The beef cattle industry has placed increased focus on mature cow size as a result of its influence on production efficiency and profitability. The objectives of this study were to evaluate relationships among lifetime measures of body weight (BW) and frame score (FS) in commercial beef females, and to assess the value of immature measures as predictors of mature cow size. Measurements of BW, hip height (HH), body condition score (BCS), and calculated FS were recorded at weaning (WN), breeding at 13 mo age (BR), and 8 subsequent periods, ceasing at approximately 5 yr of age for 232 Angus-cross females born 2004 through 2008. Correlation analysis revealed significant (P < 0.001) relationships among BW taken at WN and BR with BW measurements taken at 2.5, 3.8, and 4.8 yr of age (WN r = 0.70, 0.51, 0.61; BR r = 0.65, 0.57, 0.64, respectively). Significant relationships (P < 0.001) existed between FS collected at WN and BR, and FS at 2.5 and 3.8 yr (WN= 0.70, 0.72; BR= 0.79, 0.82, respectively). Repeatability of lifetime FS measures was 0.73. BCS was a significant (P < 0.001) source of variation in mature BW, with a unit change in BCS accounting for 41 kg BW change at 4.8 yr (P < 0.001). BW and FS were moderately to strongly related (P < 0.001) at WN, BR, 2.5, 3.8, and 4.8 yr (r = 0.62, 0.49, 0.62, 0.62, and 0.47 respectively). Prediction models for BW at 4.8 yr were similar using weaning BW alone, or with inclusion of both weaning BW and HH (R2 = 0.57 and 0.56). Similarly, breeding BW and HH were non-additive for prediction of 4.8 yr BW (R2 = 0.68, 0.58, and 0.68 for BW, HH, and BW +HH respectively). Performance at immature ages proves to be a satisfactory indicator of mature size, supporting continued incorporation of immature BW and HH and/or FS measurements into selection practices. / Master of Science

This thesis assesses the impact of the Jepara Furniture Value Chain (FVC) project, which was conducted by the Center for International Forestry Research (CIFOR) to address challenges faced by small-scale furniture producers in Jepara, Indonesia. This assessment focuses on the effect of membership in the APKJ, a producer association started as part of the project. The propensity score for association membership was estimated using unchanging firm and owner characteristics, as well as information recalled about firm operations in 2009 (before the association was formed). Propensity score matching was used to compare outcome variables of association members and non-members. Results suggest that membership in the APKJ does not have a significant effect on profit levels. Using differenced current and recalled marketing and production behaviors as outcome variables with propensity score matching indicates that members have improved their bargaining position and marketing behaviors more than non-members since 2009. Additionally, APKJ members are more likely to have obtained certificates of timber legality / Master of Science

