This study addressed the numerical modelling of flow and diffusion in packed beds of mono-sized spheres. Comprehensive research was conducted in order to implement various numerical approaches in explicit1 and implicit2 simulations of flow through packed beds of uniform spheres. It was noted from literature that the characterization of a packed bed using porosity as the only geometrical parameter is inadequate (Van Antwerpen, 2009) and is still under much deliberation due to the lack of understanding of different flow phenomena through packed beds. Explicit simulations are not only able to give insight into this lack of understanding in fluid mechanics, but can also be used to develop different flow correlations that can be implemented in implicit type simulations. The investigation into the modelling approach using STAR-CCM+®, presented a sound modelling methodology, capable of producing accurate numerical results. A new contact treatment was developed in this study that is able to model all the aspects of the contact geometry without compromising the computational resources. This study also showed, for the first time, that the LES (large eddy simulation) turbulence model was the only model capable of accurately predicting the pressure drop for low Reynolds numbers in the transition regime. The adopted modelling approach was partly validated in an extensive mesh independency test that showed an excellent agreement between the simulation and the KTA (1981) and Eisfeld and Schnitzlein (2001) correlations' predicted pressure drop values, deviating by between 0.54% and 3.45% respectively. This study also showed that explicit simulations are able to accurately model enhanced diffusion due to turbulent mixing, through packed beds. In the tortuosity study it was found that the tortuosity calculations were independent of the Reynolds number, and that the newly developed tortuosity tests were in good agreement with techniques used by Kim en Chen (2006), deviating by between 2.65% and 0.64%. The results from the TMD (thermal mixing degree) tests showed that there appears to be no explicit link between the porosity and mixing abilities of the packed beds tested, but this could be attributed to relatively small bed sizes used and the positioning and size of the warm inlet. A multi-velocity test showed that the TMD criterion is also independent of the Reynolds number. It was concluded that the results from the TMD tests indicated that more elaborate packed beds were needed to derive applicable conclusions from these type of mixing tests. The explicit BETS (braiding effect test section) simulation results confirmed the seemingly irregular temperature trends that were observed in the experimental data, deviating by between 5.44% and 2.29%. From the detail computational fluid dynamics (CFD) results it was possible to attribute these irregularities to the positioning of the thermocouples in high temperature gradient areas. The validation results obtained in the effective thermal conductivity study were in good agreement with the results of Kgame (2011) when the same fitting techniques were used, deviating by 5.1%. The results also showed that this fitting technique is highly sensitive for values of the square of the Pearson product moment correlation coefficient (RSQ) parameter and that the exclusion of the symmetry planes improved the RSQ results. It was concluded that the introduction of the new combined coefficient (CC) parameter is more suited for this type of fitting technique than using only the RSQ parameter. / Thesis (M.Ing. (Mechanical Engineering))--North-West University, Potchefstroom Campus, 2012

Neuraminidase (NA) is one of two major antigens on the surface of influenza A viruses. It is comprised of a single N-terminal transmembrane domain (TMD), a stalk domain, and a C-terminal enzymatic head domain that cleaves sialic acid, most notably to release new particles from the host cell surface. NA is only enzymatically active as a homo-tetramer. However, it is not known which properties facilitate the oligomerization of NA during assembly. Our results show that, apart from anchoring the protein to the membrane, the NA TMD also contributes to the assembly process by keeping the stalk in a tetrameric conformation. The ability of the TMD to oligomerize is shown to be dependent on its amphiphilic characteristics that was largely conserved across the nine NA subtypes (N1-N9). Over time the NA TMDs in human H1N1 viruses were found to have become more amphiphilic, which correlated with stronger oligomerization. An old H1N1 virus with a more recent N1 TMD had impaired growth, but readily acquired compensatory mutations in the TMD to restore growth, by reverting the TMD oligomerization strength back to that of the old TMD, demonstrating a biological role of the TMD in folding and assembly. NA and the other viral proteins are spatially and temporally coordinated to achieve optimal viral production. By using a co-transfection analysis, the high AU-content in the NA and HA ER-targeting sequence coding regions (for NA TMD as well as the HA signal sequence) were found to inhibit their expression. The inhibition was alleviated by the early expressed influenza RNA-binding protein NS1, which promoted translation and showed enriched foci at the endoplasmic reticulum (ER). NS1, which expresses early during infection, is therefore likely the regulator of NA and HA to prevent premature expression. These results show that the NA TMD is under substantial selection pressure at both the nucleotide and amino acid level to accommodate its roles in ER-targeting, protein folding, and post-transcriptional regulation. / <p>At the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 4: Accepted.</p>

