Este trabalho é uma contribuição importante para o desenvolvimento de um modelo numérico de arênquima pulmonar capaz de simular manobras de ventilação mecânica. O pulmão é um órgão estruturalmente complexo e hierarquizado. Por isso uma revisão bibliográfica multidisciplinar foi realizada. A revisão apresenta as propriedades mecânicas do parênquima, sua morfologia e os efeitos da tensão superficial para a contração e adesão dos septos interalveolares. Um aspecto importante para o modelo de alvéolo é um modelo de contato com adesão causada pela tensão superficial. Um modelo de contato adesivo simplificado foi desenvolvido e simulado em uma estrutura com parâmetros de mesma ordem de grandeza de um alvéolo real. A simulação foi realizada com o método dos elementos finitos não-linear e foi necessário empregar o método da corda para evitar divergência em pontos limites. Os resultados numéricos se aproximaram de resultados experimentais globai no pulmão com pressões de mesma ordem de grandeza. / This work is an important step on the development of a computational model of lung parenchyma capable to simulate mechanical ventilation maneuveres. The lung has a complex and hierarchized structure. Therefore a multidisciplinary literature review was held. The review presents the mechanical properties of the parenchyma, its morphology and the effects of surface tension to septums contraction and adhesion. An important aspect for the alveolus model is a contact model which includes the adhesion caused by surface tension. Thus a simplified model was developed and then simulated in a structure with properties of the same order of magnitude of a real alveolus. The simulation was performed with the nonlinear finite element method. The implementation of the arc-length method was also necessary in order to prevent diversion at limit points. The numerical results were close to whole lung experimental results with pressure levels of the same order of magnitude.

Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2017-05-30T13:15:36Z No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) DISSERTAÇÃO-Raquel-2016-Biblioteca-05-07-2016(1).pdf: 1876533 bytes, checksum: b455420ce9cc60dbb32b7918480c256e (MD5) / Made available in DSpace on 2017-05-30T13:15:36Z (GMT). No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) DISSERTAÇÃO-Raquel-2016-Biblioteca-05-07-2016(1).pdf: 1876533 bytes, checksum: b455420ce9cc60dbb32b7918480c256e (MD5) Previous issue date: 2016-02-25 / A via radial é objeto de interesse crescente de cardiologistas intervencionistas, por oferecer menores taxas de complicações vasculares e redução de sangramento maior, associado ao risco de morte e eventos isquêmicos. Este estudo objetiva comparar a eficácia da hemostasia com compressão mecânica em duas e três horas, e a ocorrência de complicações vasculares, por avaliação clínica e por USG com Doppler. Realizou-se uma revisão de literatura intitulada "Oclusão da artéria radial relacionada ao cateterismo cardíaco transradial", no qual se revisaram 19 artigos de periódicos publicados entre 2005 a 2015, os quais relacionaram os principais fatores predisponentes à oclusão da artéria radial após cateterismo cardíaco. No presente estudo 206 pacientes submetidos a cateterismo transradial foram randomizados em dois grupos com tempo de compressão em duas horas (T2) e três horas (T3), contendo 103 pacientes em cada grupo. Foi realizado exame clínico no local de punção, antes e depois da compressão no dia do procedimento, e após o 7º dia reavaliado através de exame clínico e USG com Doppler. No artigo intitulado "Tempo de compressão da artéria radial pós cateterismo cardíaco e complicações vasculares", descreveu-se o estudo em detalhes. Em seus resultados observou-se que a avaliação clínica realizada no dia do cateterismo cardíaco não demonstrou diferenças relevantes entre os grupos T2 e T3. Equimose foi encontrada em apenas dois pacientes (0,9%); Espasmo arterial durante a retirada do introdutor ocorreu em 56 pacientes (27,2%); Hematoma pós compressão foi encontrado em 34 pacientes (16,5%); O tamanho do hematoma encontrado na maioria dos pacientes (97,1%) foi de pequena dimensão (<5cm) , apenas um paciente e pertencente ao grupo T2 (2,9%) apresentou hematoma extenso (≥10cm); Em 24 pacientes (11,7%) ocorreu sangramento após remoção do curativo compressivo no grupo T3; Quanto ao exame ultrassonográfico com Doppler evidenciou-se redução do fluxo sanguíneo em dois pacientes de cada grupo (2,0%), presença de oclusão da artéria radial no grupo T3 (11,0%), hematoma subcutâneo em dois pacientes do grupo T2 (2,0%), pseudoaneurisma em um paciente no grupo T3 (1,0%), Edema subcutâneo em um paciente do grupo T3 (1,0%). Dissecção arterial em um paciente de cada grupo (1,0%). Não foi evidenciado presença de estenose ou fístula arteriovenosa nos grupos. Conclui-se que na amostra estudada a utilização da via transradial para cateterismo cardíaco foi segura e eficaz, não apresentando diferenças estatísticas significantes