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Impacto de 4 semanas de treinamento intervalado de alta intensidade sobre variáveis fisiológicas determinantes da aptidão aeróbia e a estratégia de corrida adotada durante um teste contra-relógio de 5 km / Impact of 4-weeks high intensity interval training program over physiological variables determinants of endurance performance and over pacing strategy adopted during a 5-km time-trial testRogerio Carvalho da Silva 09 December 2013 (has links)
Estratégia de corrida é forma pela qual os corredores distribuem a velocidade durante uma competição. Objetivando otimizar a utilização dos recursos energéticos, bem como melhorar o desempenho geral na prova, durante uma corrida de 5 km os atletas comumente adotam uma estratégia caracterizada por um início em alta velocidade, seguido por um trecho intermediário em velocidade inferior, e finalmente os atletas aumentam a velocidade quando se aproximam dos 400 m finais da prova. Sabe-se que o treinamento intervalado de alta intensidade (TIAI) realizado ao longo de 3 a 6 semanas é capaz de promover melhoras significativas nas variáveis fisiológicas determinantes do desempenho aeróbio, tais como VO2max, EC, VP, e OBLA. Uma vez que os atletas monitoram a PSE baseado em sinais internos (fisiológicos) e externos (ambiente), e desta forma alteram a velocidade para evitarem o término prematuro do exercício, acredita-se que melhoras em tais variáveis fisiológicas possam permitir que os corredores modifiquem a estratégia de corrida. Portanto, o principal objetivo do presente estudo foi analisar a influência de quatro semanas de TIAI sobre a PSE e também sobre a estratégia de corrida adotada por corredores durante um teste contra-relógio de 5 km (T5). Vinte sujeitos, homens, corredores recreacionais de longa distância foram distribuídos de forma contrabalançada em grupo controle (CON, n = 10; 33,5 ± 6,2 anos) e grupo treinamento intervalado (TINT, n = 10; 32,9 ± 8,6 anos). TINT realizou uma sessão de TIAI duas vezes por semana, enquanto que CON manteve seu programa regular de treinamento. Antes e após o período de intervenção, os corredores realizaram: 1) um teste incremental até exaustão para se obter o início do acúmulo de lactato sanguíneo (OBLA), o consumo máximo de oxigênio (VO2max), e a velocidade pico em esteira (VP); 2) um teste submáximo de carga constante para se medir a economia de corrida (EC); 3) e um teste contra-relógio de 5 km (T5) em pista para se estabelecer a estratégia de corrida. O programa de TIAI produziu uma melhora relevante no VO2max (effect size = 0,219), OBLA (effect size = 0,489), EC (effect size = -0,593), e VP (effect size = 0,622). Não foram detectadas alterações significativas na estratégia de corrida, TT5, VT5 e PSET5 durante o T5, comparando ambas as condições (pré e pós-treinamento) ou entre os grupos (TINT e CON; P > 0,05). Esses achados sugerem que melhoras nas variáveis fisiológicas induzidas por um programa de quatro semanas de TIAI não são acompanhadas por alterações similares na PSE e na estratégia de corrida durante um teste contra-relógio de 5 km / Pacing strategy has been defined as the manner by which the runners distribute their speed during a competition. In order to optimize the use of the energetic resources, as well as improve the general race performance, during a 5-km running race, athletes usually adopt a pacing strategy characterized by a fast start (400 m), followed by a period of slower speed during the middle (400 4600 m), and a significant increase in running speed during the last part of the race (400 m). It is well recognized that high-intensity interval training (HIIT) performed along 3 to 6 weeks is able to promote significant improvements in physiological variables determinants of endurance performance, such as VO2max, RE, PTS, and OBLA. Since athletes monitor their RPE based on the internal (physiological) and external (environment) signals, and change their running speed in order to prevent a premature exercise termination, its believed that improvements in such physiological variables could enable athletes to modify the pacing strategy. Thus, the main purpose of this study was to analyze the influence of 4 weeks of high-intensity interval training (HIIT) on the rating of perceived exertion (RPE) and the pacing strategy adopted by runners during a 5-km running time-trial (T5). Twenty male, recreational long-distance runners were randomly assigned into control group (CG, n = 10) or high-intensity interval-training group (HIITG, n = 10). The HIITG performed a high-intensity interval-training session twice per week, while CG maintained its regular training program. Before and after the training period, the runners performed the following tests: 1) an incremental exercise test to