Thesis (Ph. D.)--University of Oklahoma, 1996. / Includes bibliographical references.

Thesis (M.A.)--University of Missouri-Columbia, 2006. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file viewed on (February 8, 2007) Includes bibliographical references.

Objective: to compare dietary treatments and their effectiveness in reducing seizures through a systematic review and meta-analysis of clinical trials Methods: Using the PRISMA Method, the Primo database was searched to find peer-reviewed articles where researchers compared one treatment against another. The treatments of choice present in all studies are the Ketogenic Diet and the Modified Atkins Diet. Due to the nature of the experiments, the Ketogenic Diet was considered the control, as it was coined first. Results: Of the 450 articles identified, 378 met the primary peer review threshold and 190 were classified as Open Access. Eight met eligibility and were included in this review. 443 patients across all studies were assigned either a Ketogenic Diet or a Modified Atkins Diet for a median period of 3 months. 48.17% of MAD patients had a significant decrease in seizure frequency, compared to 61.11% of patients under KD. As much as the ketogenic diet showed better results overall, there was no statistical difference in the odds of achieving a significant reduction in seizures using either diet. Significance: Trials suggest that while there was not a significant difference in this study between the ketogenic diet and the modified Atkins diet, there was a trend for ketogenic diets to be more effective than the more recent Modified Atkins diet for drug-resistant epileptics. However, the sample size needs to be increased before a more accurate determination can be made.

