O fumo é a droga mais comumente usada na gestação, e suas conseqüências podem se manifestar por associação com prematuridade, retardo de crescimento fetal e baixo peso do recém-nascido, entre outras complicações. O tabaco possut vários metabólitos, sendo a nicotina e o monóxido de carbono os mais estudados. A nicotina atinge o feto através da placenta e concentrase no sangue fetal, no líquido amniótico e no leite materno. O uso do tabaco pela mãe causa aumento de substâncias vasoconstritoras e diminuição de substâncias vasodilatadoras no cordão umbilical, o que pode estar relacionado com as alterações perfusionais encontradas na unidade feto-matemo-placentária de gestantes tabagistas, e que podem estar associadas às alterações crônicas causadas pelo fumo.O objetivo deste trabalho foi pesquisar as alterações hemodinâmicas agudas na circulação da unidade feto-matemo-placentária imediatamente após o ato de a mãe fumar um cigarro padronizado, contendo O,Smg de nicotina e 6mg de monóxido de carbono. A população estudada foi constituída de gestantes normais, sem fatores de risco para doenças cardíacas fetais, porém fumantes crônicas. A amostra constou de 21 gestantes, que foram submetidas a uma ultrasonografia obstétrica e à ecocardiografia fetal antes e depois da exposição da mãe ao fumo. Foram verificadas a freqüência cardíaca e a pressão arterial maternas, a freqüência cardíaca fetal e a avaliação da resistência vascular medida pela relação S/D nos vasos uterinos e fetais. Foi avaliada a função sistólica e diastólica do coração fetal, através da fração de ejeção do ventrículo esquerdo e do índice de redundância do septum primum, respectivamente. Os resultados foram analisados pelo teste de Wilcoxon para dados não paramétricas. A média de idade das pacientes foi de 22,95 anos e a idade gestacional variou de 18 a 36 semanas. A média de cigarros fumados por dia era de 9,67. Os resultados comparados antes e depois da exposição da mãe ao fumo mostraram um aumento da pressão sistólica materna (p=0,004), da pressão diastólica materna (p=0,033), da freqüência cardíaca materna (p<O,OOI) e da freqüência cardíaca fetal (p=0,044). Ocorreu diminuição da relação S/D na artéria uterina esquerda (p=0,039) e na artéria uterina direita (p=0,014), imediatamente após o ato de fumar. A relação S/D na artéria cerebral média fetal não se alterou (p=0,078). O mesmo ocorreu com o fluxo sistólico no ductus arteriosus (p=O,l54) e na artéria pulmonar (p=0,958). Não houve alteração significativa na relação S/D na artéria umbilical (p=0,554). Também não ocorreram modificações na fração de ejeção do ventrículo esquerdo (p=0,943) e no índice de redundância do septum primum (p=0,836). A exposição da mãe ao fumo altera variáveis fisiológicas maternas e fetais, sem repercussão na função cardíaca fetal. A diminuição da resistência vascular uterina observada provavelmente esteja relacionada a um padrão dose-dependente da nicotina ou de seus componentes presentes no cigarro utilizado nesta pesquisa.

