Die rollenbasierte Modellierung ist ein aktueller Forschungszweig, welcher Verfahren für die Analyse und die Lehre benötigt. Zu diesem Zweck präsentiert die Arbeit eine Erweiterung des klassischen, objektorientierten CRC-Karten-Verfahrens um rollenbasierte Konzepte. Diese basiert auf grundlegenden Eigenschaften rollenbasierter Elemente, wie Rollen, Objekte und Kontexte, welche modular in das CRC-Karten- Verfahren eingebunden werden. Weiterhin soll anhand einer empirische Studie ermittelt werden, wie gut das rollenerweiterte R-CRC-Karten-Verfahren für die Aufgaben in Analyse und Lehre geeignet ist. Das R-CRC-Karten-Verfahren soll letztendlich eine effiziente Möglichkeit bieten, Problemstellungen rollenbasiert zu analysieren und rollenbasierte Konzepte in der Lehre zu vermitteln.

Die rollenbasierte Modellierung ist ein aktueller Forschungszweig, welcher Verfahren für die Analyse und die Lehre benötigt. Zu diesem Zweck präsentiert die Arbeit eine Erweiterung des klassischen, objektorientierten CRC-Karten-Verfahrens um rollenbasierte Konzepte. Diese basiert auf grundlegenden Eigenschaften rollenbasierter Elemente, wie Rollen, Objekte und Kontexte, welche modular in das CRC-Karten- Verfahren eingebunden werden. Weiterhin soll anhand einer empirische Studie ermittelt werden, wie gut das rollenerweiterte R-CRC-Karten-Verfahren für die Aufgaben in Analyse und Lehre geeignet ist. Das R-CRC-Karten-Verfahren soll letztendlich eine effiziente Möglichkeit bieten, Problemstellungen rollenbasiert zu analysieren und rollenbasierte Konzepte in der Lehre zu vermitteln.

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Ulcerative colitis (UC) and Crohn’s disease (CD) are the two common forms of inflammatory bowel disease (IBD). They share similar clinical and demographic features as well as harbor key differences in tissue damage and prognosis. Previous studies indicated that they contributed to the increased rick to Colorectal cancer (CRC). However, whether UC and CD share inflammatory signatures still remains controversial. In addition, no inflammatory signatures have been reported on CRC. To answer these questions, a comprehensive study has been conducted on collected microarray datasets. Our analysis suggests that although CD and UC share common inflammatory pathways, they also present difference. Especially, CD patients are likely to have type I response, while UC patients are inclined to undergo type II response. Pathway enrichment analysis on CRC uncovered two potential CRC-specific inflammatory pathways.

The aim of this study was to explore care leavers' experiences to independency after being discharged from public care. The study explored the services provided for young adults who have left public care and how they perceived the support provided for them during their transition and after. The study has also an interest on the care leavers' rights according to the UN Convention on the Rights of a Child. A qualitative study approach was used to collect data, due to the focus on the interpretation of the care leavers' experiences and to get in-depth information and descriptions about their experiences and perspectives. Semi-structured interviews were conducted with four participants who have left care. Moreover, the findings show that the participants were disadvantaged in many areas during their transition and the support received were limited. From the findings, the care leavers were lacking stability, encouragement and both emotional and adequate practical support after being discharged from care.

Every year tens of thousands of children and adolescents come in contact with different parts of the justice system in Sweden, as witnesses, victims and suspects. This essay aims at critically examine children’s rights in legal proceedings based on European union legislation and the United nations convention on the rights of the child.   Political problems are increasingly being defined at the European level of cooperation and decisions regarding Sweden’s future are more often being made by the EU. In June of 2018, Sweden’s parliament voted for the convention on the rights of the child to become law. This analysis will use systematic literature searches to collect the material and two theories about children’s participation and their possibility to act independently will be applied. The study concludes that Sweden’s work with children in legal proceedings fall short in certain regards while they follow EU: s and UN: s laws and opinions in others.  What seems to be largely lacking is commitment and knowledge regarding children’s needs.

