Over the last two decades the role of knowledge in organizations has attracted considerable attention from organizational practice and academia (Beamish & Armistead, 2001; Blackler, Reed, & Whitaker, 1993; Grant, 1996; Jasimuddin, 2006; Nonaka, 1994). A broad research community has emerged around with about 40 peer-reviewed journals (Serenko & Bontis, 2013a, 2013b; Serenko, Bontis, Booker, Sadeddin, & Hardie, 2010) which has attracted scholars from fields such as management, information management and library sciences, psychology and organizational studies, sociology and computer sciences as well as engineering and philosophy (Baskerville & Dulipovici, 2006; Gu, 2004; Lee & Chen, 2012; Martin, 2008; Venzin, Von Krogh, & Roos, 1998; Wallace, Van Fleet, & Downs, 2011). The assessment of the KM field ranges from suggestions that KM is in a state of "pre-science" with different paradigms and disagreement about fundamentals in the field (Hazlett, McAdam, & Gallagher, 2005) while others see a ‘healthy arena with a strong foundation in multiple theories and clear direction for future work (Baskerville & Dulipovici, 2006).

This report focuses on the design of a university knowledge management system (KMS), and how such a system can provide the framework for students and faculty to partake in, share, and collaborate on research activities. The collaborative environment of a university KMS, or research network, must be established in order for a university to maintain its reputation as a competitive research institution and to develop its faculty and students outside the classroom. A research network may contain a variety of features, some of which include faculty profiles, forums, communication portals, publication links, biographies, faculty keywords, interest areas and contact information. Several web-based systems provide the capabilities required for a well-functioning research network, including creating a customized system in-house. Thus, the existence of various alternatives often leads to great difficulty selecting, designing, and/or customizing a feasible system. The systems engineering process allows a university to evaluate and select the most desirable research network to suit its needs while maintaining decision objectivity. Once a system is selected, the university must integrate the research network into its existing research organization through a structured implementation plan, which includes system implementation schedule, functionality, required resources, and cost analysis. In addition, this report includes a case study performed at California Polytechnic State University, San Luis Obispo (Cal Poly). In this case study, the KMS design and systems engineering process are applied to Cal Poly, in an attempt to satisfy Cal Poly’s need for a robust research network. An implementation plan developed for Cal Poly is presented, as well.

La famiglia nell'attualità è attraversata da cambiamenti che stanno trasformando le fondamenta della identità personale, gli assiomi della vita quotidiana. Il caso della famiglia che ha attraversato una rottura ed è contrassegnata da separazione e divorzio, solleva un gran numero di questioni umane e sociali e origina diverse transizioni, che sono state al centro dell'approfondimento oggetto di questa tesi dottorale, condotto su un campione di giovani adulti italiani. Essa mostra, nella fattispecie attraverso le peculiari caratteristiche della ricerca qualitativa, i tratti salienti di specifici metodi visuali, denominati "Family map" e "Life line". Essi hanno contribuito a definire la struttura, il posizionamento relazionale dei membri della famiglia, le stesse relazioni tra essi, nonchè di concettualizzare chi "appartiene" a una famiglia che ha attraversato un cambiamento, una transizione, che porta dunque con sè un corredo di eventi correlati. L'intervistato ha partecipato di volta in volta secondo una modalità (inter)attiva e ha descritto graficamente all'interno delle quattro specifiche sezioni ed i cerchi concentrici della mappa e poi lungo la linea, quali relazioni e fatti sono più o meno importanti. L'intervistatore ha potuto rivolgere domande volte ad acquisire informazioni su alcuni processi di cambiamento e la prospettiva peculiare di tale cambiamento, così come percepita da ciascun attore, ad esempio in riferimento ad eventi passati o presenti. Attraverso