The thesis is concerned with a process usually called Competitive Intelligence. In the preface is a general view about the process, which is in following parts focused on particular discipline „disinformation“. In the first, an idea of disinformation is taken down with direction on its creation and using, also is there shown how to designed it to be effect and trusting. Compare to this in the second part are shown ways and precaution, which are used to the investigation, if its disinformation or not.

Topic of diploma thesis is design of a municipal sweeper. It is labor vehicle, which main task is collection of street and municipal garbage. The use and implementation for other functions is also possible Topic is carefully analysed. Final variant can be divided into design, ergonomic, construction and graphic part. It is innovatory product, that respects trends of his competitor‘ s products.

Suivant les récents développements historiographiques dans le champ de l’histoire des animaux, cette thèse aborde l’histoire des jardins zoologiques du côté des bêtes elles-mêmes. Elle examine donc non seulement les politiques humaines de gestion des animaux de zoo, mais aussi leurs influences sur les corps et les comportements des animaux, et leurs évolutions mutuelles. L’examen débute à la fondation du jardin zoologique, c’est-à-dire au moment de la création de la ménagerie parisienne du Jardin des Plantes en 1793, et se centre, outre sur cette institution originelle, sur le jardin zoologique de Londres, créé en 1828, et celui d’Anvers, fondé en 1843. Pour écrire l’histoire des animaux de zoo, la thèse mobilise une méthodologie qui mêle des indicateurs descriptifs – témoignages sur les corps et comportements animaux, sur les infrastructures de captivité, sur les soins et l’alimentation dont bénéficient les bêtes, .... – et quantitatifs – étude sérielle sur la longue durée des entrées et sorties d’animaux ainsi que des longévités des primates et des grands félins. L’évolution de ces différents indices est examinée au sein d’un cadre chronologique régi par les politiques des gestionnaires de zoos. Ainsi, après une première partie débutant à la fondation des institutions étudiées, une seconde s’ouvre au début du XXe siècle, alors que le marchand allemand Carl Hagenbeck ouvre en 1907 un zoo privé à Stellingen, près de Hambourg, qui popularise un nouveau type de présentation des bêtes, par lequel celles-ci sont exposées durant la journée en plein air et séparées du public par des fossés. Enfin, une troisième partie s’amorce à partir des années 1950, lorsque les zoos s’attellent à la mise en œuvre d’une nouvelle fonction, celle de protection des espèces ex situ, s’ajoutant aux trois autres traditionnellement endossées (récréative, éducative, scientifique).L’examen des vies des bêtes sous l’influence des politiques humaines aboutit à élaborer une nouvelle chronologie des zoos, qui distingue un long XIXe siècle, dévoreur de vies animales ; une seconde phase, hygiéniste, à partir de l’entre-deux-guerres, caractérisée par les volontés des gestionnaires de rationaliser les conditions de captivité, mais dont les incidences sur les vies animales sont toutefois réduites ; enfin une troisième, attentive aux animaux, du milieu des années 1970 à nos jours, qui permet la naissance d’une nouvelle économie animale des zoos, qui voit l’atténuation des ponctions en milieu naturel pour la plupart des taxons (spécifiquement les mammifères et les oiseaux).Ce faisant, l’étude met aussi en évidence, à rebours des discours finalistes de l’historiographie officielle, des permanences, immanentes à la captivité des animaux dans le contexte des zoos. Il s’agit d’une part de l’expression par les bêtes de comportements anormaux dans des proportions qui dépassent le niveau anecdotique ; il s’agit d’autre part de l’approvisionnement en milieu naturel, qui, bien qu’en déclin dans le contexte du bouleversement de l’économie animale, persiste jusqu’à nos jours en nombre important pour les taxons moins considérés, soit les poissons et les invertébrés, et se réincarne en de nouveaux avatars pour les autres (ponctions dans le cadre des programmes de protection, captures scientifiques, ...). / Following in the footsteps of recent developments in the French historiography, this dissertation aims at balancing the attention given to humans and animals. The research therefore focuses on human policies concerning the management of animals kept in zoological gardens, as well as on their consequences on the bodies and behaviors of animals, and on mutual influences between humans and animals.The study begins with the birth of the zoological garden, i.e. the creation of the Jardin des Plantes Menagerie in 1793, and focuses on this institution as well as on the London Zoo, created in 1828, and the Antwerp Zoo (1843). In order to write the history of zoo animals, the method uses both descriptive indicators – testimonies on animals bodies and behaviors, on captive environments, on animal cares, handling and food, ... – and quantitative indicators – long-term study of the arrivals and departures, births and deaths of animals and of the longevity of Primates and Pantherinae in captivity. The evolution of these indicators takes place in a chronological framework based on the policies designed to manage zoo animals. The first part begins with the foundation of the zoological gardens. The second one starts at the beginning of the 20th century, when German dealer Carl Hagenbeck opened a zoo in Stellingen, near Hamburg (1907) which popularized a new way to display the animals, in open-air enclosures separated from the public by ditches. The third part starts in the 1950’s, when zoos implemented a new function, one of ex situ conservation, in addition to their other traditional recreative, educative and scientific missions.This study of animal lives under human influence results in a new chronology of zoological gardens, discerning a long 19th century, that consumed animal lives, a second phase, hygienist, from the interwar period, marked by the managers’ willingness to rationalize the conditions of captivity, without much influence on animals lives and longevity, and a third one, from the mid-1970’s to the present time, characterized by increased attention to zoo animals and their well-being, allowing the birth of a new animal economy of zoological gardens, by which in situ captures decline for most taxa (specifically mammals and birds).The dissertation also shows, in opposition with the finalist discourses of the official historiography, somes continuities, immanent to animal captivity in the context of zoological gardens. Abnormal behaviors in animals especially appear in proportions exceeding the anecdotal level. Another important phenomenon pointing to continuities is the collecting in the wild which, although it declined at the same rhythm that the new animal economy developed, has persisted to this day, profusely for the least considered taxa (fishes and invertebrates), and resurfacing in new iterations for mammals, birds, reptiles and amphibians (capture for purposes of conservation, for scientific collecting, ...).