na ocorrência de sangramento e complicações vasculares, com a utilização do curativo compressivo para hemostasia em duas e três horas. E que o tempo de duas horas deve ser adotado pois se mostrou seguro e eficaz na hemostasia sanguínea, apresentando baixas taxas de complicações vasculares, como a oclusão da artéria radial. / The radial routeis object of growing interest of interventional cardiologists, by offering lower rates of vascular complications and bleeding reduction, associated to the risk of death and ischemic events. This study aims to compare the efficacy of hemostasis with mechanical compression of two and three hours, and the occurrence of vascular complications, by clinical assessment and USG with Doppler. We carried out a revision in the literature entitled "occlusion of the radial artery related to transradial cardiac catheterization," in which it was reviewed 19 journal articles published from 2005 to 2015, which related the main factors predisposing to occlusion of the radial artery after cardiac catheterization. In this study 206 patients undergoing to the transradial catheterization were randomized into two groups with compression time in two hours (T2) and three hours (T3) containing 103 patients in each group. Clinical examination was performed at the puncture site, before and after the compression on the day of the procedure, and after the 7th day reassessed by clinical examination and USG Doppler In the article entitled "radial artery compression time after cardiac catheterization and vascular complications," was described the study in detail. In its results it was observed that the clinical evaluation performed on the day of cardiac catheterization showed no significant differences between T2 and T3 groups. Bruising was found in only two patients (0.9%); arterial spasm during with draw al of introducer occurred in 56 patients (27.2%); post compression hematoma was found in 34 patients (16.5%); The size of the hematoma found in most patients (97.1%) was by the small dimension (<5cm), only one patients belonging to the group and T2 (2.9%) showed extensive hematoma (≥ 10cm);In 24 patients (11.7%) occurred bleeding after removal of the pressure dressing in T3 group; as to the ultrasound Doppler examination showed a reduction of blood flow in two patients in each group (2.0%), presence of radial artery occlusion in the T3 group (11.0%), subcutaneous hematoma in two patients in the T2 group (2.0%), pseudo aneurysm in 01 patients in the T3 group (1.0%), subcutaneous edema in on patient T3 group (1.0%). Arterial dissection in one patient in each group (1.0%).It was not evidenced the presence of stenosis or arteriovenous fistula in the groups. it was concluded that in the sample studied the utilization of the transradial route for the cardiac catheterization was safe and effective, without statistically significant differences in the occurrence of bleeding and vascular complications such as occlusion of the radial artery, in the use of the compressive dressing to hemostasis of two and three hours. And the time of two hours should be adopted because it proved to be safe and effective hemostasis in the blood , resulting in low rates of vascular complications , such as the radial artery occlusion.

O objetivo desta dissertação é analisar as representações sociais presentes nos discursos de bancários adoecidos pelo trabalho. A hipótese básica sustenta que a relação saúde-trabalho-adoecimento contribui para a desconstrução/construção da identidade do trabalhador, à medida em que as relações sociais são transformadas por uma nova realidade mediatizada pela doença. As transformações trazidas pela reestruturação produtiva no setor e a conseqüente mudança no perfil bancário constituem o contexto econômico e social que contribuem para o adoecimento, afetando a subjetividade do trabalhador e as formas de sociabilidade, tendo em vista as perdas dos referenciais de identidade, espaço e tempo. Conclui-se que o adoecer, além de proporcionar a construção de novas identidades, constitui-se num processo de aprendizado, dinâmico e complexo, que consiste em assimilar e produzir conhecimentos e formas de ação. / The objetive of this work is to analyse the social representations produced by bank tellers made sick at work. The basic hipothesis argues that the relation between health-work-sickness contributes for disconstruction/construction of workers identity, if we think that social relations are transformed by a new reality mediate by sickness. The productive restructuring of the financial sector has changed the characterists of the bank tellers, and these points form the social and economic context that contribute for the sickness. They affect their subjectivity and sociability, because they lose their identity, space and time references. We conclude that: to become ill, beyond the possibilities to construct new identities, is a learning process, dinamic and complex, depends on assimilate and product knowledge and action forms.