Titel: Är det lönsamt att investera i hållbarhet?   Nivå: Examensarbete på grundnivå (kandidatexamen) i ämnet företagsekonomi   Författare: Haben Ablelom Gebremeskel   Handledare: Jan Svanberg   Datum: 2024 – Mars   Syfte: Företag i dagens samhälle befinner sig i en allt mer påträngande situation där de måste arbeta hållbart eller bedriva verksamhet på ett hållbart sätt, och detta har blivit centralt sedan flera år tillbaka. I och med att hållbarhet blir allt mer viktig och finansiella sektorn spelar en viktig roll för länders samhällsekonomier började forskningsvärlden undersöka sambandet mellan ESG-betyg och företagens finansiella prestationer. Mycket av den tidigare forskning har presenterat varierande och motstridiga resultat. Till följd av detta undersöker denna studie sambandet mellan finansiella sektorns finansiella prestationer och ESG-betyg. Studiens syfte är att undersöka samt analysera om det finns ett samband mellan företagets ESG-betyg och finansiell prestation inom den europeiska finanssektorn.   Metod: Studien använder sig av en kvantitativ metod som tillämpar en deduktiv ansats. Den sekundärdata som använts har hämtats ifrån Refinitiv Eikon. Studiens urval består av 160 finansbolag som verkar i 23 olika länder inom den europeiska kontinenten, dessa företag har analyserats under en tidsperiod på 3 år. Studiens data har analyserats med hjälp av bivariat-, univariat- och multivariat analys.   Resultat och slutsats: Resultatet visade inte på något signifikant samband mellan ESG-betyg och finansiella prestationer, men inte heller mellan S-betyget samt G-betyget och finansiella prestationer. Resultatet visade ett signifikant positivt samband mellan den enskilda dimensionen E-betyget och ROA. Utifrån legitimitet- och intressentteorins antaganden stärker företag som engagerar sig i just miljöfrågor sitt legitimitet och förtroende hos företagets intressenter och i samhället.   Examensarbetets bidrag: Denna studie bidrar med en uppdaterad analys angående sambandet mellan hållbarhetsrapportering och finanssektorns finansiella prestationer. Studiens resultat bidrar med nyttig information för finanssektorns samtliga intressenter. Utifrån studiens resultat kan det konstateras att investerare, intressenter och bolag som engagerar sig i just miljöfrågor får en tydlig förklaring då studie fann ett signifikant samband mellan miljöaspekten och företagets finansiella prestationer, resterande resultat visar att europeiska finanssektorn är fortsatt till intresse för forskningsvärld.   Förslag till framtida forskning: Ytterligare undersökningar bör göras gällande relationen mellan ESG-betyg och finanssektorns finansiella prestationer, ett förslag till framtida forskning är att inkludera ytterligare variabler som står i förhållande till studerade ämnet. Detta kan göras genom att använda sig av olika databaser som publicerar företagens ESG-betyg, på så sätt kan antalet av både beroende och oberoende variabler få en ökning vilket ökar studiens trovärdighet.

Although originally conceived as an educational intervention for at-risk students, modern career academies have expanded their scope to programs designed to promote critical thinking, problem solving, and analytical skills to be successful in an advanced career path. Through the integration of career and technical education courses and a rigorous, college preparatory academic curriculum, career academies serve as a key piece of a larger strategy for developing a well- prepared STEM workforce. This study focuses on the Virginia Governor's STEM Academies, a state-wide initiative containing programs designed to expand options for the general student population to acquire STEM literacy and other critical skills, knowledge and credentials that will prepare them for high-demand, high-wage, and high-skill careers. Currently, 22 Academies exist serving students across 36 Virginia School Divisions. Using educational administrative data housed within the Virginia Longitudinal Data System, I examined the Virginia Governor's STEM Academies regarding characteristics of student participation and the relationship between Academy participation and high school and postsecondary outcomes. Using multi-level regression modeling, I found that male students, Asian and Hispanic students, and non-economically disadvantage students have a higher rate of Academy participation. After matching students with propensity score matching on demographic and early academic characteristics, I find that Academy participants are more likely to take Algebra II at an earlier grade, enroll in more Career and Technical Education and dual enrollment courses, and declare a STEM major after enrolling at a postsecondary institution. This research provides a valuable new contribution to the study of career academies after such educational programs have undergone a paradigm shift to preparing students for high-demand, high-wage, and high-skill careers. By incorporating propensity score matching and multi-level regression model, I employ a statistically rigorous approach that can serve as important benchmarking of the enrollment and academic outcomes of the Virginia Governor's STEM Academies. / Doctor of Philosophy / Although originally conceived as an educational intervention for at-risk students, modern career academies have expanded their scope to programs designed to promote critical thinking, problem solving, and analytical skills to be successful in an advanced career path. Through the integration of career and technical education courses and a rigorous, college preparatory academic curriculum, career academies serve as a key piece of a larger strategy for developing a well- prepared STEM workforce. This study focuses on the Virginia Governor's STEM Academies, a state-wide initiative containing programs designed to expand options for the general student population to acquire STEM literacy and other critical skills, knowledge and credentials that will prepare them for high-demand, high-wage, and high-skill careers. Currently, 22 Academies exist serving students across 36 Virginia School Divisions. Using educational administrative data housed within the Virginia Longitudinal Data System, I examined the Virginia Governor's STEM Academies regarding characteristics of student participation and the relationship between Academy participation and high school and postsecondary outcomes. Using multi-level regression modeling, I found that male students, Asian and Hispanic students, and non-economically disadvantage students have a higher rate of Academy participation. After matching students with propensity score matching on demographic and early academic characteristics, I find that Academy participants are more likely to take Algebra II at an earlier grade, enroll in more Career and Technical Education and dual enrollment courses, and declare a STEM major after enrolling at a postsecondary institution. This research provides a valuable new contribution to the study of career academies after such educational programs have undergone a paradigm shift to preparing students for high-demand, high-wage, and high-skill careers. By incorporating propensity score matching and multi-level regression model, I employ a statistically rigorous approach that can serve as important benchmarking of the enrollment and academic outcomes of the Virginia Governor's STEM Academies.