Since the discovery of graphene, substantial effort has been put toward the synthesis and production of 2D materials. Developing scalable methods for the production of high-quality exfoliated nanosheets has proved a significant challenge. To date, the most promising scalable method for achieving these materials is through the liquid-based exfoliation (LBE) of nanosheetsin solvents. Thin films of nanosheets in dispersion can be modified with additives to produce 2D inks for printed electronics using inkjet printing. This is the most promising method for the deposition of such materials onto any substrate on an industrial production level. Although well-developed metallic and organic printed electronic inks exist on the market, there is still a need to improve or develop new inks based on semiconductor materials such as transition metal dichalcogenides (TMDs) that are stable, have good jetting conditions and deliver good printing quality.The inertness and mechanical properties of layered materials such as molybdenum disulfide (MoS2) make them ideally suited for printed electronics and solution processing. In addition,the high electron mobility of the layered semiconductors, make them a candidate to become a high-performance semiconductor material in printed electronics. Together, these features make MoS2 a simple and robust material with good semiconducting properties that is also suitable for solution coating and printing. It is also environmentally safe.The method described in this thesis could be easily employed to exfoliate many types of 2D materials in liquids. It consists of two exfoliation steps, one based on mechanical exfoliation of the bulk powder utilizing sand paper, and the other inthe liquid dispersion, using probe sonication to liquid-exfoliate the nanosheets. The dispersions, which were prepared in surfactant solution, were decanted, and the supernatant was collected and used for printing tests performed with a Dimatix inkjetprinter. The printing test shows that it is possible to use the MoS2 dispersion as a printed electronics inkjet ink and that optimization for specific printer and substrate combinations should be performed. There should also be advances in ink development, which would improve the drop formation and break-off at the inkjet printing nozzles, the ink jetting and, consequently, the printing quality. / Sedan upptäckten av grafen har mycket arbete lagts på framställning och produktion av 2D-material. En viktig uppgift har varit att ta fram skalbara metoder för produktion av högkvalitativa  nanosheets via exfoliering. Den mest lovande skalbarametoden hittills har varit vätskebaserad exfoliering av nanosheets i lösningsmedel. Tunna filmer av nanosheets i dispersion kan anpassas med hjälp av tillsatser och användas för tillverkning av halvledare strukturer med inkjet-skrivare, vilket är den mest lovande metoden för på en industriell produktions nivå beläggaden typen av material på substrat. Även om det finns välutvecklade metalliska och organiskabläck för tryckt elektronik, så finns det fortfarande ett behov av att förbättra eller utveckla nya bläck baserade på halvledarmaterial som t.ex. TMD, som är stabila, har goda bestryknings  egenskaper och ger bra tryckkvalitet. Den inerta naturen tillsammans med de mekaniska egenskaperna som finns hosskiktade material, som t.ex. molybdendisulfid (MoS2), gör demlämpliga för flexibel elektronik och bearbetning i lösning. Dessutom gör den höga elektronmobiliteten i dessa 2D-halvledaredem till en stark kandidat som halvledarmaterial inom trycktelektronik. Det betyder att MoS2 är ett enkelt och robust material med goda halvledaregenskaper som är lämpligt för bestrykning från lösning och tryck, och är miljömässigt säker.Den metod som beskrivs här kan med fördel användas föratt exfoliera alla typer av 2D-material i lösning. Exfolieringensker i två steg; först mekanisk exfoliering av torr bulk med sandpapper, därefter används ultraljudsbehandling i lösning för att exfoliera nanosheets. De dispersioner som framställts i lösning med surfaktanter dekanterades och det övre skiktetanvändes i trycktester med en Dimatix inkjet-skrivare.Tryckprovet visar att det är möjligt att använda MoS2 -dispersion som ett inkjet-bläck och att optimering för särskildaskrivar- och substratkombinationer borde göras, såsom förbättringav bläcksammansättningen med avseende på droppbildning och break-off vid skrivarmunstycket, vilket i sin tur skulleförbättra tryckkvaliteten. / KM2 / Paper Solar Cells

