Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-06-29T14:54:00Z No. of bitstreams: 1 FernandaNelliGomesGiulianiDissertacao2016.pdf: 976160 bytes, checksum: 740837879f1aef16ef66bc330e0889b1 (MD5) / Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-06-29T14:54:22Z (GMT) No. of bitstreams: 1 FernandaNelliGomesGiulianiDissertacao2016.pdf: 976160 bytes, checksum: 740837879f1aef16ef66bc330e0889b1 (MD5) / Made available in DSpace on 2017-06-29T14:54:22Z (GMT). No. of bitstreams: 1 FernandaNelliGomesGiulianiDissertacao2016.pdf: 976160 bytes, checksum: 740837879f1aef16ef66bc330e0889b1 (MD5) Previous issue date: 2016-12-06 / The increase in life expectancy and low fertility in recent years favors the exponential growth of the elderly population, mainly of elderly people. The maintenance of functional capacity is essential for maintaining good performance in the activities of daily living and for the quality of life of these elderly people. Functional ability may be influenced by some factors such as falls, fear of falling and physical conditions of the individual. For this reason, the objective of this study was to verify the functional capacity and its relationship with falls, fear of falling and physical performance of oldest old who were aged at an outpatient clinic attended at a health unit in the Federal District. It is a cross-sectional, exploratory and analytical study. For the descriptive analysis of the sample, mean, standard deviation and frequency were performed. Non-parametric tests such as Mann-Whitney, Kruskal- Wallis, Chi-square and Pearson's correlation were applied. For the parametric tests, the student's t-test was used for independent samples. The sample consisted of 50 elderly with aged 80 years or older. Of the elderly evaluated, 64% had partial dependence on the instrumental activities and 82% were independent for the basic activities of daily living. Functional capacity was not related to the history of fall nor to the fear of falling and the physical performance of the elderly people who were longlived. However, it was found that walking speed is related to the instrumental activities of daily living. 54% of the elderly had moderate physical performance. There was a prevalence of 1 fall in the 12-month period, with the majority stumbling as the main reason, and most of the falls occurred within the elderly's residence. / O aumento da expectativa de vida e a baixa fecundidade nos ??ltimos anos, favorece o crescimento exponencial da popula????o idosa, principalmente de idosos longevos. A manuten????o da capacidade funcional ?? essencial para manuten????o do bom desempenho na execu????o das atividades de vida di??ria e para boa qualidade de vida desses idosos. A capacidade funcional pode ser influenciada por alguns fatores como, quedas, medo de cair e condi????es f??sicas do indiv??duo. Por essa raz??o, o objetivo desse estudo, foi verificar a capacidade funcional e sua rela????o com quedas, medo de cair e desempenho f??sico de idosos longevos de perfil ambulatorial, atendidos em uma unidade de sa??de do Distrito Federal. Trata-se de um estudo transversal, explorat??rio e anal??tico. Para an??lise descritiva da amostra foi feita m??dia, desvio padr??o e frequ??ncia. Foram aplicados testes n??o param??tricos como Mann-Whitney, Kruskal- Wallis, Qui-quadrado e Correla????o de Pearson. Para os testes param??tricos foi aplicado o teste t de student para amostras independentes. A amostra foi composta por 50 idosos com idade igual ou superior a 80 anos. Dos idosos avaliados, 64% apresentaram depend??ncia parcial para as atividades instrumentais e 82% eram independentes para as atividades b??sicas de vida di??ria. A capacidade funcional n??o apresentou rela????o com o hist??rico de queda nem com o medo de cair e o desempenho f??sico dos idosos longevos. Contudo encontrou-se que a velocidade de marcha apresenta rela????o com as atividades instrumentais de vida di??ria. 54% idosos longevos apresentaram desempenho f??sico moderado. Encontrou-se preval??ncia de 1 queda, no per??odo de 12 meses, tendo a maioria trope??o como principal motivo, e a maioria das quedas ocorreu dentro da resid??ncia do idoso.

