The fiber clips is a device for holding an optical fiber which is enclosed in the ferrule, adjustment it to the optimum aligning position with respect to the laser diode and fixing it on the substrate of the butterfly-type laser module by the laser welding. It is hard for the extant saddle shaped clips to be manufactured and the result causes the unable mass production and the high cost. Otherwise, the packaging process has caused PWS of laser module, would decay the coupling efficiency of laser module. Aim at the shortcomings, the purpose of this study proceeds to the creative design of the fiber clips with the systematic engineering design and make a set of the manufacturing method by the pressing die to cause automatic mass production in the future. First, identify the basic characteristics based on an analysis of the patents and then get the conditions and trend. Second, find the function needs and elaborate the specification of design. Third, the use of morphological analysis method and design process is formulated to synthesize and evaluate the improving structure. Finally, taking the design cases will develop the embodiment design and prove the propose approach for the design process. Otherwise, it develops an improvement technique and adjustment method for PWS and wishes can reduce or improve the effects of it.

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnologico / Made available in DSpace on 2012-10-16T10:28:36Z (GMT). No. of bitstreams: 0Bitstream added on 2016-01-08T21:06:46Z : No. of bitstreams: 1 103503.pdf: 2885558 bytes, checksum: 53cb489a48a1b97e5562d84ae929f7b7 (MD5) / A análise química qualitativa de minerais baseia-se em análises de amostras de características físicas e químicas. Muitas considerações realizadas pelo químico são de natureza imprecisa. Tal tipo de incerteza é difícil de ser tratada por modelos tradicionais. Para modelar o processo de análise química qualitativa de amostras de minerais, um sistema especialista baseado em lógica difusa é proposto e desenvolvido em Fuzzy CLIPS. O código fonte do sistema desenvolvido está incluído em um disquete.

Lançada em 1990, a MTV Brasil representa o primeiro empreendimento de um grande grupo internacional de mídia no País - a americana Viacom Inc, a terceira maior empresa do mundo – a operar com um conceito similar às franquias de fast food. Inicialmente licenciada para o Grupo Abril, a marca introduz o conceito de canal segmentado de televisão no Brasil, apesar de ser anterior às transmissões a cabo. Em 1996, a holding adota uma estratégia de expansão mundial mais agressiva. É criada a MTV Brasil Ltda, uma parceria da Abril com a Viacom. Em 1999, a Rede MTV adota a filosofia Thinks Globally, Acts Locally, mais adequada ao seu projeto de expansão global. Em contrapartida, a afiliada brasileira, em sua luta para adequar-se ao mercado local, reformula sua política de programação e passa a privilegiar em sua grade os não-musicais. O formato da MTV Networks e sua forma de expansão fazem da rede um emblema do processo de aculturação imposto pela globalização, equilibrando modos de produção dos países em desenvolvimento com a alta tecnologia do "Mundo Rápido". A questão que emerge é a forma como o mercado brasileiro incorpora essa nova tecnologia, a partir da trajetória da MTV Brasil, e entender até que ponto a entrada de marcas estrangeiras no segmento pode contribuir para o desenvolvimento da mídia nacional. / Launched in 1990, MTV Brazil represents the first enterprise in our country of a big international media company – the American Viacom Inc, the third largest in the world – which operates similar to the fast food chains. The brand, initially just a license to Abril Group, introduces the segmentation media concept on TV channels, even before the introduction of cable TV in Brazil. In 1996, Viacom adopted aggressive global expansion plans. MTV Brazil Ltda is created in a partnership with Abril. After 1999, MTV Networks adopted the slogan Thinks Globally, Acts Locally appropriated to the new expansion strategy. On a counterpart, the Brazilian MTV franchisee reformulated the programmee policy, focusing the non-musical shows in the schedule, in an attempt to increase regional audience. MTV format and the way the network develops, became the brand MTV in one of the greatest symbols of the enculturation imposed by globalization, in the search for a balance between the primary productive manners in the renowned Third World, with the high technology of the "Speed World". The question that emerges is how Brazilian market embodies this new technology taking MTV's Brazil trajectory and analyzing the real contribution of international brands for Brazilian media segment.

