Na América Central, em países como Honduras, El Salvador, Nicarágua e Costa Rica, tem sido descrito lesões cutâneas não ulceradas, designadas como leishmaniose cutânea não ulcerada ou atípica (LCNU) causadas por Leishmania (L.) infantum chagasi. Em Honduras, leishmaniose visceral e leishmaniose cutânea não ulcerada ou atípica são produzidas pelo mesmo agente etiológico, Leishmania (L.) infantum chagasi e ocorrem na mesma área geográfica. A LCNU é a forma clínica mais comum, afetando principalmente crianças maiores de 5 anos e adultos jovens. A lesão é definida como uma pápula, nódulo indolor, não ulcerativo, eritematoso ou da cor da pele, na presença ou ausência de halo hipopigmentado. Tendo em vista que existe uma lacuna no conhecimento do padrão de resposta imunológica tecidual da leishmaniose cutânea não ulcerada ou atípica, este trabalho visou avaliar a resposta imunológica inflamatória e regulatória in situ das lesões de pele. Foram utilizadas 20 biópsias de pele, com diagnóstico parasitológico confirmado por raspado de lesão corado por Giemsa e observado em microscópio ótico. O estudo histopatológico foi avaliado em cortes histológicos corados com hematoxilina e eosina (HE) e o padrão da resposta imune inflamatória e regulatória por meio da reação de imuno-histoquímica utilizando marcadores para linfócito T (CD4 e CD8), T regulatório (FoxP3), e antígenos intracelulares como: IL-17, TGF-beta, IL-10, IL-6 e IFN-y. As alterações histopatológicas mais significativas foram observadas na derme e caracterizadas por um infiltrado inflamatório linfohistiocitário de intensidade variável e associado à formação de granulomas epitelioides. Já as alterações histopatológicas identificadas na epiderme mostraram-se mais leves e correspondem a leve adelgaçamento, leve acantose e exocitose focal linfohistiocitária. Em 55% dos casos, o parasitismo mostrou-se discreto. A análise imuno-histoquímica das lesões cutâneas dos pacientes com LCNU mostrou no infiltrado inflamatório a presença de todos os marcadores utilizados neste estudo, em especial de linfócitos T CD8+ e CD4+, e das citocinas inflamatórias IFN-y e IL-6. A participação de células FoxP3+, TGF-beta+ e IL-10+ foi discreta, assim como das células IL-17+. Os dados mostram uma participação maior da resposta inflamatória na leishmaniose cutânea não ulcerada ou atípica, capaz de controlar o parasitismo e consequentemente a evolução do tamanho da lesão; porém, embora mais discreta, a resposta imune regulatória pode ser responsável para manter um balanço na resposta imune celular evitando danos teciduais e levando a baixa persistência parasitária no tecido, necessária para a manutenção de uma imunidade protetora e duradoura / Honduras: evaluation of the inflammatory and regulatory immune response in situ in skin lesions [dissertation]. São Paulo: \"Faculdade de Medicina, Universidade de São Paulo\"; 2017. In Central America, in countries such as Honduras, El Salvador, Nicaragua and Costa Rica, non-ulcerated skin lesions, designated as non-ulcerated or atypical cutaneous leishmaniasis (NUCL) caused by Leishmania (L.) infantum chagasi, has been reported. In Honduras, visceral leishmaniasis and non-ulcerated or atypical cutaneous leishmaniasis are caused by the same etiologic agent, Leishmania (L.) infantum chagasi and occur in the same geographical area. NUCL is the most common clinical form, affecting mainly children older than 5 years and young adults. The lesion is defined as a papule, painless nodule, non-ulcerative, erythematous or skin color, in the presence or absence of hypopigmented halo. Considering that, there is a gap in the knowledge of the tissue immune response pattern of non-ulcerated or atypical cutaneous leishmaniasis, this study aimed to evaluate the in situ inflammatory and regulatory immune response of skin lesions. Twenty skin biopsies with a confirmed parasitological diagnosis by scraping of lesion stained by Giemsa and observed under an optical microscope were used. The histopathological study was evaluated in histological sections stained with hematoxylin and eosin (HE) and the inflammatory and regulatory immune response through the immunohistochemistry reaction using T lymphocyte (CD4 and CD8), regulatory T (FoxP3) markers, and intracellular antigens such as IL-17, TGF-beta, IL-10, IL-6 and IFN-y. The most significant histopathological changes were observed in the dermis, and they were characterized by a lymphohistiocytic inflammatory infiltrate of variable intensity and associated to the formation of epithelioid granulomas. On the other hand, the histopathological changes identified in the epidermis were lighter and correspond to mild thinning, mild acanthosis and focal lymphohistiocytic exocytosis. In 55% of the cases, the parasitism was discreet. The immunohistochemistry analysis of the cutaneous lesions of patients with NUCL showed in the inflammatory infiltrate the presence of all the markers used in this study, especially CD8+ and CD4+ T lymphocytes, and the inflammatory cytokines IFN-y and IL-6. The participation of FoxP3+, TGF-beta+ and IL-10+ cells was discrete, as well as IL-17+ cells. The data show a higher participation of the inflammatory response in non-ulcerated or atypical cutaneous leishmaniasis, able to control the tissue parasitism and consequently the evolution of the lesion size; however, although discreet, the regulatory immune response may be responsible for maintaining a balance in the cellular immune response avoiding tissue damage and leading to low tissue parasitic persistence necessary for the maintenance of a protective and lasting immunity

