Syftet med studien var att öka kunskapen om hur koncentrationen hos barn i förskolan påverkas vid en lässamling om de innan har fått utföra en pedagogstyrd rörelseaktivitet. För att få besvara mina forskningsfrågor utgick jag ifrån två frågeställningar om hur rörelseaktiviteter innan en lässamling påverkar barnens koncentration under lässamlingen och om barns ålder har en påverkan på koncentrationen i lässamlingen. Metoden som användes var en observation med ett observationsschema och två kvalitativa intervjuer med en pedagog. Resultatet visade att vissa barn blev mer positivt påverkade av rörelseaktiviteten med en bättre koncentrationsförmåga under lässamlingen, medans vissa barn blev påverkade på ett mer negativt sätt som utspelade sig med en svårighet att hålla koncentrationen under lässamlingen. I resultat visades det att åldern har en betydelse för hur rörelseaktivitet kan användas. / The purpose of the study was to increase the knowledge on how children in preschools are affected by physical activities that are led by the preschool teachers before reading. In the pursuit for answers I asked two questions those where if the physical activities before the reading had any effect on the children and if the children’s age mattered. The method that I ended up using was observations by an observations list and two qualitative interviews with the preschool teacher. The results showed that some of the children were positively affected by the physical activities with an increase in concentration ability during the reading. While some of the other children showed signs of difficulty in keeping concentration. In the results I concluded that age matter on how the physical activities should be applied.

This is an ethnographic study, highlighting protecting factors for children‘s ability to focus. Schools must do its very best for children, increasing their possibilities to concentrate, since this has a significant impact on both school performance and social interaction. Schools have limited resources. Can knowledge and experience from a developing country give useful and interesting input? Are there health factors for this group of pupils in an African school? The purpose of this research is to study children’s attention abilities and investigate supporting factors for pupil’s possibilities to concentrate as well as to determine the usefulness of these experiences in a Swedish school. In this study I found five salutogenic factors, which seemed to have a positive impact on children‘s ability to concentrate: Having possibilities to study makes a big difference if you are living in Ethiopia, so the importance of expectation is one of the factors. Expectations, from both society and families encouraged the pupils to do their best. Children are seen close to each other in bare classrooms. One can see them helping each other to focus during lessons. Cooperation and fellowship seemed to provide security and happiness, and thus, in turn increased the children‘s possibilities to pay attention and absorb knowledge. Learning at appropriate level in a collective learning process possibly helped pupils with problems in the area of attention/ concentrate. In addition to these environmental, salutogenic factors figured the use of a drug.In countries around the Horn of Africa is use of the herb ―khat‖ common. Some of the children self-medicate themselves to increase their concentration ability.

Vehicle accidents by means of Public transport annually leads to a large number of passenger deaths and life long disablement. AsDu Toit, Martina Petronella a result, there is a need for preventative measures by identifying the psychomotor abilities of bus drivers during the recruitment and selection process of employment. The study was conducted among 398 bus drivers employed by a large bus company. The Vienna Test Battery was administered. It was found that distance estimation, ability to recognize forms and figures, concentration ability, eye-hand feet coordination and two-hand coordination predicted the effectiveness of bus drivers successfully. It is suggested that further research should focus on client services, attitude of bus drivers and learning potential, as factors that influence the effectiveness of bus drivers. / Industrial psychology / M.A. (Industrial Psychology)

Introdução: A nefrotoxicidade dos antiretrovirais constituem atualmente fator importante na morbidade e mortalidade de pacientes com HIV. O tenofovir DF (TDF) se enquadra em um dos antiretrovirais mais lesivos ao rim. Conhecer seu mecanismo de nefrotoxicidade e estudar medidas protetoras podem melhorar seu uso clínico. Material e Métodos: Ratos foram tratados durante 30 dias com uma de duas doses de TDF (50 ou 300mg/Kg de dieta), sendo que um grupo teve adicionado em sua dieta maleato de rosiglitazona (RSG) na dose de 92mg/Kg de dieta nos últimos 15 dias. Após esse período, os ratos foram colocados em gaiola metabólica e sacrificados. Foram estudados parâmetros bioquímicos, fluxo sanguíneo renal e os rins extraídos para expressão semiquantitativa dos transportadores epiteliais tubulares. Resultados: Os animais que receberam TDF em dose alta apresentaram insuficiência renal severa acompanhada de redução da expressão da oxido-nítrico sintase endotelial e vasoconstricção renal intensa. Todos esses parâmetros foram parcialmente revertidos pela administração de RSG. Baixas doses de TDF não causou alteração significativa do ritmo de filtração glomerular, porém induziu fosfatúria, acidose tubular proximal, poliúria e redução da capacidade de concentração urinária. Essas alterações foram associadas a redução da expressão de alguns transportadores epiteliais (cotransportador sódio-fosforo, contratransportador sódio-hidrogênio tipo 3 e aquaporina tipo 2). Não foi caracterizado síndrome de Fanconi, pois não houve proteinúria ou glicosúria. O tratamento com RSG reverteu todos os parâmetros de nefrotoxicidade estudados, normalizando as alterações bioquímicas urinárias e a expressão dos transportadores de membrana. Conclusões: Os achados desses experimentos tem potencial aplicação clínica em pacientes com nefrotoxicidade induzida pelo TDF, especialmente naqueles com hipofosfatemia e/ou redução do ritmo de filtração glomerular. / Objective: To characterize the mechanisms of tenofovir disoproxil fumarate (TDF)- induced nephrotoxicity and the protective effects of rosiglitazone (RSG), a peroxisome proliferator-activated receptor-y agonist. Methods: Rats were treated for 30 days with one of two TDF doses (50 or 300 mg/kg of food), to which RSG (92 mg/kg of food) was added for the last 15 days. Biochemical parameters were measured, and renal tissue was extracted for immunoblotting. Results: Mean daily ingestion was comparable among all the treated groups. Highdose TDF induced severe renal failure accompanied by reduced expression of endothelial nitric-oxide synthase and intense renal vasoconstriction. All of these features were ameliorated by RSG administration. Low-dose TDF did not alter the glomerular filtration rate but induced significant phosphaturia, proximal tubular acidosis and polyuria, as well as reducing urinary concentrating ability. These alterations were caused by specific downregulation of the sodium-phosphorus cotransporter, sodium/hydrogen exchanger 3 and aquaporin 2. No Fanconi\'s syndrome was identified (proteinuria was normal and there was no glycosuria). Treatment with RSG reversed TDF-induced tubular nephrotoxicity, normalizing urinary biochemical parameters and membrane transporter protein expression. Conclusion: These findings have potential clinical applications in patients presenting with TFV-induced nephrotoxicity, especially in those presenting with hypophosphatemia or a reduction in glomerular filtration rate.