Yes / Importance: Myopia is a leading cause of untreatable visual impairment and is increasing in prevalence worldwide. Interventions for slowing childhood myopia progression have shown success in randomized clinical trials; hence, there is a need to identify which children would benefit most from treatment intervention. Objectives: To examine whether genetic information alone can identify children at risk of myopia development and whether including a child’s genetic predisposition to educational attainment is associated with improved genetic prediction of the risk of myopia. Design, Setting, and Participants: Meta-analysis of 3 genome-wide association studies (GWAS) including a total of 711 984 individuals. These were a published GWAS for educational attainment and 2 GWAS for refractive error in the UK Biobank, which is a multisite cohort study that recruited participants between January 2006 and October 2010. A polygenic risk score was applied in a population-based validation sample examined between September 1998 and September 2000 (Avon Longitudinal Study of Parents and Children [ALSPAC] mothers). Data analysis was performed from February 2018 to May 2019. Main Outcomes and Measures: The primary outcome was the area under the receiver operating characteristic curve (AUROC) in analyses for predicting myopia, using noncycloplegic autorefraction measurements for myopia severity levels of less than or equal to −0.75 diopter (D) (any), less than or equal to -3.00 D (moderate), or less than or equal to −5.00 D (high). The predictor variable was a polygenic risk score (PRS) derived from genome-wide association study data for refractive error (n = 95 619), age of onset of spectacle wear (n = 287 448), and educational attainment (n = 328 917). Results: A total of 383 067 adults aged 40 to 69 years from the UK Biobank were included in the new GWAS analyses. The PRS was evaluated in 1516 adults aged 24 to 51 years from the ALSPAC mothers cohort. The PRS had an AUROC of 0.67 (95% CI, 0.65-0.70) for myopia, 0.75 (95% CI, 0.70-0.79) for moderate myopia, and 0.73 (95% CI, 0.66-0.80) for high myopia. Inclusion in the PRS of information associated with genetic predisposition to educational attainment marginally improved the AUROC for myopia (AUROC, 0.674 vs 0.668; P = .02), but not those for moderate and high myopia. Individuals with a PRS in the top 10% were at 6.1-fold higher risk (95% CI, 3.4–10.9) of high myopia. Conclusions and Relevance: A personalized medicine approach may be feasible for detecting very young children at risk of myopia. However, accuracy must improve further to merit uptake in clinical practice; currently, cycloplegic autorefraction remains a better indicator of myopia risk (AUROC, 0.87). / PhD studentship grant from the College of Optometrists (Drs Guggenheim and Williams; supporting Mr Mojarrad) entitled Genetic prediction of individuals at-risk for myopia development) and National Institute for Health Research (NIHR) Senior Research Fellowship award SRF-2015-08-005 (Dr Williams). The UK Medical Research Council and Wellcome grant 102215/2/13/2 and the University of Bristol provide core support for the Avon Longitudinal Study of Parents and Children (ALSPAC). A comprehensive list of grants funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf). This research was conducted using the UK Biobank Resource (application 17351). The UK Biobank was established by the Wellcome Trust, the UK Medical Research Council, the Department for Health (London, England), the Scottish government (Edinburgh, Scotland), and the Northwest Regional Development Agency (Warrington, England). It also received funding from the Welsh Assembly Government (Cardiff, Wales), the British Heart Foundation, and Diabetes UK.