Submitted by Biblioteca da Faculdade de Farmácia (bff@ndc.uff.br) on 2018-01-12T16:10:14Z No. of bitstreams: 1 Maria Emília Lopes.pdf: 20093800 bytes, checksum: 9bb89700f8b88159431e067064afe7dd (MD5) / Made available in DSpace on 2018-01-12T16:10:14Z (GMT). No. of bitstreams: 1 Maria Emília Lopes.pdf: 20093800 bytes, checksum: 9bb89700f8b88159431e067064afe7dd (MD5) / Há algumas décadas, dietas cetogênicas como a preconizada pelo Dr. Atkins, composta por 0% a 20% da oferta energética fornecida por carboidratos, 55% a 65% por proteínas e 25% a 35% por lipídeos são usadas visando ao emagrecimento. Mais recentemente, a indicação foi ampliada para algumas doenças neurológicas. A hipótese deste estudo é que, como o fígado recebe diretamente macronutrientes da absorção intestinal, as modificações na composição desses componentes da dieta possam levar à lesão dos hepatócitos. O objetivo geral do estudo é verificar o efeito de uma dieta com teores baixo de carboidratos e elevado de proteínas e lipídeos no fígado de ratas por análise bioquímica plasmática, histologia e citometria de fluxo do fígado. Vinte ratas, divididas em dois grupos, receberam dieta controle e dieta experimental. Os animais controles receberam dieta AIN-93M e os experimentais, dieta baseada na do Dr. Atkins, com carboidrato (8,44%), proteínas (57,19%), lipídeos (34,36%) e água, ad libitum, por oito semanas. As ratas no estro em jejum foram anestesiadas e pesadas, a glicemia capilar foi dosada e a coleta de sangue foi realizada para avaliar transaminases, ureia, creatinina, triacilglicerol, colesterol, lipoproteína de alta densidade, lipoproteína de baixa densidade, β-hidroxibutirato, malondialdeído, glucagon, insulina, interleucina-6 e fator de necrose tumoral. Seis fragmentos do fígado foram retirados e colocados em solução fisiológica a 0,9% para citometria de fluxo, e o restante do órgão colocado em solução de formalina neutra tamponada a 10% para microscopia óptica. O tecido adiposo branco periovariano bilateral foi retirado e pesado. Os resultados foram apresentados, como média e desvio padrão para a comparação, o teste t de Student, não pareado, e o teste ANOVA, seguido do teste de Tukey. Utilizou-se o teste de Pearson para estudos de correlação, sendo p<0,05 com significância. As médias de peso dos dois grupos aumentaram, sem diferença estatística no início e ao final. A média da ingestão de água foi 1,6 vezes maior no experimental. A média do consumo de dieta sempre foi significativamente menor no experimental, exceto na segunda semana. O peso do tecido adiposo foi menor no grupo experimental. Houve diferença estatística nas seguintes dosagens: transaminases, ureia, triacilglicerol, malondialdeído, e β- hidroxibutirato. Com exceção do triacilglicerol, todos foram maiores no grupo experimental. O peso do tecido adiposo periovariano foi menor no grupo de dieta experimental. A média do peso do fígado foi maior no grupo experimental. O aspecto macroscópico do fígado foi normal em ambos os grupos, e o estudo histológico do grupo experimental demonstrou sinusoides hepáticos alargados, hepatócitos de tamanho diminuído e glicogênio hepático diminuído. Não foi identificada autofagia dependende de Blimp-1 no estudo. A citometria de fluxo demonstrou que, o grupo experimental apresentou 30,85 ± 2,20% de células inviáveis; e no controle 13,22 ± 1,43%, com p<0,05. Houve correlação positiva entre o percentual de células inviáveis e malondialdeído plasmático, e negativa com triacilglicerol plasmático, o que pode sugerir serem estes possíveis indicadores plasmáticos de lesão hepática, associados à dieta experimental. Conclui-se que a dieta experimental levou à lesão hepática (apoptose) no estudo. / For many decades, ketogenic diets as Atkins diet, composed of 0% - 20% calories from carbohydrate, 55% - 65% protein and 25% - 35% lipids have been used to weight loss. More recently, the indication was expanded to some neurological diseases. The overall objective of the study is to assess the effect of a lowcarbohydrate, high-protein and lipids diet on the liver of rats by plasma biochemical analysis, histology and cytometric liver flow study.The hypothesis is that as the liver gets directly absorption of macronutrients, low- carbohydrates, high-protein and lipids diets can injure hepatocytes. Twenty female rats were divided into control diet group and experimental diet group. The control group received an AIN-93M diet and the experimental one a diet based on the Atkins's diet with carbohydrates (8.44%), protein (57.19%), lipids (34.36%) and water, ad libitum, for eight weeks. The rats in estrous cycle were anesthetized, weighted, capillary glucose was dosed and blood was collected for measurement of transaminases, urea, creatinine, triglycerides, cholesterol, high-density lipoprotein, low-density lipoprotein, β-hydroxybutyrate, malonaldehyde, glucagon, insulin, interleukin-6 and tumor necrosis factor. Six liver fragments were removed and placed in physiological solution at 0.9% for flow cytometry and the rest of the organ was put in a neutral buffered formalin 10% solution for optical microscopy. The white adipose tissue bilateral periovarian was pulled out and weighted. The results were presented as a mean and standard deviation, and the comparison between the average with Student's t-test unpaired, and ANOVA followed by Tukey test. Pearson's test was used for correlation studies. It was considered a statistically significant difference at p <0.05. The average weight of the two groups increased during the study. At the beginning and in the end of the study, there was no statistical difference in mean weight. The average water intake was 1.6 times higher in the experimental group. The average dietary intake was significantly lower in the experimental group, except in the second week. There was a statistical difference between the groups in only the following dosages: transaminases, urea, triglycerides, malondialdehyde, and β-hydroxybutyrate. Adipose tissue weight was smaller in the experimental group. The mean weight of liver was greater in the experimental. The macroscopic appearance of the liver was normal in both groups and the histological study demonstrated that the experimental group had an extended hepatic sinusoid, decreased the size of hepatocytes and decreased liver glycogen. Autophagy has not been identified. Flow cytometry showed statistical significance, in the experimental group 30.85% ± 2.20% were inviable cells while in the control group 13.22 ± 1.43% were, with p <0.05. There was a positive correlation between the percentage of non-viable cells and plasma malondialdehyde and a negative with plasma triglycerides suggesting that they are possible plasma indicators of hepatic injury associated with the experimental diet. Based on these results, it can be concluded that a low-carbohydrate and high-protein and lipids diet leads to liver damage, and apoptosis is the main cell injury process

