Central auditory processing is complex and can not be evaluated by a single method. This thesis focuses on assessment of some aspects of central auditory functions by the use of dichotic speech tests and cognitive tests that tax functions important for speech processing. Paper A deals with the cognitive effects in dichotic speech testing in elderly hearing-impaired subjects. It was found that different listening tasks in the dichotic tests put different demands on cognitive ability, shown by a varying degree of correlation between cognitive functions and dichotic test parameters. Age-related cognitive decline was strongly connected with problems to perceive stimuli presented to the left ear. Paper B presents a new cognitive test battery sensitive for functions important for speech processing and understanding, performed in text, auditory and audiovisual modalities. The test battery was evaluated in four groups, differing in age and hearing status, and has proven to be useful in assessing the relative contribution of different input-modalities and the effect of age, hearingimpairment and visual contribution on functions important for speech processing. In Paper C the test battery developed in Paper B was used to study listening situations with different kinds of background noise. Interfering noise at +10 dB signal-to-noise ratio has significant negative effects on performance in speech processing tasks and on the effort perceived. Hearing-impaired subjects showed poorer results in noise with temporal variations, and elderly subjects were more distracted by noise with temporal variations, especially by noise with meaningful content. In noise, all subjects, particularly those with impaired hearing, were more dependent upon visual cues than in the quiet condition. Hearing aid benefit in speech processing with and without background noise was studied in Paper D. The test battery developed in Paper B was used together with a standard measure of speech recognition. With hearing aids, speech recognition was improved in the background condition without noise and in the background condition of ordinary speech. Significantly less effort was perceived in the cognitive tests when hearing aids were used, although only minor benefits of hearing aid amplification were seen. This underlines the importance of considering perceived effort as a dimension when evaluating hearing aid benefit, in further research as well as in clinical practice. The results from the studies contribute to the knowledge about speech processing but also to the search for more specific evaluation of speech understanding, incorporating both sensory and cognitive factors. / The ISBN 91-85297-49-6 in the printed verison is incorrect. The correct ISBN is 91-85297-93-3.

published_or_final_version / Medical Sciences / Master / Master of Medical Sciences

While the cognitive disturbances that frequently follow severe TBI are relatively well understood, the ways in which these affect the psychosocial functioning of people with TBI are yet to be determined and have thus received little attention in treatment research. Growing evidence indicates that that a significant proportion of individuals with TBI demonstrate deficits in the perception of affective information from the face, voice, bodily movement and posture. As accurate evaluation of emotion in others is critical for the successful negotiation of social interactions, effective treatments are necessary. Until recently, however, there have been no rehabilitation efforts in this area with TBI groups. The present research aims to redress this absence. The literature on emotion perception deficits in TBI is examined, and a theoretical rationale for intervention is presented. Several lines of research are reviewed which suggest that rehabilitation targeting such deficits is tenable. These include research on emotion perception remediation with other cognitively impaired populations, findings from cognitive neuroscience suggesting the potential for neuronal restoration after brain damage, and the successful applications of remediation techniques, in particular errorless learning and self-instruction, for treating other cognitive deficits in a range of neurological disorders and TBI. Discussion of this research is followed by a description of two randomised controlled trials aimed at improving emotion perception in individuals with TBI. The findings are discussed with reference to useful theoretical models of rehabilitation, learning and emotion perception. Suggestions for future directions of research are outlined together with relevant design issues.

Diss. (sammanfattning) Uppsala : University, 2003. / Härtill 4 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 4 uppsatser.

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 4 uppsatser.

