Orientador: Florencia Cecilia Menegalli / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos / Made available in DSpace on 2018-08-24T19:01:31Z (GMT). No. of bitstreams: 1 Sartori_Tanara_M.pdf: 26131816 bytes, checksum: bc2fedf638aad16f64ae8424a5a52acb (MD5) Previous issue date: 2014 / Resumo: A microencapsulação de aditivos alimentícios é uma alternativa para que a sua liberação ocorra de forma controlada, entre outros benefícios, sendo o spray chilling uma técnica de microencapsulação interessante no que diz respeito a materiais de recheio hidrofílicos. A incorporação de aditivos microencapsulados em filmes de polissacarídeo surge como uma nova proposta, a fim de estabilizá-los e liberá-los em condições específicas para o alimento sobre o qual será aplicado. O objetivo do trabalho foi produzir micropartículas lipídicas contendo ácido ascórbico e incorporá-las em filme de amido de banana verde da variedade "Terra". As micropartículas foram produzidas com misturas dos ácidos graxos láurico e oleico em diferentes proporções, como material de parede. A proporção entre o material de parede e o material de recheio também variou. As micropartículas produzidas foram caracterizadas quanto à eficiência de encapsulação total e efetiva, distribuição de tamanho e perfil de liberação. As micropartículas incorporadas nos filmes foram escolhidas a partir da cinética de liberação (maior liberação, menor liberação e liberação intermediária). Os filmes foram produzidos pelo método de casting e caracterizados quanto à umidade, densidade, propriedades mecânicas, cor e opacidade, fração solúvel em água, permeabilidade ao vapor de água e propriedades antioxidantes. O efeito nas propriedades ópticas de maçãs revestidas com cobertura de filmes de amido de banana com micropartículas de ácido ascórbico, também foi avaliado. As características das micropartículas foram mais influenciadas pela proporção entre os ácidos graxos utilizados como material de parede, do que pela proporção entre material de parede e material de recheio. As micropartículas produzidas apresentaram altos valores de eficiência de microencapsulação total, sem diferença significativa entre os experimentos (p>0,05). Os valores de eficiência de encapsulação efetiva e os diâmetros médios das partículas foram diretamente proporcionais à quantidade de ácido oleico presente na mistura. A análise de liberação do recheio em água mostrou que as partículas com quantidade intermediária de ácido oleico no material de parede (20 %) proporcionaram melhor retenção do recheio que os demais ensaios, com liberação de apenas 37 ± 6 % ao final de 2 h. Os filmes aditivados com as micropartículas lipídicas apresentaram menor permeabilidade ao vapor de água, maior resistência à tração e menor alongamento na ruptura, quando comparados ao controle adicionado de ácido ascórbico não encapsulado. As micropartículas atuaram como agentes protetores da atividade antioxidante durante o processo de obtenção dos filmes. As coberturas contendo micropartículas retardaram o escurecimento enzimático das maçãs, mostrando a importância da proteção do ácido ascórbico pela microencapsulação / Abstract: Microencapsulation of food additives is an alternative to their controlled release, among other advantages. Spray chilling can be used when the additives are hydrophilic active ingredients The incorporation of microencapsulated additives in polysaccharide-based film arise as a new proposal in order to stabilize and release them in specific conditions for the food on which will be applied. The objective was to produce lipid microparticles containing ascorbic acid and incorporate them into film starch isolated from plantain bananas of the variety "Terra". The microparticles were produced using mixtures of lauric and oleic fatty acids in different proportions, as lipid carrier. The ratio between the lipid carrier and core material was also varied. The microparticles produced were characterized for total encapsulation efficiency and effective encapsulation efficiency, size distribution and release kinetic in water. The particles were chosen from the release profile for incorporation in the films (higher release, lower release and intermediate release). The films were produced by casting and characterized regarding moisture, density, mechanical properties, color and opacity, water solubility, permeability to water vapor and antioxidant properties. The effect on the optical properties of coated apples with banana starch coating