Submitted by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2016-01-04T12:43:24Z No. of bitstreams: 2 fabricio_paula.pdf: 833499 bytes, checksum: 4864104f710a7129c6089e9dac7beda1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2016-01-04T12:43:53Z (GMT) No. of bitstreams: 2 fabricio_paula.pdf: 833499 bytes, checksum: 4864104f710a7129c6089e9dac7beda1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2016-01-04T12:43:53Z (GMT). No. of bitstreams: 2 fabricio_paula.pdf: 833499 bytes, checksum: 4864104f710a7129c6089e9dac7beda1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2012 / Atletas de v?rias modalidades desportivas realizam mais de uma sess?o de treinamento por dia. Diversas estrat?gias t?m sido utilizadas com o intuito de acelerar a recupera??o p?s-exerc?cio. Embora a imers?o em ?gua seja uma estrat?gia comum entre os atletas, a sua efic?cia na acelera??o da recupera??o ainda n?o est? estabelecida, e os efeitos da temperatura da ?gua na imers?o sobre o desempenho n?o s?o claros. Sendo assim, este estudo avaliou os efeitos da recupera??o passiva por imers?o em ?gua, em diferentes temperaturas, sobre o desempenho ap?s uma sess?o de exerc?cio. Nove homens, jovens, fisicamente ativos, participaram de quatro sess?es experimentais randomizadas compostas por exerc?cio exc?ntrico (3 x 10 repeti??es a 100% de uma repeti??o m?xima) e 90 minutos de corrida em esteira rolante a 70%do pico de consumo de oxig?nio. Em seguida, os volunt?rios recuperaram durante 45 minutos, distribu?dos em 15 minutos de imers?o em ?gua a 15, 28 ou 38?C sentados e 30 minutos deitados em repouso a temperatura ambiente (20 ? 2? C). Na sess?o controle (CON), durante a recupera??o, os volunt?rios permaneceram sentados durante 15 minutos ? temperatura ambiente. Quatro horas ap?s o final do exerc?cio experimental, os volunt?rios foram submetidos ? corrida de intensidade autorregulada m?xima de 5 km seguido do teste de Wingate para avaliar o desempenho f?sico. A temperatura retal (Tret), a frequ?ncia card?aca (FC) e sua variabilidade (VFC) foram medidas ao longo de toda a sess?o. O consumo excessivo de oxig?nio p?s-exerc?cio (EPOC) foi medido durante a recupera??o. Os marcadores do dano muscular, creatina quinase (CK) e aspartato amino transferase (AST) e a contagem de leuc?citos totais foram medidas antes e ap?s o exerc?cio, ap?s imers?o, antes e ap?s o desempenho, e 24 horas ap?s o exerc?cio experimental. A velocidade m?dia na corrida de intensidade autorregulada m?xima de 5 km e a pot?ncia pico relativano teste de Wingate n?o foram diferentes entre as condi??es experimentais.A imers?o em ?gua a 15?C reduziu a Tret, a FC e os ?ndices de VFC a valores de repouso, ap?s a recupera??o.O EPOC foi maior na imers?o em ?gua a 15?C e a 28?C.Durante a corrida de intensidade autorregulada de 5 km e do teste Wingate, a Tret e a FC n?o foram diferentes entre as condi??es experimentais. A sess?o de exerc?cio experimental induziu dano muscular e leucocitose. Entretanto, n?o houve diferen?a nos n?veis s?ricos de CK, AST e no n?mero de leuc?citos totais entre as condi??es experimentais. A recupera??o por imers?o em ?gua,a diferentes temperaturas, n?o foi efetiva em modificar o desempenho f?sico 4 horas ap?s uma sess?o de exerc?cio prolongado. / Disserta??o (Mestrado) ? Programa Multic?ntrico de P?s-gradua??o em Ci?ncias Fisiol?gicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2012. / ABSTRACT Athletes of several sport modalities regularly train more than once a day. Several strategies have been used in order to accelerate post-exercise recovery. Although water immersion is a common strategy among athletes, it effectiveness in accelerate the recovery is not yet established, and the effects of temperature water immersion on performance are not clear. Thus, this study evaluated the effects of passive recovery water immersion at different temperatures on performance following an exercise session.Nine physically active men (24 ? 6 years old, 72 ? 13 kg, 177 ? 7 cm, peak oxygen consumption (VO2peak) of 55 ? 4 mL?kg-1?min-1), participated of four randomized experimental sessions. Each session consisted of eccentric knee flexion (3 x 10 repetitions of 100% from one maximum repetition) and 90 minutes of treadmill running at 70% of VO2peak, followed by 15 minutes of passive recovery by water immersion at 15?C, 28?C or 38?C and 30 minutes resting in supine position at room temperature (20 ? 2?C). In the control session, volunteers remained seated for 15 minutes at room temperature after exercise. After four hours of resting, in order to evaluate recovery strategies, the volunteers underwent a 5 km of maximal self-paced treadmill running followed by the Wingate test. Prior to experimental sessions, rested volunteers completed 5 km of maximal self-paced running and the Wingate test, which were used as reference performance values. Rectal temperature (Tret), heart rate (HR) and heart rate variability indexes (HRV indexes) were measured through the entire session. Excess post-exercise oxygen consumption (EPOC) was measured during recovery period. The markers of muscle damage, creatine kinase (CK) and aspartate aminotransferase (AST) and total leukocyte count were measured before and after exercise, after immersion, before and after performance tests, and 24 hours after the experimental exercise. Average speed during 5 km of maximal self-paced treadmill running and relative peak power during Wingate test were not different between experimental conditions. Water immersion at 15?C reduced Tret, HR and HRV indexes to baseline values after recovery. EPOC was higher in water immersion at 15?C and 28?C. During 5 km of maximal self-paced treadmill running and Wingate test, Tret and HR were not different between experimental conditions. The experimental exercise session induced muscle damage and leukocytosis. However, there was no difference in serum CK, AST and total leukocyte count between experimental conditions.The recovery by water immersion at different temperatures was not effective in modify the physical performance 4 hours after a session of prolonged exercise.