Exposição a substâncias tóxicas e distúrbios metabólicos são fatores que afetam as funções neuropsicológicas. Foram realizados 2 estudos descritivos com os objetivos de verificar a possibilidade de disfunções neuropsicológicas em indivíduos com histórico de exposição ocupacional ao vapor de mercúrio e em pacientes diabéticos do tipo 2 sem diagnóstico de retinopatia, em ambos os casos, comparados com controles. A bateria neuropsicológica incluiu testes de atenção (Dígitos), controle inibitório (teste de stroop), memória verbal (teste de Buschke) e visual (Reprodução Visual), destreza manual (Grooved Pegboard), fluência verbal (FAS), habilidade viso-motora (Cubos), funções executivas (teste de Wisconsin), conhecimento semântico (Vocabulário) e sintomas de depressão (Inventário Beck de Depressão) e ansiedade (Inventário de Ansiedade Traço-Estado). Adotou-se p<0,05 como nível de significância. As avaliações neuropsicológicas de 26 ex-trabalhadores de fábricas de lâmpadas de mercúrio foram comparadas com 20 controles. Os ex-trabalhadores têm diagnóstico de mercurialismo crônico ocupacional, foram expostos ao vapor de mercúrio no trabalho durante 10,2 ± 3,8 anos e estão afastados da função há 6 ± 4,7 anos. A concentração de mercúrio urinário medida um ano após o afastamento da exposição teve média de 1,8 ± 0,9 mg/gCr. Comparados com os controles, os ex-trabalhadores demonstraram pior desempenho no teste de Stroop partes 1 (p=0,004) e 2 (0,010), no teste de Buschke para recuperação de longo prazo (p=0,028), armazenamento de longo prazo (p=0,045), recuperação consistente longo prazo (p=0,006), e recuperação tardia (p=0,008), fluência verbal (p=0,010) e no Grooved Pegboard tanto para a mão dominante (p=0,019) quanto a não dominante (p=0,008). Os escores de depressão, de estado e traço de ansiedade foram significantemente superiores aos do grupo controle (p<0,001). Os indivíduos com histórico de exposição ao vapor de mercúrio demonstraram redução da velocidade de processamento de informações e déficits de recuperação espontânea de informações verbais, fluência verbal, função motora, além de sintomas de depressão e ansiedade. Os escores altos de depressão e ansiedade são esperados em indivíduos com mercurialismo crônico, mas também podem se associar a problemas psicosociais relacionados ao desemprego. O outro estudo comparou o desempenho neuropsicológico de 19 pacientes diabéticos sem diagnóstico de retinopatia (avaliada através de exame de fundo de olho) e 20 sujeitos controles não diabéticos. Os pacientes têm diabetes há 8,2 ± 8,1 anos, média de hemoglobina glicada (HbA1C) de 7 ± 1,3%, não fazem uso de insulina como tratamento, não manifestam queixas de neuropatia e apresentam valores de microalbuminúria dentro dos limites de normalidade. Nove (47%) são hipertensos. Não foram encontradas diferenças significantes (p<0,05) entre pacientes diabéticos e sujeitos controles em quaisquer medidas realizadas. Os resultados sugerem que o diabetes tipo 2 não se associa diretamente aos déficits neuropsicológicos. Há a possibilidade de que as alterações cognitivas e de humor observadas em pacientes diabéticos do tipo 2 em estudos prévios estejam relacionadas à presença de complicações como retinopatia, hipoglicemia ou neuropatia com sinais clínicos. / Neuropsychological function is known to be affected by exposure to toxic substances and metabolic disorders. Two descriptive studies were performed. The aim was to examine possible neuropsychological dysfunction in individuals with history of occupational exposure to mercury vapor, and in type 2 diabetic patients without retinopathy, in comparison with controls. The neuropsychological assessment included measures of attention (WMS Digit Span), inhibitory control (Stroop Interference Test), verbal memory (Buschke Selective Reminding Test), visual memory (WMS Visual Reproduction), manual dexterity (Grooved Pegboard), verbal fluency (FAS), visuomotor ability (WAIS Block Design), executive function (Wisconsin Card Sorting Test), verbal knowledge (WAIS Vocabulary), and depression (Beck Depression Inventory) and anxiety (State-Trait Anxiety Inventory) symptoms. P<0.05 was taken as significance level. Neuropsychological assessments of 26 fluorescent lamp ex-workers with chronic mercurialism diagnosis who had been exposed to mercury vapor for 10.2 ± 3.8 years were compared with 20 controls. The time since the cessation of exposure was 6 ± 4.7 years and the mean urinary mercury concentration was 1.8 ± 0.9 mg/gCr. Compared with the controls, the ex-workers performed worse on the Stroop Test part 1 (p=0.004) and 2 (0.010), SRT long term recall (p=0.028), long term storage (p=0.045), consistent long term recall (p=0.006), and delayed recall (p=0.008), FAS (p=0.010) and Grooved Pegboard dominant hand (p=0.019) and nondominant hand (p=0.008). Their depression, anxiety state and trait scores were higher than control’s (p<0.001). Individuals with history of exposure to mercury vapor presented slowed processing speed and verbal memory spontaneous recall, verbal fluency and motor function impairment along with symptoms of depression and anxiety. The high scores on depression and anxiety are expected in chronic mercurialism and may be also associated with psychosocial problems related to unemployment. The other study compared the neuropsychological performances of 19 diabetic patients without retinopathy diagnosis (assessed by eye fundus examination) with 20 nondiabetic control subjects. The patients had diabetes for 8.2 ± 8.1 years and their recent glycaemic control levels (HbA1C) mean was 7 ± 1.3%. Other diabetic group’s characteristics included non-insulin treatment, no neuropathy complaints, normal microalbumin urine tests, and 9 (47%) hypertensive patients. No significant (p<0.05) differences were found between the diabetic and control groups on any measure. The results suggest that type 2 diabetes is not directly related to significantly neuropsychological alterations. It is possible that cognitive decrements and mood alterations among type 2 diabetic patients described in previous studies are associated with the presence of complications such as retinopathy, hypoglicaemia, or even neuropathy with clinical signs.