Dentre os fatores etiológicos das Disfunções Temporomandibulares (DTMs) merecem destaque os hábitos parafuncionais, que muitas vezes são responsáveis pela manutenção da dor, perda de estrutura dental, como as facetas de desgaste, abfrações e por alterações na mucosa jugal e língua. Uma das terapêuticas mais utilizadas para o tratamento da DTM, está relacionada ao uso da placa estabilizadora oclusal (PEO). Apesar de seu uso ser estudado em vários artigos, não são encontrados relatos sobre as marcas encontradas nesse dispositivo devido ao atrito sofrido pelos dentes tampouco quais são os parâmetros e variáveis que poderiam estar relacionados à estas marcas. O presente estudo procurou reproduzir as marcas observadas na PEO, em 36 corpos de prova de resina acrílica ativada quimicamente, em ambiente controlado e analisou os parâmetros e variáveis para avaliação entre marcas fracas e fortes. Para reprodução das marcas nas amostras, foram utilizadas esferas de aço com diâmetros de 3 mm, 4 mm e 5 mm. Para cada diâmetro de esfera foram utilizados os seguintes parâmetros: carga de 2 kgf e 65 kgf e ciclos de repetições de 600 e 1200 vezes. As amostras foram randomizadas com números aleatórios e estabelecido padrão entre marcas fracas e fortes para cada diâmetro de esfera, com apenas uma amostra de cada triplicata. Na sequência, 3 observadores cegos fizeram suas classificações para correlação do padrão. Para correlação do padrão vs. observadores e observadores entre observadores, foi realizado o teste kappa de Fleiss. Foram obtidos níveis excelentes em todos os testes, quando não havia mistura de diâmetro de esfera, e nível razoável quando os observadores avaliaram as amostras com os diâmetros de esferas misturados. Relacionado aos resultados, as variáveis consideradas foram, diâmetro da calota impressa e profundidade calculada da calota com a fórmula da dureza Brinell. As variáveis, dureza e diâmetro de calota impressa, não demostraram robustez para estabelecer critério na avalição entre marca forte e fraca. Já a variável \"profundidade calculada de calota\" demostrou que ao passo que aumentava a profundidade calculada da calota, a marca tinha maior tendência a ser classificada como forte. Desta forma, pode-se concluir que o parâmetro carga foi o fator de maior relevância na classificação entre as marcas fracas e fortes. A variável profundidade calculada da calota mostrou relevância na classificação das marcas fortes e fracas e os diâmetros de esferas diferentes, com mesma carga e quantidade de ciclos geraram marcas diferentes. / Among the etiological factors of TMDs is the parafunctional habits, which are often responsible for the loss of dental structure, such as the wear facets and abfraction and changes in the oral mucosa, such as cheeks and tongue. One of the most used therapies for the treatment of TMD is related to the use of the occlusal splint (OS). Although its use is reported in several articles, no reports are found on the marks found in this device due to the friction suffered by the teeth, nor are the parameters and variables that are related to these marks. The present study reproduced the observed marks in the OS in 36 chemically activated acrylic resin samples in a controlled environment and analyzed the parameters and variables for evaluation between weak and strong marks. For the reproduction of the marks in the samples, stainless steel sphere with different diameters of 3 mm, 4 mm and 5 mm were used. For each sphere diameter the following parameters were used: load of 2 kgf and 65 kgf and repetition cycles of 600 and 1200 times. Samples were randomized with random numbers and established pattern between weak and strong marks for each sphere diameter, with only one sample from each triplicate. Subsequently, 3 observers made their classifications for pattern correlation. For correlation of the Standard vs. Observers and Between Observers, the Fleiss kappa test was performed. Excellent levels were obtained in all tests, when there was no sphere diameter crossing, and fair level when observers evaluated the samples with the sphere diameters crossed. Regarding the results, the variables considered were Brinell hardness, diameter of the printed cap and depth of the cap. The variables, hardness and diameter of printed cap, did not demonstrate the robustness to establish standard in the evaluation between weak and Strong marks. The variable depth of printed cap proves that while the depth of the printed cap increased, the mark had a more tendency to be classified as strong. In this way, we can conclude that the load parameter is the factor of greater relevance in the classification between the weak and strong marks. The variable depth of the printed cap demonstrated relevance in the classification of the weak and strong marks, and finally the diameters of different spheres with the same load and number of cycles created different marks.