lo specifico snodarsi grafico dei supporti - allo sesso tempo fornendo un inquadramento consistente di dati- questo lavoro ha gettato luce su cosa le relazioni familiari, gli eventi e le rappresentazioni configurano nella percezione della persona coinvolta. La scommessa posta attraverso l'uso di questi metodi visuali è quella di continuare a concepire gli individui in termini di approccio relazionale, attraverso l'interdipendenza con il sè, l'altro da sè e il mondo, lungo tutto il corso della propria esistenza. Un grande contributo di questo strumento sui generis è che ha aperto le porte a numerose altre domande che stimolano la ricerca di risposte e la stessa futura ricerca riguardante i figli di separati. / Many changes are affecting the family today, transforming the foundations of self-identity, which are the core models for everyday personal life. The situation of family disruption, such as separation and divorce, raises either a number of human and social issues, and transitions which deserved to be better understood in this PhD thesis, being carried out on a sample of young Italian adults. It shows in the form of qualitative research the main features of specific visual methods, the Family map and Life line. They contributed to define the structure, the positions of family members, the relationships between them and conceptualize who belongs to a family that has changed, with crucial events related. The interviewee has been actively identifying and describing graphically (within the four sections and the concentric circles of the map and along the line) which relations and facts are more or less relevant. The interviewer could ask questions in order to get some processes of change and the actors’ own perception of such change, e.g. with reference to current state or past events. Along a specific visual development of the graphs -while providing a helpful framework- this research throwed some light on what family relationships, events and representations are on the perception of the person involved. The challenge posed for this visual methods is to continue to conceive of individuals in terms of relational approach, through the interdependence with self, others, and the world during the course of life. A great contribution of this tool sui generis is that it opened the door to numerous additional questions concerning children of divorce, that need answers and further research.

Centros de pesquisa clínica (CPC) devem ter infraestrutura adequada, equipe treinada e gerenciamento de processos bem definidos, para atender as particularidades dos projetos científicos, as Boas Práticas Clínicas (BPC), e as diretrizes e normas nacionais e internacionais que regem este ambiente. Um sistema de gestão da qualidade é fator primordial para o sucesso de um CPC durante a condução de ensaios clínicos. Neste contexto, a ANVISA instituiu em 2009 a Instrução Normativa nº 4 (IN4) que dispõe sobre o guia de Inspeção em BPC. O objetivo deste estudo foi desenvolver e validar um questionário eletrônico capaz de medir o desempenho dos centros participantes da Rede Nacional de Pesquisa Clínica (RNPC) em uma auditoria de qualidade baseada nas BPC. Avaliamos a correlação do nosso instrumento com o guia de inspeção em BPC disposto na IN4 ANVISA e estudamos a influência de um gerente de qualidade em relação ao cumprimento aos requisitos. Foi realizado um estudo transversal nos 32 centros participantes da RNPC, por meio da aplicação de um questionário eletrônico, legitimado por uma validação de conteúdo. As questões foram agrupadas em três domínios (infraestrutura, estrutura organizacional (EO) e processos). Os dados foram pontuados de acordo com o cumprimento (1) ou não cumprimento (0) em BPC. As questões do nosso questionário foram arbitrariamente correlacionadas aos itens da IN Nº 4, atribuímos (0) ponto às questões conformes e (1) para não conforme. Esta correlação foi realizado por meio de coeficiente de correlação de postos de Spearman. O índice de cumprimento para atendimento aos itens críticos e maiores (ICCM) foi calculado para cada domínio usando a equação ICCM = -1 * (Escore IN4) + valor total escore para dado domínio e comparado usando ANOVA não-paramétrica. Os dados foram agrupados de acordo com a presença ou ausência de um gerente de qualidade no centro de pesquisa e os escores foram comparados usando o teste de Mann-Whitney, com P valor <0.05. 