Vehicle accidents by means of Public transport annually leads to a large number of passenger deaths and life long disablement. AsDu Toit, Martina Petronella a result, there is a need for preventative measures by identifying the psychomotor abilities of bus drivers during the recruitment and selection process of employment. The study was conducted among 398 bus drivers employed by a large bus company. The Vienna Test Battery was administered. It was found that distance estimation, ability to recognize forms and figures, concentration ability, eye-hand feet coordination and two-hand coordination predicted the effectiveness of bus drivers successfully. It is suggested that further research should focus on client services, attitude of bus drivers and learning potential, as factors that influence the effectiveness of bus drivers. / Industrial psychology / M.A. (Industrial Psychology)

Introdução: A nefrotoxicidade dos antiretrovirais constituem atualmente fator importante na morbidade e mortalidade de pacientes com HIV. O tenofovir DF (TDF) se enquadra em um dos antiretrovirais mais lesivos ao rim. Conhecer seu mecanismo de nefrotoxicidade e estudar medidas protetoras podem melhorar seu uso clínico. Material e Métodos: Ratos foram tratados durante 30 dias com uma de duas doses de TDF (50 ou 300mg/Kg de dieta), sendo que um grupo teve adicionado em sua dieta maleato de rosiglitazona (RSG) na dose de 92mg/Kg de dieta nos últimos 15 dias. Após esse período, os ratos foram colocados em gaiola metabólica e sacrificados. Foram estudados parâmetros bioquímicos, fluxo sanguíneo renal e os rins extraídos para expressão semiquantitativa dos transportadores epiteliais tubulares. Resultados: Os animais que receberam TDF em dose alta apresentaram insuficiência renal severa acompanhada de redução da expressão da oxido-nítrico sintase endotelial e vasoconstricção renal intensa. Todos esses parâmetros foram parcialmente revertidos pela administração de RSG. Baixas doses de TDF não causou alteração significativa do ritmo de filtração glomerular, porém induziu fosfatúria, acidose tubular proximal, poliúria e redução da capacidade de concentração urinária. Essas alterações foram associadas a redução da expressão de alguns transportadores epiteliais (cotransportador sódio-fosforo, contratransportador sódio-hidrogênio tipo 3 e aquaporina tipo 2). Não foi caracterizado síndrome de Fanconi, pois não houve proteinúria ou glicosúria. O tratamento com RSG reverteu todos os parâmetros de nefrotoxicidade estudados, normalizando as alterações bioquímicas urinárias e a expressão dos transportadores de membrana. Conclusões: Os achados desses experimentos tem potencial aplicação clínica em pacientes com nefrotoxicidade induzida pelo TDF, especialmente naqueles com hipofosfatemia e/ou redução do ritmo de filtração glomerular. / Objective: To characterize the mechanisms of tenofovir disoproxil fumarate (TDF)- induced nephrotoxicity and the protective effects of rosiglitazone (RSG), a peroxisome proliferator-activated receptor-y agonist. Methods: Rats were treated for 30 days with one of two TDF doses (50 or 300 mg/kg of food), to which RSG (92 mg/kg of food) was added for the last 15 days. Biochemical parameters were measured, and renal tissue was extracted for immunoblotting. Results: Mean daily ingestion was comparable among all the treated groups. Highdose TDF induced severe renal failure accompanied by reduced expression of endothelial nitric-oxide synthase and intense renal vasoconstriction. All of these features were ameliorated by RSG administration. Low-dose TDF did not alter the glomerular filtration rate but induced significant phosphaturia, proximal tubular acidosis and polyuria, as well as reducing urinary concentrating ability. These alterations were caused by specific downregulation of the sodium-phosphorus cotransporter, sodium/hydrogen exchanger 3 and aquaporin 2. No Fanconi\'s syndrome was identified (proteinuria was normal and there was no glycosuria). Treatment with RSG reversed TDF-induced tubular nephrotoxicity, normalizing urinary biochemical parameters and membrane transporter protein expression. Conclusion: These findings have potential clinical applications in patients presenting with TFV-induced nephrotoxicity, especially in those presenting with hypophosphatemia or a reduction in glomerular filtration rate.