Submitted by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2014-12-18T11:57:11Z No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2014-12-18T12:22:44Z (GMT) No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2014-12-18T12:22:41Z (GMT) No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2014-12-18T12:23:34Z (GMT) No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Made available in DSpace on 2014-12-18T12:23:37Z (GMT). No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) Previous issue date: 2014 / O efeito do consumo cr?nico do cigarro no perfil inflamat?rio, estresse oxidativo e desempenho f?sico t?m sido investigado em fumantes assintom?ticos, contudo, estes estudos na sua maioria ainda s?o poucos e divergentes. Sendo assim, o objetivo deste estudo foi avaliar o efeito cr?nico do tabagismo no perfil inflamat?rio, estresse oxidativo, fun??o muscular esquel?tica perif?rica e aptid?o cardiorrespirat?ria de homens adultos assintom?ticos. Os sujeitos do estudo foram divididos igualmente entre o grupo fumante (GF, n= 20) e grupo controle (GC, n= 20), composto por sujeitos n?o fumantes. A fun??o pulmonar de todos participantes foi avaliada pela espirometria. O perfil inflamat?rio foi avaliado pela mensura??o das concentra??es plasm?ticas das citocinas IL-6, TNF-?, IL-10 e pelos receptores sol?veis de TNF-? (sTNFR1 e sTNFR2). O estresse oxidativo foi avaliado pela mensura??o das concentra??es plasm?ticas das subst?ncias reativas ao ?cido tiobarbit?rico (TBARS), da atividade das enzimas antioxidantes super?xido dismutase (SOD) e catalase de eritr?citos e pela capacidade antioxidante total do plasma. A fun??o muscular esquel?tica perif?rica foi avaliada por meio das medidas de pico de torque dos m?sculos extensores e flexores de joelho e da resist?ncia e fadiga muscular dos m?sculos extensores de joelho; e a aptid?o cardiorrespirat?ria foi avaliada atrav?s da mensura??o do consumo pico de oxig?nio (VO2pico), frequ?ncia card?aca m?xima (FCmax) e dist?ncia caminhada em um teste m?ximo de caminhada/corrida. Sujeitos do GF apresentaram aumentos significativos das concentra??es plasm?ticas de TBARS e do receptor sol?vel sTNFR1 e diminui??es significativas da atividade da enzima catalase em lisado eritrocit?rio, comparados ao GC. Al?m disso, sujeitos do GF exibiram menor resist?ncia muscular dos m?sculos extensores de joelho como determinado pelas medidas de trabalho, com inalterado ?ndice de fadiga dos m?sculos extensores de joelho e pico de torque dos m?sculos extensores e flexores de joelho. A aptid?o cardiorrespirat?ria foi similar entre os sujeitos do GF e do GC. Este estudo demonstrou que homens fumantes cr?nicos e assintom?ticos exibiram altera??es no perfil inflamat?rio, no estresse oxidativo e na fun??o muscular esquel?tica perif?rica, quando comparados a n?o fumantes. / The effect of chronic cigarette smoking on inflammatory profile, oxidative stress and physical performance has been investigated in asymptomatic smokers, however, these studies are few and divergent. Thus, the aim of this study was to evaluate the chronic effect of smoking on inflammatory profile, oxidative stress, peripheral skeletal muscle function and cardiorespiratory fitness in asymptomatic adult men. The subjects of the study were divided equally between the smoking group (SG, n = 20) and control group (CG, n = 20) composed of non-smoking subjects. The lung function of all participants was assessed by spirometry. The inflammatory response was assessed by measurement of plasma concentrations of IL- 6, TNF- ?, IL -10 and soluble receptors for TNF-? (sTNFR1 and sTNFR2). Oxidative stress was evaluated by measuring plasma concentrations of thiobarbituric acid reactive substances (TBARS), the activity of antioxidant enzymes superoxide dismutase (SOD) and catalase in erythrocytes and the total antioxidant capacity of plasma. The peripheral skeletal muscle function was assessed by measuring the peak torque of the extensor and flexor muscles of the knee; and resistance and muscle fatigue of the knee extensor muscles; and cardiorespiratory fitness was assessed by measurement of peak uptake oxygen (VO2peak), maximum heart rate (HRmax) and distance walked on a maximum test of the walk/run. SG subjects showed significant increases in plasma concentrations of TBARS and soluble receptors sTNFR1 and significant decreases in erythrocyte catalase enzyme activity, compared to the CG. In addition, SG subjects exhibited less muscle strength of knee extensors muscles as determined by measures of work and unchanged fatigue index of the knee extensors muscles and peak torque of knee extensors and flexors muscles. Cardiorespiratory fitness was similar between subjects SG and CG. This study demonstrated that male chronic smokers, healthy adult, exhibited changes in the inflammatory response, oxidative stress and peripheral skeletal muscle function, when compared to non-smokers. / Disserta??o (Mestrado) ? Programa Multic?ntrico de P?s-gradua??o em Ci?ncias Fisiol?gicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2014.