A presente dissertação abordou o nível sérico da Cocaine and Amphetamine Regulated Transcript (CART) em uma população altamente vulnerável – díades mães/bebês com história de exposição ao crack na gestação. A CART é um antioxidante endógeno presente desde o período embrionário e ativado por maiores níveis de dopamina. Foram avaliados 57 recém-nascidos expostos (RNE) e 99 não expostos (RNNE), e as suas mães. Utizou-se uma amostragem consecutiva, em um delineamento transversal. Foram considerados potenciais confundidores: dados maternos, como psicopatologia, QI, intensidade do uso de outras substâncias além de crack nos últimos três meses, doenças infecto-contagiosas e outros. Também foram considerados dados dos recém-nascidos (RNs), como apgar, peso e gênero, entre outros. No primeiro artigo, foram comparados os níveis de CART entre RNs com exposição intrauterina (EIU) ao crack vs RNs controles. Além disso, comparamos os níveis séricos de CART entre as mães desses RNs, no período pós-parto imediato. A análise estatística foi através de General Linear Model. A média ajustada da CART foi significativamente maior em RN expostos em comparação aos não expostos (0,18, IC95% 0,09 - 0,27 vs 0,05, IC95% 0,02 - 0,07; p = 0,002, d = 0,68), mesmo considerando-se o efeito da intensidade do uso de álcool nos últimos três meses. Já nas mães, não houve diferença nos níveis da CART entre expostas (mediana = 0,024, amplitude interquartil 1,123, amplitude 0,006222 – 1,126010, n = 44) e não expostas (mediana = 0,031, amplitude interquartil 3,439, amplitude 0,003739 – 3,442805, n= 90, p = 0,08, Mann-Whitney U Test). No segundo artigo, foi analisada a correlação (Spearman correlation test) entre CART no SCU e no sangue periférico materno das usuárias de crack desta mesma amostra. Encontramos correlação direta e moderada (rs= 0,350, p = 0,043). Através dos resultados do primeiro estudo, confirmamos alterações no sistema REDOX destas díades, sendo a CART mais mobilizada na dupla com exposição. A falta de diferença entre as puérperas sugere que a resposta antioxidante endógena possa variar de acordo com a etapa do ciclo vital e, talvez, a cronicidade do estressor – no caso, tempo de uso de crack. Através dos resultados do segundo artigo, concluímos que há um sistema antioxidante endógeno atuando desde cedo no feto em desenvolvimento. Em conjunto, trata-se de dados inovadores, com características de neuroproteção em RNs. Estes achados podem ajudar a elucidar os caminhos neurobiológicos responsáveis pelas alterações de neurodesenvolvimento, contribuindo para a ampliação das possibilidades de intervenções precoces. / The present master’s dissertation addressed the serum level of Cocaine and Amphetamine Regulated Transcript (CART) in a highly vulnerable population - mother/newborn dyads with a history of exposure to crack/cocaine during pregnancy. CART is an endogenous antioxidant present since the embryonic period and activated by higher levels of dopamine. We evaluated 57 exposed and 99 unexposed infants, and their mothers. A consecutive sampling was used in a cross-sectional design. Potential confounders were considered: maternal data, such as psychopathology, IQ, intensity of use of other substances besides crack/cocaine in the last three months, infectious diseases and others. Data on newborns, such as apgar, weight and gender, among others, were also considered. In the first article, we compared the levels of CART among newborns with intrauterine exposure to crack/cocaine vs newborns controls. In addition, we compared the serum levels of CART among the mothers of these newborns in the immediate postpartum period. The statistical analysis was through General Linear Model. The CART adjusted mean was significantly higher in exposed infants compared to non-exposed infants (0.18, 95% CI 0.09 - 0.27 vs 0.05, 95% CI 0.02-0.07, p = 0.002, D = 0.68), even considering the effect of the intensity of alcohol use in the last three months. In the mothers, there was no difference in the CART levels between exposed (median = 0.024, interquartile range 1,123, range 0.006222 - 1.126010, n = 44) and not exposed (median = 0.031, interquartile range 3,439, range 0.003739 - 3,442,805, n = 90, p = 0.08, Mann-Whitney U Test). In the second article, the correlation (Spearman correlation test) between CART in the umbilical cord blood (UCB) and the maternal peripheral blood of the crack/cocaine users of this same sample was analyzed. We found direct and moderate correlation (rs = 0.350, p = 0.043). Through the results of the first study, we confirmed changes in the REDOX system of these dyads, with CART being more mobilized in the pair with exposure. The lack of difference between postpartum women suggests that the endogenous antioxidant response may vary according to the stage of the life cycle and perhaps the chronicity of the stressor - in this case, crack/cocaine use duration. Through the results of the second article, we conclude that there is an endogenous antioxidant system acting at an early stage in the developing fetus. Together, these are innovative data, with characteristics of neuroprotection in newborns. These findings may help elucidate the neurobiological pathways responsible for neurodevelopmental changes, contributing to the expansion of the possibilities of early intervention.