exhaustion to measure the onset of blood lactate accumulation (OBLA), maximal oxygen uptake (VO2max), and peak treadmill speed (PTS); 2) a submaximal speed-constant test to measure the running economy (RE); 3) a 5-km running time-trial on an outdoor track to establish pacing strategy. HIIT program produced a relevant improvement on the VO2max (effect size = 0.219), OBLA (effect size = 0.489), RE (effect size = -0.593), and PTS (effect size = 0.622). There were no significant differences on pacing strategy, TT5, ST5 and RPE response during the 5-km running time-trial between both conditions (pre- and post-training) or between groups (HIITG and CG; P > 0.05). These findings suggest that improvements on the physiological variables induced by a 4-week HIIT program are not accompanied by similar modifications on the RPE and running pacing strategy during a 5-km running time-trial
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Roller skis' rolling resistance and grip characteristics : influences on physiological and performance measures in cross-country skiersAinegren, Mats January 2012 (has links)
The aim of this thesis was to investigate roller ski characteristics; classical and freestyle roller skis’ rolling resistance coefficients (μR) and classical style roller skis’ static friction coefficients (μS), and to study the influence of different μR and μS on cross-country skiers’ performance and both physiological and biomechanical indices. The aim was also to study differences in skiing economy and efficiency between recreational skiers, female and male junior and senior elite cross-country skiers.The experiments showed that during a time period of 30 minutes of rolling on a treadmill (warm-up), μR decreased significantly (p<0.05) to about 60-65 % and 70-75 % of its initial value for freestyle and classical roller skis respectively. Also, there was a significant influence of normal force on μR, while different velocities and inclinations of the treadmill only resulted in small changes in μR.The study of the influence on physiological variables of a ~50 % change in μR showed that during submaximal steady rate exercise, external power, oxygen uptake, heart rate and blood lactate were significantly changed, while there were non-significant or only small changes to cycle rate, cycle length and ratings of perceived exertion. Incremental maximal tests showed that time to exhaustion was significantly changed and this occurred without a change in maximal power, maximal oxygen uptake, maximal heart rate and blood lactate, and that the influence on ratings of perceived exertion was non-significant or small.The study of classical style roller skis μS showed values that were five to eight times more than the values of μS reported from on-snow skiing with grip-waxed cross-country skis.The subsequent physiological and biomechanical experiments with different μS showed a significantly lower skiing economy (~14 % higher v̇O2), higher heart rate, lower propulsive forces coming from the legs and shorter time to exhaustion (~30 %) when using a different type of roller ski with a μS similar to on-snow skiing, while there was no difference between tests when using different pairs of roller skis with a (similar) higher μS.The part of the thesis which focused on skiing economy and efficiency as a function of skill, age and gender, showed that the elite cross-country skiers had better skiing economy and higher gross efficiency (5-18 %) compared with the recreational skiers, and the senior elite had better economy and higher efficiency (4-5 %) than their junior counterparts, while no differences could be found between the genders. / Syftet med denna avhandling var att undersöka fristils- och klassiska rullskidors rullmotståndskoefficienter (μR) och klassiska rullskidors statiska friktionskoefficienter (μS) samt effekter av olika μR och μS på längdskidåkares prestation vid rullskidåkning på rullande band. Syftet var även att undersöka s.k. åkekonomi och mekanisk verkningsgrad mellan motionärer och kvinnliga och manliga junior- och seniorlängdskidåkare på elitnivå.Experimenten visade att under en period av 30 minuters kontinuerligt rullande, på rullande band, så sjönk μR signifikant (p<0.05) till 60-65 % och 70-75 % av initiala värden, för fristils- respektive klassiska rullskidor. Undersökandet av olika normalkrafter, hastigheter och lutningars påverkan på μR resulterade i en signifikant, negativ korrelation för μR som funktion av normalkraft, medan olika hastigheter och lutningar endast medförde små förändringar av μR.Studien som undersökte fysiologiska effekter av olika μR visade, vid submaximala konstanta arbetsbelastningar, att yttre effekt, syreupptagning, hjärtfrekvens och blodlaktat förändrades signifikant vid ~50 % förändring av