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-02-21T00:25:24Z No. of bitstreams: 1 MarianaCarmemApolinarioVieira_DISSERT.pdf: 1712134 bytes, checksum: 88ad1bdccb2c21827752124eedb04a6c (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-03-03T23:34:52Z (GMT) No. of bitstreams: 1 MarianaCarmemApolinarioVieira_DISSERT.pdf: 1712134 bytes, checksum: 88ad1bdccb2c21827752124eedb04a6c (MD5) / Made available in DSpace on 2017-03-03T23:34:52Z (GMT). No. of bitstreams: 1 MarianaCarmemApolinarioVieira_DISSERT.pdf: 1712134 bytes, checksum: 88ad1bdccb2c21827752124eedb04a6c (MD5) Previous issue date: 2016-01-26 / Introdu??o: As mulheres apresentam maior decl?nio f?sico e incapacidade durante o envelhecimento em rela??o aos homens. Com isso, diversas explica??es biol?gicas v?m sendo propostas para explicar a raz?o pela qual as mulheres apresentam piores resultados de sa?de. Dentre elas, sabe-se que a hist?ria reprodutiva e poss?veis altera??es gineco-obstetricias vem sendo associada a limita??es na fun??o f?sica. Entretanto, sabe-se pouco sobre a rela??o entre a incontin?ncia urin?ria, o prolapso de ?rg?os p?lvicos e o desempenho f?sico. Objetivo: Verificar a rela??o entre incontin?ncia urin?ria, prolapso de ?rg?os p?lvicos e desempenho f?sico em mulheres de meia-idade.Metodologia: Trata-se de um estudo observacional anal?tico, de car?ter transversal, realizado com mulheres (40 a 65 anos), residentes em Parnamirim/RN. Todas as participantes foram avaliadas atrav?s de um question?rio estruturado, sendo coletados dados socioecon?micos, demogr?ficos, altera??es ginecol?gicas e desempenho f?sico. Na an?lise estat?stica, a normalidade dos dados foi verificada utilizando o teste Kolmogorov-Smirnov. Para avaliar a rela??o entre as vari?veis independentes e as de desempenho f?sico foram utilizados o test t e a ANOVA. An?lises de regress?o linear foram realizadas para observar a rela??o entre incontin?ncia urin?ria, prolapso de ?rg?os p?lvicos e o desempenho, ajustadas pelas covari?veis. Resultados: Foram avaliadas 361 mulheres, com m?dia de idade 53,0 (?5,6) anos. As mulheres que apresentavam incontin?ncia urin?ria mostraram pior desempenho no teste de sentar e levantar (p=0,04) e aquelas com prolapso de ?rg?os p?lvicos, pior equil?brio de olhos abertos (p=0,04). Ap?s as an?lises de regress?o linear m?ltipla, as altera??es ginecol?gicas permaneceram relacionadas ao teste sentar e levantar (incontin?ncia urin?ria: ? = 0,923; IC: 0,016 : 1,830) e ao equil?brio de olhos abertos (prolapso p?lvico: ? = -2,467; IC: -4,706 : -0,228). Conclus?o: As mulheres com incontin?ncia urin?ria apresentaram pior desempenho f?sico no teste de sentar e levantar da cadeira e aquelas com prolapso de ?rg?os p?lvicos apresentaram pior desempenho f?sico no teste de equil?brio com olhos abertos. / Introduction: Women have presented higher charge of physical decline and disability during aging compared to men. Consequently, several biological explanations have been proposed to explain the reason why women have worse health outcomes. Among them, has knowledge that the reproductive history and possible urogynecological changes has been associated with limitations in physical function. However, little is known about the relationship between urinary incontinence, pelvic organ prolapse and physical performance. Objective: To verify the relationship between urinary incontinence, pelvic organ prolapse and physical performance in middle-aged women. Methodology: A cross-sectional study, accomplished with women (40-65 years), living in Parnamirim-RN, between September of 2014 and July of 2015, with a sample of 361 women. All participants were assessed using a structured questionnaire, being collected socioeconomic and demographic data, urogynecological changes and physical performance. In the statistical analysis, the normality of the data was verified using the Kolmogorov-Smirnov test. To evaluate the relationship between independent variables and physical performance variables were used test t and ANOVA. Linear regression analysis was performed to observe the relationship between urinary incontinence, pelvic organ prolapse and physical performance, adjusted for covariates. Results: A total of 361 women were assessed with mean of age 52.0 (? 5.6) years. Women who had urinary incontinence showed worse performance in the chair stand test (p = 0.04) and those with pelvic organ prolapse, worse balance with open eyes (p = 0.04). After multiple linear regression analysis, urogynecological changes related to the test remained related chair stand test (urinary incontinence: ? = 0.923; CI: 0.016 : 1.830) and balance with open eyes (pelvic prolapse: ? = -2.467; CI: -4.706 : -0.228). Conclusion: Women who had urinary incontinence showed worse performance in the chair stand test and those with pelvic organ prolapse, worse balance with open eyes.