Leung Kim-chuen Andrew. / "August 2000." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2000. / Includes bibliographical references (p. 168-200). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

by Tse Kam Wah. / "September 1998." / Thesis (Ph.D.)--Chinese University of Hong Kong, 1998. / Includes bibliographical references (p. 123-145). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

The aim of this thesis was to examine fetal behavioural responses to auditory and tactile stimulation. Responses were examined for the second- and third-trimester fetuses (second-trimester ≤ 27 gestational weeks (wGA), third- trimester >27 wGA), in both experiments, respectively. Experiment 1 of this thesis examined fetal behavioural responses to the mother’s recorded and live voice, contrasting findings to an environmental sound and silent control conditions. Behavioural responses of 30 fetuses trimester (20-33 wGA, N = 13 in the 2nd and N = 17 in the 3rd trimester) Were examined in the following conditions were explored: (1) mother’s live, (2) and recorded voice, (3) an environmental sound, and (4) a silent control condition. Findings showed the strongest responses to maternal sounds as well as differential responses between gestational age groups. Younger fetuses displayed an arousal response to maternal voice, whereas third-trimester fetuses displayed an orientating response. The aim of Experiment 2 was to examine whether fetuses can differentiate between different human sources of tactile stimulation of the maternal abdomen. Behavioural responses of 28 fetuses (20-33 wGA, N = 15 in the 2nd and N = 13 in the 3rd trimester) were examined across four conditions: (1) mother’s, (2) father’s, and (3) stranger’s touch, as well as a (4) silent control condition. Differential responses to the tactile stimulation were found, especially in reaching of the uterine wall, and self- touch across the four conditions. Third- trimester fetuses touched the uterus wall for significantly longer than fetuses in the second-trimester. The strongest responses were found to the mother’s touch. Further differential responses were found between age groups, with third-trimester fetuses clearly differentiating between different sources of tactile stimulation, while second-trimester fetuses hardly showed differentiated responses. It is suggested that maturational differences in both experiments are due to the fetal development of the central nervous system, and might indicate the emergence of a proprioceptive self-awareness by the 3rd trimester.

The palaeopathology of very young individuals offers valuable information for the study of maternal, fetal, perinatal, neonatal and infant health in past populations. The primary aims of this research are to differentiate skeletal pathology from normal appearance in very young individuals, to assess the relationship between the palaeopathology of very young individuals and maternal physiological stress, and to evaluate the ways in which past communities responded to perinatal, infant and maternal mortality. The palaeopathology described below is determined through non-destructive methods analysis of skeletal remains and involves macroscopic examination and metrical analysis. The research sample is drawn from seven archaeological collections (Ardreigh, n=87; Baron Court Farm, n=55; Çatalhöyük, n=86; Gussage All Saints, n=35; Wetwang Slack, n=36; Wharram Percy, n=83; Yewden villa, n=56), two reference collections (Royal College of London, n=199; Scheuer, n=29), one of which also includes archaeological material, and five modern perinatal pathology cases. The identified skeletal pathology is considerable and ranges from minor morphological variation through to agenesis, and trauma associated with obstetric complications. There is strong evidence in the form and severity of palaeopathology for compromised maternal condition during pregnancy. Skeletal pathology was evident in two thirds of the young individuals analysed with the majority of these falling into the perinatal and neonatal age categories. There is evidence for population specific skeletal pathology, particularly with respect to non-metric variants such as intrajugular bridging and vertebral border shifting. Several causes of mortality were positively identified and many individuals display skeletal pathology indicative of a significantly compromised physiological state during gestation and early infancy. Maternal health prior to and during pregnancy is demonstrated to have had a considerable impact on the development and growth of their offspring. The palaeopathology of the past populations studied revealed that they experienced undernutrition and malnutrition, exposure to infectious diseases, accidental and intentional physical trauma and periods of social disruption. These communities also had access to supportive treatment and intervention that is evidenced in the numerous cases of healed and healing skeletal pathology. The response of the living towards the death of mothers and very young individuals in the past populations studied is revealed through their funerary treatment of these individuals and provides insight into the broader socio-cultural and personal contributions to burial practices in each community.