μR. Försökspersonernas frekvens och sträcka per frekvens samt skattning av upplevd ansträngning resulterade dock i mestadels icke signifikanta eller små förändringar. Protokollen med successivt ökande arbetsbelastning (maxtest) resulterade i signifikant förändrad tid till utmattning, vid ~50 % förändring av μR. Detta inträffade utan signifikant skillnad i maximal syreupptagning, hjärtfrekvens och blodlaktat, vilket även mestadels gällde för skattning av upplevd ansträngning.Experimenten som undersökte klassiska rullskidors μS visade att dessa erhöll värden som är fem till åtta gånger högre än vad som rapporterats från studier av μS på snö med fästvallade skidor.Den efterföljande studien som undersökte fysiologiska och biomekaniska influenser av olika μS visade, vid submaximala konstanta arbetsbelastningar, att åkekonomin försämrades (~14 % högre syreförbrukning), hjärtfrekvensen ökade, den framåtdrivande kraften från benen på rullskidorna minskade samt att det blev kortare tid till utmattning (~30 %), vid maxtest, när skidåkarna använde rullskidor med en μS i likhet med vad som rapporterats för skidåkning på snö. För arbetsförsöken med olika rullskidor av olika fabrikat med en högre, och likartad, μS förelåg ingen skillnad i de undersökta variablerna.Studien som undersökte åkekonomi och mekanisk verkningsgrad som funktion av prestationsnivå, ålder och kön, visade att elitskidåkarna hade bättre åkekonomi och verkningsgrad (5-18 %) i jämförelse med motionärerna, att seniorerna hade bättre åkekonomi och verkningsgrad (4-5 %) än juniorerna och att ingen skillnad kunde konstateras mellan könen.
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Interação da variabilidade da freqüência cardíaca e do lactato sanguíneo durante o exercício resistido em idosos saudáveisSimões, Rodrigo Polaquini 22 February 2008 (has links)
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Previous issue date: 2008-02-22 / Universidade Federal de Minas Gerais / The anaerobic threshold (AT) is an important parameter for prescription of physical
exercise in various clinical conditions, because represent the intensity of effort at
which the aerobic metabolism begins to be supplemented by anaerobic metabolism
for the production of energy. In this context, different methods to identify AT have
been described, for example by analysis of blood lactate and the respiratory gas
exchanges, yet such methods require expensive equipment and materials. Low cost
non-invasive techniques such as heart rate variability (HRV) have been proposed to
determine the AT; however, they are most commonly applied in discontinuous
protocols on a cycle ergometer or treadmill. Therefore, the objectives of this study
were to evaluate the behavior of HRV and blood lactate during resistance exercise
(RE) with increasing resistances at a percentage of one repetition maximum (1RM),
and investigate the existence of an aerobic-anaerobic transition point in the
metabolism during lower leg exercise in healthy older adults. Secondarily, our
objective was to evaluate the relationship between different methods, as well as the
degree of concordance between the same. Ten healthy men ranging in age from 60
to 70 years old (mean and SD: 64 ± 4 years, 166 ± 3 cm, 70 ± 7 kg), underwent
medical examination, ergonomic testing and laboratory exams (hemogram,
triglycerides, total and fractional cholesterols, glycemia and uric acid. The protocol
for RE was administered on Leg Press 45° (Pró-Fitness) equipment. The protocol
resistance loads used were determined by 1RM test; the volunteer complete one full
cycle on the equipment at the maximum resistance load that the volunteer could
achieve, and the resistance load increases were calculated from this test value at
rates of 10% of 1RM until a 30% increase and then at increments of 5% until
exhaustion. At each percentage increase of effort, the volunteer performed 4 minutes
of exercise followed a rest interval of 15 minutes. Heart rate was captured throughout
the protocol by a Polar Vantage Heart rate monitor connected to a Polar Advantage
Interface that transmitted the data in real time to a Soyo Notebook computer. The
blood samples were collected before the initial effort and immediately after the end of
each resistance load. Blood lactate and HRV were analyzed at rest conditions with
the volunteer positioned on the equipment and at each percentage of effort. The
indexes utilized for HRV analysis were RMSSD, RMSM, SD1, SD2 and SD1/SD2
ratio. To identify the aerobic-anaerobic transition point, blood lactate concentrations
were used (gold standard) as well as SD1 and RMSSD indexes; and these points
were denominated as lactate threshold (LT), SD1 threshold (SD1T) and RMSSD
threshold (RMSSDT). The level of significance for all statistical tests was set at 5%.