This document outlines the foundation and first year results of the H.E.L.P. Honduras organization, which was formed as a student-based, student-governed international outreach initiative at the Marriott School of Management at Brigham Young University. Specifically, in its first year the organization focused on providing microcredit and service relief to victims of Hurricane Mitch in Honduras.After studying the case of H.E.L.P. Honduras, readers should conclude that educators interested in sponsoring sustainable student-run service learning organizations at private universities must address three primary issues: the problem of student selection and turnover, the need for administrative and faculty endorsement, and the need for sustainable internally-generated funds.This document outlines how the H.E.L.P. organization has changed in the three years since its inception, and it provides tactical suggestions meant to guide all parties interested in replicating the H.E.L.P. model. It also contains suggestions on how the current teaching and implementation model could more closely match with the basic tenets of service learning.After reading the following information and reviewing related literature, readers should conclude that at private universities, such as Brigham Young University, students and faculty interested in managing student-based initiatives need to take more time to build support across their institution. They also need to improve the process of student selection, find sustainable sources of funds, and tightly ground their work in the basic tenets of service learning.

Youth gangs, so-called Maras, in Central America have for a long time been one of the major factors contributing to the great amount of organized crime and violence in the Central American countries. The citizens in this region are exposed to violence and other crimes from the gangs on a daily basis. The vast amount of teens joining but also being forced to join the gangs is due to the high levels of poverty in the countries. Becoming a member in a gang is often seen as the only option to make a living. The study focuses on three countries in Central America: El Salvador, Guatemala and Honduras. The reason why the author chose these three countries is because they are the ones with the highest youth gang activity in the region as well as the ones who have faced and still are facing high levels of violence and corruption. They have all faced political, economic, and social challenges after civil wars and increasing drug trafficking in the region. The method used in the study is qualitative through an analysis of secondary sources on young women in youth gangs. The material is analyzed from a gender perspective and also power and social control theory. The maras mainly recruit teen boys, but also young girls and women. Teen girls are in some cases forced to join the gangs but many times they join the gangs as self- protection from other local maras. The young girls are used for different tasks and duties while in the gang, but also face abuse by being taken advantage of in a male dominated environment. The essay focuses on the role of young women in gangs. The research questions are: why the young girls join the gangs? What are their roles in the gangs? Are their roles differentiate to the mens?  It is important to observe how the youth gangs function, reflect the patriarchal structures of society in general which has created differences between the sexes where males are seen as superior to females, which also is evident in criminal youth gangs. The essay shows that the main reasons why young women join gangs are because they are looking for a safe environment due to lacking support and safety at home. The young women’s roles in the gang differentiate from the men in the way that they are assigned tasks according to traditional gender roles where the women are expected to do domestic tasks and excluded from some of the gang activities because of their gender.

The period of Reconstruction following the American Civil War, and its legacy, have been the subjects of long debate among historians. Scholars, though, have yet to fully explore important connections between American Reconstruction, the New South that followed, and the period of U.S. imperialism in Central America in the late nineteenth century. The storied career of Major Edward Austin Burke—a Kentucky-born Louisiana Democrat who went on to become a proponent of expansionism and imperialism in Honduras—illuminates the transnational implications of Reconstruction and its aftermath. Through careful examination of personal papers, news accounts, promotional materials, Congressional testimonies and other government records, this thesis finds the roots of Burke’s involvement in Central America in postbellum New Orleans. It demonstrates the importance of participation in Reconstruction and New South politics to the long political career of one of the most prominent U.S. imperialists in Central America in the late nineteenth century.