Liu Bao Yi. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2004. / Includes bibliographical references (leaves 83-104). / Abstracts in English and Chinese. / ABSTRACT --- p.i / ACKNOWLEDGEMENT --- p.v / TABLE OF CONTENTS --- p.vi / LIST OF ABBREVIATIONS --- p.xii / LIST OF FIGURES --- p.xivv / LIST OF TABLES --- p.xv / PUBLICATION RELATED TO THIS THESIS --- p.xvii / Chapter PART 1 --- INTRODUCTION AND LITERATURE RESEARCH / Chapter CHAPTER 1 --- INTRODUCTION --- p.1 / Chapter CHAPTER 2 --- MECONIUM STAINED LIQUOR --- p.3 / Chapter 2.1 --- AMNIOTIC FLUID --- p.3 / Chapter 2.1.1 --- Function of Amniotic Fluid --- p.3 / Chapter 2.1.2 --- Composition Of Amniotic Fluid --- p.3 / Chapter 2.1.3 --- Regulation Of Amniotic Fluid --- p.4 / Chapter 2.1.4 --- Abnormality Of Amniotic Fluid Volume --- p.4 / Chapter 2.2 --- MECONIUM STAINED LIQUOR --- p.6 / Chapter 2.2.1 --- Formation And Composition Of Meconium --- p.6 / Chapter 2.2.2 --- Peristalsis Of Fetal Gastrointestinal Tract --- p.7 / Chapter 2.2.3 --- Meconium Stained Liquor(MSL) --- p.7 / Chapter 2.2.3.1 --- Maturation Theory --- p.7 / Chapter 2.2.3.2 --- Cord Compression Theory --- p.9 / Chapter 2.2.3.3 --- Fetal Hypoxia Theory --- p.10 / Chapter 2.2.4 --- Fetal Effect Of Meconium In Amniotic Cavity --- p.11 / Chapter 2.2.5 --- Meconium Aspiration Syndrome --- p.12 / Chapter 2.2.6 --- Clinical Significance And Limitation Of Studies --- p.13 / Chapter 2.3 --- Purpose Of Study --- p.14 / Chapter CHAPTER 3 --- OXIDATIVE STRESS AND FETAL HYPOXIA --- p.16 / Chapter 3.1 --- OXIDATIVE STRESS --- p.16 / Chapter 3.2 --- FREE RADICALS --- p.16 / Chapter 3.2.1 --- Sources Of Free Radicals --- p.17 / Chapter 3.2.1.1 --- Biological Source Of Free Radicals --- p.17 / Chapter 3.2.1.2 --- Intracellular Source Of Free Radicals --- p.17 / Chapter 3.2.1.3 --- Composition Of Free Radicals And Reactive Oxygen Species --- p.18 / Chapter 3.2.2 --- Cellular Components At Risk From Free Radicals Damage --- p.20 / Chapter 3.2.2.1 --- Proteins --- p.20 / Chapter 3.2.2.2 --- Nucleic Acids And DNA --- p.21 / Chapter 3.2.2.3 --- Membrane Lipids --- p.21 / Chapter 3.2.3 --- Lipid Peroxidation --- p.21 / Chapter 3.2.3.1 --- Chemical Substances Of Membranes --- p.21 / Chapter 3.2.3.2 --- The Reactions Of Lipid Peroxidation --- p.22 / Chapter 3.2.3.3 --- Lipid Peroxidation In Pregnancy --- p.23 / Chapter 3.2.4 --- Protection Against Lipid Peroxidation --- p.24 / Chapter 3.2.5 --- Isoprostanes --- p.26 / Chapter 3.2.5.1 --- Definition --- p.26 / Chapter 3.2.5.2 --- Formation Of Isoprostanes --- p.26 / Chapter 3.2.5.3 --- Metabolism Of Isoprostanes --- p.27 / Chapter 3.2.5.4 --- Biological Characteristics Of Isoprostanes --- p.29 / Chapter 3.2.5.5 --- Isoprostanes As Mediators Of Oxidantive Stress --- p.29 / Chapter 3.3 --- FETAL HYPOXIA --- p.30 / Chapter 3.3.1 --- Fetal Metabolism And Energy Supply --- p.30 / Chapter 3.3.2 --- Free Radical Generation And Fetal Hypoxia-Reoxygenation --- p.33 / Chapter 3.3.3 --- Fetal Hypoxia And Fetal Brain Injury --- p.34 / Chapter 3.3.4 --- Measurement Of Fetal Hypoxia --- p.35 / Chapter 3.3.4.1 --- Acid-Base Balance --- p.35 / Chapter 3.3.4.2 --- Fetal Heart Rate Monitoring --- p.36 / Chapter 3.3.4.3 --- Apgar scores --- p.37 / Chapter 3.3.4.4 --- Pulse Oximetry --- p.37 / Chapter 3.3.4.5 --- Lipid Peroxides --- p.38 / Chapter CHAPTER 4 --- AMNIOINFUSION --- p.40 / Chapter 4.1 --- AMNIOINFUSION --- p.40 / Chapter 4.2 --- AMNIOINFUSION FOR OLIGOHYDRAMNIOS --- p.40 / Chapter 4.3 --- AMNIOINFUSION FOR MECONIUM STAINED LIQUOR --- p.41 / Chapter 4.4 --- PURPOSE OF THE STUDY --- p.42 / Chapter PART 2 --- CLINICAL PROTOCOLS AND MEASUREMENT OF ISOPROSTANES / Chapter CHAPTER 5 --- CLINICAL