The principal result showed that the mean of the RMSSD, RMSM and SD1 indexes
reduced significantly at 30% 1RM in relation to the rest condition, and blood lactate
presented an exponential increase at 30% 1RM, that was significantly greater in
relation to the rest condition at 35%. There was no significant difference in relation to
absolute and relative values for resistance loads at which the aerobic-anaerobic
transition point was identified (absolute values: LT = 101 ± 32 kg, SD1T = 96 ± 28 kg,
RMSSDT = 97 ± 21 kg; Relative values: LT = 30 ± 6%, SD1T = 29 ± 6%, RMSSDT =
29 ± 5%). Additionally, good concordance and good correlation were found between
LT and RMSSDT (r = 0.78) and between LT and SD1T (0.81). It can be concluded
that the behavior of HRV and blood lactate change markedly at 30% 1RM during
resistance exercise on the Leg Press 45°. It was possible at this percentage to
identify the aerobic-anaerobic metabolism transition point by blood lactate as well as
by HRV in healthy older men. / físico em várias condições clínicas, pois representa a intensidade de esforço a qual o
metabolismo aeróbio passa a ser suplementado pelo metabolismo anaeróbio para a
produção de energia. Neste contexto, tem sido descritos diferentes métodos para a
determinação do LA por meio de análises da concentração sangüínea de lactato e
das trocas gasosas respiratórias, entretanto, tais métodos necessitam de
equipamentos e materiais de alto custo. Desta forma, técnicas não-invasivas e de
baixo custo como as análises da variabilidade da freqüência cardíaca (VFC) têm sido
propostas para determinação do LA, no entanto, em sua grande maioria tem sido
aplicadas em protocolos descontínuos em cicloergômetro ou esteira. Assim, os
objetivos deste estudo foram avaliar o comportamento da VFC e do lactato
sangüíneo durante o exercício físico resistido (EFR) com o incremento de resistência
em percentual de uma repetição máxima (1RM), e investigar a existência de um
ponto de transição do metabolismo aeróbio-anaeróbio durante o exercício resistido
de membros inferiores em idosos saudáveis. Secundariamente, tivemos como
objetivo avaliar o relacionamento entre os diferentes métodos, bem como o grau de
concordância dos mesmos. Foram avaliados 10 homens saudáveis com faixa etária
entre 60 e 70 anos (média e DP: 64 ± 4 anos, 166 ± 3 cm, 70 ± 7 kg), sendo
submetidos à avaliação médica, teste ergométrico e solicitado exames laboratoriais
(hemograma, triglicérides, colesterol total e frações, glicemia e ácido úrico). O
protocolo de EFR foi aplicado no equipamento Leg Press 45° (Pró-Fitness) sendo
que para a determinação das cargas que seriam utilizas, foi realizado previamente o
teste de 1RM, no qual o voluntário fez apenas um ciclo completo do movimento no
equipamento com a carga máxima suportada, e a partir deste valor, foi estabelecido
o protocolo de incremento de cargas, partindo de 10% de 1RM, com acréscimos
subseqüentes de 10% até a carga de 30%, e de 5% a partir desta, até a exaustão
voluntária. Em cada percentual de esforço, o voluntário foi submetido a 4 minutos de
exercício e 15 minutos de repouso pós-esforço. A freqüência cardíaca (FC) foi
captada durante todo protocolo por um cardiofreqüencímetro (Polar Vantage)
interligado a uma interface (Polar Advantage), que transmitia os dados online para o
computador (Notebook Soyo). Para a analise do lactato, foram coletadas amostras
de sangue previamente ao início do esforço e imediatamente após o término de
cada carga aplicada. Tanto o lactato sangüíneo quanto a VFC foram analisados nas
