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Arbetet med miljöfrågorna är svåra att strukturera och därför har olika internationella miljöstandarder skapats. SS-EN ISO 14000 är en serie internationella miljöstandarder, som i dagligt tal kallas ISO 14000 och i denna standard ingår ISO 14001 vilken kan användas som grund vid uppbyggandet av ett miljöledningssystem och det är införandet av denna som analysen vilar på. Syftet med uppsatsen är att undersöka vilka hinder som kan uppstå vid införandet av ISO 14001-standarden. Även att identifiera vilka lösningar som finns att tillgå gällande hindren. Dessutom utforskas vilka de olika incitamenten är som driver en verksamhet till att vilja integrera miljöfrågor bland övriga beslut. Slutligen granskas fördelar med att införa miljöledningssystemet ISO 14001.

Radio wave propagation measurements provide a way to accurately and reliably characterize environments to assist in the development and optimization of wireless communication systems. As digital radio systems occupy wider bandwidths and use multipath signal combining to enhance quality of service, knowledge of time dispersion and the multipath structure of radio channels become increasingly important. The wideband measurement system presented herein provides a practical means to precisely measure the delays and strengths of individual multipath components which arrive at a radio receiver. Presented in this Thesis are fundamental theory, practical implementation, and simulation models for a sliding correlator measurement system. The sliding correlator technique is explained in detail and large-scale measurement survey is presented. Techniques for statistically quantifying the characteristics of propagation using the sliding correlator measurements are presented and compared. The development of simulations of the sliding correlator system is described, and simulation results are used to test conventional and newly developed post-processing algorithms. This Thesis presents a practical view of the sliding correlator measurement system, but its foundations are rooted in the theoretical results which are explained and derived herein. Propagation researchers and students in the wireless communication field may find this work and the cited references useful for continued study of wideband propagation measurements or for application of the sliding correlator system as a wideband measurement solution. / Master of Science

In recent years, the concept of burnout has been expanded and is currently a concern in all professions and occupational groups. Nowadays it is widely acknowledged that people in almost any occupation could develop burnout. To-date, only two studies have examined students' experiences of burnout. Therefore, research regarding this phenomenon in students seems warranted. The objective of this study was to firstly investigate the psychometric properties of adapted versions of the Maslach Burnout Inventory and Utrecht Work Engagement Scale in a sample of students from a tertiary institution, and secondly to consider the role of biographical variables in relation to burnout and engagement levels. A cross-sectional survey design was used to attain the research objectives. For the purposes of this study, an availability sample of students (N=353) majoring in Organisational Behaviour was drawn at one point in time. The adapted Maslach Burnout Inventory - Student Survey (MBI-SS) and the Utrecht Work Engagement Scale - Student Survey (UWES-S) as well as a biographical questionnaire were administered. Structural equation modelling confirmed two-factor models of Burnout (consisting of Exhaustion and Cynicism) and Engagement (consisting of Vigour and Dedication). Biographical variables which appear to be predictive of differences in levels of student burnout are home language, overall health status and consideration given to quitting their studies, while engagement is related to home language, academic year of study and consideration given to quitting studies. Recommendations for future research were also made / Thesis (M.A. (Industrial Psychology))--North-West University, Potchefstroom Campus, 2006.

This thesis deals with the involvement of the Austrians in the 2nd tank division SS "Das Reich." The introductory part analyzes personnel cast of the division and aims at finding the answer to the question, in which period the largest number of the Austrians served in the division and possibly how many. The main focus is put on the question, whether the Austrians in the division who owned the highest army decorations of the Third Reich were represented by below-average or above-average numbers in view of their total number. We can not omit to mention a social profile of these decorated men, which provides us with broader point of view of their personalities. Last but not least, the thesis deals with the question, whether the Austrians took part in war crimes committed by the division. Key words: division "Das Reich", Waffen-SS, Austrians, social profile, war crimes, high decorations

