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Notre étude interroge de manière systématique ce qu’est l'âme humaine et comment elle constitue un individu dans la pensée de Fārābī. Nous y avons établi que la triade néoplatonicienne nature, âme et intellect structure sa pensée naturelle et qu’elle correspond en l'homme à la substantialité, la vie – en tant que principe général aux êtres vivants – et la pensée. Cette triade est liée à la notion de substantification et permet de comprendre la manière par laquelle différentes fonctions, naturelles, animées et intellectives, peuvent émaner d’une substance une. La constitution de l'individu humain se présente ainsi comme une substantification progressive par ces trois principes. Elle est marquée par une forte téléologisation qui assure l’unité substantielle de l’homme, puisque, lors de la génération de ce dernier, la substance réalisée par la nature puis par l'âme est dès le départ en vue de la réalisation de l'intellect et de sa perfection ultime, comprise comme un retour à soi. Face aux lectures dualistes de son époque, Fārābī revient à une compréhension particulière de l'âme comme forme du corps, et comme principe de l'unité le plus parfait dans le monde sublunaire. Sa compréhension originale de l'hylémorphisme permet de soutenir en même temps la séparabilité de l'intellect, à travers des éléments issus de la tradition néoplatonicienne, notamment l’organisation des fonctions et principes présents en l’homme en différents rangs intermédiaires. / Our work examines in a systematic way what is the human soul and how it constitutes an individual in al-Fārābī’s thought. We have shown in it that the Neoplatonist triad of nature, soul and intellect structures his natural thought and that it corresponds in man to substantiality, life – as a principle shared with all the living creatures – and thought. This triad is linked to the notion of substantification and allows us to understand the way different functions can emanate from what is a single substance. The way man is constituted by these three principles is presented as a progressive substantification characterized by a strong teleologisation. This teleologisation insures man’s substantial unity since, in the process of his generation, the substance realized first by nature and then by soul exists for the sake of its realization by the intellect and the attainment of man’s perfection, perceived as a return to the self. Facing the dualist positions of his time, al-Fārābī upheld a particular reading of the soul as the form of a body and as the most accomplished principle of unity in the sublunary world. His original comprehension of hylemorphism asserts the separability of the intellect through his usage of neoplatonist elements, notably the organization of the principles and functions that are present in the human substance into various intermediary ranks

This dissertation proposes an exploration of a variety of themes in philosophy of science through the lens of a case study in evolutionary biology. It draws from a careful analysis and comparison of the hypotheses from Bill Martin and Tom Cavalier-Smith. These two scientists produced contrasted and competing accounts for one of the main events in the history of life, the origin of eukaryotic cells. This case study feeds four main philosophical themes around which this dissertation is articulated. (1) Theorizing: What kind of theory are hypotheses about unique events in the past? (2) Representation: How do hypotheses about the past represent their target? (3) Evidential claims: What kind of evidence is employed and how do they constrain these hypotheses? (4) Pluralism: What are the benefits and the risks associated with the coexistence of rival hypotheses? This work both seeks to rearticulate traditional debates in philosophy of science in the light of a lesser-known case of scientific practice and to enrich the catalogue of existing case studies in the philosophy of historical sciences.

Bio-membranes: A Biological Approach to Architecture The desire to introduce an area of study which can potentially inform the field of architecture on a theoretical as well as on a practical level, is the primary aim of this creative project. More specifically, the interest of this work is focused on the identification of useful processes deriving from the world of biology and their utilization in the world of architecture. The designation of an alternative path for perceiving and understanding processing and principles that may be of use in the reconfiguration of various architectural design applications is in quest. In search of a biological model that can potentially inform the field of architecture and provide enough feedback concerning the understanding of "processing" and "principles", biomembrane systems have been designated as the appropriate subject of study. The study and analysis of the structural and functional aspects of the bio-membranes as well as the extraction of useful principles that are derived from this study consist the first part of this work. The second part describes the implementation of these principles into various architectural applications while it challenges existing paradigms and introduces new ways of looking into the realm of architectural theory. / Department of Architecture

This research study investigated preschoolers' naive theory of the human body in understanding the cause of death. The empirical investigation showed that urban and suburban preschoolers (ages 5 and 6) have an understanding of a naive theory of the human body and that some do make reference to a 'vitalistic causality' in explaining organ function. Furthermore, most of the participants gave an external explanation for the cause of death (e.g. gunshots, poison, sticks), but those participants who gave an internal (biological) explanation for the cause of death were well-informed about the biological teleology of body organs. These findings conclude that education, socio-economic factors and culture influence the acquisition of a naive theory of biology. The need for guidance to educators, in explaining the concept of death to preschoolers, was further emphasised. / Educational Studies / M.Ed. (Psychology of Education)