Atualmente as estruturas estão sendo avaliadas para um maior número de ações em relação há algumas décadas. Esta melhoria ao longo da fase de concepção é dada devido ao fato de que está se tornando mais competitivo o fornecimento de estruturas leves e esbeltas, sendo solicitados, cada vez mais, projetos com menor custo de implantação. Devido a isto, é necessário avaliar as estruturas não apenas sujeitas a cargas estáticas, mas também a carregamentos dinâmicos. As ações dinâmicas que atuam sobre uma estrutura podem ser muito mais prejudiciais do que as estáticas quando não são bem consideradas e dimensionadas. Ações dinâmicas podem ser provenientes de tremores de terra, vento, equipamentos em funcionamento, deslocamento de pessoas, veículos em movimento, motores desbalanceados, entre outras fontes, o que pode causar vibrações na estrutura, podendo levar a mesma ao colapso. A fim de controlar e reduzir as amplitudes de vibração, entre outras alternativas é possível a instalação de amortecedores de massa sintonizado (AMS), que é um dispositivo de controle passivo. O AMS tem várias vantagens, tais como a grande capacidade de reduzir a amplitude de vibração, fácil instalação, baixa manutenção, baixo custo, entre outras. Para se obter a melhor relação custo-benefício, ou seja, a maior redução de amplitude aliada a um menor número de amortecedores ou a uma menor massa, a otimização dos parâmetros do AMS tornase fundamental. Neste contexto, este trabalho visa, através de simulação numérica, propor um método para otimizar parâmetros de AMSs quando estes devem ser instalados em edifícios submetidos à excitação sísmica. Inicialmente é considerado apenas um único AMS instalado no topo do edifício e em seguida também são feitas simulações com múltiplos AMSs (MAMS), e por fim são descartados os AMSs desnecessários, obtendo assim a melhor resposta da estrutura. Para tanto, uma rotina computacional é desenvolvida em MatLab usando o método de integração direta das equações de movimento de Newmark para determinar a resposta dinâmica da estrutura. Para fins de análise podem ser considerados tanto sismos reais quanto artificiais. Os acelerogramas artificias são gerados a partir do espectro proposto por Kanai e Tajimi. Primeiramente, a estrutura é analisada somente com o seu amortecimento próprio para fins comparativos e de referência. Em seguida, a otimização do ou dos AMSs é feita, na qual a função objetivo é minimizar o deslocamento máximo no topo do edifício, e as variáveis de projeto, são a relação de massas (AMS - Estrutura), rigidez e amortecimento do ou dos AMSs. Para a otimização são utilizados os algoritmos Firefly Algotithm e Backtracking Search Optimization Algorithm. De acordo com as configurações do AMS, após a otimização dos seus parâmetros são determinadas as novas respostas dinâmicas da estrutura. Finalmente, pode-se observar que o método proposto foi capaz de otimizar os parâmetros do ou dos AMSs, reduzindo consideravelmente as respostas da estrutura após a instalação do mesmo, minimizando o risco de dano e colapso do edifício. Desta forma, este trabalho mostra que é possível projetar AMS e MAMS de forma econômica e eficaz. / Currently, structures are being evaluated for a greater number of actions when compared to a few decades ago. This improvement in designing stage is happening because projects providing lightweight and slender structures, with lower implantation costs, are being more requested. Thus, evaluating structures not only subjected to static loads, but also to dynamic loads has become necessary. Dynamic loads acting on a structure are more damaging than static loads, if they are not well considered and dimensioned. Dynamic loads could occur from earthquakes, wind, equipment, movement of people or vehicles, among other sources, which cause vibrations in structures and may lead to a collapse. Tuned mass damper (TMD), a passive control device, can be installed as an alternative to reduce vibration amplitudes. TMD has several advantages, such as large capacity to reduce amplitude of vibration, easy installation, low maintenance, low cost, among others. Optimizing TMD parameters is fundamental for obtaining best cost-benefit relation, i.e., greater amplitude reduction along with lower number of dampers or lower mass. In this context, this study aims at proposing, through numerical simulation, a method for optimizing TMD parameters when installing them on buildings under seismic excitation. Initially, a single-TMD case is considered, then simulations with multiple-TMDs (MTMDs) are run; lastly, unnecessary TMDs are discarded, obtaining the best structural response. For this purpose, a computational routine is developed on MatLab using Newmark direct integration method for equations of motion to determine the dynamic structural response. Both real and artificial earthquakes are considered for purposes of analysis. Artificial accelerograms are generated from proposed Kanai-Tajimi spectrum. First, structure is analyzed only with its own damping for comparison and reference. Second, a single or multiple-TMD optimization is carried out, in which the objective function is to minimize the maximum displacement at the top of the building, and the design variables are modal mass ratio (Structure-TMD), stiffness and damping of a single or multiple-TMD. Firefly and Backtracking Optimization algorithms are used for optimization. According to TMD settings, new dynamic structural responses are determined after optimizing parameters. Finally, the proposed method could optimize parameters of single or multiple-TMDs, considerably reducing structural responses after their installation, minimizing the risk of damage and building collapse. Thus, this study shows the possibility of designing TMDs or MTMDs both economically and effectively.