La nicotine est considérée comme étant la « molécule » addictogène de la cigarette et du tabac. Mais différentes études cliniques, utilisant notamment des substituts nicotiniques, débouchent pratiquement toutes sur une même conclusion : efficacité ne dépassant que de peu celle d’un placebo, et très limitée dans le temps, contrastant avec le pouvoir hautement addictif du tabac, qu'il soit chiqué, prisé ou fumé. Dans ce travail de thèse, nous avons essayé de mettre en évidence le rôle que pourraient avoir certains des autres composés présents dans le tabac ou produits par pyrolyse. Nous avons d’abord utilisé des extraits aqueux de fumée et de tabac pour approcher un aspect global de ce que les fumeurs absorbent chaque fois qu’ils fument une cigarette, nous rapprochant ainsi des conditions physiologiques du fumeur. Puis nous avons choisi un certain nombre de substances. La cotinine, métabolite de la nicotine. L’harmane, une ß-carboline, synthétisée au cours de la combustion et dans l’organisme des fumeurs. La norharmane, une ß-carboline, présente en partie dans le tabac et synthétisée dans la fumée par pyrolyse. La technique utilisée tout au long de ce travail est l’enregistrement électrophysiologique. Cette technique s’applique très bien à l’étude in vivo de différents systèmes neuronaux y compris le système dopaminergique. Nous l’avons utilisée chez le rat, la souris WT et la souris Knockout ß2 (ß2KO). Nous nous sommes intéressés à deux aspects de l’activité cellulaire des neurones dopaminergiques de l’aire tegmentale ventrale : la fréquence de décharge (le firing) et les bouffées (bursts). En parallèle, nous avons conduit des expériences de liaison (binding) sur des cultures de cellules exprimant le récepteur nicotinique α4ß2. Nos résultats les plus significatifs ont montré que : Les bursts sont le plus souvent absents après les injections d’extraits de tabac et de fumée. Cela pourrait, entre autres, impliquer qu’il existe dans le tabac et la fumée des composés autres que la nicotine qui bloquent les effets de la nicotine sur les bursts. Les effets des extraits de tabac et de fumée sur le firing et les bursts ne sont plus présents chez les souris ß2 KO, ce qui implique que l’ensemble des composés du tabac agit essentiellement sur les récepteurs nicotiniques porteurs de la chaine ß2, même si des hypothèses alternatives existent. L’harmane a des effets activateurs très puissants sur le firing des neurones dopaminergiques, et ces effets sont bloqués à 80% par la mécamylamine, ce qui démontre qu’un des principaux composés du tabac et de la fumée autre que la nicotine agit par un mécanisme essentiellement nicotinique. Les expériences de binding confirment que les effets du tabac et de la fumée impliquent les récepteurs nicotiniques d’une façon majeure, mais d’une façon qui diffère légèrement de celle de la nicotine.Les résultats que nous avons obtenus montrent que les effets pharmacologiques du tabac ne se résument pas à ceux de la seule nicotine. Ils peuvent constituer un point de départ pour d’autres travaux, notamment pour étudier de plus près les effets des ß-carbolines. Il est nécessaire d’identifier les types de récepteurs sur lesquels elles se fixent, en utilisant des agonistes et antagonistes de récepteurs aux neurotransmetteurs contrôlant l’activité des neurones dopaminergiques. Des expériences sur des souris transgéniques chez lesquelles différents types de sous-unités de récepteurs nicotiniques ont été supprimés doivent également être envisagées, pour déterminer les mécanismes d’action des composants autres que la nicotine contenus dans le tabac et sa fumée sur les neurones dopaminergiques / Nicotine is generally considered as the sole tobacco addictive compound. However, nicotine replacement therapy studies almost all end with the same conclusion: the effectiveness of nicotine replacement is very limited on the short-term, and hardly exceeds that of placebo on the long-term. In addition, studies dealing with the effects of denicotinized cigarettes have provided evidence that these cigarettes have an addictive potential. In the present work, we tried to determine the behavioral role of some tobacco or smoke compounds other than nicotine at the neuronal level. We first compared the effects of nicotine with those of whole tobacco and smoke extracts, given that these preparations closer mimic the smoking situation than nicotine alone. We then examined the effects of a number of selected tobacco or smoke compounds. Cotinine, a major nicotine metabolite. Harmane and norharmane, two ß-carbolines synthesized in smoke as well as in the body of smokers. The technique used consists in the in vivo recording of the firing rate and bursts of dopamine neurons in the ventral tegmental area after intravenous injections of compounds in rats and mice. This electrophysiological technique is known to be a useful way to investigate the properties of selected compounds. In the case of mice, we used wild type and ß2 KO mice. We also made a series of in vitro experiments investigating the binding properties of the compounds on cells expressing high densities of α4ß2 nicotinic receptors. The main results of our studies are the following: Bursts are absent most of the times after the injection of the extracts. These results suggest that tobacco and smoke extracts contain compounds that inhibit the burst-promoting effects of nicotine. Increased firing is no longer present in ß2 KO mice treated with tobacco or smoke extracts, indicating that tobacco and smoke components, as a whole, primarily acts on nicotinic receptors that carry the ß2 chain, although alternative hypotheses may exist. Harmane very strongly activates the firing of dopaminergic neurons. Up to 80% of this effect is blocked by mecamylamine, demonstrating that that a major component of tobacco and smoke other than nicotine acts primarily through a nicotinic mechanism. The binding experiments confirm that the effects of tobacco and smoke involve nicotinic receptors in a major way, but in a way that slightly differs from that of nicotine. Our results may constitute a new starting point for further work, especially for a closer look at the effects of ß-carbolines. Attempts to identify the types of receptors involved in these effects are needed, using agonists and antagonists of neurotransmitter receptors that control the activity of dopamine neurons. Experiments on transgenic mice with deletion of different types of subunits of nicotinic receptors should also be made, to determine the different mechanisms of action of tobacco and smoke compounds other than nicotine on dopaminergic neurons