<p>Molecular recognition via noncovalent interactions plays a key role in many biological processes such as antigen-antibody interactions, protein folding, the bonding and catalytic transformation of substrates by enzymes, etc. Amongst these noncovalent interactions, electrostatic interactions, hydrogen bonding, π-π interactions, and metal-to-ligand bonding are the most prominent. Exploring noncovalent interactions in host-guest systems that range from small hydrocarbon systems to more complex systems is the main motivation of this thesis. The present study involves the design, synthesis and characterization of clip-shaped molecules as host structures, and an examination of their binding properties with a variety of guests using NMR spectroscopy. </p><p>Several clips with a hydrocarbon or glycoluril backbone were synthesized. The binding of cations to small, hydrocarbon-based clips suggests that binding is enhanced by the rigidity and cooperativity between the two sidewalls of the clip. Binding is also very much dependant on the solvent properties. </p><p>Glycoluril-based clips built with aromatic sidewalls provide a deep cavity for binding guest molecules. The binding properties of these hosts were studied with several guests such as cations, Lewis acids and Lewis bases. Lewis basic binding sites in the acenaphthene-terminated clip were dominating in guest binding. Complexation-induced conformational changes in the wall-to-wall distance were observed for this clip.</p><p>In contrast, for a porphyrin-terminated clip with metal centers, very strong binding to a series of Lewis basic guests of various sizes into the clip cavity was observed. Conformational locking of guests with long alkyl chains was achieved, suggesting that, this clip could be useful as a potential molecular tool for the structural characterization of acyclic molecules with several stereogenic centers. This porphyrin clip was also shown to bind substituted fullerenes in the cavity.</p>

Molecular recognition via noncovalent interactions plays a key role in many biological processes such as antigen-antibody interactions, protein folding, the bonding and catalytic transformation of substrates by enzymes, etc. Amongst these noncovalent interactions, electrostatic interactions, hydrogen bonding, π-π interactions, and metal-to-ligand bonding are the most prominent. Exploring noncovalent interactions in host-guest systems that range from small hydrocarbon systems to more complex systems is the main motivation of this thesis. The present study involves the design, synthesis and characterization of clip-shaped molecules as host structures, and an examination of their binding properties with a variety of guests using NMR spectroscopy. Several clips with a hydrocarbon or glycoluril backbone were synthesized. The binding of cations to small, hydrocarbon-based clips suggests that binding is enhanced by the rigidity and cooperativity between the two sidewalls of the clip. Binding is also very much dependant on the solvent properties. Glycoluril-based clips built with aromatic sidewalls provide a deep cavity for binding guest molecules. The binding properties of these hosts were studied with several guests such as cations, Lewis acids and Lewis bases. Lewis basic binding sites in the acenaphthene-terminated clip were dominating in guest binding. Complexation-induced conformational changes in the wall-to-wall distance were observed for this clip. In contrast, for a porphyrin-terminated clip with metal centers, very strong binding to a series of Lewis basic guests of various sizes into the clip cavity was observed. Conformational locking of guests with long alkyl chains was achieved, suggesting that, this clip could be useful as a potential molecular tool for the structural characterization of acyclic molecules with several stereogenic centers. This porphyrin clip was also shown to bind substituted fullerenes in the cavity.

Le domaine de la chimie supramoléculaire s'est récemment étendu à la construction d'édifices associant un mouvement moléculaire lors du processus de reconnaissance supramoléculaire. Une attention toute particulière est portée sur des architectures dynamiques au sein desquelles la complexation est contrôlée par un stimulus externe. Ces systèmes présentent un fort potentiel pour l'électronique moléculaire avec la mise au point de véritables machines moléculaires. Dans ce contexte, la reconnaissance de molécules neutres constitue un objectif difficile à atteindre à cause du faible choix d'interactions hôte-invité. Pour relever ce défi, nous avons synthétisé des structures originales de type clips moléculaires construits autour de plates-formes plus ou moins flexibles et des parois enrichies en électrons utilisant le donneur tétrathiafulvalène (TTF). Nous présentons dans ce manuscrit les différentes stratégies envisagées pour la synthèse de ces pinces portant des unités électroactives et les résultats obtenus pour la reconnaissance d'espèces invitées électrodéficientes plane (TCNQ-F4) ou tridimensionnelle (fullerène C60) favorisées par les interactions de type donneur-accepteur.