O objetivo desta dissertação é analisar as representações sociais presentes nos discursos de bancários adoecidos pelo trabalho. A hipótese básica sustenta que a relação saúde-trabalho-adoecimento contribui para a desconstrução/construção da identidade do trabalhador, à medida em que as relações sociais são transformadas por uma nova realidade mediatizada pela doença. As transformações trazidas pela reestruturação produtiva no setor e a conseqüente mudança no perfil bancário constituem o contexto econômico e social que contribuem para o adoecimento, afetando a subjetividade do trabalhador e as formas de sociabilidade, tendo em vista as perdas dos referenciais de identidade, espaço e tempo. Conclui-se que o adoecer, além de proporcionar a construção de novas identidades, constitui-se num processo de aprendizado, dinâmico e complexo, que consiste em assimilar e produzir conhecimentos e formas de ação. / The objetive of this work is to analyse the social representations produced by bank tellers made sick at work. The basic hipothesis argues that the relation between health-work-sickness contributes for disconstruction/construction of workers identity, if we think that social relations are transformed by a new reality mediate by sickness. The productive restructuring of the financial sector has changed the characterists of the bank tellers, and these points form the social and economic context that contribute for the sickness. They affect their subjectivity and sociability, because they lose their identity, space and time references. We conclude that: to become ill, beyond the possibilities to construct new identities, is a learning process, dinamic and complex, depends on assimilate and product knowledge and action forms.

Submitted by Rosivalda Pereira (mrs.pereira@ufma.br) on 2017-10-04T20:26:41Z No. of bitstreams: 1 ElisangelaSantos.pdf: 3205873 bytes, checksum: 0ea1c3dc20ca9f96a31dac45e32d26af (MD5) / Made available in DSpace on 2017-10-04T20:26:41Z (GMT). No. of bitstreams: 1 ElisangelaSantos.pdf: 3205873 bytes, checksum: 0ea1c3dc20ca9f96a31dac45e32d26af (MD5) Previous issue date: 2017-09-04 / Introduction: Excessive salt consumption has been observed in most countries over the last years, ranging from nine to 12 grams per person per day, above the limit recommended by the World Health Organization which is five grams at the most. Currently, high sodium intake has been considered a major risk factor for development of diseases. The 24-hour urinary sodium excretion is considered the gold standard method for evaluation of sodium consumption; however, difficulties associated with accuracy of urine collections may interfere with the results. Estimation of sodium intake by spot urine samples, at population level, has been increasingly used as a suitable and inexpensive alternative. Methods: Cross-sectional study with 1,211 African descendants from Alcântara, Maranhão. Demographic, lifestyle, clinical and laboratory data were evaluated. The urinary excretion estimation of sodium and the estimated glomerular filtration rate (eGFR) were obtained using the Kawasaki and the CKDEPI equations, respectively. In order to identify variables related to sodium excretion, the multivariate linear regression model was used and the variables with p value < 0.20 were included in the analysis. A multivariate linear regression model was used to determine the relationship between eGFR and sodium excretion. A significance level of 5% was used and the data were analyzed using the STATA 14.0 software. Results: Most individuals were women (52.8%) with a mean age of 37.5 ± 11.7 years. The prevalence of hypertension was 21.3%. The mean excretion of sodium was 204.6 ± 15.3 mmol/d and the eGFR was 111.8 ± 15.3 mL / min / 1.73 m². Hypertensive individuals showed higher sodium excretion (217.9 ± 90.1 mmol / d vs 199.2 ± 83.0 mmol \ d; p = 0.002). After the adjusted analysis, the waist circumference (PR = 1.16), triglycerides (RP = 1.13), systolic blood pressure (RP = 1.19) and eGFR (RP = 1.24) remained related with urinary sodium excretion. According to the multivariate linear regression, the eGFR was correlated independently with sodium excretion (β = 0.11, p <0.001), age (β = -0.67, p <0.001), female gender (β = -0.20, p <0.001) and BMI (β=-0.09; p <0.001). Conclusion: Urinary excretion of sodium was high in spot urine sample. Furthermore, association with waist circumference, triglycerides, systolic blood pressure and eGFR was observed. The eGFR was negatively correlated with age, female gender and body mass index. Conversely, there was a positive correlation between eGFR and urinary sodium excretion. / Introdução: Nos últimos anos, o consumo de sal tem sido excessivo na maioria dos países, variando de nove a 12 