containing microparticles of ascorbic acid was also evaluated. The characteristics of the microparticles were more influenced by the ratio of the fatty acids used as lipid carrier, than by the ratio between the lipid carrier and core material. The microparticles produced higher values of total microencapsulation efficiency without significant difference between experiments (p>0.05). The values of effective encapsulation efficiency and particle average diameters were directly proportional to the amount of oleic acid present in the mixture. The analysis of core release in water showed that the particles with intermediate amount of oleic acid in the lipid carrier (20 %) showed improved retention of the core than the other tests, releasing just 37 ± 6 % after 2 h. Films additivated with lipid microparticles showed lower water vapor permeability, higher tensile strength and lower elongation when compared to control added ascorbic acid unencapsulated. The microparticles acted as protective agents of the antioxidant activity of ascorbic acid during the process of production of films. Coatings containing microparticles retarded the enzymatic browning of apples, showing the importance of the protection of ascorbic acid by microencapsulation / Mestrado / Engenharia de Alimentos / Mestra em Engenharia de Alimentos

Orientadores: Giselle Maria Marchi, Carlos Alberto de Souza Costa / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-20T00:33:33Z (GMT). No. of bitstreams: 1 Lima_AdrianoFonsecade_D.pdf: 9531567 bytes, checksum: fc2513cfde23700314d21174d7e5694a (MD5) Previous issue date: 2012 / Resumo: Os objetivos do presente trabalho foram: a) avaliar os efeitos citotóxicos de aplicações sucessivas do agente clareador a base de peroxido de carbamida (PC) 10% sobre células odontoblásticas; b) avaliar a toxicidade "in vivo" do tratamento clareador em dentes de ratos Wistar; c) verificar se o ácido ascórbico (AA) e capaz de reduzir os efeitos tóxicos do tratamento clareador na polpa de ratos Wistar; d) verificar a eficácia da laserterapia em diferentes parâmetros de aplicação na modulação da resposta de células odontoblastóides frente a agressão causada pelos agentes clareadores. Para isso, no Capitulo 1, foi avaliado a toxicidade de aplicações sucessivas de agentes clareadores a base de PC10% e do peróxido de hidrogênio (PH) 35% sobre células odontoblástóides MDPC--23. As células foram expostas ao subprodutos clareadores por 1h durante 1 ou 5 dias, e então foi avaliado o metabolismo celular, atividade da fosfatase alcalina (ALP) e os danos a membrana celular. Pôde--?se observar que uma aplicação de PC10% não causou danos as células odontoblastóides, no entanto, as aplicações sucessivas causaram severa toxicidade à estas células. Tanto PC10% como PH35% causaram redução na atividade da ALP. No Capitulo 2, o objetivo foi avaliar se o AA seria capaz de reduzir a inflamação causada pelo agentes clareadores na polpa de ratos Wistar. Grupos foram estabelecidos com e sem administração de AA, e as soluções aplicadas 1h e 30min antes da realização do procedimento clareador. Foi observado necrose do tecido pulpar dos ratos apos 6h e 24h o clareamento. O AA não foi capaz de impedir a necrose do tecido, no entanto, melhor capacidade de reparação foi verificada na polpa dental destes animais. No capitulo 3 e 4, foram analisados se 1 ou 3 sessões de laserterapia poderiam modular a resposta celular apos exposição aos agentes clareadores. As células foram expostas ao agente clareador, e apos isso, foram realizadas as sessões de laserterapia (InGaAsP --? 780nm --? doses de 4, 10 e 15J/cm²) com intervalo de 24 h entre cada uma delas. O clareamento causou redução do metabolismo celular e da atividade da FA; a laserterapia não foi capaz de modular positivamente o metabolismo celular. No entanto, a dose de 4 J/cm² aumentou a atividade da FA nas células com e sem exposição ao agente clareador. A laserterapia não foi capaz de modular o metabolismo celular, nem a atividade de FA, expressão gênica de FA e colágeno--?I (COL--?I). No entanto, a laserterapia causou redução da expressão gênica de fibronectina (FN), nas células sem exposição ao agente clareador. Diante dos resultados obtidos, pode--?se concluir que aplicações consecutivas de PC10% podem causar extensos danos as células MDPC--?23; o PH 35% causou necrose da câmara pulpar de ratos Wistar, e que o AA não foi capaz de impedir os danos causados pelo tratamento clareador; uma aplicação do laser nas doses de energia