High voltage transmission lines are used for distributing electricity and have to work reliably as it directly affects their performance. Therefore, inspections and maintenances are required in order to keep them working and to find damages as soon as possible. These inspections are still done by humans, which costs a lot of resources, as it is not only dangerous but also cost- and time consuming. This Bachelor's thesis proposes an alternative way of inspection that can be done by presenting an expert system that is able to help the flight controller of an unmanned aerial vehicle. The implementation is done by splitting the main objective into smaller scenarios, each building the fundamentals for developing further flight missions. CLIPS is the expert system programming language used in order to write scripts for each scenario. Tests to verify the functionality and executability of the implemented concept were done using three dfferent methods. The first test was made using a simulation, the next step was to use the hardware that is used in the field and the last test was to execute the implementation on a real copter. / Hochspannungsleitungen werden zur Verteilung von Strom verwendet und müssen zuverlässig funktionieren, da sich ihre Zuverlässigkeit direkt auf die Leistung auswirkt. Deshalb sind Inspektionen und Wartungen erforderlich, um die Funktionsfähigkeit aufrechtzuerhalten und Schäden so schnell wie möglich zu erkennen. Diese Inspektionen werden noch immer vom Menschen durchgeführt, was viele Ressourcen kostet, da es nicht nur gefährlich, sondern auch kosten- und zeitaufwendig ist. Diese Bachelorarbeit schlägt eine alternative Art und Weise Inspektionen durchzuführen vor, indem sie ein Expertensystem verwendet, das in der Lage ist bei der Führung des Flug-Controllers eines unbemannten Luftfahrzeugs zu helfen. Die Umsetzung erfolgt durch die Aufteilung des Hauptziels in kleinere Szenarien, die jeweils die Grundlagen für die Entwicklung weiterer Flugmissionen bilden. CLIPS ist die verwendete Expertensystem-Programmiersprache, um Skripte für jedes Szenario zu schreiben. Tests zur Uberprüfung der Funktionalität und Ausführbarkeit des implementierten Konzepts wurden mit Hilfe von drei verschiedenen Methoden durchgeführt. Der erste Test wurde mit einer Simulation erhoben. Der nächste Schritt war die Verwendung von Hardware, die in echten Einsätzen benutzt wird und der letzte Test war die Ausführung der Implementierung auf einem echten Quadrocopter.

