Made available in DSpace on 2013-08-07T18:58:55Z (GMT). No. of bitstreams: 1 000433597-Texto+Completo-0.pdf: 15467920 bytes, checksum: 9f51c8872afcde7d0ee58dd5e8cbe752 (MD5) Previous issue date: 2011 / Esta tesis tiene como objetivo analizar los murales producidos por Aldo Locatelli, entre los años 1951 y 1955, las habitaciones y los salones del segundo piso del ala del Gobierno de Palacio Piratini. Al ser trabajado las pinturas: La formación de personas etnográfico sur-riograndense, La fundación de Río Grande (ambas producidas en el Salón Alberto Pasqualini), El Negrinho Pastoreo (ubicado en la Sala, que lleva el mismo nombre) y El Estado (ejecutado en sala de espera de la Oficina del Gobernador), está destinado a ser, esencialmente, a fin de establecer una red de relaciones que participan tanto el artista y los elementos externos en su producción pictórica. En este sentido, desde el estudio de los murales de carácter histórico, formativo y folklórico, que aluden al Rio Grande do Sul, se tratará de analizar las representaciones y cuestiones formales presentes en estas obras, junto con los elementos del contexto cultural e intelectual de la época. spa / A presente dissertação tem por objetivo central analisar os murais elaborados por Aldo Locatelli, entre os anos de 1951 e 1955, nas salas e salões do segundo piso da Ala Governamental do Palácio Piratini. Ao serem trabalhados as pinturas A formação histórico-etnográfica do povo rio-grandense, A fundação de Rio Grande (ambos elaborados no Salão Alberto Pasqualini), O Negrinho do Pastoreio (localizado no Salão que leva o mesmo nome) e O Estado (executado na Antessala do Gabinete do Governador), pretende-se, fundamentalmente, estabelecer a rede de relações que envolveram tanto o artista quanto os elementos externos à sua produção pictórica. Nesse sentido, a partir do estudo dos murais de caráter histórico, formativo e folclórico que aludem ao Rio Grande do Sul, buscar-se-á analisar as representações e as questões formais presentes nas citadas obras, em conjunto com os elementos do contexto cultural e intelectual do período.

Esta dissertação busca identificar os referentes a partir dos quais o jornalista Aldo Obino (1913-2007) registrou o desenvolvimento do sistema das artes visuais de Porto Alegre, na década de 1950. A pesquisa parte dos pressupostos de que o jornalismo, a partir dos valores próprios do seu campo, constrói perspectivas do circuito artístico em épocas e lugares determinados; empresta visibilidade a certos espaços, agentes eventos e ideias; e orienta os leitores em relação à movimentação do circuito de cultura de seu território. Obino atuou na imprensa por aproximadamente 60 anos, produzindo relatos sobre a cena cultural do Rio Grande do Sul a partir do Correio do Povo, jornal em que assinava a coluna diária Notas de Arte, objeto empírico deste estudo. Para nos aproximarmos da trajetória e do legado do autor, recorremos ao seu arquivo pessoal, cedido por sua família. Utilizamos o método da análise de conteúdo e adotamos um corpus de 314 textos, que corresponde às colunas publicadas entre 1950 e 1959 que abordam temas ligados às artes visuais. A análise objetivou determinar os espaços, os sujeitos, os fatos e os valores estéticos e ideológicos que emergem da coluna, de forma a vislumbrar o mapa do sistema de artes visuais nela proposto. Observamos a centralidade de Porto Alegre como lugar mais recorrentemente mencionado, o que evidencia a importância do parâmetro da proximidade, típico do jornalismo, na estruturação desse conjunto de textos. Constatamos que os artistas, como sujeitos-criadores, foram os protagonistas das ações abordadas na coluna, o que aponta para a existência de um processo de personalização através do qual Obino participa da construção da notoriedade de agentes. Os eventos, como exposições e salões de arte, foram identificados como referência central enquanto pautas catalisadoras do atributo de atualidade nas Notas de Arte, inclusive em forma de morte e efeméride. Na abordagem de certas tendências e debates, notamos, por parte do colunista, a corroboração de alguns valores então hegemônicos no sistema artístico e