avaliadas não foi capaz de modular a resposta celular apos o clareamento. Apenas três aplicações de laser na dose de 4 J/cm² foram capazes de aumentar a atividade da FA produzida pelas células odontoblastóides / Abstract: The objectives of the present study were: a) to evaluate the cytotoxic effects of consecutive applications of a bleaching agent based on 10% cabamide peroxide (CP) on odontoblastic cells; b) to evaluate the "in vivo" toxicity of the bleaching treatment on the pulp tissue of Wistar rats; c) to evaluate if the ascorbic acid (AA) is capable to reduce the toxic effects of the bleaching treatment to the dental pulp of the Wistar rats; d) to analyze the efficacy of the lasertherapy with different patterns on the odontoblastic cell response, in face of the deleterious effects caused by the bleaching agents. At the Chapter 1, the toxicity of consecutive applications of a 10%CP gel and 35% hydrogen peroxide (HP) on odontoblast--like cells was evaluated. The cells were exposed to the bleaching products for 1h during 1 or 5 days, and the cell metabolism, alkaline phosphatase (ALP) activity and cell membrane damage were evaluated. It could be observed that 1 application of 10%CP did not cause deleterious effect to the odontoblastic cells, however, consecutive applications caused severe toxicity to these cells. Both 10%CP and 35%HP promoted reduction on the ALP activity. At the Chapter 2, the aim was to evaluate if AA would be able to reduce the inflammation caused by the bleaching agents on the dental pulp of Wistar rats. Groups were formed with and without AA administration, and the solutions were applied 1h and 30min before the bleaching procedure. Pulp necrosis was observed 6h and 24h after bleaching. The AA was not capable to prevent the tissue necrosis, however, faster tissue repair was observed in the dental pulp of the animals treated with AA. At the Chapters 3 and 4, were evaluated if 3 or 1 lasertherapy sessions would modulate the cell response after exposition to bleaching agents. The cells were exposed to the bleaching agent, and the lasertherapy was performed after this (InGaAsP - 780nm-- doses 4, 10 e 15 J/cm²), with interval of 24h between each session. The bleaching reduced the cell metabolism and ALP activity, and the lasertherapy was not able to influence positively the cell metabolism. Nevertheless, the energy dose of 4 J/cm² increase the ALP activity on cell with or without exposition to bleaching agente when 3 session of laser were performed. The lasertherapy was not capable to modulate the cell metabolism, ALP activity and gene expression of ALP and colagen--I (COL--I). Nevertheless, one session of laser irradiation decreased the gene expression of fibronectin (FN), on the cells without exposition to bleaching agent. It can be concluded that consecutive applications of 10%CP can cause extensive damage to the MDPC--23 cells; HP35% caused pulp necrosis at the teeth of the Wistar rats, and AA was not capable to prevent the damages caused by the bleaching treatment; one application of the laser, in the energy doses evaluated, was not capable to modulate the cell response after bleaching. Three applications of laser with the energy dose of 4 J/cm² increased the ALP activity produced by the odontoblast--like cells / Doutorado / Dentística / Doutor em Clínica Odontológica

L’infection par le Virus de l’Hépatite C (VHC) est un problème majeur de santépublique touchant environ 170 millions de personnes dans le monde. A l’heure actuelle, il n’existe aucun vaccin pour lutter contre le VHC et les traitements curatifs disponibles sont chers, donnent lieu à des effets secondaires très sévères et ne sont efficaces que pour une partie des patients. Le développement de nouvelles stratégies antivirales représente donc un enjeu crucial dans la lutte contre le VHC. Dans le but de développer de nouvelles molécules bloquant différentes étapes du cycle viral, une meilleure compréhension de chacune des ces étapes est nécessaire. Au cours de mon travail de thèse, nous avons étudier le mécanisme d’entrée du VHC dans ses cellules cibles, les hépatocytes. Dans un premier temps nous avons caractérisé un inhibiteur naturel de l’entrée du VHC, appelé EWI-2wint. Ce travail a notamment permis de mettre en évidence l’importance de la dynamique membranaire de l’un des récepteurs du virus, la protéine CD81, dans ce processus. Dans un second axe, nous avons étudié l’effet de la monensine sur l’infection par le VHC. Nous avons ainsi montré que cet