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Abstract This thesis explores the influence of masculinity in twentieth century American foreign policy through examining the career of Guy “Machine Gun” Molony. Molony was an Irish American mercenary from New Orleans, whose career saw the transformation of Honduras from a banana republic to a recipient of dollar diplomacy. Unlike the majority of mercenaries who did not use their experience to build successful careers, Molony made a name for himself in American newspapers, becoming respected and even feared by policemen and politicians. His life tells a fascinating tale of the individual male in American foreign policy, where rebellious youth used war and instability to create heroic images of themselves. This thesis argues that the U.S. State Department borrowed from the independent mercenary model, building on a foundation laid out by men like Molony to implement dollar diplomacy. Guy Molony’s career is a telling example of how perceived ideas of manhood carried imperial intentions during the era of manifest destiny and the Monroe Doctrine. Although scholars tend to focus on Western expansion when examining the ideology of manifest destiny, this thesis explores how mercenaries like Guy Molony, followed by the U.S. State Department, continued to look southward to Central America as a means for American expansion.

Background : Atrazine is an agricultural herbicide used extensively in corn production worldwide. Atrazine is an endocrine disruptor and has been linked to many other deleterious health outcomes. Exposure assessment studies have been carried out in Iowa among farm and non-farm populations. However, commercial pesticide applicators have been left out of those studies. Atrazine is also used in developing countries in grain production. In developing countries there is great concern about acute pesticide poisonings, but chronic exposure to less acutely toxic pesticides has not been studied extensively. This study assessed the in-home contamination of atrazine among commercial pesticide applicators in Iowa and then quantitatively analyzed these results with results from similar studies. Occupational inhalation exposure to atrazine was also assessed in Honduras. Methods : Dust samples were taken from 29 commercial pesticide applicator households in four different locations. This sampling was done once during the atrazine application season and again six months later during winter months to assess atrazine persistence. Occupational and household characteristics were analyzed for associations with atrazine dust levels. Data from two previous studies that analyzed farm and non-farm household dust samples for atrazine were combined with data from the commercial applicator's homes. This new and larger dataset was analyzed to identify which population has the greatest risk for take-home atrazine exposure and what determinants were associated with in-home atrazine dust levels. Lastly, corn production practices in Honduras were evaluated and personal air samples were taken from pesticide applicators during atrazine application to assess inhalation exposure. Results : The first study found that atrazine levels persist into the winter months in the homes of commercial applicators. Atrazine handling (days, pounds, and acres sprayed) were all positively associated with in-home atrazine levels. Commercial applicators that change their shoes inside had higher atrazine levels. More frequent floor cleaning was associated with lower atrazine levels. The second study identified commercial applicators' homes as the most contaminated compared with farmers who apply atrazine to their own land, farmers who hire out atrazine application, and non-farm homes. Farmers that apply their own atrazine also had significantly higher atrazine levels in their homes. The association between atrazine handling and household atrazine levels was highly significant in this study (p < 0.001). In Honduras, atrazine is applied to corn fields with tractor/boom equipment and manual backpack sprayers. Despite applying about one-fifteenth the amount of atrazine, backpack sprayers are exposed to nearly equal amounts of atrazine via inhalation exposure and likely have greater exposure via the dermal route. Among backpack sprayers, which type of spray nozzle used is associated with inhalation exposure. Among tractor/boom applicators, tractor drivers have much lower inhalation exposure than workers who operate and observe the boom. Conclusions : The amount of atrazine handled is the most important determinant for predicting in-home atrazine levels in Iowa. Ubiquitous atrazine contamination and its distribution within homes and among household type provide strong evidence for the take-home pathway. While some improvements have been made in Honduras regarding pesticide application, poor farm workers and small farmers still use antiquated pesticide application techniques which leads to a higher risk of inhalation and dermal exposure.

The first study on Ateles geoffroyi in Honduras, this research focused on the population of spider monkeys in Parque Nacional Pico Bonito, Atlántida, Honduras. Subgroup size of spider monkeys in Parque Nacional Pico Bonito ranged from 1-23 (n=55) individuals, with a mean subgroup size of 6.93 ± 4.53 individuals, which was larger than nearly all subgroup sizes reported in Central and South America. Mean subgroup composition consisted of 1.65 ± 1.16 adult males, 2.67 ± 1.69 adult females and 1.75 ± 1.92 juveniles. Sex ratio of adult males to adult females was 1:1.62, which was consistent with most Central and South American Ateles studies in the literature.¶ Of a possible 23 identified food tree species from 15 families, and 7 unidentified tree and vine species, spider monkeys were confirmed to consume fruits, leaves and/or seeds from 8 identified tree species, 1 unidentified tree species, and 1 unidentified vine species. Several of the confirmed genera consumed by Ateles in Parque Nacional Pico Bonito were consistent with other studies conducted in Central and South America, including Dialium, Ficus, and Coccoloba.¶ Combining pelage analysis and discriminant analysis of cranial and dental measurements from 140 skins and 253 adult crania, the taxonomy of the Central American Ateles geoffroyi was revised to recognize the taxa Ateles geoffroyi yucatanensis, A. g. vellerosus, A. g. pan, A. g. geoffroyi, A. g. frontatus, A. g. ornatus, and A. g. grisescens, with the recognition of a potential new taxon from northern Honduras, resulting in a revised distribution of Ateles geoffroyi, based on the pelage and cranial analyses.

