function as a reducing agent, a free radical scavenger, and an enzyme cofactor. Much research has examined the potential of vitamin C supplements to enhance exercise capacity in trained athletes; however, little is known regarding the effects of vitamin C supplements on the promotion of leisure-time physical activity in the general population. This area deserves attention since 1/3 of Americans have below adequate vitamin C status, and since aversion to exercise, fatigue, and altered mood states are the earliest signs of poor vitamin C status. This study analyzed the effect of supplementing 500 mg twice daily of vitamin C on self-reported leisure-time activity levels and mood states in young men. Twenty-nine healthy, young men, aged 18-35 years, were stratified by age, BMI, smoking status, and plasma vitamin C concentrations and assigned to either a control (CON) or experimental group (VTC) for the 8-week randomized, double-blinded, parallel arm trial. Subjects were instructed to keep track of their leisure-time physical activity by filling out the validated Godin Leisure-Time Exercise Questionnaire weekly for the entire study. In addition, subjects took the self-administered Profile of Mood States (POMS) at baseline, week 4, and week 8 to observe mood states. Plasma vitamin C concentrations were analyzed at the initial screening, week 4, and week 8 of the study. Plasma vitamin C concentrations significantly differed by group at week 4 and week 8. Furthermore, vitamin C supplementation significantly increased self-reported mild, moderate, and strenuous activity levels during the 8-week trial. Overall, total physical activity scores increased nearly 50% in the VTC group as compared to 18% in the CON group (p=0.001). However, mood states were not significantly impacted by vitamin C supplementation during the trial. This study provides the first experimental evidence that supplementing 500 mg of vitamin C twice daily can be effective in increasing leisure-time physical activity in healthy young men. This study, however, was unable to link improvements in physical activity rates to improved mood states. Since sedentary behaviors have been implicated in the rise of obesity in the U.S., further research should be conducted to substantiate the finding that vitamin C supplementation increases physical activity. / Dissertation/Thesis / M.S. Nutrition 2012

Orientador: Rogério Lopes Vieites / Banca: Nobuyoshi Narita / Banca: Angela Vacaro de Souza / Banca: Silvia Antoniali do Carmo / Banca: Gisela Ferreira / Resumo: Este trabalho, objetiva estudar a atemoia, cultivar 'Thompson', em três diferentes tratamentos de pós-colheita: uso de ácidos orgânicos, atmosfera modificada ativa e irradiação ionizante (60Co). Os frutos foram selecionados e armazenados em câmara fria nas condições de 15 ± 0,2ºC e 90 ± 2% de UR. Para cada experimento houve três repetições e dois frutos por repetição. Foram seis tratamentos realizados, sendo dois ácidos orgânicos (ascórbico e cítrico); nas concentrações de 1%, 2% e 3% cada tratamento submerso em sua solução de ácido orgânico por 10 minutos e posteriormente seca à sombra. Na atmosfera modificada ativa, foram quatro tratamentos, sendo eles: T0 - 21% de O2, 0,03% CO2 e 78% de N2 (ambiente);T1 - 4% de O2, 5% CO2 e 91% de N2, T2 - 4% de O2, 6% CO2 e 90% de N2, T3 - 4% de O2, 7% CO2 e 89% de N2 e T4 - 4% de O2, 8% CO2 e 88% de N2. No experimento de irradiação ionizante (60Co), foram utilizados os tratamentos T0= Sem irradiação (controle), T1=0,2kGy, T2=0,4kGy, T3=0,6kGy, T4=0,8kGy, T5=1,0kGy e T6= 1,2kGy. Em todos os comparativos de todos os experimentos as amostras foram analisadas a cada três dias até dezoito dias de armazenamento. No tratamento controle os frutos foram lavados em água corrente e posteriormente imersos em solução clorada a 150 mg L-1, por 10 minutos e posteriormente secos à temperatura ambiente; exceção feita ao tratamento controle de irradiação ionizante, o qual não recebeu este tratamento. Em todos os tratamentos, foram realizadas as análises: ... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: This work aims to study atemoia, 'Thompson' cultivar, in three different post-harvest treatments: use of organic acids, active modified atmosphere and ionizing irradiation ( 60Co). The fruits were selected and stored in a cold room under conditions of 15 ± 0.2°C and 90 ± 2% RH. For each experiment there were three replicates and two fruits per replicate. Six treatments were carried out, being two organic acids (ascorbic and citric); at concentrations of 1%, 2% and 3% each treatment submerged in its organic acid solution for 10 minutes and then dried in the shade. In the active modified atmosphere, there were four treatments, being them T0 - 21% O2, 0.03% CO2 and 78% N2 (environment), T1 - 4% O2, 5% CO2 and 91% N2, T2 - 4 % of O2, 6% CO2 and 90% N2, T3 - 4% O2, 7% CO2 and 89% N2 and T4 - 4% O2, 8% CO2 and 88% N2. In the experiment of ionizing irradiation (60Co), the treatments T0 = Without irradiation (control), T1 = 0.2kGy, T2 = 0.4kGy, T3 = 0.6kGy, T4 = 0.8kGy, T5 = 1.0kGy and T6 = 1.2kGy. In all comparisons of all experiments the samples were analyzed every 3 (three) days to 18 (eighteen) days of storage. In the control treatment the fruits were washed in running water and then immersed in chlorinated solution at 150 mg L-1 for 10 minutes and then dried at room temperature; exception to the control treatment of ionizing radiation, which did not receive this treatment. In all treatments, the analyzes were: peeling and pulp chromatography, fresh mass loss, soluble solids (SS), titratable acidity (TA), pH, ascorbic acid (AA), reducing sugars, respiratory rate, specific activity of polyphenol-oxidase (PPO) and peroxidase (POD), total antioxidant activity and total phenolic compounds. The experiments were conducted in a completely randomized design (D.I.C.), in a factorial scheme (treatment x storage), composed by the treatments of the different experiments and eight storage times. The results ... / Doutor

Made available in DSpace on 2016-08-15T20:31:34Z (GMT). No. of bitstreams: 1 JaquelineMS_DISSERT.pdf: 4682432 bytes, checksum: 0dde1ad54c115ad938d4f20561abad2b (MD5) Previous issue date: 2009-09-15 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The objective of this study was to evaluate the influence of vitamin C supplementation in the diet of fish species piau três pintas (L. reinhardit), which was held to monitor the performance and yield production, analysis of the nutritional composition (carcass and fillet ), and glycemic parameters. The experiment lasted 90 days (fingerlings/ juvenile). 1040 fingerlings were used, housed in 16 tanks for breeding, with a capacity of 500 liters. The design was randomized blocks with four treatments and four replications, and the control diet was designed to meet the requirement of vitamin C as trade recommendations and other diets were prepared to contain levels of extra dietary supplementation of vitamin C (250; 500 and 750 mg ascorbic acid / kg diet). For the analysis of the nutritional composition were used 6 fish per experimental unit. All diets were isonitrogenous and isocaloric (28% PB and 3100 kcal / kg diet). No effect was observed significant regression in performance and glycemic parameters in supplementation levels of vitamin C. However, the fillet yield linearly decreasing the effect of treatments (&#1088;<0.05). Regarding the chemical composition of nutritional was observed in effect response to significant levels of supplementation and in some cases equating to the control. Thus, we observed increased linearly on the concentration of mineral matter (&#1088;<0.05) and decreasing trend for levels of energy rude (&#1088;<0.05). Therefore, it is concluded that the conditions of this work, the inclusion of vitamin C in commercial level was sufficient to provide productive performance benefits for chemical composition and nutritional stress reduction management and harvesting, equal to those diets that were supplemented. / O objetivo deste estudo foi avaliar a influência da suplementação de vitamina C na dieta de peixes da espécie piau três pintas (L. reinhardit), no qual