隨著資訊科技的蓬勃發展，使用者的資訊搜尋行為有了新面貌，線上公用目錄亦面臨重大轉變及挑戰。圖書館界應站在使用者角度來思考，設計及建置一個使用者滿意的線上公用目錄系統。國際圖書館協會聯盟（IFLA）在2005年提出的《Guidelines for Online Public Access Catalogue (OPAC) Displays》報告中，認為線上公用目錄的設計該有其原則，尤其應該考慮到使用者的需求。 　　本研究旨在從使用者角度出發，建構一套適合國內大專院校圖書館線上公用目錄的設計原則。本論文參考國內外線上公用目錄設計內容，除了參酌IFLA的原則基礎外，並融入其他學者專家、機構團體對於未來線上公用目錄的意見及建議，彙整一套從使用者角度思考的線上公用目錄設計原則草案。為了獲取使用者的意見，本研究共舉辦三場焦點團體訪談，藉由使用者的想法來修正草案內容，再將修正後之草案，經由分別針對學生與館員的問卷調查，來進行最後的原則項目清單之確認。 　　根據研究結果，確認使用者認同的線上公用目錄設計原則總計六大類35項原則。該六大類分別為「使用者需求」、「介面設計」、「內容及資料安排」、「檢索技術」、「個人化服務」及「資源整合」，並依平均數高低區分為不同重要性。未來圖書館員與廠商欲進行線上公用目錄設計的溝通，或評鑑線上公用目錄時可作為參考之用；並經由本研究發現使用者與館員的想法差異相當大，圖書館在建置線上公用目錄前應更瞭解使用者的資訊使用行為及習慣。 / The behavior of users’ information search has changed in the past years in accordance with the development of information technology. Therefore, Open Public Access Catalogue (OPAC) is facing great transformation and challenges. Libraries should design and construct an OPAC system from users’ perspective. In 2005, a report from International Federation of Library Association and Institution (IFLA) titled “Guidelines for Online Public Access Catalogue (OPAC) Displays” outlined principles in designing OPAC and highlighted the importance of users’ need. This study aims to offer a draft of design guidelines of OPAC for universities and colleges in Taiwan. It refers to IFLA guidance, local and abroad interfaces of OPACs, and blends in the feedback from scholars and educational institutions on the OPAC design. It also held three focus groups in order to gauge users’ views on how to improve the drafted guidelines. Then the revised guidelines were used to conduct further questionnaires on librarians and students. From there, it gave birth to the final guidelines. The analysis of the study came up six major categories and 35 principles. The six categories are: users’ need, design interface, content and information arrangement, retrieval technique, personalized service and information integration. This study could serve as the future guidance when librarians are in talks with vendors in their OPAC design, and when the evaluation of OPAC system is needed. This study also revealed that there is a gap between the opinion of users and librarians. Libraries should thus pay more attention in understanding what users want when constructing OPAC.