PROTOCOLS --- p.43 / Chapter 5.1 --- ETHICS --- p.43 / Chapter 5.2 --- CLINICAL PROTOCOLS --- p.43 / Chapter 5.2.1 --- Artificial Rupture Of Membranes (Amniotomy) --- p.43 / Chapter 5.2.2 --- Classification of Meconium Stained Liquor --- p.44 / Chapter 5.2.3 --- Electronic Fetal Heart Rate Monitoring --- p.44 / Chapter 5.2.4 --- Monitoring The Progress of Labour --- p.44 / Chapter 5.2.5 --- Umbilical Cord Blood Gas Analysis --- p.45 / Chapter 5.2.6 --- Apgar Score --- p.45 / Chapter 5.2.7 --- Meconium Aspiration --- p.46 / Chapter 5.2.8 --- Clinical Outcome --- p.46 / Chapter CHAPTER 6 --- MEASUREMENT OF ISOPROSTANES --- p.50 / Chapter 6.1 --- BLOOD PREPARATION --- p.50 / Chapter 6.2 --- REAGENTS --- p.50 / Chapter 6.3 --- GAS CHROMATOGRAPHY AND MASS SPECTROMETRY (GC-MS) --- p.51 / Chapter 6.4 --- PROCEDURES --- p.51 / Chapter 6.5 --- DATA RELIABILITY --- p.53 / Chapter PART 3 --- RESULTS AND DISCUSSION / Chapter CHAPTER 7 --- MECONIUM STAINED LIQUOR (MSL) DURING LABOUR AND NEONATAL CORD BLOOD 8-IS〇-PGF2α CONCENTRATION --- p.54 / Chapter 7.1 --- OBJECTIVE --- p.54 / Chapter 7.2 --- MATERIALS AND METHOD --- p.55 / Chapter 7.3 --- STATISTICAL ANALYSIS --- p.56 / Chapter 7.4 --- RESULTS --- p.57 / Chapter 7.5 --- DISCUSSION --- p.65 / Chapter 7.6 --- CONCLUSION --- p.67 / Chapter CHAPTER 8 --- EVALUATION OF PROPHYLACTIC AMNIOINFUSION FOR INTRAPARTUM MECONIUM STAINED LIQUOR --- p.69 / Chapter 8.1 --- OBJECTIVE --- p.69 / Chapter 8.2 --- MATERIALS AND METHOD --- p.69 / Chapter 8.2.1 --- Study Group: 226}0ب MSL+AI' --- p.69 / Chapter 8.2.2 --- The Procedure Of Amnioinfusion --- p.70 / Chapter 8.2.3 --- Other Study Group --- p.71 / Chapter 8.3 --- STATISTIC ANALYSIS --- p.71 / Chapter 8.4 --- RESULTS --- p.72 / Chapter 8.4.1 --- Comparison Between The 'MSL+AI' And 'MSL-AI' Groups --- p.72 / Chapter 8.4.2 --- Comparison Between 226}0بMSL+AI'And 'Clear Liquor' Groups --- p.74 / Chapter 8.5 --- DISCUSSION --- p.77 / Chapter 8.6 --- CONCLUSION --- p.79 / Chapter CHAPTER 9 --- COMMENTS AND FUTURE RESEARCH --- p.80 / BIBLIOGRAPHY --- p.83

"February 2002." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2002. / Includes bibliographical references (p. 171-209). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

Made available in DSpace on 2014-06-11T19:30:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-11-01Bitstream added on 2014-06-13T19:19:35Z : No. of bitstreams: 1 cambri_lt_dr_rcla.pdf: 6115778 bytes, checksum: d91311fdbb6890a5a464bd78199ad770 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Este estudo teve por objetivo analisar as alterações que a desnutrição fetal provoca na homeostase glicêmica e na capacidade aeróbia, e quais alterações persistem na idade adulta, mesmo após a realimentação, em modelo experimental utilizando ratos. Adicionalmente, visou verificar a susceptibilidade de animais precocemente desnutridos aos efeitos metabólicos da sobrecarga de frutose. Ratas Wistar adultas (90 dias) foram alimentadas durante a prenhez com dieta balanceada (B) - 17% proteína ou hipoproteica (H) - 6% proteína. Imediatamente após o nascimento, as crias do sexo masculino foram distribuídas em grupos de acordo com o regime alimentar até o final do experimento: Balanceada: dieta B durante todo o período experimental; Balanceada/Frutose: dieta B até o nascimento e dieta rica em frutose (F) - 60% frutose até o final do experimento; Hipoproteica/Balanceada: dieta H até o nascimento e dieta B até o final do experimento; Hipoproteica/Frutose: dieta H até o nascimento e dieta F até o final do experimento. Realizou-se duas séries de experimentos, a primeira observando os animais até a idade adulta (90 dias) e a segunda até a idade