Submitted by JOSIANE SANTOS DE OLIVEIRA (josianeso) on 2018-10-02T15:15:54Z No. of bitstreams: 1 Bruno Albornoz Cutin_.pdf: 7029333 bytes, checksum: 4d860679c9aa06afa62aa8f896a6950d (MD5) / Made available in DSpace on 2018-10-02T15:15:54Z (GMT). No. of bitstreams: 1 Bruno Albornoz Cutin_.pdf: 7029333 bytes, checksum: 4d860679c9aa06afa62aa8f896a6950d (MD5) Previous issue date: 2016-03-23 / UNISINOS - Universidade do Vale do Rio dos Sinos / O presente trabalho pretende ampliar o conhecimento relacionado ao desenvolvimento de habilidades sociais na infância, principalmente no que está nas capacidades do design. A fim de auxiliar os profissionais desta área a desenvolverem projetos com maior propriedade sobre o tema, buscou-se compreender como se dá o processo de projetar personagens que estimulem o desenvolvimento das HS e como projetar um SPS dessas personagens, nos quais todos elementos auxiliem nesse desenvolvimento. Foram pesquisados todos os temas considerados importantes para o desenvolvimento da atividade projetual (Design Estratégico e Sistema Produto Serviço / Personagem: Design e Construção / Brinquedos, Personagens e as Habilidades Sociais). O workshop foi realizado com profissionais das áreas de: design, psicologia e comunicação. As atividades foram elaboradas, coordenadas e avaliadas por um conselho. Ao final foram desenvolvidas duas personagens (Golf e Ploft) com seus respectivos SPS. / This paper aims to expand knowledge related to the development of social skills in childhood, especially on what is in the capabilities of the design. In order to assist professionals in this area to develop projects with greater ownership of the issue, we sought to understand how is the process of designing characters that encourage the development of Social Skills (SS) and how to design a PSS these characters, in which all elements assist in the SS development. It has been researched all issues considered important for the development of design activity / workshop (Strategic Design and Product System and Service / Character: Design and Construction / Toys, Character and Social Skills). The workshop was held with professionals in the areas of: design, psychology and communication. The activities were designed, coordinated and evaluated by a board. At the end it was developed two characters (Golf and Ploft) with their SPS.

