A liquidação das operações internacionais com valores mobiliários suscita questões de grande relevância em decorrência das diferenças entre os sistemas jurídicos envolvidos e a pluralidade de participantes. O objetivo desta tese é analisar as normas jurídicas brasileiras em relação às estrangeiras relevantes, por força de operações transfronteiriças que tenham por objeto valores mobiliários escriturais, notadamente operações de compra e venda de ações, para verificar a situação do sistema jurídico brasileiro e sua estrutura de pós-negociação em relação a outros países. Haverá descrição e análise da estrutura de liquidação de operações domésticas e da estrutura envolvida em operação com componente estrangeiro. Como aspectos necessários para a compreensão do tema, abordam-se as consequências jurídicas decorrentes da imobilização e desmaterialização dos valores mobiliários e da interposição de intermediários entre o investidor final e o emissor dos valores mobiliários usual nas operações transfronteiriças. Todo o trabalho considera as tendências e esforços de harmonização das normas aplicáveis que vem ocorrendo no plano internacional, podendo-se verificar que as normas e estruturas brasileiras para liquidação de operações com valores mobiliários são sólidas, adequadas e precisam apenas de aprimoramentos pontuais para atingir os melhores padrões internacionais. / The settlement of international securities transactions raises important issues due to the differences among legal systems and the pluralism of participants involved. The purpose of this thesis is to analyze Brazilian legal rules in relation to relevant foreign rules by virtue of cross border transactions involving book entry securities, mainly purchase and sale of shares, in order to assess the situation of the Brazilian post trading system and structure compared to other countries. There will be a description and analysis of domestic settlement structure and cross border structures involved in transactions with foreign elements. Other relevant topics are the legal consequences arising from securities immobilization and dematerialization and from the existence of intermediaries between the final investor and the issuer, frequent in cross-border transactions. The whole thesis considers the existing trends and efforts to harmonize legal rules, and the conclusion is that Brazilian rules and structure for securities settlement are sound, appropriate and meet the best international standards, although minor adjustments may be implemented.