inhibiteur pharmacologique bloque une étape tardive du processus d’entrée du VHC.L’ensemble des données accumulées au cours de ma thèse permettent de mieux comprendre le mécanisme d’entrée du VHC et ouvrent la voie au développement de nouveaux outils thérapeutiques. / Hepatitis C, whose causal agent is called Hepatitis C Virus (HCV), is a global health burden with about 170 million people infected. Currently, no vaccine exists again HCV and treatments are effective for only a part of infected people. Therefore, new treatments are urgently needed, as well as a better understanding of the viral life cycle.To do so, we studied the entry process of HCV in its targets cells through the characterisation of HCV entry inhibitors. Firstly, we have shown that EWI-2wint, a natural inhibitor of HCV entry, blocks this process by changing the partitionning of CD81, one of the HCV receptors. In addition, we have studied the effect of monensin on HCV infection and found that this pharmacological inhibitor impairs a late step of HCV entry.Altogether, our results allow a better understading of the HCV entry process and open the way to the development of new therapeutic agents.

This paper is about the new programming language from Microsoft, C# (See Sharp) and the .NET Framework. They are still in beta-version, but will be released on the market in February 2002. This paper presents C#, not in detail but the characteristics that distinguish the language. A comparison is done with C++ and Java, since C# is most resembling to these languages. Both C# and Java have been developed from the mother- language C++. Microsoft never mention that C# have been originated from Java, but the syntax and the functionality are very similar. C# can only be executed on Microsoft?s new .NET platform. Many of C#?s strengths and characteristics come from the platforms framework (.NET Framework), so the framework is also presented in the paper. One can?t talk about C# without talk about .NET, because they live in a kind of symbiosis. Our purpose with this paper was to investigate what language C# is and if it has a future. The investigation has been done through studying literature, research on the Internet and an interview with an employee at the company Wireless Opinion, who are planning a crossover to the .NET platform. Since .NET and C# are not yet on the market we can?t get any concrete experiences as answers in the interview. The answers are more their thoughts about C# and .NET. The conclusion of this investigation is that C# itself isn?t a new revolution regarding programming languages, despite its several advantages towards other languages. However the combination of C# and the .NET Framework contributes with new technologies which can give great opportunities in the future. To understand this paper you ought to have some experience of object oriented programming. / Denna uppsats handlar om Microsofts nya programmeringsspråk, C# (See Sharp) och .NET Framework. Dessa är fortfarande i betaversion men kommer att släppas på marknaden i februari 2002. I uppsatsen presenteras C#, dock ej i detalj, utan de egenskaper som utmärker språket. En jämförelse görs med C++ och Java, då C# påminner om dessa språk mest. Både C# och Java har utvecklats från moderspråket C++. Microsoft nämner aldrig själva att C# skulle härstamma från Java, men syntaxen och funktionaliteten är mycket snarlik. C# kan endast exekveras på Microsoft nya .NET plattform. Mycket av C#s styrka och egenskaper kommer från plattformens ramverk (.NET Framework), så även ramverket presenteras i uppsatsen. Man kan inte tala om C# utan att tala om .NET, ty de lever i en slags symbios. Vårt syfte med uppsatsen var att undersöka vad C# är för språk och om det har någon framtid. Undersökningen har gjorts genom litteraturstudier, efterforskningar på Internet och en intervju. Intervjun gjordes med en anställd på företaget Wireless Opinion, vilka planerar en övergång till .NET plattformen. Eftersom .NET och C# inte finns på marknaden ännu så går det inte att få konkreta erfarenheter som svar i intervjun. Svaren är mer deras tankegångar om C# och .NET. Slutsatsen av denna undersökning är att C# i sig inte är en ny revolution när det gäller programmeringsspråk trots att det har flera fördelar gentemot andra språk. Däremot bidrar kombinationen av C# och .NET plattformen med nya teknologier som kan ge stora möjligheter i framtiden. För att förstå denna uppsats bör man ha någon erfarenhet av objektorienterad programmering.