This research study investigated preschoolers' naive theory of the human body in understanding the cause of death. The empirical investigation showed that urban and suburban preschoolers (ages 5 and 6) have an understanding of a naive theory of the human body and that some do make reference to a 'vitalistic causality' in explaining organ function. Furthermore, most of the participants gave an external explanation for the cause of death (e.g. gunshots, poison, sticks), but those participants who gave an internal (biological) explanation for the cause of death were well-informed about the biological teleology of body organs. These findings conclude that education, socio-economic factors and culture influence the acquisition of a naive theory of biology. The need for guidance to educators, in explaining the concept of death to preschoolers, was further emphasised. / Educational Studies / M.Ed. (Psychology of Education)

This dissertation clarifies the concept of evolvability, the increased capacity of some organisms or systems to support evolution, especially the evolution of life-like complexity. I survey the literature, which is spread over the fields of population genetics, developmental biology, artificial life, and microbial and molecular evolution. Finding that researchers have often used the term vaguely and incompatibly I identify five distinct kinds or senses of evolvability. I also identify five key constituent ideas, which I discuss in the context of organismic evolvability, a sense of evolvability with deep roots in the traditional fields of animal development and macroevolution. In these fields research into evolvability has historically been hampered by an insufficiently detailed knowledge of development. Research in molecular evolution has produced a thorough knowledge of the folding of RNA into secondary structure, which can be regarded as a model of development. This has motivated new approaches to evolvability based on representing development via a single genotype-phenotype mapping function. I build on these approaches to invent new mathematical methods to formalise the traditional ideas. I create an exact model illustrating a classic example of evolvability, the capacity for repeated segmentation and simple modularity. I analyse this with two new formal approaches. First is the genospace algebra, a propositional calculus based on graph theory. It is a formal language for describing genotype-phenotype maps. It provides a system for making calculations, proofs, and diagrams about mutational structures in genotype space, and it is flexible enough to allow description at arbitrary degrees of resolution. Second is a pair of concepts, the genetic leverage and the genetic fulcrum. The leverage provides a crude numerical measure of evolvability, and the fulcrum provides a heuristic for identifying the genomic and developmental causes of evolvability. Besides its specific relevance to diversification and development, evolvability is also crucial to the fundamental question of how evolution produces ordinary biological life. Simulation systems that implement only a conventional textbook model of evolution -– systems possessing only variation, inheritance, and selection –- fail to evolve anything resembling the complexity of the biological world. Research into evolvability is our best bet to illuminate the "missing ingredient" for life-like evolution.

Le contexte historique et épistémologique de l’émergence de la génétique des comportements en tant que discipline trouve ses racines dans différentes disciplines biologiques :la génétique, la biologie de l’évolution et la biologie moléculaire. Ces dernières font partie du paradigme néodarwinien moléculaire. De cette origine, elle a hérité deux grands domaines de recherche, la génétique quantitative et la génétique moléculaire. Ils ont chacun des objectifs et des méthodologies différents. Les études concernant l’intelligence, les comportements agressifs, les comportements addictifs et l’orientation sexuelle permettent notamment d’illustrer ces différences. Elles permettent également de faire un état des lieux des recherches menées dans ce domaine parfois hautement polémique. En fait, la génétique des comportements est marquée par deux ères épistémologiques, l’ère génomique qui a débuté dans les années 1980 et l’ère post-génomique, qui comme son nom l’indique, lui succède dès le début des années 2000. Les résultats apportés par l’ensemble de ces recherches imposent une conclusion, les approches théoriques et techniques phares de l’ère génomique sont insuffisantes à rendre compte de la complexité des phénomènes développementaux liés aux comportements. L’ère post-génomique tente donc de combler les faiblesses de l’ère précédente. Ainsi, la biologie développementale revient au premier plan et ce retour est souhaité depuis longtemps par un courant philosophique majeur né dans les années 1990, la Developmental Systems Theory. L’ère post-génomique est également caractérisée par un pluralisme pragmatique, à la fois théorique et expérimental. La nécessité de multiplier les modes d’appréhension des comportements s’impose car leur complexité intrinsèque est reconnue et tend à être assumée. Les résultats plus récents apportés par les recherches sur l’intelligence, les comportements agressifs, addictifs et l’orientation sexuelle illustrent cette évolution épistémologique. L’opposition entre inné et acquis échoue à rendre compte de la complexité et du dynamisme développemental des phénotypes comportementaux./ The historical and epistemological context of the birth of behavioral genetics as a discipline has its roots in different biological domains: genetics, evolutionary biology and molecular biology. They are parts of the molecular neo-Darwinian paradigm. From this multiple outset, behavioral genetics has inherited two major areas of research, quantitative genetics and molecular genetics. They each have different purposes and methodologies. The study of researches on IQ, aggressive behaviors, addictive behaviors and sexual orientation illustrate these differences. It also permits to make an overview of results provided in this field that is sometimes highly controversial. In fact, behavioral genetics is marked by two epistemological eras, the genomic era that began in the 1980s and the postgenomic era that began by the early 2000s. The results provided by all these researches lead to one conclusion, the theoretical and technical approaches of the genomic era is insufficient to show the complexity of developmental phenomena associated with behaviors. The postgenomic era attempts to correct the weaknesses of the previous era. Thus, developmental biology comes back in the foreground and the necessity of this return has been defended by a major philosophical theory born in 1990, the Developmental Systems Theory. The postgenomic era is also characterized by a theoretical and experimental pragmatic pluralism. The complexity of the developmental patterns of behaviors is recognized and tends to be assumed. The latest results produce by researches on IQ, aggressive behaviors, addiction and sexual orientation illustrate these epistemological changes. The opposition between nature and nurture fails to properly apprehend the developmental dynamism of behavioral phenotypes. / Doctorat en Philosophie / info:eu-repo/semantics/nonPublished