Melanoma is a pigmented tumor that originates from the melanocytes; pigmented cells present throughout the body, including skin and iris. The cutaneous form is the most common type, and it represents about 5% of the skin tumors diagnosed in Brazil. Although it does not have a high incidence, it represents about 80% to 85% of all skin tumor deaths. The second most frequent type of melanoma is ocular. It represents 5% of all melanoma cases and is a potentially lethal disease, especially when it causes metastasis. The main therapeutic approach for melanomas, in general, is surgery, with resection of the cutaneous lesion or enucleation in the case of ocular melanoma. Other techniques such as adjuvant immunotherapy, palliative chemotherapy, and radiotherapy are also used. However, they have low efficacy and several side effects. Photodynamic therapy is a therapeutic modality based on the interaction of light at specific wavelength and photosensitizer, in the presence of molecular oxygen, leading the cell to death. As melanoma is a pigmented cancer, it usually does not respond well to photodynamic therapy due to the high absorption of light on the surface of the tumor, making volumetric eradication impossible. This project investigated optical strategies for the diagnosis and treatment of melanoma. For the diagnosis, it was evaluated the fluorescence lifetime technique to differentiate melanoma and normal skin. A sensitivity of 99.4%, specificity of 97.4% and accuracy of 98.4% were achieved using linear discrimination analysis. For the cutaneous melanoma treatment, PDT combined to optical clearing agents (OCAs) was investigated. Vascular and cell-target photosensitizers were evaluated combined or not to OCAs. OCA improved PDT response in all pigmented tumors treated, but the best results were achieved when a dual-photosensitizer treatment combined to OCA was performed. The treatment of conjunctival melanoma was conducted using 2-photon excitation photodynamic therapy. The advantage of this technique is the use of infrared light, in a wavelength that melanin has a low absorption, improving the light penetration into the tumor. The tumor histology shows that apoptosis was induced only at the treatment site, with no damage to the surrounding tissue. Additionally, a single TPE-PDT session could treat the entire tumor. / O melanoma é um tumor pigmentado que surge dos melanócitos, células pigmentadas presentes em todo o corpo, incluindo a pele e a íris. A forma cutânea é a mais comum e representa cerca de 5% dos tumores cutâneos diagnosticados no Brasil. Embora não tenha uma alta incidência, representa cerca de 80% a 85% de todas as mortes por tumor de pele. O segundo tipo de melanoma mais frequente é o ocular. Representa 5% de todos os casos de melanoma e é uma doença potencialmente letal, especialmente em casos de metástase. A principal abordagem terapêutica para melanomas, em geral, é a cirurgia, com ressecção da lesão cutânea ou enucleação no caso do melanoma ocular. Outras técnicas, como imunoterapia adjuvante, quimioterapia paliativa e radioterapia também são usadas, porém, apresentam baixa eficiência e muitos efeitos colaterais. A terapia fotodinâmica é uma modalidade terapêutica baseada na interação da luz em um comprimento de onda específico e um fotossensibilizador, na presença de oxigênio molecular, levando a célula à morte. Como o melanoma é um câncer pigmentado, geralmente não responde bem à terapia fotodinâmica devido à alta absorção de luz na superfície do tumor, impossibilitando a erradicação volumétrica. Este projeto investigou estratégias ópticas para o diagnóstico e tratamento do melanoma. Para o diagnóstico, foi avaliada a técnica de tempo de vida de fluorescência para distinguir melanoma de pele normal. Utilizando análise de discriminação linear, obteve-se uma sensibilidade de 99,4%, especificidade de 97,4% e precisão de 98,4%. Para o tratamento de melanoma cutâneo, a PDT combinada com clareadores ópticos (OCAs) foi investigada. Um fotossensibilizador que tem como alvo vaso sanguíneo e um fotossensibilizador de alvo celular foram avaliados combinados ou não com OCAs. OCAs são soluções hiperosmóticas que desidratam o tecido, diminuindo o espalhamento da luz e melhorando a penetração de luz em profundidade. OCA melhorou a resposta de PDT em todos os tumores melanóticos tratados, mas os melhores resultados foram obtidos quando a PDT foi realizada com a combinação dos fotossensibilizadores e clareador óptico em uma única sessão. O tratamento do melanoma conjuntival foi realizado utilizando a terapia fotodinâmica por excitação de 2 fótons (TPE-PDT). A vantagem desta técnica é o uso de luz na região do infravermelho, em um comprimento de onda que melanina tem baixa absorção, melhorando a penetração de luz no tumor. A histologia do tumor mostrou que a apoptose foi induzida apenas no local do tratamento, sem danos no tecido adjacente. Além disso, uma única sessão de TPE-PDT foi capaz de tratar todo o tumor.