27 centros responderam ao questionário (84,4%). Nosso instrumento representa aproximadamente 40% dos itens do roteiro de inspeção da IN4 ANVISA. A pontuação obtida com o questionário correlaciona-se significativamente ao escore correspondente à IN4/ANVISA (r-=0,95, -0,89 a -0,98, CI95%, P<0.0001). A mediana do ICCM foi menor que 75% em todos os domínios estudados. Apenas 14,81% dos centros contam com a presença de um gerente de qualidade. A presença de um gerente de qualidade foi associada ao melhor desempenho nos domínios infraestrutura e estrutura organizacional (P<0.05). O instrumento desenvolvido para medir o desempenho em BPC apresenta alta correlação com a Instrução Normativa Nº 4 ANVISA e poderia ser utilizado para auditoria interna de qualidade. A IN4/ANVISA mostrou ser muito rigorosa e todos os centros participantes da RNPC apresentaram pelo menos uma não conformidade em itens críticos ou maiores. A presença de um gerente de qualidade pode ajudar a melhorar o desempenho em qualidade em centros de pesquisa clínica / Clinical research centers (CRC) must have an adequate infrastructure, trained staff and well defined management process in order to conduct scientific clinical research protocols with distinct demands and to fulfill the regulatory rules including good clinical practices (GCP) and national or international additional regulatory rules. A quality management system plays a significant role in the success or failure of a CRC in conducting clinical trials. In this context, the Brazilian Health Surveillance Agency (ANVISA), published in 2009 a guide regarding quality audits in the CRC (The Normative Statute #4 of the Agência Nacional de Vigilância Sanitária - IN4 ANVISA). The aim of this study was to develop and validate an electronic questionnaire to measure how CRC that is part of the National Clinical Research Network (Rede Nacional de Pesquisa Clínica/RNPC) performed in a quality audit, using as a source document the GCP. We also evaluated the correlation between our instrument and IN4/ANVISA guide and studied the influence of a quality manager on the level of compliance with quality requirements. It was a transversal study that evaluated 32 CRC of the RNPC. They fulfilled an electronic questionnaire, validated by contend valid index. The questions were divided into tree domains (infrastructure (I), organization structure (OS), focused on human resources and process (P)). Data were scored according compliance (1) or non-compliance (0) with GCP. The questions between our questionnaire where arbitrary related to IN4/ANVISA guide and scored as non-conformity (1) or conformity (0). The correlation of the two measurements above was done using a Spearman rank method. The critical and major non-conformities index (ICCM) obtained with IN4/ANVISA score was calculated for each study domain using the equation ICCM=-1*score + maximal domain score and compared using non-parametric ANOVA. Data were grouped according the presence or absence of a CRC quality manager and the scores compared using Mann-Whitney rank test. The P valor was set to <0.05. Results: 27 CRCs answered the questionnaire (84,4%). Our instrument covered around 40% of all items checked by IN4/ANVISA inspection quality guide. The score obtained with our questionnaire significantly correlates with IN4/ANVISA score (r-=0,95, -0,89 to -0,98, CI95%, P<0.0001). The median of ICCM was lesser than 75% for all domain studied. Only 14,8 % of CRCs had a quality manager. The presence of a quality manager was associated with best performance in infrastructure and OS scores studied (P<0.05). The instrument designed to measure performance GCP showed high correlation with IN4/ANVISA guide and could be used to perform the internal quality audit. The IN4/ANVISA guide showed to be very strict and all CRC presented at least one critical or major quality non-conformities. The presence of quality manager could help CRC improve quality performance