This thesis focuses on eight Swedish museums, who collected intangible and tangible memories of how everyday life was affected during the first year of the coronavirus pandemic in 2020-2021. These contemporary collecting projects were conducted by Eskilstuna stadsmuseum, Jönköpings läns museum, Klostret i Ystad, Nordiska museet, Skellefteå museum, Stockholms läns museum, Värmlands museum and Västerbottens museum. Through semi-structured qualitative interviews with the museum professionals responsible for the collecting process, the aim was to collect data on how the projects were organised and which collecting methods that were used. Further, the aim was to discuss and analyse the contemporary collecting projects from the theoretical perspectives of cultural memory studies and participatory memory practices. The results of the study show that the museums started the collecting projects in haste when the pandemic broke out and that the main collecting method being used was questionnaires. Other collecting methods, such as interviews, field studies and collecting of photographs, diaries, social media posts and tangible objects, were used as a complement. The museum’s purpose was to reach out as wide as possible with the collecting projects, to collect memories from different social groups in society. In conclusion, the collected materials, the intangible and tangible memories collected from participating individuals, will together take place in cultural memory side by side with documentations of historical events and be of use for future generations. Memories were collected all over Sweden, from people of different age and gender. The projects would not have been possible to conduct without the voluntary participation of people sharing their memories of how everyday life was affected during the coronavirus pandemic. This is a two years master’s thesis in Museum and Cultural Heritage Studies.

Hoarding disorder is a mental illness that affects about 2-5 % of the population. The most prominent symptoms of hoarding disorder are the inability to discard things and the excessive acquisition of possessions. The home becomes cluttered, often to the point where one no longer can use the rooms for their intended purposes. For example, one can no longer sleep in the bed or use the kitchen for cooking because of the clutter that takes up space. People with hoarding disorder often experience shame because of their disability and as a consequence they withdraw from social engagements and risk isolation. The purpose of this study was to give a literary review of treatment methods for hoarding disorder and their efficacy in Swedish, but also to show the impact of shame on treatment effect through Thomas Scheff’s theory of shame. The primary treatment method is Cognitive behavioral therapy designed especially for hoarding disorder, and has been tested in different forms such as individual-, group-, and internet based treatment. New treatments using Compassion-focused therapy and Acceptance and commitment therapy have also been developed. Studies on hoarding disorder and shame have shown a correlation between shame, symptom severity and identity. These new treatments address the shame experienced and they can hopefully increase the efficacy rate for hoarding treatment. Important factors for treatment progress were, among others, continued high motivation, frequent contact with clinician and a supportive family. A surprising result was that one study showed almost equal result in treatment led by a non-professional as a professional. More research is needed to further develop effective treatment.

Indiana University-Purdue University Indianapolis (IUPUI) / Type II nephronophthisis (NPHP2) is an autosomal recessive renal cystic disorder characterized by mutations in the inversin gene. Humans and mice with mutations in inversin have enlarged cystic kidneys. Increased kidney size in NPHP2 may involve altered cell growth, apoptosis, electrolyte transport and fluid accumulation in the cysts. To test this hypothesis, histology and transcriptome analysis were performed on one-day old wild-type and inv/inv mice to uncover molecular pathways altered in the mutant mice. Histology of inv/inv mice kidneys showed dilated cystic tubules compared to wild type. Pathway analysis of transcriptome data showed that inversin exerts its effects on kidneys, at least in part, through the transcriptional regulation of genes implicated in inflammation, immune response, cellular metabolism, cell cycle and ion transport. Genes involved in inflammation or immune response were upregulated whereas the genes involved in cell cycle progression and ion transport were downregulated. To validate the array findings from inv/inv mice kidneys, functional consequence of inversin loss on transepithelial ion transport was measured by electrophysiological techniques in shRNA mediated inversin-depleted renal cell type isolated from mouse cortical collecting duct (mCCD). Depletion of inversin decreased vasopressin-induced Na+ absorption, but did not alter Cl- secretion in mCCD cells. Addition of amiloride, a specific blocker of the epithelial sodium channel (ENaC), abolished basal ion transport in both inversin knockdown and control cells indicating ENaC involvement. Loss of inversin decreased Na+ absorption and this effect, in part, was mediated by transcriptional and post-translational regulation of ENaC mediators. To better understand inversin function in renal cells, transcriptome analysis was performed in control and inversin-depleted mCCD cells. Pathway analysis showed that inversin-depletion altered the genes represented in cell cycle, cellular assembly and organization, DNA replication, cell proliferation and ion transport in this isolated renal cell type. In concordance with the array data from inv/inv mice kidneys, a decrease in the expression of cell cycle, ion transport and apoptotic genes were observed accompanied by an upregulation of genes implicated in inflammatory or immune response indicating a direct effect of inversin on renal cells. Together, this study utilized a combination of transcriptome and functional analyses to unravel the role of inversin in renal cells. These data demonstrate that loss of inversin can cause a delay in cell cycle progression with a decrease in cell proliferation and apoptosis which in turn can perturb the development of the renal tubule. Also, a decrease in Na+ reabsorption together with differential regulation of other ion transporters can result in altered electrolyte transport contributing to cystogenesis, cyst growth, fluid accumulation and cyst expansion in NPHP2.

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