gramas por pessoa por dia, ultrapassando o recomendado pela Organização Mundial de Saúde que é de cinco gramas de sal, no máximo. Atualmente o consumo elevado de sódio passou a ser considerado um dos principais fatores de risco para desenvolvimento de doenças. A avaliação do consumo, por meio da excreção em urina de 24h é considerada o método padrão ouro, entretanto, as dificuldades associadas com a acurácia da coleta da urina podem interferir nos resultados, estimativa a partir da coleta de urina isolada, a nível populacional, é cada vez mais utilizada como uma alternativa conveniente e acessível. Métodos: Estudo transversal realizado com 1211 afrodescendentes de Alcântra-Ma. Foram avaliados dados demográficos, de estilo de vida e clínico laboratoriais. A estimativa da excreção urinária de sódio foi avaliada por meio da equação de Kawasaki e a taxa de filtração glomerular estimada (TFGe) pela equação do CKD-EPI. Para identificar as variáveis relacionadas com a excreção de sódio foi utilizado o modelo de regressão linear multivariado e as variáveis com p-valor<0,20 foram consideradas na análise. Para determinar a relação entre TFGe e excreção de sódio foi utilizado um modelo de regressão linear multivariada. O nível de significância adotado para a análise foi de 5% e os dados foram analisados no software STATA 14.0. Resultados: A maioria dos indivíduos eram mulheres (52,8%), com média de idade de 37,5±11,7 anos. A prevalência de hipertensão foi de 21,3% e a média de excreção de sódio foi de 204,6±15,3 mmol/d e da TFGe de 111,8±15,3 ml/min/1,73m². Indivíduoas hipertensos apresentaram maior excreção de sódio (217.9±90,1mmol/d vs 199,2±83,0 mmol\dia; p=0,002). Após análise ajustada, a circunferência da cintura (RP=1,16), triglicerídeos (RP=1,13), pressão arterial sistólica (RP=1,19) e TFGe (RP=1,24) permaneceram associadas à excreção urinária de sódio. De acordo com a regressão linear multivariada, a TFGe se correlacionou independentemente com a excreção de sódio (β = 0,11; p <0,001), idade (β = -0,67; p <0,001), sexo feminino (β = -0,20; p <0,001) e IMC (β = -0,09; p <0,001). Conclusão: A excreção urinária de sódio, avaliada em amostra isolada de urina, foi elevada e aspresentou associação com a circunferência da cintura, triglicerídeos, pressão arterial sistólica e TFGe. A TFGe foi correlacionada negativamente com idade, sexo feminino e índice de massa corporal, e positivamente com a excreção urinária de sódio.

Les troubles du contrôle postural (TCP) sont une cause majeure d’invalidité dans la maladie de Parkinson (MP) au stade évolué et sont fréquemment associés aux RBD (REM sleep behavior disorders). Les substrats anatomiques des TCP sont mal connus. Ils reposent en partie sur des lésions de la région locomotrice mésencéphalique (noyau pédonculopontin-PPN et noyau cunéiforme), également impliquée dans le contrôle du sommeil/vigilance et oculomoteur. Les saccades oculaires sont un modèle de contrôle moteur dont la quantification est robuste et les réseaux largement élucidés. Dans la MP au stade évolué, il existe une altération des saccades volitionnelles qui pourrait être associée aux TCP. Des dysfonctions des sous-réseaux du PPN pourraient participer à la survenue des TCP, du sommeil/vigilance et oculomoteurs.Notre objectif est de préciser les corrélats physiologiques et anatomo-fonctionnels des TCP, et le substrat de l’association clinique entre TCP et RBD dans la MP. Nous confrontons l’étude de l’initiation du pas (ajustements posturaux anticipatoires-APA) et d’autres tests de marche-équilibre à l’étude des saccades, et analysons les réseaux locomoteurs, de vigilance et oculomoteurs du PPN en IRM fonctionnelle. Nous montrons pour la première fois que les patients avec instabilité posturale ont un allongement de la latence des antisaccades et de la durée des APA, inter-corrélés. La durée des APA est corrélée aux anomalies de connectivité fonctionnelle entre le PPN et la SMA/préSMA. La présence de RBD est sous-tendue par des anomalies du réseau PPN-cortex cingulaire antérieur. L’allongement de la latence des antisaccades est associé à une désorganisation du réseau PPN-FEF. / Postural control (PC) impairment is a major cause of disability in Parkinson’s Disease (PD) and is frequently associated with RBD (REM-sleep behavior disorders-RBD). The networks underlying PC impairment in PD are not well known. They include lesions of the mesencephalic locomotor region (pedunculopontine nucleus-PPN, and cuneiform nucleus), which is also involved in the control of sleep/vigilance. Saccades are a model of motor control, their quantification is reliable and their networks have been largely elucidated. PD patients at evolved stages have predominant volitional saccades alterations which could be