realizou-se o monitoramento do desempenho e rendimento produtivo, análise da composição química nutricional (carcaça e filé), bem como parâmetros glicêmicos. O experimento de campo teve duração de 90 dias de (alevino p/ juvenil). Foram utilizados 1040 alevinos, alojados em 16 aquários de criação, com capacidade de 500 litros. O delineamento utilizado foi em blocos casualizados com quatro tratamentos e quatro repetições, sendo que a ração controle foi elaborada para atender a exigência de vitamina C conforme recomendações comerciais e as demais rações foram elaboradas para conter níveis de suplementação extra dietética de vitamina C (250; 500 e 750 mg ácido ascórbico/kg ração). Para as análises da composição química nutricional foram utilizados 6 peixes/unidade experimental. Todas as dietas foram isoprotéicas e isocalóricas (28 % de PB e 3100 kcal/kg de ração). Não observou-se efeito significativo da regressão no desempenho produtivo e parâmetros glicêmicos nos níveis suplementares de vitamina C. No entanto, o rendimento de filé apresentou resposta linear decrescente ao efeito dos tratamentos (&#1088;<0,05). Em relação à composição química nutricional, observou-se efeito-resposta significativo para os níveis de suplementação e em alguns casos equiparando-se ao controle. Assim, foi observado resposta linear crescente sobre os teores de matéria mineral (&#1088;<0,05) e tendência decrescente para teores de energia bruta (&#1088;<0,05). Portanto, conclui-se que nas condições de realização deste trabalho, a inclusão de vitamina C no nível comercial foi suficiente para propiciar desempenho produtivo, benefícios para composição química nutricional e redução do estresse de manejo e despesca, igual para àquelas rações que receberam suplementação.

This graduation thesis was developed at the Department of Vegetable Growing and Floriculture in year 2013/2014. The work solves the issue of the pumpkin production (Cucurbita maxima Duch.) in the system of ecological and conventional production including quality parameter evaluation. The differences in the quality between products coming from organic and conventional agriculture are explained in the literary part. The study also characterizes the ecological production legislative. The theoretical part deals with the description and cultivation of the pumpkins. The experimental part is focused on the evaluation of content substances, such as vitamin C, dry matter, carotenoids. Another of the monitored parameters are color change and weight loss during storage. In the measured parameters were found significant differences in the content of dry matter and discoloration.

Devido à alta perecibilidade do mamão papaia (Carica papaia L.), estudos póscolheita, com foco nas boas práticas de estocagem e transporte, são importantes na cadeia de comercialização desse fruto. O uso de ozônio (O3) tem sido recomendado como um tratamento alternativo aos compostos clorados tradicionais para o controle de podridões de diversos frutos. Nesse contexto o presente trabalho tem como objetivos: estudar o efeito do (O3) e de outros tramentos alternativos no intuito de eliminar a antracnose (Colletotrichum gloeosporioides Penz) no mamão papaia armazenado em câmaras ozonizadas em concentrações de 0 a 0,5 ppm de ozônio; avaliar a sanitização superficial desse fruto através da imersão em água ozonizada em concentrações de 0 a 4 ppm de O3 durante 30 e 60 segundos e otimizar o tratamento hidrotérmico em temperaturas de 45 a 65 ºC por períodos de 30 a 60 segundos. O uso de (O3) em concentrações entre 0,2 e 0,5 ppm, em câmara ozonizada, resultou em mamões com manchas na casca do fruto por possível oxidação de componentes da parede celular. Foi observado ainda que a imersão das frutas em água ozonizada em concentrações de 1 a 4 ppm de O3 não foi efetiva na eliminação da antracnose, razão pela qual foi necessário o uso do tratamento hidrotérmico prévio ao uso do (O3), sendo que os melhores resultados obtidos foram nas temperaturas próximas de 55ºC por 1 minuto. O uso de ozônio não afetou a superfície cuticular dos mamões enquanto que