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Diese Arbeit beschäftigt sich mit der operativen Therapie der großen intramuralen Uterusmyomen durch vorübergehende Unterbrechung der uterinen Blutversorgung durch temporäres Anlegen von mikrochirurgischen Gefäßclips (Yasargil® Gefäßclip-System) an den Uterusarterien und utero-ovarielle Gefäßgänge zur Minimierung intraoperativer Blutungen und zur Erleichterung der laparoskopischen Enukleation von sehr großen intramuralen Uterusmyomen. Die vorliegende Studie konzentrierte sich auf die chirurgische Behandlung von sehr großen intramuralen Uterusmyomen, die zu den schwierigsten und komplexesten Fällen der endoskopischen Myomenukleation gehören.:INHALTSVERZEICHNIS 1. Abkürzungsverzeichnis………………………….......................................…..…….…4 2. Einführung in die Thematik ..…………………….......................................….……....6 2.1. Epidemiologie…………………………......................................…..……..…..…6 2.2. Prävalenz ……………………………......................................……….……...….6 2.3. Risikofaktoren ………………………..........................................……….…...….6 2.4. Terminologie und Lokalisation ..…………......................................………...….7 2.4.1. Intramurale Myome (FIGO-Typ 3, 4, 5)…..........................................…7 2.4.2. Submuköse Myome (FIGO-Typ 0, 1, 2)...…..........................................8 2.4.3. Subseröse Myome (FIGO-Typ 6, 7) .…......................................………9 2.4.4. Zervikale Myome (FIGO Typ 8)…......................................………….…9 2.5. Ätiologie .…………………………………......................................…………….11 2.6. Pathophysiologie …………………………....................................…………….11 2.7. klinische Charakteristika ……………………....................................………….11 2.8. Diagnostik …………………………………....................................…………….12 2.8.1. Bimanuelle Untersuchung des Beckens…….....................................12 2.8.2 Radiologische Untersuchung.………....................................…………12 2.9. Therapie ………………………………………...................................………….13 2.9.1 Medikamentöse Therapie …………………....................................…..13 2.9.1.1 Nichtsteroidale entzündungshemmende Medikamente ….........13 2.9.1.2 Levonorgestrelhaltiges Intrauterinsystem .......………….......….13 2.9.1.3 Tranexamsäure ......................……………………………......…..14 2.9.1.4 GnRH-Analoga ...........................………………………......….…14 2.9.2 Operative Therapie ...…………………………………………......……....15 2.9.2.1 Hysteroskopische Myomektomie .....………………………........…….15 2.9.2.2 Laparoskopische Myomektomie..…………………….......……………15 2.9.2.3 Abdominale Myomektomie…………………………….......…….……..15 2.9.2.4 Hysterektomie …………………………………………..….......….……16 2.9.3 Interventionelle Techniken …………………………….......……..……..16 2.9.3.1 Uterusarterienembolisation (UAE) .....................………........……...16 2.9.3.2 Hochintensiver fokussierter Ultraschall (HIFUS) .………........……..17 2.10 Ziel der Studie / Fragestellung …………………………..………........……….18 3. Originalpublikation ...…….…………………………….……………………........…….19 4. Zusammenfassung der Arbeit …………………….….……………………........…….28 5. Literaturverzeichnis……………………………………….…………………….......…..30 6. Anlagen ..........................…….………………………………………………….......…34 6.1 Erklärung über die eigenständige Abfassung der Arbeit ………….……...............34 6.2 Erklärung zu den Beiträgen der Mitautoren bei diesem Publikationsmanuskript..35 6.3 Verzeichnis der wissenschaftlichen Veröffentlichungen ....……………......………36 6.4 Danksagung ………………………………………………………………......…...…..37

Στην παρούσα διπλωματική εργασία γίνεται μια προσπάθεια αντικειμενοποίησης και μοντελοποίησης του μετεγχειρητικού πόνου συνεπεία προγραμματισμένων ορθοπαιδικών επεμβάσεων στην άρθρωση του γόνατος με την βοήθεια εργαλείων μηχανικής μάθησης. Σκοπός της εν λόγω μοντελοποίησης είναι η δημιουργία ενός ευφυούς συστήματος αξιολόγησης και εκτίμησης του μετεγχειρητικού πόνου και η εξέταση της υπόθεσης του κατά πόσο η χρήση ως παραμέτρου μιας αντικειμενικής τιμής όπως αυτή που προέρχεται από την καταγραφή των σωματοαισθητικών προκλητών δυναμικών μπορεί να επηρεάσει την ακρίβεια του συστήματος μας. Συγκεκριμένα χρησιμοποιήθηκαν παράμετροι από το ιστορικό του ασθενούς, τα σωματομετρικά του χαρακτηριστικά, τα δεδομένα του χειρουργείου και της αναλγησίας που δόθηκε σε αυτό, η αυτοαξιολόγηση του ίδιου του ασθενούς μέσω της κλίμακας αυτοαξιολόγησης του πόνου NRS και τέλος αυτό που διαφοροποιεί την παρούσα διπλωματική είναι η προσπάθεια συσχέτισης μιας αντικειμενικής παραμέτρου που τα τελευταία χρόνια έχει συσχετιστεί με τον πόνο, αυτή των σωματοαισθητικών προκλητών δυναμικών. / In this paper we made an attempt of objectification and modeling of postoperative pain as a result of planned orthopedic surgery in the knee joint with the help of machine learning tools. The purpose of this modeling is to create an intelligent system evaluation and assessment of postoperative pain and the case is whether the use as an objective parameter value as derived from the recording of somatosensory evoked potentials may affect the accuracy of the system our. Specific parameters used by the patient's history, the anthropometric characteristics, data of surgery and analgesia given to this, self-evaluation of the patient using the scale of self-assessment of pain NRS and finally what differentiates this thesis is the attempt correlation of an objective parameter in recent years has been associated with pain, that of somatosensory evoked potentials.