condições de repouso, com o voluntário posicionado no equipamento, e em cada
percentual de esforço. Os índices utilizados para a análise da VFC foram o RMSSD,
RMSM, SD1, SD2 e a razão SD1/SD2. Para a identificação do ponto de transição
aeróbio-anaeróbio as concentrações de lactato sangüíneo foram utilizadas como
padrão ouro, sendo também utilizados os índices SD1 e RMSSD; estes pontos foram
denominados de limiar de lactato (LL), limiar de SD1 (LSD1) e limiar de RMSSD
(LRMSSD). O nível de significância adotado em todos testes estatísticos foi de 5%.
Os principais resultados mostraram que os índices RMSSD, RMSM e SD1 reduziram
significativamente a partir dos 30% de 1RM em relação à condição de repouso, tal
como o lactato sangüíneo apresentou aumento exponencial a partir dos 30% de
1RM. Não houve diferença significativa para os valores absolutos e relativos da
carga na qual o ponto de transição aeróbio-anaeróbio foi identificado (valores
absolutos: LL = 101 ± 32 kg, LSD1 = 96 ± 28 kg, LRMSSD = 97 ± 21 kg; valores
relativos: LL = 30 ± 6%, LSD1 = 29 ± 6%, LRMSSD = 29 ± 5%). Adicionalmente, boa
concordância e fortes correlações foram encontradas entre o LL e LRMSSD (r =
0,78) e entre o LL e LSD1 (0,81). Conclui-se que o comportamento da VFC e do
lactato sangüíneo se modifica marcantemente a partir dos 30% de 1RM durante o
exercício resistido realizado no Leg Press a 45°, sendo que neste percentual foi
possível identificar o ponto de transição do metabolismo aeróbio-anaeróbio, tanto
por meio da lactacidemia como pela VFC em idosos saudáveis.
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Determinação das zonas de transição metabólica durante a corrida mediante os limiares de variabilidade da frequência cardíaca / Determination of transition metabolic zones during running using hert rate variability thresholdsEduardo Marcel Fernandes Nascimento 17 January 2011 (has links)
O propósito do presente estudo foi obter evidências de validade e reprodutibilidade dos limiares de variabilidade da frequência cardíaca (VFC) durante a corrida. Dezenove sujeitos homens, saudáveis e praticantes de corrida (30,4 ± 4,1 anos; 175,9 ± 6,4 cm; 74,3 ± 8,5 kg) foram submetidos a um teste progressivo máximo em esteira rolante com velocidade inicial 5 km.h-1 e incrementos de 1 km.h-1 a cada 3 minutos (1% de inclinação constante) até exaustão voluntária. Todos os indivíduos realizaram o reteste em um intervalo de tempo entre 48 horas e uma semana. Foram realizadas as medidas das trocas gasosas, do lactato sanguíneo e da VFC (plotagem de Poincaré). Os limiares aeróbio (LAe) e anaeróbio (LAn) foram determinados pelos limares de lactato, ventilatórios e da VFC. Para a comparação entre os métodos foi uitlizada ANOVA para medidas repetidas, acompanhada de teste de post hoc de Bonferroni. A reprodutibilidade das variáveis analisadas foram verificadas pela plotagem de Bland-Altman e pelo coeficiente de correlação intraclasse (CCI). Os resultados do presente estudo demonstraram que a velocidade correspondente ao segundo e terceiro modelos utilizados para se determinar o LA pela VFC não eram significativamente diferentes (p > 0,05) do primeiro limiar de lactato e ventilatório. Em relação ao LAn, não foram observadas diferenças significativas nas velocidades correspondentes ao LAn detectado pelos diferentes métodos (p > 0,05). Os valores do CCI estavam entre 0,69 a 0,80 (p < 0,001). Conclui-se que o LAe e o LAn podem ser identificados pela análise da VFC, desde que se utilize os procedimentos empregados na presente investigação / The aim of the present study was to