- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
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Isolierung und Charakterisierung der gamma-Tocopherolmeth yltransferase / Isolation and Characterization of the Gamma-To copherolmethyltransferaseKoch, Maria 31 October 2001 (has links)
No description available.
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Charakterisierung der Eaf 1-Funktion für die Biogenese der Aminopeptidase 1 / Characterisation of the Eaf 1 function for the aminopeptidase 1 biogenesisBenkert, Tanja 03 July 2008 (has links)
No description available.
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Nuclear hormone receptor regulation of microRNAsBethke, Axel 06 October 2009 (has links)
Progression of metazoans through different developmental programs requires temporal control that is achieved by molecules originating from endocrine tissues that diffuse throughout the whole body of the animal to coordinate program execution by activating cell specific gene expression patterns. These programs then define cascades of successive, distinct developmental stages or the choice between alternative fates for the same stage. A model for this developmental control is found in the nematode C. elegans, where environmental cues signal through insulin and TGF-beta cascades to regulate the daf-12/nuclear hormone receptor (NHR) ligand synthesis that then coordinates organism wide developmental timing and fate choice. For cell intrinsic aspects of C. elegans temporal control of development, microRNAs play an important role but their connection to organism wide endocrine control is unknown. This work shows how the DAF-12/NHR directly activates let-7 family microRNAs during the L3 stage to repress L2 stage activator hbl-1 to prevent L2 stage programs from reoccurring. The interaction of upstream transcription factors with the downstream cis-regulatory elements in promoters of the let-7 family microRNAs are further analyzed in detail and identify potential DAF-12 coregulators that might connect daf-12 endocrine signaling also to later stage developmental control. These observations are the first to integrate microRNAs into establishedendocrine signaling cascades. In addition they reveal specific details about how organism wide upstream, endocrine signaling pathways induce downstream cell intrinsic changes of gene expression and developmental progression. This work postulates a "molecular switch" that actively drives stage transitions, consisting of a NHR that directly activates microRNAs to actively repress mediators of old stages while directly activating translation of protein coding genes mediating the new stage.
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Guanylatkinase: Von einem aktiven Enzym zu einem inaktiven Multidomänen-Protein.Spangenberg, Oliver 02 May 2001 (has links)
No description available.
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Thermodynamic driving forces in protein regulation studied by molecular dynamics simulations / Molekulardynamische Studien zu thermodynamischen Triebkräfte von ProteinregulierungHensen, Ulf 22 January 2009 (has links)
No description available.
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Anpassung antioxidativer Systeme an Licht und Temperatur: / holzige und krautige Pflanzen im Vergleich / Acclimation of antioxidative systems to light and temperature: / woody and herbaceous plants in comparisonPeltzer, Detlef 28 March 2001 (has links)
No description available.
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