The metabolic syndrome is a cluster of disorders (obesity, dyslipidaemia, hyperinsulinaemia and hypertension) which individually or collectively lead to an increase in the risk of cardiovascular disease. Over the years it has been associated with endothelial dysfunction, raised markers of chronic inflammation, insulin resistance and clotting dysregulation. Studies have shown that the prevalence of the metabolic syndrome in adults over the age of 20 years to be 24%, with approximately 12 million adults within the United Kingdom fulfilling the criteria for diagnosis. Numbers of individuals with the metabolic syndrome continue to rise following population trends of increasing sedentary lifestyle, high calorie intake, smoking, and stress. Associated is an increase in obesity, type 2 diabetes, cardiac disease, stroke and death. The increase is such that we can no longer be complacent about how we address the metabolic syndrome or its associated components. The management of the metabolic syndrome is varied and includes alterations in diet, physical exercise, and oral medication. It is well documented that a 10% reduction in weight leads to reductions in lipid abnormalities, diabetes and diabetes-related deaths, other total morbidity and deaths. Many dietary regimens have been postulated to benefit not only weight gain but improve cardiovascular risk. To address this we investigated the effect three different diets (low fat; low carbohydrate, high fat; and low glycaemic load) had on the metabolic syndrome to assess whether it is the changes in dietary caloric or macronutrient intake, or overall weight loss that had the greater influences on those aspects of metabolic syndrome which could potentially reduce cardiovascular risk.

Thesis (M.A.) - Carleton University, 2006. / Includes bibliographical references (p. 121-129). Also available in electronic format on the Internet.

Submitted by Programa de P?s-Gradua??o Engenharia El?trica (ppgee@ifpb.edu.br) on 2018-06-05T13:47:22Z No. of bitstreams: 1 49- Everson Pereira de Andrade - ESTUDO DA ESPECTROSCOPIA DIEL?TRICA DA MANGA TOMMY ATKINS NA FAIXA DE MICRO-ONDAS.pdf: 1850442 bytes, checksum: 909f819ce8e6c6e86c5c8d4f884f08bd (MD5) / Approved for entry into archive by Programa de P?s-Gradua??o Engenharia El?trica (ppgee@ifpb.edu.br) on 2018-06-05T13:59:34Z (GMT) No. of bitstreams: 1 49- Everson Pereira de Andrade - ESTUDO DA ESPECTROSCOPIA DIEL?TRICA DA MANGA TOMMY ATKINS NA FAIXA DE MICRO-ONDAS.pdf: 1850442 bytes, checksum: 909f819ce8e6c6e86c5c8d4f884f08bd (MD5) / Made available in DSpace on 2018-06-05T13:59:34Z (GMT). No. of bitstreams: 1 49- Everson Pereira de Andrade - ESTUDO DA ESPECTROSCOPIA DIEL?TRICA DA MANGA TOMMY ATKINS NA FAIXA DE MICRO-ONDAS.pdf: 1850442 bytes, checksum: 909f819ce8e6c6e86c5c8d4f884f08bd (MD5) Previous issue date: 2018-06-05 / A assinatura diel?trica da manga Tommy Atkins pelo m?todo da sonda coaxial, com compara??o da constante diel?trica e a tangente de perda em diversos est?dios de matura??o de frutos de um mesmo lote, produzidos na regi?o de Petrolina-PE ? apresentada neste trabalho. ? verificado a varia??o dos par?metros diel?tricos da fruta em diversas frequ?ncias, durante o processo de matura??o, considerando as transforma??es fisiol?gicas para a taxa de respira??o, forma??o de etileno, do amido, dos a??cares e ?cidos sol?veis titul?veis. Os resultados mostram uma grande correla??o entre os par?metros diel?tricos e o est?dio de matura??o da manga, quando se verifica a varia??o di?ria da constante diel?trica e fator de perdas. A assinatura diel?trica obtida permite identificar o pico de matura??o, que, para o manejo da amostra utilizada, ocorre aproximadamente no sexto dia ap?s a colheita. Os resultados tamb?m sugerem que os par?metros diel?tricos podem ser importantes indicadores na an?lise da manga Tommy Atkins, principalmente pela possibilidade de efetuar medidas externas, n?o destrutivas, o que pode se tornar uma ferramenta imprescind?vel para os produtores.

No description available.