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-04-17T23:20:36Z No. of bitstreams: 1 BrunaSilvaOliveira_TESE.pdf: 2168230 bytes, checksum: e104821a58eb464892a9329229db3c08 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-04-20T23:37:21Z (GMT) No. of bitstreams: 1 BrunaSilvaOliveira_TESE.pdf: 2168230 bytes, checksum: e104821a58eb464892a9329229db3c08 (MD5) / Made available in DSpace on 2017-04-20T23:37:21Z (GMT). No. of bitstreams: 1 BrunaSilvaOliveira_TESE.pdf: 2168230 bytes, checksum: e104821a58eb464892a9329229db3c08 (MD5) Previous issue date: 2016-11-25 / Introdu??o: o comprimento do tel?mero (TL) tem sido apontado como um poss?vel biomarcardor do envelhecimento celular, pois ocorre encurtamento fisiol?gico e progressivo do seu tamanho com o decorrer das replica??es celulares. Adicionalmente a esse encurtamento fisiol?gico, a disfun??o do TL tamb?m ? favorecida pela exposi??o ao estresse oxidativo, a inflama??o e ap?s o estresse psicossocial cr?nico. Existe ainda uma lacuna de conhecimento sobre as altera??es do TL durante o curso de vida em popula??es de mulheres idosas brasileiras, havendo a necessidade de estudos que possibilitem melhor entendimento da influ?ncia de contrastes sociais, condi??es socioecon?micas desfavor?veis, bem como exposi??o ao estresse social cr?nico no TL. Objetivos: 1) desenvolver uma revis?o sistem?tica para explorar as evid?ncias sobre associa??es entre estresse cr?nico durante o curso de vida e TL; 2) investigar poss?veis associa??es entre TL e adversidades na inf?ncia (social e econ?mica) em mulheres idosas com diferentes n?veis de escolaridade; 3) avaliar se o TL est? relacionado com doen?as cr?nicas e biomarcadores inflamat?rios em mulheres idosas; e 4) verificar se tel?meros mais curtos est?o associados com pior desempenho f?sico e maior autorrelato de limita??es funcionais em idosas. Materiais e m?todos: foi desenvolvida uma revis?o sistem?tica seguindo protocolo publicado em 2014. Concomitantemente, realizou-se um estudo observacional anal?tico de car?ter transversal com uma amostra de mulheres (n=106) com diferentes n?veis de escolaridade (ensino m?dio incompleto e ensino m?dio completo) na faixa et?ria de 64-74 anos e residentes no munic?pio de Natal (Rio Grande do Norte). Os dados foram coletados no per?odo de maio de 2014 a mar?o de 2015. A quantifica??o relativa do tamanho dos tel?meros (T/S) de leuc?citos foi realizada por meio da qPCR em tempo real em 83 mulheres. O question?rio padronizado incluiu informa??es sociodemogr?ficas, adversidades na inf?ncia, medidas antropom?tricas, autorrelato de sa?de, fun??o cognitiva, h?bitos de vida, condi??es cr?nicas de sa?de, capacidade funcional e desempenho f?sico (short physical performance battery, velocidade da marcha e for?a de preens?o manual). Foram analisados tamb?m biomarcadores inflamat?rios (interleucina-6 e prote?na c reativa). Para an?lise estat?stica, foram considerados p<0,05 e intervalos de confian?a de 95%. A normalidade dos dados foi verificada por meio do teste de Kolmogorov-Smirnov. Uma vez que o TL apresentou distribui??o n?o normal, foi realizada a transforma??o da medida em logaritmo natural para as an?lises subsequentes. Foram aplicados os testes T de Student para amostras independentes, Qui-quadrado e realizados modelos de regress?o linear m?ltipla ajustados pelos potenciais fatores de confus?o. Resultados: na revis?o sistem?tica, os resultados foram relatados de acordo com o Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Considerando os dezoito estudos inclu?dos na revis?o, no geral, observou-se que indiv?duos expostos ao estresse cr?nico, caracterizado por pobreza, exposi??o ? viol?ncia e cuidar de familiar doente apresentaram tel?meros mais curtos em rela??o aos indiv?duos n?o expostos ?s adversidades. An?lises do estudo transversal sobre TL e curso de vida mostraram que as idosas com ensino m?dio incompleto apresentaram maior TL em compara??o com o grupo de ensino m?dio completo (2.8 ? 0.9 e 2.0 ? 0.9, respectivamente; p = 0,0001). As mulheres que n?o conclu?ram o ensino m?dio foram expostas a mais adversidades na inf?ncia, e entre estas, as que sofreram duas ou mais adversidades apresentavam TL mais longo do que as mulheres expostas a ?1 adversidades (p = 0,03); entre as mulheres com, no m?nimo, ensino m?dio completo, essa diferen?a n?o foi significativa (p = 0,49). Em an?lises ajustadas por idade, escolaridade e abuso parental de ?lcool, observou-se tend?ncia linear de maior TL com maior n?mero de adversidades (p = 0,02) e a diferen?a no TL entre os n?veis de escolaridade permaneceu significativa (p = 0,002). N?o se observou diferen?a entre os grupos educacionais em rela??o ?s seguintes vari?veis: colesterol, triglic?rides, glicemia em jejum, hemoglobina glicada, prote?na c reativa e interleucina-6 (p>0,05). Condi??es cr?nicas de sa?de, medidas antropom?tricas, fatores de risco cardiovasculares e marcadores inflamat?rios n?o foram associados com o TL, mesmo ap?s o ajuste para idade, escolaridade e adversidades na inf?ncia (p>0,05). Igualmente, o TL n?o foi relacionado com nenhuma das vari?veis utilizadas para avaliar o desempenho f?sico e a capacidade funcional (p>0,05). Conclus?es: a rela??o positiva inesperada entre menor escolaridade e adversidades na inf?ncia com TL sugere que os participantes sobreviveram a duras condi??es de vida e que, provavelmente, essas mulheres t?m o TL mais longo em rela??o ao daquelas de sua coorte de nascimento. A aus?ncia de rela??o entre TL e doen?as cr?nicas, risco cardiovascular, inflama??o e desempenho f?sico, n?o deu suporte ? hip?tese de que o TL ? um