associated with some aspects of postural control disorders. Dysfunctions of specific PPN networks could be involved in PC impairment, sleep/vigilance and oculomotor disorders. Our goal is to specify the neurophysiological and anatomo-functional correlates of postural control impairment and to specify the substrates underlying the co-occurrence of postural control disorders and RBD in PD. We confront the study of gait initiation (anticipatory postural adjustments-APA) with the antisaccades paradigm, and we analyze the PPN functional locomotor, vigilance and oculomotor networks. We show for the first time that PD patients with postural instability have prolonged antisaccades latencies and APA duration, and that these disorders are intercorrelated. APA duration is correlated with PPN-SMA/préSMA functional connectivity abnormalities, the presence of RBD is associated with disruptions in the PPN-anterior cingular cortex network and prolonged antisaccade latencies are possibly underlined by PPN-FEF functional disorganization.

Le but de cette étude était d'évaluer le rôle des boucles des ganglions de la base et des voies dopaminergiques sur les mécanismes « bottom-up » et « « top-down » du contrôle de l'attention visuelle (AV). Nous avons comparé les performances sur 3 tâches informatisés, appropriées à l'étude de la capture attentionnelle (CA), des mécanismes de sélection de la réponse motrice et d'initiation du mouvement, de deux groupes de patients avec maladie de Parkinson (MP) - un groupe étant évalué dans trois différentes conditions de stimulation électrique (sans stimulation, ou stimulation sélective de la partie sensorimotrice, SM, ou de la partie associative, AS, du noyau subthalamique, NST), l'autre groupe étant évalué dans deux différentes conditions de traitement médical (avec ou sans levodopa) - avec celles d'un groupe des sujets contrôles. Nos résultats suggèrent dans la MP un affaiblissement des mécanismes « top-down » de contrôle de l'AV, ce qui pourrait aussi expliquer indirectement l'augmentation de la CA. Le traitement dopaminergique est efficace dans le rétablissement des mécanismes « top-down » de l'AV, suggérant une implication des voies dopaminergiques dans ce domaine cognitif. Ces voies semblent aussi jouer un rôle dans les mécanismes « bottom-up » de l'attention, comme l'a suggéré le renforcement de la CA sous traitement dopaminergique. La stimulation du NST a montré un effet similaire à celui obtenu par un traitement dopaminergique, en favour d'une implication directe des boucles des ganglions de la base dans le contrôle de l'AV. Nos résultats ont mis en évidence une spécialisation fonctionnelle de différents sous-territoires du NST en ce qui concerne les mécanismes de « top-down ». La stimulation SM produit des effets marqués sur les processus d'initiation de mouvement et des effets positifs sur les mécanismes endogènes de l'AV, alors que la stimulation de la partie AS semble être plus particulièrement efficace dans l'amélioration des mécanismes de sélection de cible. / We aimed to investigate the possible role of cortico-basal ganglia loops and dopaminergic pathways in the mechanisms of top-down and bottom-up control of visual attention (VA). We compared the performances on 3 computerized tasks, respectively suitable to study attentional capture (AC), motor response selection and movement initiation, of two groups of patients with Parkinson's disease (PD), one evaluated in different sets of electrical stimulation (without stimulation, or selective stimulation of the sensorimotor, SM, or associative, AS, parts of the subthalamic nucleus, STN), the other in different conditions of medication (with or without levodopa), with those of a group of controls. Our results showed that in PD there is a weakening of the mechanisms underlying the top-down control of VA, which also would account indirectly account for the enhancement of AC. Dopaminergic treatment proved to be effective in restoring the top-down mechanisms of VA, suggesting an involvement of dopaminergic pathways in this cognitive domain. These pathways seem to play a role also in the bottom-up mechanisms of attention, as suggested by the enhancement of AC under dopaminergic treatment. The STN-stimulation showed a similar effect to that obtained by dopaminergic treatment, establishing a direct involvement of the basal ganglia loops in VA control. Our results highlighted a functional specialization of different sub-territories of the STN in relation to the top-down mechanisms. SM stimulation produced marked effects on the movement initiation processes and appreciable positive effects on endogenous VA mechanisms, while AS stimulation seems to be especially effective in improving the mechanisms of target selection.