o tratamento hidrotérmico proporcionou um recobrimento das fissuras naturais do fruto. O aumento da concentração de ozônio de 2 para 4 ppm proporcionou uma perda de mais de 40% do conteúdo de Vitamina C. O ozônio não alterou o grau de maturação (ratio) e cor dos frutos. / Postharvest studies are important for marketing chain of papaya fruit (Carica papaya L.) with focus on good agricultural practices for storage and transportation due to the high perishibility of this fruit. The use of ozone (O3) has been recommended as an alternative treatment to traditional chlorine compounds for the control of several decay organisms. Within that the present work objectivated study the effects of O3 and other alternative treatments to control antracnose (Colletotrichum gloeosporioides Penz) on the papaya fruit stored in chambers with ozone concentrations of 0 to 0.5 ppm; evaluate the superficial healthyness of papayas by immersion in ozone water at concentrations of 0 to 4 ppm for 30 to 60 seconds; optimize the hydrothermal treatment at temperatures of 45 to 65°C for periods of 30 to 60 seconds. The use of O3 at concentrations of 0.2 and 0.5 ppm in ozoned chamber result in spots on the fruit epidermis by the possible oxidation of cell wall components. It was noted, however, that immersion in ozoned water of the fruits at concentrations of 1 to 4 ppm of O3 were not effective in the removal of antracnose. So it is necessary to use hydrothermal treatments before the use of O3. Best results were obtained an temperatures close to 55°C for 1 minute. The use of ozone did not affect the fruit cuticular surface, while the hydrothermal treatment provided the recovering of the natural fissures of the fruit. The increased ozone concentration from 2 to 4 ppm provided a loss of more than 40% of the Vitamin C content. Ozone did not affect the degree of ripening (ratio) and the skin color of the papayas.

1. A brief historical introduction is given. It deals with the general features of wound healing in which epithelial participation is the dominant feature. 2. In Section A the influence of ascorbic acid on healing of skin wounds in rats is discussed. 3. Second wounds were inflicted at the same site as the initial wounds one month after the latter had healed. 4. In Section B the influence of ascorbic acid on healing of skin wounds in guinea pigs is investigated. 5. In order to discover the action ascorbic acid has on ear wounds, the tips of guinea pigs' ears were cut off. 6. The influence of ascorbic acid on the regeneration of corneal epithelium in guinea pigs is discussed. 7. The effect of ascorbic acid on healing of muco-periosteum was studied. 8. The influence of pantothenic acid on healing of skin wounds in rats was studied. 9. Pantothenic acid (Bepanthen-Salbe) ointment was applied directly to skin wounds.

Devido à alta perecibilidade do mamão papaia (Carica papaia L.), estudos póscolheita, com foco nas boas práticas de estocagem e transporte, são importantes na cadeia de comercialização desse fruto. O uso de ozônio (O3) tem sido recomendado como um tratamento alternativo aos compostos clorados tradicionais para o controle de podridões de diversos frutos. Nesse contexto o presente trabalho tem como objetivos: estudar o efeito do (O3) e de outros tramentos alternativos no intuito de eliminar a antracnose (Colletotrichum gloeosporioides Penz) no mamão papaia armazenado em câmaras ozonizadas em concentrações de 0 a 0,5 ppm de ozônio; avaliar a sanitização superficial desse fruto através da imersão em água ozonizada em concentrações de 0 a 4 ppm de O3 durante 30 e 60 segundos e otimizar o tratamento hidrotérmico em temperaturas de 45 a 65 ºC por períodos de 30 a 60 segundos. O uso de (O3) em concentrações entre 0,2 e 0,5 ppm, em câmara ozonizada, resultou em mamões com manchas na casca do fruto por possível oxidação de componentes da parede celular. Foi observado ainda que a imersão das frutas em água ozonizada em concentrações de 1 a 4 ppm de O3 não foi efetiva na eliminação da antracnose, razão pela qual foi necessário o uso do tratamento hidrotérmico