biomarcador do envelhecimento na popula??o em estudo, por?m corrobora outros estudos que revelaram que o TL pode ser considerado um marcador de longevidade, independentemente de condi??es de sa?de e desempenho f?sico. / Introduction: Telomere length (TL) has been pointed out as a possible biomarker of cellular aging, as its physiological size progressively shortens with the course of cellular replications. In addition to this physiological shortening, TL dysfunction is also stimulated by exposure to oxidative stress, inflammation and after chronic psychosocial stress. There is also a lack of knowledge about TL changes during the course of life in populations of older Brazilian women, and there is a need for studies which foster a better understanding of the influence of social contrasts, unfavorable socioeconomic conditions, as well as exposure to chronic social stress in TL. Objectives: 1) To develop a systematic review to explore the evidence on associations between chronic stress over the life course and TL; 2) To investigate possible associations between TL and childhood adversities (social and economic) in older women with different levels of education; 3) To evaluate whether TL is related to chronic diseases and inflammatory biomarkers in older women; and 4) To verify whether shorter telomeres are associated with poorer physical performance and higher self-reported functional limitations in older adults. Materials and methods: A systematic review was developed following a protocol published in 2014. An observational cross-sectional analytical study was concomitantly carried out with a sample of women (n = 106) with different levels of education (incomplete secondary education and complete secondary education) in the age group of 64-74 years residing in the municipality of Natal (Rio Grande do Norte). Data were collected from May 2014 to March 2015. The relative quantification of leukocyte telomere size (T/S) was performed by real-time qPCR in 83 women. The standardized questionnaire included sociodemographic information, childhood adversities, anthropometric measures, self-reported health, cognitive function, life habits, chronic health conditions, functional capacity and physical performance (short physical performance battery, gait speed and manual grip strength). Inflammatory biomarkers (interleukin-6 and c-reactive protein) were also analyzed. For statistical analysis, p<0.05 and 95% confidence intervals were used. The normality of the data was verified by the Kolmogorov-Smirnov test. Since TL presented non-normal distribution, the transformation of the measure into natural logarithm was performed for subsequent analyzes. Student's t-tests were applied for independent samples, and Chi-square and multiple linear regression models were adjusted for potential confounding factors. Results: The results of the systematic review were reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Considering the eighteen studies included in the review, we generally observed that individuals exposed to chronic stress, characterized by poverty, exposed to violence and/or caring for a sick relative had shorter telomeres compared to individuals who were not exposed to adversity. Analyzes of the cross-sectional study on TL and life course showed that the older adults with incomplete secondary education presented higher TL compared to the group of complete secondary education (2.8 ? 0.9 and 2.0 ? 0.9, respectively; p = 0.0001). Women who did not complete high school were exposed to more adversity in childhood, and among them, those who suffered two or more adversities had longer TL than women exposed to ?1 adversity (p = 0.03); among women with at least complete secondary education, this difference was not significant (p = 0.49). In analyzes adjusted for age, educational level and parental alcohol abuse, a linear trend of higher TL for greater number of adversities (p = 0.02) was observed, and the difference in TL between education levels remained significant (p = 0.002). No difference between the education groups was observed for the following variables: cholesterol, triglycerides, fasting glycemia, glycated hemoglobin, c-reactive protein and interleukin-6 (p>0.05). Chronic health conditions, anthropometric measures, cardiovascular risk factors and inflammatory markers were not associated with TL, even after adjusting for age, schooling and childhood adversities (p>0.05). Similarly, TL was not related to any of the variables used to assess physical performance or functional capacity (p>0.05). Conclusions: The unexpected positive relationship between TL and lower education level and childhood adversities suggests that participants survived harsh living conditions and that these women probably have longer TL in relation to others among their birth cohort. The lack of relationship between TL and chronic diseases, cardiovascular risk, inflammation and physical performance did not support the hypothesis that TL is an aging biomarker in the population under study, but corroborates other studies that have shown TL to be considered as a marker of longevity, regardless of health conditions and physical performance.