Il y a désormais un consensus autour de l’idée que nous devons réduire l’usage des pesticides (Plan Ecophyto). Il est donc nécessaire de développer des systèmes de cultures réduisants l’utilisation des pesticides au profit d’un système de production dans lequel on stimule les mécanismes de défense «naturels» des plantes. Dans ce contexte, on voit aujourd’hui se développer de nombreuses solutions d’origines chimique ou biologique à base de stimulateurs de défenses des plantes (SDP) mais dont l’efficacité est souvent jugée aléatoire. Dans ce travail, notre choix a porté sur l’utilisation des rayonnements UV-C pour stimuler les défenses de la laitue et de la tomate contre Botrytis cinerea. L’idée d’exploiter les rayonnements UV-C, comme stimulateurs des défenses des plantes à intérêt alimentaire en culture, n’a jamais été testée. Nos résultats démontrent clairement un effet stimulateur des défenses des plantes par des doses faibles et répétées d’UV-C (inférieur à 1,70 kJ/m2). Cette stimulation est associée au renforcement de la paroi cellulaire, à l’augmentation des composés phénoliques et à l’augmentation de l’activité de certaines enzymes antioxydantes. Lorsque le traitement par les rayonnements UV-C est combiné à l’agent biologique Bacillus subtilis aucun effet synergique ou même additif n’a été observé par rapport à un traitement simple UV-C ou B. subtillis. / There is now a consensus around the idea that we must reduce theuse of pesticides (Plan Ecophyto). It is therefore necessary to develop cropsystems that have less need to be protected by pesticides in favor of aproduction system in which the "natural" defense mechanisms arestimulated. In this context, many solutions of chemical or biological originbased on stimulation of plant defense are now being developed but theireffectiveness is often judged to be random. In this work, we chose to useUV-C radiation to stimulate the defenses of lettuce and tomato againstBotrytis cinerea. The idea of exploiting radiation UV-C, as a stimulant ofplant food-borne defenses in culture, has never been tested. Our resultsclearly demonstrate a stimulatory effect of plant defenses by low andrepeated doses of UV-C (less than 1.70 kJ/m2). This stimulation isassociated with a reinforcement of the cell wall, an increase in the phenoliccompounds and the activity of certain antioxidant enzymes. When treatmentwith UV-C radiation is combined with a biological agent Bacillus subtilis, nosynergistic or even additive effect has been observed compared with asimple UV-C or B. subtillis treatment. / Se ha establecido en el mundo entero la importancia sobre el controlde uno de los principales organismos fitopatológicos como lo es Botrytiscinérea, el cual demanda en la actualidad a los productores aplicarcontroles cónsonos con la protección del medio ambiente. Por consiguiente,se evaluó el uso de diferentes dosis de luz ultravioleta sola o encombinación con un agente de biocontrol (Basillus subtilis), con la finalidadde estimular las defensas naturales de dos especies vegetales (lechuga ytomate). Al respecto, los resultados establecieron que dosis menores de1,70 kJ/m2 de UV-C logran disminuir la sensibilidad de las plantas, sinafectar significativamente el desenvolvimiento del aparato fotosintético deambas especies. Así como, se observó un efecto antagónico del biocontrolsobre la UV-C cuando se combinan.

No description available.