obtain evidences of validity and reliability of the thresholds of heart rate variability (HRV). Nineteen male subjects, healthy and runners (30,4 ± 4,1 years; 175,9 ± 6,4 cm; 74,3 ± 8,5 kg) performed a progressive maximal test on a treadmill with initial velocity 5 km.h-1 e increases of 1 km.h-1 every 3 minutes (1% slope) until voluntary exhaustion. All subjects performed the retest at an interval of time between 48 hours and one week. It was measured gas exchange, blood lactate and heart rate variability (Poincaré plot). The aerobic threshold (AT) and anaerobic (AnT) were determined by lactate, ventilatory and heart rate variability. ANOVA for repeated measures and post-hoc test of Bonferroni was used to compare the methods. To analyze the reproducibility of the variables were used the Bland- Altman plots and intraclass correlation coefficient (ICC). The results of this study show that the velocity at the second and third models employed to determine the AT by HRV were not significantly different (p > 0.05) of the first lactate threshold and ventilatory. Similarly, there were no significant differences in the velocities corresponding to AnT detected by different methods (p> 0.05). The ICC values were between 0.69 to 0.80 (p < 0.001). We conclude that the AT and the AnT can be estimated by HRV analysis, since it utilizes the procedures employed in this study
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Physiological characteristics of sodium lactate infusion during resistance exercise / Fysiologisk karakteristika av natriumlaktat infusion under styrketräningDanielsson, Sebastian January 2019 (has links)
Previous studies that utilized sodium lactate infusion did not use resistance exercise protocol or analyzed muscle biopsies, or performed sex specific analysis. Aim: We initiated a project where resistance exercise was performed with low and high levels of lactate, acquired by venous lactate infusion where the specific aim of this study was to investigate and chart the physiological characteristics of sodium lactate infusion during a bout of resistance exercise on whole group level and sexes separated Method: A randomized, placebo controlled, cross-over design was implemented where male (n = 8) and female (n = 8) subjects accustomed to resistance exercise visited the laboratory three times for preliminary testing and training familiarization. In the following two experimental trials subjects arrived in an overnight fasted state. A resting state muscle biopsy was extracted from m. vastus lateralis and repeated blood samples were initiated which followed by 20 minute of baseline infusion of either infusate in resting state at 0.05 mmol/kg/min infusion rate with additional bolus doses during subsequent exercise. Following a brief warm up, unilateral knee-extensions (6 x 8-10 reps at 75% of 1-RM) were performered with or without venous infusion of sodium lactate, with volume matched saline as control. Exercise load and volume were matched between trials. Four additional biopsies were extracted at post-exercise, recovery period, and 24-hour post-exercise. Results: Sodium lactate infusion vs saline infusion respectively during resistance exercise yielded significantly higher blood lactate with sodium lactate (6.78 ± 0.33 mmol/l vs 2.99 ± 0.17 mmol/l), plasma lactate (8.86 ± 0.39 mmol/l vs 4.39 ± 0.22 mmol/l), blood sodium (143 ± 0.4 mmol/l vs 142 ± 0.3 mmol/l), blood pH (7.42 ± 0.01 vs 7.34 ± 0.01), but lower blood potassium (3.9 ± 0.1 mmol/l vs 4.2 ± 0.1 mmol/l), all immediately following exercise. Sodium lactate