The subject of this thesis is to document and reflect upon the design process for Temple University’s planned production of Rachel Atkins’ adaptation of William Wycherley’s The Country Wife. This account will discuss the process from inception through when production was postponed for public health reasons due to the global pandemic caused by the novel coronavirus COVID-19. This work will also serve to provide detailed descriptions of the costumes to be used by the costume shop to re-mount the production in August 2020. / Theater

Submitted by Élida Maeli Fernandes Quirino (maely_sax@hotmail.com) on 2018-06-15T18:49:55Z No. of bitstreams: 1 CARMELITA DE FÁTIMA AMARAL RIBEIRO - DISSERTAÇÃO PPGEA 2004..pdf: 33723212 bytes, checksum: fad7e8ae9b6ebe264a6a71d2aababe92 (MD5) / Made available in DSpace on 2018-06-15T18:49:55Z (GMT). No. of bitstreams: 1 CARMELITA DE FÁTIMA AMARAL RIBEIRO - DISSERTAÇÃO PPGEA 2004..pdf: 33723212 bytes, checksum: fad7e8ae9b6ebe264a6a71d2aababe92 (MD5) Previous issue date: 2004-03 / A manga (Mangifera indica L) é uma das frutas tropicais mais populares do mundo, ela se destaca pelo sabor, aroma e valor nutritivo. Apesar da alta tecnologia utilizada na produção de manga, ainda existem grandes perdas pós-colheitas, devido a fatores climáticos, físicos e químicos. Uma das principais causas da deterioração de alimentos frescos e também conservados é a quantidade de água livre presente nos mesmos. Este trabalho foi conduzido com o objetivo de estudar o processo de desidratação osmótica e cinética de secagem para obtenção de produtos secos de manga Tommy Atkins. As soluções utilizadas no processo de desidratação osmótica foram de sacarose e xarope de milho. A desidratação osmótica foi realizada de acordo com um planejamento fatorial completo 23, com pontos centrais e axiais, totalizando 17 ensaios. A influência dos fatores (temperatura, concentração e tempo) e suas interações sobre as respostas foram analisadas através de análise de variância (ANOVA), teste F e coeficiente de determinação (R2). Verificou-se que estes fatores mostraram ter efeito significativo sobre a perda de peso, perda de água e ganho de sólidos de manga desidratada, dentro das faixas estudadas, ou seja, com aumento desses fatores maior foi a influencia sobre as respostas estudadas. Neste estudo os fatores concentração e temperatura foram os de maior influência no processo de desidratação osmótica. As condições ótimas encontradas de desidratação osmótica utilizada como pré-tratamento para obtenção de uma maior perda de água e um menor ganho de sólidos foram: temperaturas de 50 e 40°C, concentração de 40 e 50% e tempo de imersão de 90 e 160 minutos, para a manga desidratada em solução de sacarose e xarope de milho, respectivamente. A etapa de secagem convencional das amostras in natura e desidratadas foi realizada em secador de leito fixo, nas temperaturas de 30, 40 e50°C e velocidade do ar de 2,1 m/s"1. Os dados experimentais de secagem convencional foram ajustados pelo modelo de Page. O produto final foi avaliado pelo pH, acidez e açúcares totais e redutores. / The mango {Mangifera indica. L) it is one of the more popular tropical fruits of the world, she stands out for the flavor, smell and nutritious value. In spite of the high technology used in the production of mango, great losses powder-crops still exist, due to climatic, physical and chemical factors. One of the main causes of the deterioration of fresh and also conserved victuals is the amount of present free water in the same ones. This work was driven with the objective of studying the process of osmotic and kinetic dehydration of drying conventional for obtaining of dry products of mango Tommy Atkins. The solutions used in the process of osmotic dehydration were of sucrose and corn syrup. The osmotic dehydration was accomplished in agreement with a planning complete fatorial 23, with central and axial points, totalizando 17 rehearsals. The influence of each variable and its interactions on the answers were analyzed through variance analysis (ANOVA), test F and determination coefficient (R2). It was verified that the factors (temperature, concentration and time) showed to have significant effect on the weight loss, loss of water and gain of solids of dehydrated sleeve, inside of the studied strips, that is to say, with those factors adulfs increase it went to it influences on the studied answers. In this study the factors concentration and temperature were the one of larger influence in the process of osmotic dehydration. The found great conditions of osmotic dehydration used as pré-treatment for obtaining of a larger loss of water and a smaller gain of solids were: temperatures of 50 and 40°C, concentration of 40 and 50% and time of immersion of 90 and 160 minutes, for the mango dehydrated in sucrose solution and corn syrup, respectively. The stage of drying conventional of the samples in natura and dehydrated it was accomplished in dryer of fixed bed, in the temperatures of 30, 40 and 50°C and speed ofthe air of 2,1 m/s"1. The experimental data of were drying conventional adjusted by Page model. The final product was evaluated by the pH, acidity and total sugars and reducers.