também o elogio da renovação e do intercâmbio nesse meio. Dessa forma, verificamos um grau de ambiguidade em termos de posicionamento. No mais, vimos que Obino se vincula a um estilo impressionista de crítica de arte, utiliza um tom de intimidade para se aproximar do leitor e tematiza o desenvolvimento do circuito das artes em conexão com o crescimento da cidade. O seu registro se associa fortemente ao território, de forma que a capital gaúcha é presença constante, apresentando-se como cenário ou como personagem dos seus relatos. / This essay intends to identify the referents from which the journalist Aldo Obino (1913-2007), registered the development of Porto Alegre visual arts system held during the decade of 1950. The research makes certain assumptions given that the journalism, starting from its own field values, builds perspectives of the artistic circuit in determined places and times; it lends visibility to certain places, agents events and ideas; and orientates the readers regarding the movement of its territory circuit of culture. For approximately 60 years, Obino acted in the press, producing reports on the cultural scene of Rio Grande do Sul for Correio do Povo, the local newspaper in which he signed the daily column Notas de Arte, empirical object of this research. In order to approach Obino’s trajectory and legacy, we draw upon his personal archive, provided by his family. It was used the method of content analysis and a sample of 314 texts was adopted. This material corresponds to the columns published between 1950 and 1959 that discuss issues pertaining to visual arts. The analysis aimed to determine the spaces, the subjects, the facts and the aesthetic and ideological values that emerge from his column, to envision the proposed map of visual arts system. We observed the centrality of Porto Alegre as more recurrently mentioned place, which highlights the importance of the proximity parameter, characteristic of journalism, in the structuring of this set of texts. We noticed that the artists, as subject-creators, were the protagonists of the actions addressed in the column, which points to the existence of a customization process through which Obino participates of agent’s notoriety construction. The events, such as exhibitions and halls of art, were identified as points reference while catalytic guidelines of actuality attribute in Notas de Arte even in the form of death and ephemerid. In certain trends and debates approach, we perceived on the part of the columnist, some hegemonic values confirmation in the artistic system, and also the compliment of renovation and exchange in this environment. Therefore, we checked some ambiguity on positioning. We also visualized that Obino is linked to an impressionist style of art criticism; he uses an intimacy tone to bring close the reader and thematises the development of the arts circuit in connection with the growth of the city. His trademark is strongly associated to the territory, in such a way that the capital from Rio Grande do Sul is an on-going presence, performing itself as scenery or as a character of his chronicles.

Esta dissertação busca identificar os referentes a partir dos quais o jornalista Aldo Obino (1913-2007) registrou o desenvolvimento do sistema das artes visuais de Porto Alegre, na década de 1950. A pesquisa parte dos pressupostos de que o jornalismo, a partir dos valores próprios do seu campo, constrói perspectivas do circuito artístico em épocas e lugares determinados; empresta visibilidade a certos espaços, agentes eventos e ideias; e orienta os leitores em relação à movimentação do circuito de cultura de seu território. Obino atuou na imprensa por aproximadamente 60 anos, produzindo relatos sobre a cena cultural do Rio Grande do Sul a partir do Correio do Povo, jornal em que assinava a coluna diária Notas de Arte, objeto empírico deste estudo. Para nos aproximarmos da trajetória e do legado do autor, recorremos ao seu arquivo pessoal, cedido por sua família. Utilizamos o método da análise de conteúdo e adotamos um corpus de 314 textos, que corresponde às colunas publicadas entre 1950 e 1959 que abordam temas