Objective. Coronary heart disease has been on the rise in poorer countries and decreasing in developed countries over the last twenty years. However, the cardiac-related health-related quality of life (HRQOL) in poorer countries has not been studied. This study aimed to compare HRQOL following heart attack in a developing country in the East with that of a developed country in the West. Using the self-regulation of health and illness behaviour, the relationships between illness beliefs, coping cognitions and HRQOL are studied. Design. This study was a cross-sectional correlational survey and data were collected shortly before myocardial infarction patients were discharged from hospital. Methods. A sample of 243 individuals from the UK and Indonesia were recruited. Illness beliefs were assessed with the B-IPQ, along with coping cognitions (Brief-COPE) and health-related quality of life (MacNew questionnaire). Results. Illness beliefs and coping cognitions predicted HRQOL in the combined sample. Some aspects of socio-demographic and clinical variables were concurrently associated with HRQOL. Conclusion. The results demonstrate that people in the East have low illness beliefs and these are associated with worse HRQOL compared with those in the West. The findings suggest that there is an urgent need for smoking cessation campaigns in the East, while the West could benefit more from tailored-cardiac rehabilitation programme.

No description available.

Le syndrome du canal carpien (SCC) est un syndrome canalaire fréquent, qui fait partie des troubles musculo-squelettiques (TMS) d’origine professionnelle. Sa survenue en lien avec le travail sur ordinateur reste débattue.Pour faire le point sur la question, nous avons effectué une revue de la littérature et une méta-analyse sur l’éventuel lien entre le SCC et le travail sur ordinateur, confronté le résultat à celui obtenu dans deux grandes cohortes, l’une européenne et l’autre Nord-américaine et détaillé les expositions à certains facteurs biomécaniques chez les participants de la cohorte française présentant une douleur de la main.La revue de la littérature et la méta-analyse n'ont pas montré d'association entre le travail sur ordinateur et le SCC, avec un méta-OR à 1,67 (IC 95%, 0,79 à 3,55). Cependant, peu d’études longitudinales, avec des définitions standardisées du SCC, faisaient partie de cette analyse.Pour contourner ces limites, nous avons utilisé la cohorte française COSALI et la cohorte américaine Predi CTS study. Les analyses multivariées ajustées sur l'âge, le sexe, l'obésité et la présence d'antécédents médicaux n’ont pas montré que l'exposition au travail sur l’ordinateur était un facteur de risque de SCC.Ces deux études montrent que le travail sur ordinateur n’apparait pas comme un facteur de risque du SCC, contrairement à ce qui a pu être longtemps relayé.L’analyse exploratoire de la relation entre douleur de la main et travail sur ordinateur, ajustée sur les expositions biomécaniques dans la cohorte COSALI, montre dans certains groupes un possible lien entre douleur de la main et travail sur ordinateur, sous certaines conditions qui vont nécessiter des analyses ultérieures. / Carpal tunnel syndrome (CTS) is a common ductal syndrome which is part of occupational musculoskeletal disorders (MSDs). Its occurrence in connection with computer work remains debated.To review this issue, we conducted a review of the literature and a meta-analysis on the possible link between CTS and computer work, compared the result to that obtained in two large cohorts, one European and the other North American and detailed exposures to certain biomechanical factors in the French cohort in participants with pain in the hand.The literature review and meta-analysis show no association between CTS and computer work with a meta-OR at 1.67 (95% CI, 0.79 to 3.55). However, few longitudinal studies, with standardized CTS definitions were included in this analysis.To circumvent these limits, we used the French COSALI cohort and the American cohort PrediCTS study. Multivariate analyzes adjusted for age, gender, obesity and medical history did not show that computer exposure was a risk factor for CTS as it has long been relayed.The exploratory analysis of the relationship between hand pain and computer work adjusted to the biomechanical exposures in the COSALI cohort show in some groups a possible link between hand pain and computer work, under certain conditions, which will require further analysis.