<p>The main issue of this thesis is making the behaviour model of Bluetooth EDR (enhanced data rate) baseband signal processing. This Bluetooth baseband project is part of the soft defined radio project at electrical engineering department, Linköping University.</p><p>In this project, both the basic rate and EDR model were built and simulated. The GFSK and π/4 DQPSK digital modulation and demodulation were implemented in C code. The BER was tested to evaluate the demodulation results. Furthermore, the error correction (FEC) and the error checking (HEC,CRC) were also implemented according to the Bluetooth standards. The CRC flag was detected to test the payload demodulation results.</p><p>Especially, GFSK and π/4 DQPSK specifications have to be combined with each other at sample rate of ADC.</p><p>Finally, the basic rate and EDR model were simulated to measure the BER and CRC performance.</p><p>From the simulation results, the receiver filter, synchronization and channel condition were three key points in this Bluetooth EDR system implementation.</p><p>So we get further understanding about the Bluetooth system specification and DSP implementation methods.</p>

<p>On November 1989 the <strong>Convention on the Rights of the Child </strong>was adopted by the United Nations General Assembly. Today more than 20 years later the convention is ratified by all countries in the world except the USA. A question asked is however if the convention after 20 years of development work has in fact accomplished some positive effects for children around the world?</p><p> </p><p>The aim of this thesis is to evaluate the implementation of the Convention on the Rights of the Child in selected states and to reach this aim some questions need to be answered:</p><p> </p><ol><li>What do the selected states do to realize the <strong>best interest of the child</strong>?</li><li>What do the selected states do to guarantee all children’s right to<strong> survival and development</strong>?</li><li>Do all children in the selected states have the same right to <strong>health and health services</strong>?</li><li>Do all children in the selected states have the same <strong>right to education</strong>?</li></ol><p> </p><p>The material studied in this thesis is those reports that are to be sent periodically to the Committee on the Rights of the Child by all states. The result of this study shows that the Convention on the Rights of the Child has made some positive progresses when it comes to the situation of the child in the world. In the selected states of this study the awareness of the Rights of the Children is noticeable and according to the periodic reports the states continue to work and develop the implementation of the convention.</p>

A comprehensive understanding of how the body and all its components function is essential when this knowledge is exploited for medical purposes. The achievements in biological and medical research during last decades has provided us with the complete human genome and identified signaling pathways that governs the cellular processes that facilitates the development and maintenance of higher order organisms. This has brought about the realization that diseases such as cancer is a consequence of genomic aberrations that effects these signaling pathways, endowing cancer cells with the capacity to circumvent homeostasis by acquiring features like self-sustained proliferation and insensitivity to apoptosis. The increased understanding of biology and medicine has been made possible by the development of advanced methods to carry out biological and clinical analyses. The demands of a method often differ regarding in what context it will be applied. It may be acceptable for method to be laborious and time consuming if it is used in basic research, but for medical purposes molecular methods need to be fast and straightforward to perform. Innovative technologies should preferentially address the demands of both researchers and clinicians and provide data not possible to obtain by other methods. An example of such a method is the in situ proximity ligation assay (in situ PLA). In this thesis I have used this method to determine the activity status, at the single-cell level, of the transforming growth factor-β (TGF-β) signaling pathway and activating protein-1 (AP-1) family of transcription factors.  Both of these pathways are frequently involved in cancer development and progression. In addition to this research I herein also present further modifications of in situ PLA, and analyses thereof, to increase the utility and resolution of this assay.

Abstract The development of colorectal cancer ( CRC ) is believed to follow series progress of pathological changes and with correspondent genetic changes of many genes. This includes intestinal epithelial crypts, aberrant focus, adenoma and carcinoma, each of that commonly involved genetic and proteomic alterations. And in genetic level, it usually includes mutations of APC, p53, K-ras and microsatellite instability. The somatic mutations of APC gene mostly occur in MCR ( Mutation Cluster Region ) in codon 1286-1513. The p53 mutations is dispersed in whole gene with 3 hot spots: codon 175, 248 273. K-ras codon 12 and 13 mutations is preferentially involved in polyps growth of CRC. And microsatellite instability is found in 15-25% CRC patients. We collect polyps and various stages CRC samples in Taiwan, and design 6 primer pairs of APC and p53 which is widely used in western countries to analyze mutations of the local CRC genetic changes. We also use two-dimensional electrophoresis and mass spectrometry to identify protein expression changes in CRC. We have found 30 proteins that exhibited either a significant decrease or increase between normal colon tissue and carcinoma, and 3 out of ( TSD1, TSD2, and TSD3 ) these were significantly associated with tumor progression. TSD3 is annotated by mass spectrometry and is identified to be a c1q-related protein. Though there are no report on the function of c1q-related protein, a NCBI virtual northern analysis shows its expression is varied in various cancer. On the other hand, there are only about 56 % genetic changes of APC and p53 during carcinogensis, which is much less than the 70-85 % mutational rate in western CRC patients. It indicates different genetic mutational pattern of CRC in Taiwan.