A presente tese de doutoramento é composta de três ensaios independentes (ainda que complementares) sobre a História do Pensamento Econômico, mais especificamente, da Macroeconomia. O primeiro ensaio - \"Uma Breve História sobre a Abordagem de Desequilíbrio na Macroeconomia\" - é uma versão revista e ampliada do artigo apresentado no XXXVIII Encontro Nacional de Economia da ANPEC em 2010 (Uma Breve História sobre a Abordagem de Desequilíbrio na Economia). Nossa argumentação vai de encontro às interpretações de Romer (1989) e Mankiw (2005) sobre a compreensão histórica daquele episódio, como também a hipótese levantada por Backhouse & Boianovsky (2005) sobre o fracasso da Macroeconomia do Desequilíbrio. O segundo ensaio se chama \"Uma Análise Histórica (e Retórica) do Discurso Doutrinário de Robert E. Lucas Jr.\". Se no primeiro ensaio argumentamos que parte do \"fracasso\" da Abordagem de Desequilíbrio deveu-se ao surgimento de um método entendido como superior pela maior parte dos economistas (o método de Lucas), neste investigamos o conteúdo daqueles artigos em que Lucas busca convencer os leitores da superioridade do seu método não a partir da comparação dos resultados obtidos por seu modelo em comparação a uma estrutura alternativa, mas sim com uma retórica polemista, fazendo uso de uma série de estratagemas retóricos. Nossa intenção é checar a validade de algumas de suas teses históricas e teóricas, bem como fazer um escrutínio dos expedientes retóricos utilizados pelo autor. O terceiro ensaio - \"Tese da Ancestralidade, Reinvenção da Tradição ou Superação Positiva? Uma Investigação sobre a \"Macroeconomia\" anterior a Keynes e as Causas do Sucesso da Teoria Geral\" - é derivada do segundo ensaio. Partimos da contraposição de hipóteses históricas de dois grandes autores da Macroeconomia sobre o estado da teoria \"macroeconômica\" anterior a Keynes, e as causas do sucesso da Teoria Geral. De um lado, Robert Lucas trata a Macroeconomia fundada por Keynes como um desvio na tradição equilibrista das análises de flutuação, cujo sucesso foi um \'feliz acidente histórico\', provocado principalmente por fatores alheios as vontades e até as simpatias de Keynes. De outro, Olivier Blanchard argumenta que o que havia antes de Keynes era uma grande diversidade de métodos e ausência de um aparato hegemônico, e o sucesso de Keynes deveu-se exclusivamente aos avanços teóricos e metodológicos apresentados naquela obra. / This PhD thesis contains three independent (although complementary) essays on the History of Economic Thought, more specifically on Macroeconomics History. The first essay - A Brief History of the Disequilibrium Approach in Macroeconomics - is a revised and expanded version of paper presented at the XXXVIII Meeting of ANPEC. Our argumentation challenges Romer (1989) and Mankiw (2005) interpretations about that episode. We also disagree (at some level) with Backhouse & Boianovsky (2005) hypothesis about the so-called \"failure\" of Non-Market-Clearing Approach. The second essay - A Historical (and Rhetorical) Analysis of Robert E. Lucas Junior\'s Doctrinaire Speech - is still a work in progress. If the first essay we argue that part of the \"failure\" of Disequilibrium Approach was due to the emergence of a method perceived as superior by most economists (lucasian method), here we investigate the content of those articles where Lucas seeks to persuade its readers of the superiority of his method not from the scrutiny of the results obtained by a specific model in comparison to an alternative structure, but mainly through a polemicist rhetoric. Our intention is to check the validity of some of its historical and theoretical arguments, and make a scrutiny of rhetorical expedients used by the author. The third essay - Ancestry Thesis, Reinvention of a Tradition or Cumulative Progress? A Research on \"Macroeconomics\" before Keynes and some Speculation about the causes of General Theory\'s Success\" - is derived from the second paper. We start from the juxtaposition of historical hypotheses of two great authors about the state\'s theory of \"macroeconomic\" before Keynes, and the causes of the success of the General Theory. On one hand, Robert Lucas argues that Macroeconomics as developed by Keynes was a deviation in the tradition of equilibrist fluctuation analysis, whose success was a fortunate historical accident. On the other, Olivier Blanchard argues that what was before Keynes was a great diversity of methods and the absence of a hegemonic apparatus, and the success of Keynes was due exclusively to theoretical and methodological advances made in that work.

Title: Technique of Hurdle Clearing in 400 Meters Hurdles (Study Review) Authors: Jiří Jakoubek Supervisor: PhDr. Aleš Kaplan, Ph.D. Aims: The aim of this thesis is to describe technique of hurdle clearing in 400 meters hurdle race using study review and to examine this technique at particular athlete during training and racing sessions in 400 meters hurdles race. Methods: Technique was compared and examined at young athlete. Two kinograms were used for analysis, one from training and one from racing session. The comparison was made using third hurdle in second track. One hurdle clearance from each training and racing session was used, where individual phases from hurdle crossing were clearly visible. For better and well- arranged comparative analysis the same athlete was always examined. Technique of hurdle clearing was analysed using 3D kinematic analysis. The captured record was transmitted into appropriate format and elaborated in Kinovea program. For superior quality of presented snapshots program Corel photo-point 9.0 was used. Results: The analyzed athlete was found to have imperfect technique of hurdle clearing. Different quality of technique during training and racing sessions used for hurdle crossing was apparent at several points. Among the nodal points of proband's technique, which were...

The main question this master thesis wants to answer is how much from their disposable income the Czech households save and how do they use their savings on the capital market. The thesis analyse situation and trend of the Czech households saving rate, changings of the marginal saving rate and checks in which financial instruments the Czech households alocate their savings. The thesis also focus on comparison of the Czech households data with the foreign households especially with the German, the Belgium and the Britain households as well as with Visegrád group households. Middle part of the thesis contains a forecast of future progress, which is compared with the similar forecast from year 2006, as well as the relationship of the government and the household's savings rate and possibilities and impacts of its regulation.The thesis is finished with the conclusion which summarize the most important results.