Centros de pesquisa clínica (CPC) devem ter infraestrutura adequada, equipe treinada e gerenciamento de processos bem definidos, para atender as particularidades dos projetos científicos, as Boas Práticas Clínicas (BPC), e as diretrizes e normas nacionais e internacionais que regem este ambiente. Um sistema de gestão da qualidade é fator primordial para o sucesso de um CPC durante a condução de ensaios clínicos. Neste contexto, a ANVISA instituiu em 2009 a Instrução Normativa nº 4 (IN4) que dispõe sobre o guia de Inspeção em BPC. O objetivo deste estudo foi desenvolver e validar um questionário eletrônico capaz de medir o desempenho dos centros participantes da Rede Nacional de Pesquisa Clínica (RNPC) em uma auditoria de qualidade baseada nas BPC. Avaliamos a correlação do nosso instrumento com o guia de inspeção em BPC disposto na IN4 ANVISA e estudamos a influência de um gerente de qualidade em relação ao cumprimento aos requisitos. Foi realizado um estudo transversal nos 32 centros participantes da RNPC, por meio da aplicação de um questionário eletrônico, legitimado por uma validação de conteúdo. As questões foram agrupadas em três domínios (infraestrutura, estrutura organizacional (EO) e processos). Os dados foram pontuados de acordo com o cumprimento (1) ou não cumprimento (0) em BPC. As questões do nosso questionário foram arbitrariamente correlacionadas aos itens da IN Nº 4, atribuímos (0) ponto às questões conformes e (1) para não conforme. Esta correlação foi realizado por meio de coeficiente de correlação de postos de Spearman. O índice de cumprimento para atendimento aos itens críticos e maiores (ICCM) foi calculado para cada domínio usando a equação ICCM = -1 * (Escore IN4) + valor total escore para dado domínio e comparado usando ANOVA não-paramétrica. Os dados foram agrupados de acordo com a presença ou ausência de um gerente de qualidade no centro de pesquisa e os escores foram comparados usando o teste de Mann-Whitney, com P valor <0.05. 27 centros responderam ao questionário (84,4%). Nosso instrumento representa aproximadamente 40% dos itens do roteiro de inspeção da IN4 ANVISA. A pontuação obtida com o questionário correlaciona-se significativamente ao escore correspondente à IN4/ANVISA (r-=0,95, -0,89 a -0,98, CI95%, P<0.0001). A mediana do ICCM foi menor que 75% em todos os domínios estudados. Apenas 14,81% dos centros contam com a presença de um gerente de qualidade. A presença de um gerente de qualidade foi associada ao melhor desempenho nos domínios infraestrutura e estrutura organizacional (P<0.05). O instrumento desenvolvido para medir o desempenho em BPC apresenta alta correlação com a Instrução Normativa Nº 4 ANVISA e poderia ser utilizado para auditoria interna de qualidade. A IN4/ANVISA mostrou ser muito rigorosa e todos os centros participantes da RNPC apresentaram pelo menos uma não conformidade em itens críticos ou maiores. A presença de um gerente de qualidade pode ajudar a melhorar o desempenho em qualidade em centros de pesquisa clínica / Clinical research centers (CRC) must have an adequate infrastructure, trained staff and well defined management process in order to conduct scientific clinical research protocols with distinct demands and to fulfill the regulatory rules including good clinical practices (GCP) and national or international additional regulatory rules. A quality management system plays a significant role in the success or failure of a CRC in conducting clinical trials. In this context, the Brazilian Health Surveillance Agency (ANVISA), published in 2009 a guide regarding quality audits in the CRC (The Normative Statute #4 of the Agência Nacional de Vigilância Sanitária - IN4 ANVISA). The aim of this study was to develop and validate an electronic questionnaire to measure how CRC that is part of the National Clinical Research Network (Rede Nacional de Pesquisa Clínica/RNPC) performed in a quality audit, using as a source document the GCP. We also evaluated the correlation between our instrument and IN4/ANVISA guide and studied the influence of a quality manager on the level of compliance with quality requirements. It was a transversal study that evaluated 32 CRC of the RNPC. They fulfilled an electronic questionnaire, validated by contend valid index. The questions were divided into tree domains (infrastructure (I), organization structure (OS), focused on human resources and process (P)). Data were scored according compliance (1) or non-compliance (0) with GCP. The questions between our questionnaire where arbitrary related to IN4/ANVISA guide and scored as non-conformity (1) or conformity (0). The correlation of the two measurements above was done using a Spearman rank method. The critical and major non-conformities index (ICCM) obtained with IN4/ANVISA score was calculated for each study domain using the equation ICCM=-1*score + maximal domain score and compared using non-parametric ANOVA. Data were grouped according the presence or absence of a CRC quality manager and the scores compared using Mann-Whitney rank test. The P valor was set to <0.05. Results: 27 CRCs answered the questionnaire (84,4%). Our instrument covered around 40% of all items checked by IN4/ANVISA inspection quality guide. The score obtained with our questionnaire significantly correlates with IN4/ANVISA score (r-=0,95, -0,89 to -0,98, CI95%, P<0.0001). The median of ICCM was lesser than 75% for all domain studied. Only 14,8 % of CRCs had a quality manager. The presence of a quality manager was associated with best performance in infrastructure and OS scores studied (P<0.05). The instrument designed to measure performance GCP showed high correlation with IN4/ANVISA guide and could be used to perform the internal quality audit. The IN4/ANVISA guide showed to be very strict and all CRC presented at least one critical or major quality non-conformities. The presence of quality manager could help CRC improve quality performance

The Diploma thesis deals with the possible strategies that non-profit organizations can use for the establishment of a social enterprise. These strategies were designed on various relationship models non-profit and social enterprise can have. These models are different in the extent to which social enterprises and non-profit organizations share social and economic activities. These models and also possible motivations of non-profit organizations, which lead to the establishment of a social enterprise are described in the theoretical section. In the practical part, these models are applied to the decision-making process of non-profit organization Life 90, z. ú., which is planning to establish a social enterprise. is evaluated considering its pros and cons from the point of view of non-profit organisations.. These findings and each model and its applicability for Czech non-profit organizations were evaluated as a result of my thesis. KEY WORDS Social entrepreneurship, non-profit organizations, NGOs, commercialization, hybridization, case study, EMES International Research Network

Museums are increasingly reckoning with their roles in the colonization of Indigenous peoples as they seek to engage diverse forms of participation and justify their social relevance. Many are turning to digital solutions to aid with these endeavors, including digital repatriation/return platforms. How users interact with these platforms to create knowledge and how these platforms contribute to a larger decolonial aspiration is not well understood. In this study, I explore these issues, drawing on postcolonial/decolonial theories and affordance theory, using the Reciprocal Research Network (RRN). The RRN was co-designed by the Museum of Anthropology, U’mista Cultural Society, Musqueam Indian Band, and Stó:lō Nation/Tribal Council to meet the need for museums to involve Indigenous communities in heritage work. With an actor-network theory approach, I interviewed nine stakeholders (users, developers, and steering group members) of the RRN and explored the platform and documents to identify RRN actors’ specific enactments of decolonial aspirations as affordances. My exploration revealed that the RRN is bound as a network by the Item Search, which allowed for multiple entry points into a vast collection of heritage objects. These multiple entryways broke down technical and cultural barriers to and allowed for plurality in interaction with heritage. The RRN also allowed a direct contestation of museums’ data ownership by allowing users to dictate how shared knowledge is used. The RRN also was deeply embedded in Vancouver, BC, and its surrounding area, where multiple points of offline/online interaction allowed for deep explorations of the histories of First Nations peoples and aided in projects aimed at their revival. However, platform logics and museums’ lack of participation in relationship-building threatened the decolonial aspirations of the RRN. Broadly, my findings indicate that the RRN, as a communal heritage platform, is a necessary step towards building relations with Indigenous communities that requires further participation on museums’ part to develop.