ligados às artes visuais. A análise objetivou determinar os espaços, os sujeitos, os fatos e os valores estéticos e ideológicos que emergem da coluna, de forma a vislumbrar o mapa do sistema de artes visuais nela proposto. Observamos a centralidade de Porto Alegre como lugar mais recorrentemente mencionado, o que evidencia a importância do parâmetro da proximidade, típico do jornalismo, na estruturação desse conjunto de textos. Constatamos que os artistas, como sujeitos-criadores, foram os protagonistas das ações abordadas na coluna, o que aponta para a existência de um processo de personalização através do qual Obino participa da construção da notoriedade de agentes. Os eventos, como exposições e salões de arte, foram identificados como referência central enquanto pautas catalisadoras do atributo de atualidade nas Notas de Arte, inclusive em forma de morte e efeméride. Na abordagem de certas tendências e debates, notamos, por parte do colunista, a corroboração de alguns valores então hegemônicos no sistema artístico e também o elogio da renovação e do intercâmbio nesse meio. Dessa forma, verificamos um grau de ambiguidade em termos de posicionamento. No mais, vimos que Obino se vincula a um estilo impressionista de crítica de arte, utiliza um tom de intimidade para se aproximar do leitor e tematiza o desenvolvimento do circuito das artes em conexão com o crescimento da cidade. O seu registro se associa fortemente ao território, de forma que a capital gaúcha é presença constante, apresentando-se como cenário ou como personagem dos seus relatos. / This essay intends to identify the referents from which the journalist Aldo Obino (1913-2007), registered the development of Porto Alegre visual arts system held during the decade of 1950. The research makes certain assumptions given that the journalism, starting from its own field values, builds perspectives of the artistic circuit in determined places and times; it lends visibility to certain places, agents events and ideas; and orientates the readers regarding the movement of its territory circuit of culture. For approximately 60 years, Obino acted in the press, producing reports on the cultural scene of Rio Grande do Sul for Correio do Povo, the local newspaper in which he signed the daily column Notas de Arte, empirical object of this research. In order to approach Obino’s trajectory and legacy, we draw upon his personal archive, provided by his family. It was used the method of content analysis and a sample of 314 texts was adopted. This material corresponds to the columns published between 1950 and 1959 that discuss issues pertaining to visual arts. The analysis aimed to determine the spaces, the subjects, the facts and the aesthetic and ideological values that emerge from his column, to envision the proposed map of visual arts system. We observed the centrality of Porto Alegre as more recurrently mentioned place, which highlights the importance of the proximity parameter, characteristic of journalism, in the structuring of this set of texts. We noticed that the artists, as subject-creators, were the protagonists of the actions addressed in the column, which points to the existence of a customization process through which Obino participates of agent’s notoriety construction. The events, such as exhibitions and halls of art, were identified as points reference while catalytic guidelines of actuality attribute in Notas de Arte even in the form of death and ephemerid. In certain trends and debates approach, we perceived on the part of the columnist, some hegemonic values confirmation in the artistic system, and also the compliment of renovation and exchange in this environment. Therefore, we checked some ambiguity on positioning. We also visualized that Obino is linked to an impressionist style of art criticism; he uses an intimacy tone to bring close the reader and thematises the development of the arts circuit in connection with the growth of the city. His trademark is strongly associated to the territory, in such a way that the capital from Rio Grande do Sul is an on-going presence, performing itself as scenery or as a character of his chronicles.