The template system of C++ is expressive enough to allow the programmer to write programs which are evaluated during compile time. This can be exploited for example in generic programming. However, these programs are very often hard to write, read and maintain. We introduce a simple translation from lambda calculus into C++ templates and show how it can be used to simplify C++ metaprograms. This variation of lambda calculus is then extended with Hindley-Milner type system and various other features (Haskell-like syntax, user-defined data types, tools for interaction with existing C++ template code and so on). We then build a compiler capable of transforming programs written in this language into C++ template metaprograms. Powered by TCPDF (www.tcpdf.org)

This thesis is a study in the ideological foundations of Victorian civic pride. It argues that the Victorian civic renaissance had an extensive intellectual genealogy. The thesis hopes to foster a reevaluation of the Victorian city in its intellectual context, and broaden the perimeters of enquiry within urban history. In doing so, it contributes to the debate over middle class identity in Victorian England. The four chapters indicate the dominant strands of thinking that determined the development of the Victorian city. The first chapter addresses the pre-Reformation ideal of civil society. It throws new light upon the work of Southey, Cobbett, Pugin, and Ruskin. By contrasting the edifices of the virtuous, medieval past against the civic symbols of the faithless and individualist present, they fostered a corporatist civic tradition which powerfully influenced the Victorian city. The second chapter describes the defence of the industrial city by liberal civic elites. Their rhetoric was as concerned with defending Nonconformity and the historical role of the middle class as the manufacturing city. Influenced by the French Doctrinaires, advocates of liberal civic thought championed the city, and its inhabitants, as the harbingers of liberty, prosperity and progress. Chapter three charts how Victorian 'merchant princes' looked to ancient Greece and Renaissance Italy to support their wealth and industry. It emphasises the draw of Periclean Athens and medieval Florence as potent civic ideals. Their successful combination of commerce and culture made the cities instrumental models in the development of Victorian civic pride. The final chapter explains how the Saxon spirit of local self-government became part of a national identity. The English polity based upon a system of decentralization and multiple municipal centres was contrasted against Norman centralization which resulted in Parisian despotism. _With the growth of statist legislation in the 1840s this narrative of local self-government was placed under strain. The chapter discusses how Saxon civic thought influenced central policy and urban identity.

Les ellagitannins C-arylglucosidiques sont des polyphenols naturels capable d’inhiber totalement la topoisomérase 2, une enzyme ciblée par les chimiothérapies utilisées contre le cancer. La challenge de cette these c’était trouver une approche biomimétique a la synthèse de ces molecules. La synthèse totale de la punicacorteine A, un simple membre de cette classe, a demande le développement de nouvelle méthodologies liée (i) à la chimie des sucres, pour la formation de la liaison C-arylglucosidique sur le glucose en forme ouverte et (ii) à la chimie des phénols pour générer l’unité biarylique en façon atroposelective. L’utilisation de complexes de cuivre-amine a permis de réaliser le couplage. L’étape suivante de la liaison C-arylglucosidation a ainsi pu être étudiée et le composé attendu a pu être obtenu par réaction dans une solution de tampon phosphate. Le dernière étape de la synthèse (galloylation sélective) n’est pas encore réalisée mais, à ce stade, une déprotection permettre d’obtenir un premier ellagitannin C-arylglucosidique naturel, l’épi-punicacortéine A 5-O-dégalloylée. / C-arylglucosidic ellagitannins belong to a family of biologically-active plant-derived polyphenols. Preliminary studies by Prof. Quideau’s group showed that some of these ellagitannins are potent inhibitors of human topoisomerase 2, current target of anticancer chemotherapies. The challenge of this thesis was the development of a biomimetic synthetic approach to this class of molecule. The total synthesis of punicacortein A, a simple member of this class, required the development of novel methodologies related (i) to sugar chemistry, to install the C-arylglucosidic bond on an open chain glucose, and (ii) to phenol chemistry, to generate the biaryl-unit in an atropoisomerically-controlled manner. This issue was addressed by using copper-amine complexes as oxidizing agents. We managed to obtain the C-arylglycosidic compound by reaction in phosphate buffer. At this stage, a single deprotection step led to the first natural C-arylglucosidic ellagitannin, 5-O-degalloyl epipunicacortein A.