Cancer is a very complex genetic disease driven by combinations of mutated genes. This complexity strongly complicates the identification of driver genes and puts enormous challenges to reveal how they influence cancerogenesis, prognosis or therapy response. Thousands of molecular profiles of the major human types of cancer have been measured over the last years. Apart from well-studied frequently mutated genes, still only little is known about the role of rarely mutated genes in cancer or the interplay of mutated genes in individual cancers. Gene expression and mutation profiles can be measured routinely, but computational methods for the identification of driver candidates along with the prediction of their potential impacts on downstream targets and clinically relevant characteristics only rarely exist. Instead of only focusing on frequently mutated genes, each cancer patient should better be analyzed by using the full information in its cancer-specific molecular profiles to improve the understanding of cancerogenesis and to more precisely predict prognosis and therapy response of individual patients. This requires novel computational methods for the integrative analysis of molecular cancer data. A promising way to realize this is to consider cancer as a disease of cellular networks. Therefore, I have developed a novel network-based approach for the integrative analysis of molecular cancer data over the last years. This approach directly learns gene regulatory networks form gene expression and copy number data and further enables to quantify impacts of altered genes on clinically relevant downstream targets using network propagation. This habilitation thesis summarizes the results of seven of my publications. All publications have a focus on the integrative analysis of molecular cancer data with an overarching connection to the newly developed network-based approach. In the first three publications, networks were learned to identify major regulators that distinguish characteristic gene expression signatures with applications to astrocytomas, oligodendrogliomas, and acute myeloid leukemia. Next, the central publication of this habilitation thesis, which combines network inference with network propagation, is introduced. The great value of this approach is demonstrated by quantifying potential direct and indirect impacts of rare and frequent gene copy number alterations on patient survival. Further, the publication of the corresponding user-friendly R package regNet is introduced. Finally, two additional publications that also strongly highlight the value of the developed network-based approach are presented with the aims to predict cancer gene candidates within the region of the 1p/19q co-deletion of oligodendrogliomas and to determine driver candidates associated with radioresistance and relapse of prostate cancer. All seven publications are embedded into a brief introduction that motivates the scientific background and the major objectives of this thesis. The background is briefly going from the hallmarks of cancer over the complexity of cancer genomes down to the importance of networks in cancer. This includes a short introduction of the mathematical concepts that underlie the developed network inference and network propagation algorithms. Further, I briefly motivate and summarize my studies before the original publications are presented. The habilitation thesis is completed with a general discussion of the major results with a specific focus on the utilized network-based data analysis strategies. Major biologically and clinically relevant findings of each publication are also briefly summarized.

No description available.

La recherche sur les soucoupes volantes commence à la fin des années 1940 en France. Elle est principalement le fait de ceux qui se nomment « soucoupistes ». En parallèle de cette activité exercée essentiellement à titre individuel, l’armée mène également ses propres enquêtes. Son intérêt pour la question ne se dément pas depuis les années 1940, même si les informations concernant son implication et son action se révèlent peu accessibles. De leur côté les soucoupistes s’agrègent et les premiers groupements privés d’envergure apparaissent dans les années 1950 et se généralisent à la fin des années 1960. La décennie 1970 correspond, quant à elle, à l’âge d’or de l’ufologie en France : les organisations se comptent par centaines et les ufologues par milliers. Un véritable réseau de recherche scientifique sur les ovnis apparait donc. Ce réseau s’articule autour des groupements de personnes et des individus -qui publient dans des revues spécialisées- et tente de se connecter à une ufologie scientifique publique en plein essor. Cette dernière, placée sous l’égide du CNES, prend le nom de GEPAN. Ce service, plusieurs fois rebaptisé, existe toujours aujourd’hui. Il s’appuie sur l’armée –principalement la gendarmerie- et certaines administrations qui le pourvoient en informations OVNI. L’ufologie française –en déclin depuis les années 1980- se caractérise donc par la coexistence d’un réseau de recherche privé et d’un réseau public qui, hormis en de rares occasions, collaborèrent très peu, cette situation contribuant à la maigreur des résultats obtenus par les ufologues. / The research about unidentified flying objects has started in the late 1940s in France. All this is the doing of those who are commonly known in French as the soucoupistes (the researchers in this field). Currently with this mainly individual initiative, the army also has made their own enquiries. Their interest for the question has proved consistent since the 1940s although the details about their implication and their action have been uneasy to know. As for them, the soucoupistes (or French ufologists) have joined together and the first major private groups have come out in the 1950s to become widespread in the late 1960s. Nonetheless, the decade of the 1970s was the golden age of ufology research in France : there were hundreds of organizations and thousands of ufologists. A real reasearch network came out. This network has revolved both around groups of people and individuals, who publish in specialized reviews, and they try to connect to a booming public scientific ufology. The latter, which is under the aegis of the CNES, is known as GEPAN. The department has been often renamed but still exists today. It is based on the army, mainly on the police force, but also on some administrations which provide them with information about UFO. French ufology, which has been in decline since the 1980s, is characterized by the coexistence of a private research network and a public one. Except for a few occasions, both of them have hardly collaborated and this situation explains why ufologists haven’t found many results.