<p align="justify">Les glioblastomes sont les tumeurs cérébrales malignes les plus répandues chez l’adulte et l’enfant, et les plus agressives avec une médiane de survie inférieure à quinze mois. Deux caractéristiques biologiques rendent leur traitement particulièrement difficile. Tout d’abord, la capacité d’invasion du parenchyme cérébral par les cellules gliales tumorales rend la résection chirurgicale totale impossible. De plus, ces cellules développent une résistance aux stimuli pro-apoptotiques rendant la plupart des agents chimiothérapeutiques peu efficaces contre ce type de tumeur. Actuellement, le seul agent chimiothérapeutique efficace dans le traitement des glioblastomes est le témozolomide. Malheureusement des mécanismes de résistance acquise peuvent apparaître chez des patients traités avec cette molécule. Nous avons donc étudié ces mécanismes moléculaires de résistance acquise au témozolomide et dans un deuxième temps nous avons tenté de trouver de potentielles molécules susceptibles de lutter contre les gliomes. </p align="justify"><p><p align="justify">Nous avons rendu résistants deux modèles de cellules gliales tumorales au témozolomide par un traitement incrémental durant plusieurs mois. Grâce à une analyse de type Affymétrix, nous avons comparé l’expression de l’ensemble des gènes entre les lignées normales et les lignées rendues résistantes. Deux familles de gènes sont ressorties comme impliquées dans ce processus de résistance :les transporteurs glucose et les aldo-kéto réductase 1C (akr1c). Pour les transporteurs glucose, il se pourrait que leur implication se fasse au niveau du métabolisme des cellules résistantes en permettant d’apporter plus de substrat énergétique et ainsi contourner les effets pro-autophagiques du témozolomide. Dans le cas des akr1c, il semblerait que leur surexpression ait pour but d’augmenter la prolifération des cellules tumorales résistantes. </p align="justify"><p><p align="justify">Nous avons, par la suite, étudié les propriétés anticancéreuses de métabolites fongiques, les phyllostictines, extraites du champignon Phyllosticta cirsii. Quatre métabolites naturels et deux dérivés hémisynthétiques ont été testés démontrant des activités plus ou moins importantes sans toutefois montrer in vitro de biosélectivité entre cellules tumorales et cellules normales. Les phyllostictines semblent se lier au groupement thiol libre comme nous l’avons déterminé sur le glutathion ou la cystéine. Il reste à déterminer la cible des phyllostictines dans les cellules tumorales et à améliorer la sélectivité de ces molécules.</p align="justify"> / Doctorat en Sciences biomédicales et pharmaceutiques / info:eu-repo/semantics/nonPublished

El protagonista fundamental de esta tesis doctoral es Aldo van Eyck. Mención aparte del interés suscitado por el conjunto de su trayectoria profesional y por su propia figura, la principal motivación del presente trabajo consiste en aproximarse a la visión que el maestro holandés tenía de la relación que se establece entre 'arquitectura' y 'sociedad' o, más específicamente, de cómo los arquitectos pueden (y deben) introducir mejoras significativas en los modos de vida de las personas (usuarios). Es decir, la tesis pretende analizar el concepto de "dimensión humana de la arquitectura" de Aldo van Eyck. Ya en el capítulo introductorio se definía la 'dimensión humana de la arquitectura' como el modo consciente en que ésta (la arquitectura) considera la interacción con sus futuros usuarios, con el claro objetivo de elaborar propuestas encaminadas a introducir mejoras en sus vidas. De acuerdo con esta definición, varios son los términos clave que la caracterizan. Por un lado, las palabras "consciente" y "considera" explicitan que existe una reflexión intencionada y voluntaria sobre la figura del usuario en la arquitectura, consecuencia por tanto de una preocupación o interés previo por el tema; en este sentido, se puede entender que, si no se da esta circunstancia (esta consideración consciente), difícilmente podrá hablarse de dimensión humana de la arquitectura. Y por otro lado, la palabra "interacción" evidencia que existe un intercambio, un recorrido de ida y vuelta entre la arquitectura y sus usuarios, de manera que el arquitecto acumula información sobre las características y condicionantes de éstos a través de la observación y la reflexión personal, para posteriormente tratar de elaborar propuestas capaces de mejorar sus modos de vida. Esto es, sin ánimo de restarle importancia a la culminación de objetivos lograda por una determinada intervención arquitectónica, es en su intencionalidad y compromiso respecto a los futuros usuarios donde verdaderamente se origina l / Fernández-Llebrez Muñoz, JÁ. (2013). La dimensión humana de la arquitectura de Aldo Van Eyck. Escrita y Construida: Reconocimiento de sus ideas y Estudio de su iglesia en La Haya [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/27638

Yes / The aldo-keto reductase 1C3 (AKR1C3) isoform plays a vital role in the biosynthesis of androgens and is considered an attractive target in prostate cancer (PCa). No AKR1C3-targeted agent has to date been approved for clinical use. Flufenamic acid and indomethacine are non-steroidal anti-inflammatory drugs known to inhibit AKR1C3 in a non-selective manner as COX off-target effects are also observed. Recently, we employed a scaffold hopping approach to design a new class of potent and selective AKR1C3 inhibitors based on a N-substituted hydroxylated triazole pharmacophore. Following a similar strategy, we designed a new series focused around an acidic hydroxybenzoisoxazole moiety, which was rationalised to mimic the benzoic acid role in the flufenamic scaffold. Through iterative rounds of drug design, synthesis and biological evaluation, several compounds were discovered to target AKR1C3 in a selective manner. The most promising compound of series (6) was found to be highly selective (up to 450-fold) for AKR1C3 over the 1C2 isoform with minimal COX1 and COX2 off-target effects. Other inhibitors were obtained modulating the best example of hydroxylated triazoles we previously presented. In cell-based assays, the most promising compounds of both series reduced the cell proliferation, prostate specific antigen (PSA) and testosterone production in AKR1C3-expressing 22RV1 prostate cancer cells and showed synergistic effect when assayed in combination with abiraterone and enzalutamide. Structure determination of AKR1C3 co-crystallized with one representative compound from each of the two series clearly identified both compounds in the androstenedione binding site, hence supporting the biochemical data. / University of Turin (Ricerca Locale grant 2015-2017) and Prostate Cancer UK grant S12-027.