infusion elicited main effect of trials and muscle lactate increased from baseline (8.5 ± 0.9 mmol·kg-1 dw vs 7.0 ± 0.6 mmol·kg-1 dw) to post-exercise (31.5 ± 2.8 mmol·kg-1 dw vs 26.9 ± 3.2 mmol·kg-1 dw) with sodium lactate and saline infusion respectively. Blood glucose, hemoglobin and muscle pH was not affected by sodium lactate infusion. Conclusions: Utilization of the sodium lactate infusion method during a bout of resistance exercise may be used as tool to effectively increase blood/plasma lactate and, to lesser extent, muscle content of lactate. However, a concomitant slightly alkalizing effect of blood likely will occur. / Tidigare studier som använt natriumlaktat infusion använde inte styrketräningsprotokoll, eller analyserade muskelbiopsier eller utförde könsspecifika analyser. Syfte och frågeställningar: Vi initierade ett projekt där styrketräning utfördes med låga eller höga nivåer av laktat som erhölls genom venös natriumlaktat infusion med det specifika syftet att undersöka och kartlägga fysiologisk karakteristiska av naturiumlaktat infusion under styrketräningsövning på helgrupps- och könsseparerad nivå. Följande frågeställningar inrättades; hur påverkar natriumlaktat infusion under styrketräning helblod- och plasma laktat, glukos, natrium, kalium, plasma volym genom hemoglobin och hematokrit, blod pH, muskellaktat- och muskel pH samt om skillnader i respons finns efter att könsspecifika analyser utförts på dessa variabler. Metod: En randomiserad, placebokontrollerad cross-over design implementerades där styrketräningsvana män (n = 8) och kvinnor (n = 8) besökte laboratoriet tre gånger för preliminäraför tester och träningsfamiliarisering. I efterföljande två experimentella försök anlände försökspersonerna i ett över nattligt fastande tillstånd. En baslinje biopsi extraherades från m. vastus lateralis och repeterade blodprover initierades med efterföljande 20 minuter av baslinje infusion av endera infusat i vilotillstånd med 0.05 mmol/kg/min infusionshastighet med ytterligare bolusdoser under efterföljande träning. Efter en kort uppvärmning utfördes unilaterala knäextensioner (6 x 8-10 reps vid 75% av 1-RM) med eller utan venös infusion av natrium laktat, med volymmatchande saltlösning som kontroll. Träningsbelastning och volym matchades mellan försök. Ytterligare fyra biopsier extraherades vid efter-träning, återhämtningsperiod, och efter 24 timmar. Resultat: Natriumlaktat respektive saltlösnings infusion under styrketräning gav signifikant högre blodlaktat med natriumlaktat infusion (6.78 ± 0.33 mmol/l mot 2.99 ± 0.17 mmol/l), plasmalaktat (8.86 ± 0.39 mmol/l mot 4.39 ± 0.22 mmol/l), blodnatrium (143 ± 0.4 mmol/l mot 142 ± 0.3 mmol/l), blod pH (7.42 ± 0.01 mot 7.34 ± 0.01), men lägre blod kalium (3.9 ± 0.1 mmol/l mot 4.2 ± 0.1 mmol/l), alla direkt efter träning. Natriumlaktat infusion framkallade huvudeffekt av försök och muskellaktat ökade från baslinje (8.5 ± 0.9 mmol·kg-1 dw mot 7.0 ± 0.6 mmol·kg-1 dw) till efter-träning (31.5 ± 2.8 mmol·kg-1 dw mot 26.9 ± 3.2 mmol·kg-1 dw) med natriumlaktat respektive saltlösnings infusion. Blodglukos, hemoglobin och muskel pH påverkades inte av natriumlaktat infusion. Slutsats: Användande av natriumlaktat infusion som metod under styrketräning kan effektivt användas som verktyg för att höja blod/plasma laktat, och i mindre utsträckning, muskellaktat. Emellertid är samtidig alkalisering av blod en sannolik följd. / Potential sex differences in the molecular response to resistance exercise with lactate infusion
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