Introduction: Chronic orofacial pain (COFP) is distressing and disabling to sufferers and can be costly to patients, health services and society. Frequently, no underlying medical pathology can be found to account for the condition. Despite this, patients are treated according to a biomedical model, often by mechanistic and invasive procedures, which tend to be unsuccessful and not evidence based. Evidence suggests that cognitive behavioural therapy (CBT) based management may produce improved outcomes for patients. However, published studies can tell us little about which intervention components are effective, or recommend an optimum way for these components to be applied. Aim: To develop an evidence based intervention for the management of COFP that is feasible and acceptable to patients and practitioners. Method: The Medical Research Council’s guidelines for developing complex interventions were used as a framework for the research. Evidence from multiple sources was synthesised to produce the draft components of an intervention to manage COFP. An exploratory trial investigated preliminary outcomes, acceptability, feasibility and explored parameters for a full scale randomised control trial. Results: The intervention was acceptable to participants and could be feasibly implemented. No conclusions could be drawn relating to the effectiveness of the intervention. Participants were not affected at baseline for a number of outcomes, which implies that cut off points should be introduced into the inclusion and exclusion criteria of any future studies. Conclusion: The study produced an intervention which is acceptable and feasible to participants, however it is not known if it is effective. A number of recommendations are made for progression to a larger, definitive trial.

Both spinal pain and temporomandibular disorders (TMD) commonly occur in the general population. Previous studies demonstrate neurophysiologic and biomechanical couplings between the trigeminal and cervical regions. This investigation tested the null hypothesis of no relationship between spinal pain (neck, shoulder and/or low back) and TMD, by using questionnaires and clinical examinations of the jaw function. In an age- and sex-matched case-control study, the specific aim was to compare the prevalence of signs and symptoms of TMD among cases with long-term spinal pain and controls without spinal pain. The results showed that subjects with spinal pain had signs and symptoms of TMD significantly more often than did controls. The associations remained after excluding all participants with jaw pain. Furthermore, the comorbidity pattern was similar, regardless of location of spinal pain. In a cross-sectional study, the specific aim was to test whether there is a reciprocal cross-sectional dose-response-like relationship between spinal pain and TMD. Two different designs were used, one with frequency/severity of spinal pain as independent variable, and the other, with frequency/severity of TMD symptoms as independent variable. The analysis showed increasing odds for presence of TMD symptoms with increasing frequency/severity of spinal pain, and increasing odds for presence of spinal pain with increasing frequency/severity of TMD symptoms. In a case-control study within a 2-year prospective cohort, the specific aim was to test whether there is a reciprocal temporal relationship between signs and symptoms in trigeminally, and symptoms in spinally, innervated areas. Incidence of symptoms in these areas was analyzed in relation to presence of spinal pain, headaches, and signs and symptoms of TMD at baseline. The main findings were that presence of signs of TMD at baseline increased the onset of spinal pain and symptoms in the trigeminal area, and that spinal pain increased the onset of symptoms in the trigeminal area. An augmentation effect between the significant baseline variables was observed for the incidence of headaches and jaw pain. In conclusion, the investigation demonstrated a cross-sectional and temporal relationship between spinal pain and TMD; thus, the null hypothesis was rejected. The results indicate common pathophysiological mechanisms in the development of spinal pain and TMD. The comorbidity and reciprocal influence that were found call for an integrated and multidimensional approach in the management of individuals with long-term spinal pain and TMD.