?rea de concentra??o: Fisiologia do exerc?cio. / Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2017-10-10T19:50:28Z No. of bitstreams: 3 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) fabricio_paula.pdf: 833499 bytes, checksum: 4864104f710a7129c6089e9dac7beda1 (MD5) fabricio_paula_ficha_catalografica.pdf: 6515 bytes, checksum: ceb6a05cf27cd3c4b848cec8be9fdd04 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2017-11-08T14:36:13Z (GMT) No. of bitstreams: 3 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) fabricio_paula.pdf: 833499 bytes, checksum: 4864104f710a7129c6089e9dac7beda1 (MD5) fabricio_paula_ficha_catalografica.pdf: 6515 bytes, checksum: ceb6a05cf27cd3c4b848cec8be9fdd04 (MD5) / Made available in DSpace on 2017-11-08T14:36:13Z (GMT). No. of bitstreams: 3 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) fabricio_paula.pdf: 833499 bytes, checksum: 4864104f710a7129c6089e9dac7beda1 (MD5) fabricio_paula_ficha_catalografica.pdf: 6515 bytes, checksum: ceb6a05cf27cd3c4b848cec8be9fdd04 (MD5) Previous issue date: 2012 / Atletas de v?rias modalidades desportivas realizam mais de uma sess?o de treinamento por dia. Diversas estrat?gias t?m sido utilizadas com o intuito de acelerar a recupera??o p?s-exerc?cio. Embora a imers?o em ?gua seja uma estrat?gia comum entre os atletas, a sua efic?cia na acelera??o da recupera??o ainda n?o est? estabelecida, e os efeitos da temperatura da ?gua na imers?o sobre o desempenho n?o s?o claros. Sendo assim, este estudo avaliou os efeitos da recupera??o passiva por imers?o em ?gua, em diferentes temperaturas, sobre o desempenho ap?s uma sess?o de exerc?cio. Nove homens, jovens, fisicamente ativos, participaram de quatro sess?es experimentais randomizadas compostas por exerc?cio exc?ntrico (3 x 10 repeti??es a 100% de uma repeti??o m?xima) e 90 minutos de corrida em esteira rolante a 70% do pico de consumo de oxig?nio. Em seguida, os volunt?rios recuperaram durante 45 minutos, distribu?dos em 15 minutos de imers?o em ?gua a 15, 28 ou 38?C sentados e 30 minutos deitados em repouso a temperatura ambiente (20 ? 2? C). Na sess?o controle (CON), durante a recupera??o, os volunt?rios permaneceram sentados durante 15 minutos ? temperatura ambiente. Quatro horas ap?s o final do exerc?cio experimental, os volunt?rios foram submetidos ? corrida de intensidade autorregulada m?xima de 5 km seguido do teste de Wingate para avaliar o desempenho f?sico. A temperatura retal (Tret), a frequ?ncia card?aca (FC) e sua variabilidade (VFC) foram medidas ao longo de toda a sess?o. O consumo excessivo de oxig?nio p?s-exerc?cio (EPOC) foi medido durante a recupera??o. Os marcadores do dano muscular, creatina quinase (CK) e aspartato amino transferase (AST) e a contagem de leuc?citos totais foram medidas antes e ap?s o exerc?cio, ap?s imers?o, antes e ap?s o desempenho, e 24 horas ap?s o exerc?cio experimental. A velocidade m?dia na corrida de intensidade autorregulada m?xima de 5 km e a pot?ncia pico relativano teste de Wingate n?o foram diferentes entre as condi??es experimentais. A imers?o em ?gua a 15?C reduziu a Tret, a FC e os ?ndices de VFC a valores de repouso, ap?s a recupera??o. O EPOC foi maior na imers?o em ?gua a 15?C e a 28?C. Durante a corrida de intensidade autorregulada de 5 km e do teste Wingate, a Tret e a FC n?o foram diferentes entre as condi??es experimentais. A sess?o de exerc?cio experimental induziu dano muscular e leucocitose. Entretanto, n?o houve diferen?a nos n?veis s?ricos de CK, AST e no n?mero de leuc?citos totais entre as condi??es experimentais. A recupera??o por imers?o em ?gua,a diferentes temperaturas, n?o foi efetiva em modificar o desempenho f?sico 4 horas ap?s uma sess?o de exerc?cio prolongado. / Disserta??o (Mestrado) ? Programa Multic?ntrico de P?s-gradua??o em Ci?ncias Fisiol?gicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2012. / Athletes of several sport modalities regularly train more than once a day. Several strategies have been used in order to accelerate post-exercise recovery. Although water immersion is a common strategy among athletes, it effectiveness in accelerate the recovery is not yet established, and the effects of temperature water immersion on performance are not clear. Thus, this study evaluated the effects of passive recovery water immersion at different temperatures on performance following an exercise session.Nine physically active men (24 ? 6 years old, 72 ? 13 kg, 177 ? 7 cm, peak oxygen consumption (VO2peak) of 55 ? 4 mL?kg- 1?min-1), participated of four randomized experimental sessions. Each session consisted of eccentric knee flexion (3 x 10 repetitions of 100% from one maximum repetition) and 90 minutes of treadmill running at 70% of VO2peak, followed by 15 minutes of passive recovery by water immersion at 15?C, 28?C or 38?C and 30 minutes resting in supine position at room temperature (20 ? 2?C). In the control session, volunteers remained seated for 15 minutes at room temperature after exercise. After four hours of resting, in order to evaluate recovery strategies, the volunteers underwent a 5 km of maximal self-paced treadmill running followed by the Wingate test. Prior to experimental sessions, rested volunteers completed 5 km of maximal self-paced running and the Wingate test, which were used as reference performance values. Rectal temperature (Tret), heart rate (HR) and heart rate variability indexes (HRV indexes) were measured through the entire session. Excess post-exercise oxygen consumption (EPOC) was measured during recovery period. The markers of muscle damage, creatine kinase (CK) and aspartate aminotransferase (AST) and total leukocyte count were measured before and after exercise, after immersion, before and after performance tests, and 24 hours after the experimental exercise. Average speed during 5 km of maximal self-paced treadmill running and relative peak power during Wingate test were not different between experimental conditions. Water immersion at 15?C reduced Tret, HR and HRV indexes to baseline values after recovery. EPOC was higher in water immersion at 15?C and 28?C. During 5 km of maximal self-paced treadmill running and Wingate test, Tret and HR were not different between experimental conditions. The experimental exercise session induced muscle damage and leukocytosis. However, there was no difference in serum CK, AST and total leukocyte count between experimental conditions.The recovery by water immersion at different temperatures was not effective in modify the physical performance 4 hours after a session of prolonged exercise.