jovem (60 dias). Os animais foram avaliados quanto a: tolerância à glicose (teste de tolerância à glicose); sensibilidade à insulina (teste de tolerância à insulina) e capacidade aeróbia (teste da máxima fase estável de lactato - MFEL). Foram também analisadas concentrações séricas de glicose, triglicerídeos, colesterol total, LDL-C, HDL-C, ácidos graxos livres, proteínas totais, albumina, concentrações de glicogênio e lipídios totais no fígado; peso e concentração de lipídios totais do tecido adiposo das regiões mesentérica, retroperitonial e subcutânea e metabolismo da glicose pelo músculo sóleo (captação e oxidação da glicose, síntese e concentração de glicogênio)... (Resumo completo, clicar acesso eletrônico abaixo / This study aimed to analyze the alterations that the fetal malnutrition causes in the glycemic homeostasis and in the aerobic capacity, and if this changes persist into adulthood, after the nutritional recovery in an experimental model using rats. Additionally, it aimed to verify the susceptibility of early malnourished animals metabolic effects of fructose overload. Pregnant Wistar rats were fed with a balanced (B) diet or a low-protein (L) diet. After birth and until the end of the experiment, the male offspring were distributed into four groups according to the diet received: B: B diet during the whole experiment; balanced/fructose (BF): B diet until birth and fructose-rich (F) diet afterwards; low protein/balanced (LB): L diet until birth and B diet afterwards; low protein/fructose (LF): L diet until birth and F diet afterwards. Two series of experiments were performed, in the first the animals were observed until adulthood (90 days) and in the second, until young age (60 days). The animals were evaluated for: glucose tolerance (glucose tolerance test), insulin sensitivity (insulin tolerance test) and aerobic capacity (maximal lactate steady state - MLSS). Serum concentration of glucose, triglycerides, total cholesterol, LDL-C, HDL-C, free fatty acids, total proteins and albumin, liver glycogen and liver total lipids, weight and total lipids in adipose tissue in mesenteric, retroperitoneal and subcutaneous regions, and glucose metabolism by soleous muscle (glucose uptake and oxidation, glycogen concentration and synthesis) were analyzed in two conditions: rest and after acute physical exercise in the intensity of MLSS. The results of the first series of experiments show that early high fructose consumption impaired body weight gain and reduced adipose tissue weight of some regions, independently of the nutritional... (Complete abstract click electronic access below)

Made available in DSpace on 2015-09-25T12:23:30Z (GMT). No. of bitstreams: 1 AdrianaSuelyDeOliveiraMelo.pdf: 1630120 bytes, checksum: 950aa60ce902a0cf32710f0a25ba7bcb (MD5) Previous issue date: 2000-01-01 / A presente dissertação cumpre as exigências do Programa de Mestrado em Saúde Coletiva da Universidade Estadual da Paraíba (UEPB) e é resultante do acompanhamento de uma coorte de 115 gestantes atendidas por equipes urbanas do Programa de Saúde da Família do município de Campina Grande, PB. A dissertação está organizada nos seguintes tópicos: Introdução, Objetivos, Métodos, Resultados e Conclusão. Os resultados estão escritos em forma de dois artigos para serem apresentados às revistas da área. O primeiro artigo, intitulado estado nutricional materno, ganho de peso gestacional e peso ao nascer, consiste no estudo descritivo da coorte pesquisada. Já o segundo, resulta do estudo analítico da referida coorte e recebe o seguinte título: Determinantes do crescimento fetal e peso ao nascer em gestantes acompanhadas pelo programa de saúde da família.