Auxiliary absorbers provide an effective means to attenuate the vibrations of a structural or mechanical system (the "primary structure"). The simplest auxiliary absorber, a tuned mass damper (TMD), provides reliable narrow-band attenuation but is not robust to the effects of detuning. Strongly nonlinear tuned mass dampers (NTMDs) are capable of wide-band, irreversible energy transfer known as "energy pumping" but can also exhibit high amplitude solutions which significantly amplify the response of the primary structure. Semi-active tuned mass dampers (STMDs) incorporate an actuating element in order to achieve real-time tuning adjustment capability. This thesis presents a global dynamic analysis of the response of a primary structure with an NTMD and then explores the performance of a novel absorber configuration consisting of an NTMD and STMD attached to the primary structure in series. The global dynamic analysis is conducted using a new cell mapping method developed by the author and introduced within the thesis: the parallelized multi-degrees-of-freedom cell mapping (PMDCM) method. The benefits of the additional STMD component are explored for two distinct applications: (1) restoring the performance of a linear TMD which develops a weak nonlinearity due to operation outside of the intended range or other means, and (2) acting as a safety device to eliminate or minimize convergence to the detached high-amplitude response. In the weakly nonlinear case, the STMD is shown to reduce the effects of the nonlinearity and improve attenuation capability by constraining the motion of the NTMD. In the strongly nonlinear case, the STMD effectively eliminates the complex response behavior and high amplitude solutions which were present in the original system, resulting in a single low amplitude response. Experimental tests using an adjustable-length pendulum STMD verify the numerical results.

This study addressed the numerical modelling of flow and diffusion in packed beds of mono-sized spheres. Comprehensive research was conducted in order to implement various numerical approaches in explicit1 and implicit2 simulations of flow through packed beds of uniform spheres. It was noted from literature that the characterization of a packed bed using porosity as the only geometrical parameter is inadequate (Van Antwerpen, 2009) and is still under much deliberation due to the lack of understanding of different flow phenomena through packed beds. Explicit simulations are not only able to give insight into this lack of understanding in fluid mechanics, but can also be used to develop different flow correlations that can be implemented in implicit type simulations. The investigation into the modelling approach using STAR-CCM+®, presented a sound modelling methodology, capable of producing accurate numerical results. A new contact treatment was developed in this study that is able to model all the aspects of the contact geometry without compromising the computational resources. This study also showed, for the first time, that the LES (large eddy simulation) turbulence model was the only model capable of accurately predicting the pressure drop for low Reynolds numbers in the transition regime. The adopted modelling approach was partly validated in an extensive mesh independency test that showed an excellent agreement between the simulation and the KTA (1981) and Eisfeld and Schnitzlein (2001) correlations' predicted pressure drop values, deviating by between 0.54% and 3.45% respectively. This study also showed that explicit simulations are able to accurately model enhanced diffusion due to turbulent mixing, through packed beds. In the tortuosity study it was found that the tortuosity calculations were independent of the Reynolds number, and that the newly developed tortuosity tests were in good agreement with techniques used by Kim en Chen (2006), deviating by between 2.65% and 0.64%. The results from the TMD (thermal mixing degree) tests showed that there appears to be no explicit link between the porosity and mixing abilities of the packed beds tested, but this could be attributed to relatively small bed sizes used and the positioning and size of the warm inlet. A multi-velocity test showed that the TMD criterion is also independent of the Reynolds number. It was concluded that the results from the TMD tests indicated that more elaborate packed beds were needed to derive applicable conclusions from these type of mixing tests. The explicit BETS (braiding effect test section) simulation results confirmed the seemingly irregular temperature trends that were observed in the experimental data, deviating by between 5.44% and 2.29%. From the detail computational fluid dynamics (CFD) results it was possible to