Living cells are made up of networks of interacting genes, proteins and other bio-molecules. Simple interactions between network components in forms of feedback regulations can lead to complex collective dynamics. A key task in cell biology is to gain a thorough understanding of the dynamics of intracellular systems and processes. In this thesis, a combined approach of mathematical modelling, computational simulation and analytical techniques, has been used to obtain a deeper insight into the dynamical aspects of a variety of feedback systems commonly encountered in cells. These systems range from model system with detailed available molecular knowledge to general regulatory motifs with varying network structures. Deterministic as well as stochastic modelling techniques have been employed, depending primarily on the specific questions asked. The first part of the thesis focuses on dissecting the principles behind the regulatory design of the Tryptophan Operon system in Escherichia coli. It has evolved three negative feedback loops, namely repression, attenuation and enzyme inhibition, as core regulator mechanisms to control the intracellular level of tryptophan amino acid, which is taken up for protein synthesis. Despite extensive experimental knowledge, the roles of these seemingly redundant loops remain unclear from a dynamical point of view. We aim to understand why three loops, rather than one, have evolved. Using a large-scale perturbation/response analysis through modelling and simulations and novel metrics for transient dynamics quantification, it has been revealed that the multiple negative feedback loops employed by the tryptophan operon are not redundant. In fact, they have evolved to concertedly give rise to a much more efficient, adaptive and stable system, than any single mechanism would provide. Since even the full topology of feedback interactions within a network is insufficient to determine its behavioural dynamics, other factors underlying feedback loops must be characterised to better predict system dynamics. In the second part of the thesis, we aim to derive these factors and explore how they shape system dynamics. We develop an analytical approach for stability and bifurcation analysis and apply it to class of feedback systems commonly encountered in cells. Our analysis showed that the strength and the Hill coefficient of a feedback loop play key role in determining the dynamics of the system carrying the loop. Not only that, the position of the loop was also found to be crucial in this decision. The analytical method we developed also facilitates parameter sensitivity analysis in which we investigate how the production and degradation rates affect system dynamics. We find that these rates are quite different in the way they shape up system behaviour, with the degradation rates exhibiting a more intricate manner. We demonstrated that coupled-loop systems display greater complexity and a richer repertoire of behaviours in comparison with single-loop ones. Different combinations of the feedback strengths of individual loops give rise to different dynamical regimes. The final part of the thesis aims to understand the effects of molecular noise on dynamics of specific systems, in this case the Tryptophan Operon. We developed two stochastic models for the system and compared their predictions to those given by the deterministic model. By means of simulations, we have shown that noise can induce oscillatory behaviour. On the other hand, incorporating noise in an oscillatory system can alter the characteristics of oscillation by shifting the bifurcation point of certain parameters by a substantial amount. Measurement of fluctuations reveals that that noise at the transcript level is most significant while noise at the enzyme level is smallest. This study highlights that noise should not be neglected if we want to obtain a complete understanding of the dynamic behaviour of cells.

A new approach to the discovery of high absorbing semiconductors for solar cells was taken by working under a set of design principles and taking a systemic methodology. Three transition metal chalcogenides at varying states of development were evaluated within this framework. Iron pyrite (FeS���) is well known to demonstrate excellent absorption, but the coexistence with metallic iron sulfides was found to disrupt its semiconducting properties. Manganese diselenide (MnSe���), a material heavily researched for its magnetic properties, is proposed as a high absorbing alternative to iron pyrite that lacks destructive impurity phases. For the first time, a MnSe��� thin film was synthesized and the optical properties were characterized. Finally, CuTaS���, a known but never characterized material, is also proposed as a high absorbing semiconductor based on the design principles and experimental results. / Graduation date: 2013

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本文針對臺灣以技術創新作為策略發展主軸的企業案例，以五芒星模型（Five Star Model），分析其從代工轉為品牌經營商時，在組織設計上，所採取的措施和手段，作為後進者依循的組織設計原則。 五芒星模型，以策略、組織結構、流程、薪酬制度和人力資源五大組織設計的基本元素，分析各項元素中組織設計的原則。而本文以華碩電腦、宏達國際電子兩家分別在個人電腦及手機業內卓然有成的臺灣企業作為分析案例。觀察他們在從代工，轉型到品牌經營商時，在策略、組織結構、流程、薪酬制度以及人力資源上，所採取的行動，並將這五大組織設計元素分析出來的結果，作歸納整理，形成一套可資遵循的準則，俾使後續臺灣其他有心以技術創新作為發展品牌的廠商，能夠在進行組織變革時，依著此準則，降低失敗的風險，提高成功的可能。 / This thesis will focus on Taiwanese enterprises which run their business with innovative technologies. We try to analyze these cases with Five Star Model. Figure out what they have done during their organization changes for transition from OEM to OBM. Through the five basic elements in the model, we could easily observe their actions and build the rules for those who want to find organizational design guidance. The Five Star model list Strategies, Organization Structure, Process, People, and Reward System, as the five basic elements in organization design. Researchers could use this model to analyze the enterprise and identify the organization design principles. In this thesis, Asustek Computers, and HTC are the enterprise which we are interested in. They both are the outstanding Taiwanese companies in PC and Mobile phone categories. Both companies are famous on their innovation thinking and design. They also do the same thing to change their business model – from OEM to OBM (Own Brand Manufacturing). We observe their actions in the transition from OEM to OBM, and use Five Star Model to analyze their policy in strategies, organization structure, process, people, and reward systems. Try to identify what they have done and list their organization change thinking in these categories. We will build the guidance through Five Star Model, and provide them to those who want to use the same scheme to build their own brand. Lower the risk of failure and promote the chances to be successful.