prévio ao uso do (O3), sendo que os melhores resultados obtidos foram nas temperaturas próximas de 55ºC por 1 minuto. O uso de ozônio não afetou a superfície cuticular dos mamões enquanto que o tratamento hidrotérmico proporcionou um recobrimento das fissuras naturais do fruto. O aumento da concentração de ozônio de 2 para 4 ppm proporcionou uma perda de mais de 40% do conteúdo de Vitamina C. O ozônio não alterou o grau de maturação (ratio) e cor dos frutos. / Postharvest studies are important for marketing chain of papaya fruit (Carica papaya L.) with focus on good agricultural practices for storage and transportation due to the high perishibility of this fruit. The use of ozone (O3) has been recommended as an alternative treatment to traditional chlorine compounds for the control of several decay organisms. Within that the present work objectivated study the effects of O3 and other alternative treatments to control antracnose (Colletotrichum gloeosporioides Penz) on the papaya fruit stored in chambers with ozone concentrations of 0 to 0.5 ppm; evaluate the superficial healthyness of papayas by immersion in ozone water at concentrations of 0 to 4 ppm for 30 to 60 seconds; optimize the hydrothermal treatment at temperatures of 45 to 65°C for periods of 30 to 60 seconds. The use of O3 at concentrations of 0.2 and 0.5 ppm in ozoned chamber result in spots on the fruit epidermis by the possible oxidation of cell wall components. It was noted, however, that immersion in ozoned water of the fruits at concentrations of 1 to 4 ppm of O3 were not effective in the removal of antracnose. So it is necessary to use hydrothermal treatments before the use of O3. Best results were obtained an temperatures close to 55°C for 1 minute. The use of ozone did not affect the fruit cuticular surface, while the hydrothermal treatment provided the recovering of the natural fissures of the fruit. The increased ozone concentration from 2 to 4 ppm provided a loss of more than 40% of the Vitamin C content. Ozone did not affect the degree of ripening (ratio) and the skin color of the papayas.

abstract: The common cold is a significant cause of morbidity world-wide, with human rhinovirus infections accounting for a majority colds suffered each year. While the symptoms of the common cold are generally mild and self-limiting, vulnerable populations such as individuals with asthma can experience severe secondary complications including acute asthma exacerbation which can result in severe morbidity. Most human rhinovirus types utilize Intercellular Adhesion Molecule-1 (ICAM-1) as a receptor to enter cells and initiate infection. Expression of this cell-surface protein is elevated in the respiratory tract of asthma patients. The theoretical basis for this research is the observation that plasma measures of the soluble form of Intercellular Adhesion Molecule-1 (sICAM-1) decrease in response to vitamin C supplementation. As rhinovirus infection occurs in the upper respiratory tract, the primary aim of this study was to evaluate change in sICAM-1 concentration in nasal lavage of asthmatic individuals in response to vitamin C supplementation. Otherwise healthy asthmatic adults between the ages of 18-65 years who were not currently using steroidal nasal sprays, smoking, or actively training for competitive sports were recruited from a university community and surrounding area to participate in an 18-day double-blind randomized placebo-controlled supplement study with a parallel arm design. 13 subjects were stratified based on age, gender, BMI and baseline plasma vitamin C level to receive either 500 mg vitamin C twice daily (VTC, n=7) or placebo (PLC, n=6). Biochemical measures included nasal lavage sICAM-1, plasma sICAM-1, plasma histamine, and plasma vitamin C. Survey measures included Wisconsin Upper Respiratory Symptom Survey-21 to assess colds, Daytime Symptom Diary Scale to assess asthma symptoms, and measures of diet quality including a vitamin C food frequency questionnaire and Rapid Eating Assessment for Participants. No between group comparison of means reached significance (Mann-Whitney U test, p>0.05). Nasal lavage sICAM-1 levels were decreased in VTC group by 37% at study day 4, although this finding did not reach significance. Findings in this study can be used to develop future investigations into the response of nasal lavage sICAM-1 to vitamin C supplementation. / Dissertation/Thesis / Masters Thesis Nutrition 2014