attribute these irregularities to the positioning of the thermocouples in high temperature gradient areas. The validation results obtained in the effective thermal conductivity study were in good agreement with the results of Kgame (2011) when the same fitting techniques were used, deviating by 5.1%. The results also showed that this fitting technique is highly sensitive for values of the square of the Pearson product moment correlation coefficient (RSQ) parameter and that the exclusion of the symmetry planes improved the RSQ results. It was concluded that the introduction of the new combined coefficient (CC) parameter is more suited for this type of fitting technique than using only the RSQ parameter. / Thesis (M.Ing. (Mechanical Engineering))--North-West University, Potchefstroom Campus, 2012

Abstract Epidemiological studies on malocclusions in Finland have so far concentrated on children and adolescents. Regarding the Finnish adult population, there is scarce epidemiological knowledge available on malocclusions even though the number of adults seeking orthodontic treatment has increased during the last decades. Occlusion is an important factor in the function of the masticatory system, and its role in the aetiology of temporomandibular disorders (TMD) is one of the most disputed topics in dentistry. Malocclusions can affect the characteristics of the facial soft tissue profile. The aim of the study was to investigate the prevalence of malocclusions and the role of occlusion in TMD as well as the association of facial characteristics with malocclusions and facial aesthetics. The study population consisted of subjects from the Northern Finland Birth Cohort 1966 (NFBC1966). Data were collected using questionnaires, standardized clinical examination and facial photos. The profile photographs were analysed using linear and angular soft tissue cephalometric measurements. The most common malocclusion in the NFBC1966 subjects was lateral crossbite. This study showed a significant association between asymmetric malocclusions and TMD. TMD signs associated significantly with lateral crossbite, scissors bite, negative overjet, and the length and lateral deviation in slide between retruded contact position and intercuspal position (RCP-ICP). Soft tissue profile characteristics were highly correlated with negative overjet. The ANB-angle was significantly associated with the perception of facial attractiveness. In conclusion, malocclusions were associated with signs and symptoms of TMD in the Finnish adult population. Overjet appeared to affect the facial profile more than overbite. Facial convexity seemed to be a more important determinant of facial aesthetics for orthodontists than for dentists and laypersons. / Tiivistelmä Suomalaiset epidemiologiset tutkimukset purennan poikkeamista ovat tähän asti keskittyneet tarkastelemaan lapsia ja nuoria. Tarkkaa epidemiologista tietoa suomalaisen aikuisväestön purennan poikkeamista on tällä hetkellä saatavilla vain niukasti, vaikka oikomishoitoon hakeutuvien aikuispotilaiden määrä on Suomessa viime vuosina lisääntynyt. Purennalla on tärkeä merkitys purentaelimistön toiminnassa ja sen rooli purentaelimistön toimintahäiriöiden (TMD) etiologiassa on yksi kiistanalaisimpia aiheita hammaslääketieteessä. Purennan poikkeamat voivat vaikuttaa myös kasvojen pehmytkudosprofiilin piirteisiin. Tutkimuksen tarkoituksena oli selvittää purennan poikkeamien esiintyvyyttä ja tutkia kasvojen piirteiden yhteyttä purennan poikkeamiin sekä kasvojen estetiikkaan. Lisäksi tutkittiin purennan poikkeamien yhteyttä TMD:hen. Tutkimusjoukko koostui Pohjois-Suomen syntymäkohortti 1966 -tutkimukseen osallistuneista. Tutkimuksen aineisto kerättiin kyselomakkeiden, standardoidun kliinisen tutkimuksen ja kasvovalokuvien avulla. Profiilivalokuvien analysointi perustui pehmytkudoksen kefalometrisiin lineaari- ja kulmamittauksiin. Tässä tutkimuksessa yleisin purennan poikkeama oli sivualueen ristipurenta. Asymmetriset purennan poikkeamat olivat merkittävästi yhteydessä TMD:hen; erityisesti sivualueen ristipurenta, saksipurenta, negatiivinen horisontaalinen ylipurenta sekä nivelaseman ja keskipurennan (RCP-ICP) välisen liu’un pituus ja sivuttainen deviaatio. Negatiivisen horisontaalisen ylipurennan todettiin vaikuttavan voimakkaasti kasvojen profiiliin. ANB-kulma oli merkitsevästi yhteydessä kasvojen arvioituun viehättävyyteen. Purennan poikkeamilla näyttää olevan yhteys TMD:n oireisiin ja kliinisiin löydöksiin suomalaisessa aikuisväestössä. Horisontaalinen ylipurenta näyttää vaikuttavan kasvojen profiiliin enemmän kuin vertikaalinen ylipurenta. Kasvojen kuperuus painottuu enemmän oikomishoidon erikoishammaslääkärien näkemyksessä kasvojen estetiikasta hammaslääkäreihin ja maallikoihin verrattuna.