Solid tumors are complex structures comprising besides the cancer cells vasculature, extracellular matrix (ECM), soluble molecules and a plethora of various other cell types. These components form a so-called tumour microenvironment. From the numerous cell types that are part of tumor microenvironment, tumor infiltrating lymphocytes (TILs) play a major role in patient prognosis. Their presence is also of major importance with regard to new biological therapies based on immune checkpoint inhibitors. Crucial role of TILs is also reflected by the new approaches in cancer diagnostics namely by Immunoscore method (currently used in clinical settings). Immunoscore is based on localization and quantification of CD3+ and CD8+ TILs in thin histological sections of tumor tissue. The question remains to which extent the information obtained from 2D slices reflects the situation in tumor microenvironment considering its spatial heterogeneity. The development of new methodological approaches allowing evaluation of histological information in 3D is the key to answer this question. The theoretical part of this work first describes the heterogeneity of the tumor microenvironment and the role of immune cells within it. Then, the role of spatial heterogeneity and its possible influence on the histopathological...

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The main objective of this study was to make an inventory of abandoned eucalyptus plantations due to remaining tree stumps in the Brazilian Pampa biome, focusing on the two counties Pedras Altas and Candiota. In the study, the term “ghost fields” was used for abandoned eucalyptus plantations – land areas that were previously planted with eucalyptus and subsequently left unproductive for a number of years, no longer used for eucalyptus and not converted into e.g. pasture or soybean plantation. After three successive rotations, typically every 21 years, eucalyptus land needs to be processed mechanically to remove remaining stumps and allow new plantation, but stump clearing is costly, and in some cases, non-industrial owners leave the fields ghosted. More than half of the native vegetation, primarily grassland, in the Pampa has been converted into agriculture and forestry, and eucalyptus species are especially popular for plantation because of speedy growth and adaptability to harsh conditions. The loss of native grasslands to continuous short-rotation eucalyptus plantation for commercial use has resulted in soil degradation and biodiversity loss. The demand for productive land, and importance of conserving native vegetation, made it relevant to investigate the extent of ghost fields and the correlation between suppressed native vegetation and ghost fields and between suppressed native vegetation and eucalyptus plantation in general. The study showed that 11 percent (2,727 out of 24,746 hectares) of eucalyptus plantation in the focus area, comprising Pedras Altas and Candiota County, was ghosted for a period of 1-11 years between 2012-2023. Based on extrapolation of the findings in the focus area, 26,323 hectares (11 percent) out of the total 239,297 hectares of eucalyptus plantation in the Pampa may have been ghosted for a number of years between 2012-2023 because of remaining tree stumps. 500 (out of 980) hectares of ghost fields in Pedras Altas County and 543 (out of 1747) hectares of ghost fields in Candiota County were connected to areas with recent suppression of native vegetation (2004-2022). 8,240 (out of 13,200) hectares of eucalyptus plantation, including ghost fields, in Pedras Altas County and 4,829 (out of 11,546) hectares of eucalyptus plantation, including ghost fields, in Candiota County were connected to areas with recent suppression of native vegetation.

Le risque systémique menaçant le système financier est une préoccupation majeure pour les régulateurs. Les indicateurs adéquats de risque systémique devraient vraiment les aider à accomplir les lois réglementaires appropriées. La thèse propose un modèle dynamique du système bancaire pour calculer un indicateur de risque systémique de deux composantes :La probabilité d'un évènement déclencheur qui provient de la baisse des prix des actifs, et les pertes correspondantes dans le système Financier.La thèse prouve également l'existence et l'unicité de deux modèles d'équilibre de compensation : Le premier avec un modèle de différentes hiérarchies de dette et le second modèle avec plusieurs stratégies de liquidation / Systemic risk threatening the financial system is a major concern for regulators. Adequate indicators of systemic risk would help them perform appropriate regulatory laws.The thesis proposes a dynamic model of banking system to calculate a systemic risk indicator of two components : The probability of a triggering event originated from external asset price decline, and the corresponding losses through the financial system. The thesis also proves the existence and uniqueness of two clearing equilibrium: the first deals with a model of différent debt seniorities, the second with a model of several illiquid asset following a proportional liquidation strategy.