<p>&nbsp / <font face="Times New Roman" size="3"><font face="Times New Roman" size="3">possessing more information on which projects could be carried out in the hometowns, and which finally executes these projects. The study concludes that the existence of HTAs in the USA is explained by the socially enforced institution of the </font></font><i><font face="Times New Roman" size="3"><font face="Times New Roman" size="3">hijos del pueblo </font></font><font face="Times New Roman" size="3"><font face="Times New Roman" size="3">(sons of the town) having a duty to help their hometowns, as well as the private benefits of preserving Gar&iacute / funa traditions and the possibility of helping repatriate dead immigrants. Fulfilling this duty (and the consequent prestige attained) provides the incentives to send CRs home. In the cases studied, CRs were used to partly finance potable water projects, electricity projects, road paving, a community centre and the construction of a Catholic temple. In most of the cases HTAs worked with a local development organisation, known as </font></font><i><font face="Times New Roman" size="3"><font face="Times New Roman" size="3">Patronato</font></font><font face="Times New Roman" size="3"><font face="Times New Roman" size="3">, which formed specific committees for executing projects, for example the water and the electricity committees. For the construction of the temple, a religious organisation known as </font></font><i><font face="Times New Roman" size="3"><font face="Times New Roman" size="3">Pastoral </font></font><font face="Times New Roman" size="3"><font face="Times New Roman" size="3">was the local partner.</font></font></i></i></i></p> <p align="left">The term Collective Remittances (CRs) refers to the money sent by migrant associations, known as Hometown Associations (HTAs), to Community-Based Organisations (CBOs) in their hometowns for financing public works projects. Few cases of CR are known in Honduras. The only ones reported are among the Gar&iacute / funaethnic group living on the Caribbean Coast, and with a large migrant community in New York City (NYC). This mini-master&rsquo / s thesis is the first study written on CRs in Honduras. It studies CR experiences in four Gar&iacute / funa hometowns and their corresponding HTAs in NYC. It answers three questions: How do CRs work in each case? What are the determinants for HTAs to provide CRs to the hometowns? And what are the determinants for local CBOs in the hometowns to use the CRs effectively to provide public goods in the hometowns? CR is conceptualised as a <font face="Times New Roman" size="3">that chooses which local group and project to finance, and the local CBO, which is the </font><i><font face="Times New Roman" size="3"><font face="Times New Roman" size="3">agent </font></font></i></p>

Water governance exerts an impact on the socio-politic life of Honduras. For instance, the new legal framework changes institutions. New water organisations are created, and new processes and proceedings are proposed. These times when strategies from developed countries are transferred to developing countries, such as water governance, the need for an evaluation is desirable to disentangle the problems and to look forward at opportunities and find alternatives. The journey from government to governance describes the change from the traditional government behaviour towards new governance. In countries like Honduras, as in developing countries, this change describes a complex process in which the imported strategies are conflicting with existing established socio-political patterns. The new water management approach as applied in Honduras needs to take into account the socio-political reality and the availability of resources, if the water governance process would gain relevance. Honduras is a relatively new democratic country after many years of military regime, thus the government needs also to be part of the governance process. This doctoral thesis studies and highlights the characteristics of the traditional Honduran government approach, and the effects that the new governance approach has posed in the country. The difficulties emerging from this shift of approaches are discussed, and explored. The research finds support in the exploration of Honduran political and institutional sociological history to elaborate the causes and motives for current governmental attitudes. The research relates to concepts of development strategies, institutionalism and regulation modes. This thesis argues that governance has achieved a pseudo empirical implementation in Honduras, and that new mechanisms need to be devised to balance the suggested governance mode using new notions of regulatory space, and the theoretical meta-governance approach, in order to balance between the imported measures and the reality. New governance theoretical notions are exposed to encourage and explore new alternatives for the water governance in the Honduras context. It is necessary to realise that institutional changes occur in a long-term adjustment period in order to build trust among actors and water authorities. Moreover, this thesis deems it pertinent that the government as the voter-elected entity should take the decisive lead of the governance approach. / QC 20100903