Cette thèse a pour objet l’invention de soi chez Patrick Modiano. Le syntagme invention de soi peut s’interpréter de trois manières différentes selon que l’on met l’accent sur la recherche de l’identité pour répondre à la question qui suis-je ?, ou que l’on interroge la rhétorique pour y chercher les idées et arguments pour composer son discours ou encore que l’on ne fasse appel qu’à sa mémoire puisque rien de nouveau n’a été inventé. De ses trois approches, la première guide en majorité les travaux de cette thèse, menée à l’aide des outils traditionnels de l’analyse littéraire et en excluant toute approche psychanalytique que Patrick Modiano récuse pour lui-même. La démarche suivie l’est en trois points. Dans un premier temps, il s’agit de rechercher ce qui alimente l’œuvre romanesque de Patrick Modiano, entre l’Histoire et plus particulièrement l’histoire de la Collaboration en France entre 1940 et 1944 ou de la fin de la guerre d’Algérie, très présente dans plusieurs de ses romans, ses sources littéraires et plus spécialement des auteurs antisémites de l’entre-deux guerres qu’il cite souvent et sa vie partagée, c'est-à-dire partagée avec ses lecteurs. Ensuite il s’agit de se demander chez cet auteur qui pratique quasiment exclusivement le Je-narrateur, quel est le genre de ses récits entre roman, autobiographie et autofiction. Enfin la question de son identité est posée : qu’est ce pour lui être né en 1945, être le fils d’un collaborateur ou présumé tel, être fils d’un Juif ou encore être écrivain ? Ces analyses nous permettent de répondre à la question posée par cette thèse et de déterminer de quelle manière Patrick Modiano s’invente soi-même dans ses récits. Est-ce en s’inventant de fausses dates de naissance, une fausse date de mariage de ses parents, une fausse sœur ou un faux oncle ou ne serait-ce pas plutôt en s’inventant à chaque récit une identité imaginaire comme si elle était la sienne, pour l’abandonner au récit suivant et en reprendre alors une nouvelle ? / This dissertation addresses the question of the invention of oneself by Patrick Modiano. The terms invention of oneself can be interpreted on three ways, depending on the manner the accent is made on the definition of identity, answering the question : “Who am I?”, or finding the ideas and arguments to prepare a discourse as it is done in the rhetoric or questioning one’s memory as nothing new can be invented. Amongst these three approaches, the first one about the question of identity is mainly studied with the literary tools, excluding the psychoanalytical view which is rejected by Patrick Modiano himself. A three steps approach is followed. At first we analyze how the Patrick Modiano’s romanesque art is influenced by History, mainly the history of the French collaboration during World War II but also by the history of the Algeria war at the beginning of the sixties, his literary sources mainly among French anti-Semite authors who published their books just before World War II, and of course his shared life, that is to say the life he is sharing with the readers. The following question concerns the literary genre of the novels written by an author using the I narrator. Is he writing novels, autobiographies or autofictions? The last issue is about the question of identity: what does it mean for Patrick Modiano to be born in 1945, to be the son of a supposed collaborator, or the son of a Jew, or to be a writer? Answering these different questions should help to approach the definition of the invention of oneself. Is it related to the invention of several birth dates, a false date for the wedding of his parents or imaginary family members for himself or on the opposite is it related to the invention of a new imaginary identity at each novel till the previous identity is abandoned and a new imaginary identity is created in the following novel?