Made available in DSpace on 2014-12-17T14:13:25Z (GMT). No. of bitstreams: 1 JairSVJ.pdf: 494758 bytes, checksum: ff6d790cbf26c2b6783c7734bbfc33e1 (MD5) Previous issue date: 2008-09-29 / Funda??o de Amparo a Pesquisa do Estado da Bahia / The identification of the factors that interfere in the decline of functional conditions is useful in the planning of actions addressing the improvement in the conditions of the lives of elderly people. The purpose of this investigation was to analyze the relationship between social demographics and health aspects of the functional condition in elderly women of low income of the Brazilian northeast. This crosssectional study involved a representative sample of 222 women with an average age of 70 years (? 7.1), belonging to coexisting groups and that were resident in the urban area of the municipal district of Jequi? /Bahia. In order to achieve this objective, a battery of physical tests of functional aptitude was carried out previously tested in pilot study, anthropometric measurements collected with a comparison of the measures referred to the reported weight and height as well as the application of an interview with questions containing subjects related to social demographic variables, clinical conditions and health, physical conditions and behaviors. Descriptive statistics Proceedings (frequency, average, standard deviation and percent distribution) were used for statistic analysis, and the calculation of the respective odds ratio by binary logistics regression, for the analysis of factors hierarchically grouped; p<0.05. The prevalence of 56% (n=122) of women considered with moderated or serious type of functional limitations was found, In which from multi-varied hierarchical analysis, significant association was verified with the age group over 80 years (p=0.02), conditions of widowhood (p=0.04), presence of arterial hypertension (p=0.001), and physical inactivity during leisure time (p=0.03). On the other hand for functional incapacities the prevalence was of 46.8% (n=104) being associated to the increase of the age (p=0.01), hospitalization (p=0.02), absence of physical activities along their lives (p=0.001) and the occurrence of alterations in the cognitive function (p=0.001). The normative table for the parameters of physical fitness generated conducive to health professionals in the diagnosis of health conditions and the prescription of physical exercises. The identified characteristics that are associated with the functional limitations / functional incapacities suggest a complex causal net in the determination of the functional condition in elderly women. However, actions addressed to the incentive of the practice of physical activities in the leisure time and the preservation of the cognitive function can contribute to a life with more quality for these people. This research was multidisciplinary approach to involve elements of psychology, nutrition and Physical Education in the elucidation of the object of study related to the functional condition of elderly women / A identifica??o de fatores que interferem no decl?nio da condi??o funcional ? ?til no planejamento de a??es direcionadas as melhorias nas condi??es de vida das pessoas idosas. O prop?sito dessa investiga??o foi o de analisar a rela??o dos aspectos s?cio-demogr?ficos e referentes a sa?de com a condi??o funcional em mulheres idosas de baixa renda do nordeste brasileiro. Este estudo teve um delineamento transversal, tendo uma amostra representativa de 222 mulheres, com m?dia de 70 anos (? 7,2) pertencentes a grupos de conviv?ncia e que eram residentes na zona urbana do munic?pio de Jequi?, Bahia. Para tanto foi conduzida uma bateria de testes de desempenho f?sico para avalia??o da aptid?o funcional previamente testada em estudo piloto, coletadas medidas antropom?tricas com a compara??o de medidas referidas com as reportadas para o peso e estatura, al?m da aplica??o de uma entrevista contendo quest?es relativas ?s vari?veis s?cio-demogr?ficas, condi??es cl?nicas, sa?de percebida, condi??es f?sicas e comportamentais. Para an?lise estat?stica foram utilizados procedimentos da estat?stica descritiva (freq??ncia, m?dia, desvio padr?o e distribui??o percent?lica) e o c?lculo da respectiva raz?o de chances mediante regress?o log?stica bin?ria, para an?lise de fatores hierarquicamente agrupados; p<0,05. Encontrou-se uma preval?ncia de 56% (n=122) de mulheres consideradas com limita??es funcionais do tipo moderada ou grave, nos quais a partir de an?lise multivariada hierarquizada, verificaram-se associa??o significativa com a faixa et?ria superior a 80 anos (p=0,02), condi??es de viuvez (p=0,04), presen?a de hipertens?o arterial (p=0,001), e inatividade f?sica no lazer (p=0,03). J? para as incapacidades funcionais a preval?ncia foi de 46,8% (n=104) sendo associada ao aumento da idade (p=0,01), hospitaliza??o (p=0,02), aus?ncia de pr?ticas de atividades f?sicas ao longo da vida (p=0,001) e a ocorr?ncia de altera??es na fun??o cognitiva (p=0,001). A tabela normativa para os par?metros de aptid?o f?sica gerada favorece aos profissionais de sa?de no diagn?stico das condi??es de sa?de e na prescri??o de exerc?cios f?sicos. As caracter?sticas identificadas que se associaram ?s limita??es funcionais/incapacidades funcionais sugerem uma complexa rede causal na determina??o da condi??o funcional em mulheres idosas. No entanto, a??es direcionadas ao incentivo da pr?tica de atividades f?sicas no lazer e a preserva??o da fun??o cognitiva podem contribuir para uma vida com mais qualidade a estas pessoas. Esta investiga??o teve a abordagem multidisciplinar ao envolver elementos da psicologia, nutri??o e da Educa??o F?sica na elucida??o do objeto de estudo relacionado ? condi??o funcional de mulheres idosas.