Made available in DSpace on 2014-06-11T19:28:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-07-30Bitstream added on 2014-06-13T19:57:58Z : No. of bitstreams: 1 marques_km_me_jabo.pdf: 511891 bytes, checksum: cbe08f410b0271751205fef6028e0959 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / A conveniência que os produtos minimamente processados oferecem faz com que os figos-da-índia tornem-se uma opção para este mercado. O trabalho foi dividido em três etapas, sendo o objetivo na primeira avaliar as formas de preparo, e a necessidade de enxágue; o da segunda verificar o efeito de embalagens e temperaturas de armazenamento; e o da terceira foi avaliar o uso de produtos naturais, ácido ascórbico e cloreto de cálcio, visando à manutenção da qualidade e o aumento da vida de prateleira de figos-da-índia minimamente processados. Foram realizadas determinações da perda de massa fresca e da composição gasosa no interior das embalagens, de coloração da polpa, dos teores de sólidos solúveis, acidez titulável, açúcares solúveis (na primeira etapa), açúcares redutores, ácido ascórbico e carotenoides, assim como avaliações microbiológicas, pH e análise sensorial quanto a aparência e cor (na segunda e terceira etapa), sabor (na terceira etapa) e intenção de compra. Estas avaliações foram feitas a cada quatro dias na primeira etapa, e a cada três dias na segunda e terceira etapas. Frutos inteiros apenas descascados foram os preferidos quanto à intenção de compra e apresentaram a melhor manutenção da qualidade. O enxágue em solução com água clorada contendo 10 mg L-1 de cloro livre dos frutos reduziu o crescimento de microrganismos e o armazenamento a 3 ºC manteve a qualidade microbiológica e sensorial dos frutos inteiros por até oito dias. A associação do armazenamento a 3 ºC com a embalagem de PET com tampa, manteve a qualidade sensorial e microbiológica dos frutos por até doze dias. Os produtos naturais, ácido ascórbico e cloreto de cálcio, pouco afetaram as características físicas e químicas dos figos-da-ínida minimamente processados e não aumentaram sua vida útil / The practicality of fresh-cut fruit and vegetables is also applied to the prickly pear what become an option to its marketing. This work was divided into three stages; being the first goal to evaluate the preparation methods and also the need for rinsing; the second goal was to check the packaging effect and storage temperatures and thirdly evaluating the use of natural products, ascorbic acid and calcium chloride, aiming to maintain quality and increase of shelf-life for fresh-cut prickly pear. There were performed determinations of fresh mass loss and gas composition inside packages, of pulp color, of soluble-solid content, titratable acidity, soluble sugars (first stage), reducing sugars, ascorbic acid content, carotinoids, well as microbiologic analysis, pH and sensory analysis for purchasing intention, appearance and color (second and third stages) and flavor (third stage). These analyses were made each four days for first and second stage analyses and each three for the third one. Whole fruit peeled was chosen as the preferred for purchasing intention and also presented the best maintenance of the quality, and the rinse solution with chlorine water containing 10 mg L-1 of free chlorine has reduced the growth of microorganisms. The storage at 3 °C maintained the microbiological and sensory quality of whole fruit until eight days. The association between storage temperature at 3ºC with the PET top packaging maintained the microbiological and sensory quality of fruits until twelve days. The natural products, ascorbic acid and calcium chloride, barely affected the physical and chemical characteristics of fresh-cut prickly pear and do not increased the shelf-life