Magister Chirurgiae Dentium - MChD (Orthodontics) / The aim of the study is to compare the frictional resistance generated between two types of self-ligating brackets; Smart-Clip Metal SL (3M Unitek) and Damon Clear SL (Ormco), with conventional stainless steel brackets, Victory Series (3M Unitek) when coupled with various stainless steel and nickel-titanium archwires. Materials and Methods: All brackets had a 0.022" slot and tested using three archwires: 0.016" nickel-titanium, 0.019 x 0.025" nickel-titanium and 0.019 x 0.025" stainless steel archwires. Friction was evaluated for the upper right quadrant of the typodont. For each testing procedure, new brackets and archwire was employed to eliminate the influence of wear. Results: The mean results showed that the Smart-Clip self-ligating brackets generated significantly lower friction than both the Damon Clear self-ligating brackets and Victory Series brackets. However, the analysis of the various bracket-archwire combinations displayed that Damon Clear SL brackets generated the lowest friction when tested with 0.016" round nickeltitanium archwire and significantly higher friction than Smart-Clip and Victory Series brackets when tested with 0.019 x 0.025" stainless steel rectangular archwires. All brackets showed higher frictional forces as the wire size increased. Clinical relevance: The production of high levels of friction during orthodontic sliding mechanics presents a clinical challenge to the orthodontists. The generation of high levels of friction may reduce the effectiveness of the mechanics, decrease tooth movement efficiency and further complicate anchorage control. The amount of friction is variable in the orthodontic system and can be altered somewhat by the orthodontist's choices.

The ability to determine nucleic acid sequences is one ofthe most important platforms for the detailed study ofbiological systems. Pyrosequencing technology is a relativelynovel DNA sequencing technique with multifaceted uniquecharacteristics, adjustable to different strategies, formatsand instrumentations. The aims of this thesis were to improvethe chemistry of the Pyrosequencing technique for increasedread-length, enhance the general sequence quality and improvethe sequencing performance for challenging templates. Improvedchemistry would enable Pyrosequencing technique to be used fornumerous applications with inherent advantages in accuracy,flexibility and parallel processing. Pyrosequencing technology, at its advent, was restricted tosequencing short stretches of DNA. The major limiting factorwas presence of an isomer of dATPaS, a substitute for thenatural dATP, which inhibited enzyme activity in thePyrosequencing chemistry. By removing this non-functionalnucleotide, we were able to achieve DNA read-lengths of up toone hundred bases, which has been a substantial accomplishmentfor performance of different applications. Furthermore, the useof a new polymerase, called Sequenase, has enabled sequencingof homopolymeric T-regions, which are challenging for thetraditional Klenow polymerase. Sequenase has markedly madepossible sequencing of such templates with synchronizedextension. The improved read-length and chemistry has enabledadditional applications, which were not possible previously.DNA sequencing is the gold standard method for microbial andvial typing. We have utilized Pyrosequencing technology foraccurate typing ofhuman papillomaviruses, and bacterial andfungal identification with promising results. Furthermore, DNA sequencing technologies are not capable oftyping of a sample harboring a multitude of species/types orunspecific amplification products. We have addressed theproblem of multiple infections/variants present in a clinicalsample by a new versatile method. The multiple sequencingprimer method is suited for detection and typing of samplesharboring different clinically important types/species(multiple infections) and unspecific amplifications, whicheliminates the need for nested PCR, stringent PCR conditionsand cloning. Furthermore, the method has proved to be usefulfor samples containing subdominant types/species, and sampleswith low PCR yield, which avoids reperforming unsuccessfulPCRs. We also introduce the sequence pattern recognition whenthere is a plurality of genotypes in the sample, whichfacilitates typing of more than one target DNA in the sample.Moreover, target specific sequencing primers could be easilytailored and adapted according to the desired applications orclinical settings based on regional prevalence ofmicroorganisms and viruses. Pyrosequencing technology has also been used forclone-checking by using preprogrammed nucleotide additionorder, EST sequencing and SNP analysis, yielding accurate andreliable results. <b>Keywords:</b>apyrase, bacterial identification, dATPaS, ESTsequencing, fungal identification, human papillomavirus (HPV),microbial and viral typing, multiple sequencing primer method,Pyrosequencing technology, Sequenase, single-strandedDNA-binding protein (SSB), SNP analysis