The left-wing terrorism in Italy in the 1970s and the Red brigades as its most significant symptom resulted in the long-term view from the fight between the partisans and the fascists in the Second World War and from the short-term view from the students' and labourers' protests in the end of 1960s. The Red brigades were founded in 1970 and were composed mainly by students from Trento (Curcio, Cagol), communists from Reggio Emilia (Franceschini, Gallinari) and labourers from Milano (Moretti). They began in the first years of their functioning with agitation in the factories, burning the cars of the high managers and kidnapping. The thesis follows gradual radicalisation of the group and the change of their aims - from this moment on mostly politicians, judges, state magistrates. The transformation of the Red brigades related to the personal changes in the leadership - after Curcio and Franceschini were arrested and Cagol killed, radical Moretti became very influential. The organisation under his leadership started to kill intentionally its victims and the wave of brutal attacks culminated in the spring 1978 in kidnapping and murder of former Prime Minister Aldo Moro. The Red brigades however became strongly socially isolated and several ideological differences among the members of the administration...

Formulated as a feminist project, written as a pulp fiction, Architectural Flirtations: A Love Storey begins with our claim that the architectural discipline is centered around a culture of critique, which is based in what bell hooks calls “a system of imperialist, white supremacist, heterosexist, capitalist, patriarchy,” and that the values instilled by this culture not only begin with, but are reinforced and reproduced by, the education of young architects. Sounds serious. Right? In a move toward a more vulnerable, ethical and empowering culture of architecture, the project aims to displace the culture of critique, by questioning and undermining relationships of power and privilege through practices that are explicitly critical, queer feminist, and Campy. In other words, it takes seriously, in an uncertain, improper and playful way, what is usually deemed unserious within the architectural discipline, in order to undermine the usual order of things. All of the (love) storeys take place on March 21st, the spring equinox, in and around a 1977 collaborative row house project called Case Unifamiliari in Mozzo, Italy, designed by Aldo Rossi and Attilio Pizzigoni. Beda Ring, PhD researcher, constructs a Campy renovation of one of these row houses, full of theatricality, humor, and significant otherness; while architectural pedagogue, Brady Burroughs, guides a student group from KTH in an Architecture and Gender course; and Henri T. Beall, practicing architect, attends to the details upstairs. / <p>QC 20161025</p>

Made available in DSpace on 2015-04-14T13:47:35Z (GMT). No. of bitstreams: 1 433597.pdf: 15467920 bytes, checksum: 9f51c8872afcde7d0ee58dd5e8cbe752 (MD5) Previous issue date: 2011-08-26 / A presente disserta??o tem por objetivo central analisar os murais elaborados por Aldo Locatelli, entre os anos de 1951 e 1955, nas salas e sal?es do segundo piso da Ala Governamental do Pal?cio Piratini. Ao serem trabalhados as pinturas A forma??o hist?rico-etnogr?fica do povo rio-grandense, A funda??o de Rio Grande (ambos elaborados no Sal?o Alberto Pasqualini), O Negrinho do Pastoreio (localizado no Sal?o que leva o mesmo nome) e O Estado (executado na Antessala do Gabinete do Governador), pretende-se, fundamentalmente, estabelecer a rede de rela??es que envolveram tanto o artista quanto os elementos externos ? sua produ??o pict?rica. Nesse sentido, a partir do estudo dos murais de car?ter hist?rico, formativo e folcl?rico que aludem ao Rio Grande do Sul, buscar-se-? analisar as representa??es e as quest?es formais presentes nas citadas obras, em conjunto com os elementos do contexto cultural e intelectual do per?odo.