Introduction: Helicobater pylori interferes with vitamin C homeostasis and low levels of vitamin C may be a risk factor for H. pylori infection. Objective: to investigate the vitamin C serum and gastric juice levels of patients infected and non-infected by H. pylori. Additionally assess the association of vitamin C levels with H.pylori status, gastric pH and histological changes of gastric mucosa of dyspeptic patients with normal upper GI endoscopy. Methods: We studied 42 dyspeptic patients undergoing upper GI endoscopy had biopsies for diagnosis of H. pylori infection and gastric mucosa changes. We also collected 5 ml of blood (for dosage of serum vitamin C) and 10 ml of gastric juice. We measure pH of gastric juice. We used high-performance liquid chromatography to assess Vitamin C in serum and gastric juice. Results: The average age was 52 years (SD±11.8), 84.4% female, overweight BMI median 27,7) with adequate dietary intake of vitamin C. Twenty four (53.3%) patients had H. pylori infection. The median serum vitamin C levels in infected and non-infected was 3.9 and 3.4 μg (p = 0.59). The median gastric juice levels of vitamin C was 9,8 μg in infected and 18.4 μg in non-infected (p = 0.03). The histology showed normal mucosa in eight 8 (20%), chronic non-atrophic gastritis in 23 (55%) and chronic atrophic gastritis in 11 (26%) patients. There was no significant association of histology with Vitamin C serum levels (p = 0.26) or gastric (p = 0.29). Conclusion: Vitamin C serum levels were within the normal range, and most patients had adequate food ingestion of vitamin C. Serum levels of vitamin C were similar in individuals infected and non-infected while vitamin C levels in the gastric juice of patients infected were reduced compared with patients non-infected. Serum levels of vitamin C were higher in the gastric juice than in serum, regardless the patients were infected or not. / Introdução: A infecção por Helicobater pylori influencia na homeostase da vitamina C e níveis baixos da mesma podem determinar risco para a infecção. Objetivo: Investigar os níveis de vitamina C no soro e suco gástrico de pacientes infectados e não infectados por H. pylori e estudar sua associação com a infecção, com o pH gástrico e com as alterações anatomopatológicas da mucosa gástrica de pacientes dispépticos funcionais. Métodos: Foram estudados 42 pacientes dispépticos submetidos a endoscopia digestiva alta e biópsia para diagnóstico da infecção por H. pylori e de alterações anatomopatológicas da mucosa gástrica, classificadas de acordo com o Sistema Sidney. Aspirado suco gástrico com mensuração do pH e coleta de 5 ml de sangue para dosagem de vitamina C no soro. A dosagem da Vitamina C no soro e no suco gástrico foi realizada por cromatografia líquida de alta performance. Resultados: A idade média foi de 52 anos (DP±11,8), 84,4% do sexo feminino, com sobrepeso (IMC mediana=27,7), com adequada ingestão alimentar de vitamina C. Vinte e quatro (53,3%) pacientes apresentavam infecção por H. pylori. A mediana dos níveis de vitamina C no soro dos infectados foi 3,9 μg/ml e nos não infectados 3,4 μg/ml (p=0,59). A mediana dos níveis de vitamina C no suco gástrico foi 9,8 μg/ml nos infectados e 18,4 μg/ml nos não infectados (p=0,03). A histologia demonstrou mucosa normal em 8 (20%), gastrite crônica não atrófica em 23 (55%) e gastrite crônica atrófica em 11 (26%) pacientes, sem associação significativa com os níveis séricos (p=0,26) ou gástricos (p=0,29) da vitamina C. Conclusões: O nível sérico da vitamina C nos pacientes estudados esteve dentro dos valores de referência normais e o consumo de vitamina C foi adequado na maioria. Os níveis séricos da vitamina C foram semelhantes em indivíduos infectados e não infectados enquanto os níveis de vitamina C apresentaram-se reduzidos no suco gástrico dos pacientes infectados por H. pylori em comparação com os não infectados. Os níveis séricos de vitamina C foram mais altos no suco gástrico do que no soro, independentemente da condição de infectado ou não.