O envelhecimento populacional ocorrido nas últimas décadas provocou um aumento da prevalência das doenças crônicas. Neste contexto, o estudo do comprometimento cognitivo entre idosos assume grande importância, sobretudo as condições que podem preceder as manifestações clínicas da Doença de Alzheimer. O objetivo deste estudo foi detectar os efeitos de um programa de exercícios resistidos no desempenho cognitivo e na força muscular de idosos sedentários com comprometimento da memória. Trinta e um idosos sedentários sem demência ou depressão foram distribuídos aleatoriamente em dois grupos: Grupo Atividade Física e Grupo Controle. O programa de exercícios resistidos durou nove meses e consistiu de três séries de seis exercícios por sessão, realizados em aparelhos com sistema de alavancas, por aproximadamente uma hora, duas vezes por semana. Ambos os grupos foram submetidos aos seguintes testes cognitivos a cada três meses: Teste Comportamental de Memória de Rivermead (RBMT), Amplitude de Dígitos Diretos e Indiretos do WAIS, Escala de Queixas de Memória e Teste Cognitivo de Cambridge (CAMCOG). Após nove meses, o grupo que realizou os exercícios resistidos teve um aumento significativo do escore padronizado do RBMT (p=0,021) e da força muscular (p<0,001), sem diferença significativa dos demais parâmetros avaliados. Estes resultados indicam que os exercícios resistidos supervisionados podem melhorar o desempenho da memória em idosos sedentários com prévio comprometimento, além de determinar o aumento da força muscular. / The aging population in last decades increased the prevalence of chronic diseases. In this context, the study of cognitive impairment among elderly people assumes great importance, principally of conditions than can precede the clinics manifestations of Alzheimer disease. The objective was to detect the effects of resistance training program on cognitive performance and muscle strength of sedentary elderly with memory impairment. Thirty-one sedentary patients aged 60 and older, without dementia or depression, were randomly assigned to two groups: Physical Activity Group and Control Group. The resistance training program occurred on nine months, consisted of three series of six exercises by workout, performed with lever-kind weight training machines, nearly one hour, two times for week. Both groups were submitted by cognitive tests each three months: Rivermead Behavioral Memory Test (RBMT), WAIS forward digit span and backward digit span, and subjective Memory Complains Scale, and CAMCOG. Before nine months, the resistance training group had a significant increase in RBMT profile score (p=0.021) and muscle strength (p<0.001). There weren\'t significant differences in others parameters assessed. These findings showed that supervised resistance training can enhance a memory performance in sedentary elderly with previous impairment and improve muscle strength.

Pharmacological interventions to treat Human Immunodeficiency Virus (HIV) with antiretrovirals (ARVs), have dramatically improved the survival rates of HIV positive children maturing into adulthood. However, HIV-associated neurocognitive decline still persists in the era of ARVs. Within the framework of brain plasticity, a number of researchers have begun to assess the feasibility of cognitive rehabilitation therapy as a complement to ARVs to reverse neurocognitive decline as a result of HIV (e.g., Becker et al., 2012). Only one study has been conducted in South Africa, by Zondo & Mulder (2014), assessing the efficacy of cognitive rehabilitation in a paediatric sample. The current research builds on the above mentioned study by implementing an experimental approach to examine the effect of cognitive rehabilitation in a sample of both HIV positive and HIV negative children. Five HIV positive and six HIV negative children were assigned to either an experimental or control group. The experimental group underwent two months of cognitive rehabilitation therapy remediating sustained attention, whereas the control group took part in placebo activities. Sustained attention measures were taken before and after the intervention training sessions, using a sustained attention subtest from the Test of Everyday Attention for Children (TEA-CH). A Mann Whitney U Test revealed that the experimental group (Mdn=38.50) did not differ significantly from the control group (Mdn = 37.00) after the cognitive rehabilitation intervention, U=12.00, z= -.55, p= .66, r= -.17. But a Wilcoxon Signed Rank Test found that there was a significant improvement from pretest scores (Mdn=31.00) to posttest scores (Mdn=38.00) following the rehabilitation for HIV positive participants in the sample, T=15.00, z = -2.02, p= .04, r= -.90. This raises the possibility that cognitive rehabilitation could be used as a low cost intervention in underdeveloped contexts

Individuals are living longer now than they have in the past. As a result, there is an increased incidence in illnesses that are more prevalent in later life. One group of illnesses that is more prevalent is age related dementia. Alzheimer's disease (AD) and vascular dementia (VaD) are two common types of dementia found in the older adult population. Recent research suggests that these two types of dementia may both have a vascular component that is instrumental in their development. Not only may this vascular component be present in both these illnesses, but also it may be related to a more severe cognitive decline in the aging process. Results indicate that both cardiovascular disease and general and spousal social support in middle age are all three independent significant predictors of mild cognitive impairment and other non-normative cognitive impairment in later life. However, results do not indicate that social support moderates the relationship between cardiovascular disease and cognition.