Orientador: Laymert Garcia dos Santos / Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciencias Humanas / Made available in DSpace on 2018-08-05T01:28:26Z (GMT). No. of bitstreams: 1 Leite_Marcelo_D.pdf: 18137235 bytes, checksum: d2ccf296709649c706ae95e568a4a4e8 (MD5) Previous issue date: 2005 / Resumo: A tese central deste trabalho é que a aceitação pública despertada pelo Projeto Genoma Humano só se explica pelo uso político e retórico de um determinismo genético crescentemente irreconciliável com os resultados empíricos da pesquisa genômica atual. A complexidade verificada no genoma humano e em suas interações com o meio desautoriza a manutenção de uma noção simples e unidirecional de causalidade, contrariamente ao pressuposto na idéia de gene como único portador de informação, esteio da doutrina do determinismo genético. Um complexo de metáforas informacionais e/ou lingüísticas continuo vivo nos textos publicados por biólogos moleculares na literatura científica, notadamente nos artigos veiculados nos periódicos de alto impacto Nature e Science de 15 e 16 fevereiro de 2001, respectivamente. Tais metáforas inspiram um tipo de discurso ambíguo que modula nuances variadas de retórica determinista, conforme se dirija aos próprios pares ou ao público leigo" O campo da genômica ainda está longe de rejeitar a conjunção problemática das noções de gene pré-formacionista e de gene como recurso desenvo/vimenta/ na base da metáfora do gene como informação. Essa fusão inspirada pela terminologia cibernética propicia uma versão asséptica de gene, distanciada da natureza, puramente sintática, móvel e virtual o bastante para circular desimpedida nos circuitos de produção de valor como recurso genético passível de garimpagem e de patenteamento. Críticos dã tecnociência devem desafiar o campo da genômica a reformular drasticamente as metáforas que dão suporte a seu programa hegemônico de pesquisa / Abstract: The central thesis of this work is that the public support generated for the Human Genome Project and the hype surrounding it can be explained only by the political and rhetorical uses of genetic determinism, a notion which increasingly cannot be reconciled with the empirical results of on-going genomic research. The complexity that has been uncovered in the human genome and in its interactions with the environment implies that a simple and unidirectional notion of causality cannot be maintained, contrary to a presupposition of the idea of the gene as the sole carrier of iliformation, an idea that contributes to sustain the doctrine of genetic determinism. A complex of informational and/or linguistic metaphors lives on in the texts published by molecular biologists in the scientific press, most notably in the issues published February 15thand 16thof 2001 ofthe high impact journals Nature and Science, respectively. These metaphors generate an ambiguous type of discourse that modulates various nuances of deterministic rhetoric, depending on whether it addresses peers or the lay publico The field of genomics is still a long way ITom rejecting the questionable conflation of the notions of gene as preformation and gene as developmental resource which underpins the metaphor of gene as information. This conflation inspired by cybernetics terminology enables an aseptic version of the gene, separated ITom nature, portable and virtual enough to flow unimpeded through the channels ofvalue production as genetic resource suitable for mining and patenting. Critics of technoscience should challenge the field of genomics to drastically reshape the metaphors which have supported its hegemonic research agenda / Doutorado / Doutor em Ciências Sociais