Orientador: Helaine Maria Besteti Pires Mayer Milanez / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-27T21:43:52Z (GMT). No. of bitstreams: 1 Schweller_MarianaSalhabDall'Aqua_M.pdf: 1766000 bytes, checksum: e03c3a8a2bf2836ec2f7e49bc907e1fd (MD5) Previous issue date: 2015 / Resumo: Introdução: A Hepatite C é um dos maiores problemas atuais de saúde pública, com mais de 150 milhões de pessoas contaminadas. A evolução da doença geralmente é assintomática e suas complicações são cirrose, fibrose hepática e hepatocarcinoma. Na gestação o tratamento não é recomendado, com possível piora da doença no período. Objetivo: identificar a prevalência de Hepatite C em gestantes que realizaram acompanhamento pré-natal no Hospital da Mulher Professor José Aristodemo Pinotti - Centro de Atenção Integral à Saúde da Mulher (CAISM) da UNICAMP, analisando dados clínicos, epidemiológicos e resultados perinatais. Metodologia: estudo de corte transversal cuja amostra foi composta por gestantes atendidas nos ambulatórios de pré-natal do CAISM entre 2005 e 2014 com sorologia positiva para Hepatite C. As pacientes foram identificadas através de listas informatizadas do serviço, e seus prontuários levantados para análise de dados sociodemográficos, epidemiológicos e desfechos perinatais. A análise dos dados foi feita através da distribuição percentual ou de médias. Resultados: na população de 29.327 gestantes atendidas pelo pré-natal entre 2005 e 2014, a prevalência de Hepatite C foi de 0,2%. Das 47 mulheres incluídas no estudo, a idade média foi de 32,5 anos, houve 49% de prevalência de baixa escolaridade, metade das participantes não planejaram a gestação, sendo que 38% destas não faziam uso de métodos contraceptivos. Além disso, 34% apresentaram coinfecção pelo HIV e 34% relataram uso de drogas. O número médio de gestações por paciente foi 3. Não se observou um pior desfecho perinatal, com peso médio de 2827,5 gramas ao nascimento e idade gestacional média de 39 semanas e 4 dias. Conclusões: Entre as pacientes infectadas pelo vírus C, observamos maior prevalência da raça branca, baixa escolaridade e coinfecção com HIV. Como principais fatores de risco para contaminação pela doença, foram identificados o uso de drogas, histórico de transfusões sanguíneas e a coinfecção com o HIV. Além disso, foram observadas maiores taxas de aborto, cesáreas e prematuridade neonatal em relação a outros estudos, fatores relacionados ao aumento da morbimortalidade materna, fetal e neonatal / Abstract: Introduction: Hepatitis C is a leading public health problem, with more than 150 million people infected. Disease evolution is usually asymptomatic, and complications are cirrhosis, liver fibrosis and hepatocellular carcinoma. Treatment is not recommended during pregnancy, but it may influence disease evolution. Objective: To identify Hepatitis C prevalence in pregnant women attended at Professor Doctor José Aristodemo Pinotti Women's Integrated Healthcare Center (CAISM) of the UNICAMP Medical School during prenatal period, analyzing clinical and epidemiological data, including perinatal outcomes. Methods: Authors performed a cross-sectional study with pregnant women who tested positive for Hepatitis C and gave birth at CAISM, between 2005 and 2014. Demographic, epidemiological and perinatal data were extracted from each patient¿s hospital records. Data analysis was made through media or percentage distribution. Results: Among 29.327 women treated at CAISM between 2005 and 2014, Hepatitis C prevalence was 0,2%. The mean maternal age at delivery was 32.5 years, 49% had low education and 49% did not plan the pregnancy. Among them, 38% did not use contraceptive methods. In addition, 34% had coinfection with HIV and 34% reported use of drugs. The average number of pregnancies per woman was 3, and there was no significant evidence of disease influence in pregnancy outcomes. Newborns¿ average weight was 2,827.5 grams, and the average of the gestational age was 39 weeks and 4 days. Conclusions: Among patients infected with Hepatitis C, there was predominance of the white race, low education and HIV coinfection. Drug addiction, blood transfusions and HIV co-infection were the main risk factors for contamination. When compared with other similar studies, this study found higher rates of abortion, cesarean sections and neonatal prematurity. These factors are associated with perinatal morbidity and mortality / Mestrado / Saúde Materna e Perinatal / Mestra em Ciências da Saúde