Yes / Background: Myopia has been shown to have a complex mode of inheritance, being influenced by both genetic and environmental factors. Here, an introduction into myopia genetics is given, with the shortcomings of current genetic prediction for myopia discussed, including the proportionally limited research on genetic prediction in people of non-European ancestry. A previously developed genetic risk score derived from European participants was evaluated in participants of non-European ancestry. Methods: Participants from UK Biobank who self-reported their ethnicity as “Asian”, “Chinese”, or “Black” and who had refractive error and genetic data available were included in the analysis. Ancestral homogeneity was confirmed using principal component analysis, resulting in samples of 3500 Asian, 444 Chinese, and 3132 Black participants. A published refractive error GWAS meta-analysis of 711,984 participants of European ancestry was used to create a weighted genetic risk score model which was then applied to participants from each ethnic group. Accuracy of genetic prediction of refractive error was estimated as the proportion of variance explained (PVE). Receiver operating characteristic (ROC) curves were developed to estimate myopia prediction performance at three thresholds: any myopia (equal to or more than 0.75D), moderate myopia (between -3.00D and -4.99D) and high myopia (equal to or more than -5.00D). Odds ratios for myopia were calculated for the participants in the top 10th or 5th percentile of genetic risk score distribution, comparing them to the remainder of the population. Results: The PVE value for refractive error was 6.4%, 6.2%, and 1.5% for those with Asian, Chinese and Black ethnicity, respectively (compared to 11.2% in Europeans). Odds ratios for any myopia and moderate myopia development for those within the top 10th and 5th percentile of genetic risk were significant in all ethnic groups P<0.05). However, the genetic risk score was not able to reliably identify those at risk of high myopia, other than for participants of Chinese ethnicity (P<0.05). Conclusion: Prediction of refractive error in Asian, Chinese and Black participants was ~57%, 55% and 13% as accurate in comparison to prediction in European participants. Further research in diverse ethnic populations is needed to improve prediction accuracy. / This research has been conducted using the UK Biobank Resource (applications #17351). UK Biobank was established by the Wellcome Trust; the UK Medical Research Council; the Department for Health (London, UK); Scottish Government (Edinburgh, UK); and the Northwest Regional Development Agency (Warrington, UK). It also received funding from the Welsh Assembly Government (Cardiff, UK); the British Heart Foundation; and Diabetes UK. Collection of eye and vision data was supported by The Department for Health through an award made by the NIHR to the Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, and UCL Institute of Ophthalmology, London, United Kingdom (grant no. BRC2_009). Additional support was provided by The Special Trustees of Moorfields Eye Hospital, London, United Kingdom (grant no. ST 12 09). Many parts of this project were performed during the time that author Neema Ghorbani Mojarrad was supported by the College of Optometrists with a Postgraduate Scholarship.

Transcendence is a composition in three movements representing categories of human needs and self-actualization. Psychologist Scott Kaufman makes an analogy between each category of needs and aspects of a sailboat. Transcendence makes similar correlations between the music in the three movements and types of human needs. The first movement, for solo piano titled Seeds of Time, represents Kaufman's description of a boat's hull and our basic needs for security. The second movement, Arcane Pathways, is for quintet (flute, clarinet, piano, violin, violoncello) and signifies the boat's sails and our need for growth. The third movement is an SATB choir and piano work titled Abadi, symbolizing the sailboat in motion and our ongoing journey of self-actualization. In this approach to life humans forge paths toward living meaningful lives and for the well- being of others. The metaphor of self-actualization manifests in the music as it evolves and cycles through themes present in all three movements. The increased number of instruments and performers as the composition goes through its three movements parallels Kaufman's ideas of transcendence which involve growing as individuals until we eventually contribute to and connect with the wider community and world around us.

Yes / Objectives The Computer-Aided Risk Score (CARS) estimates the risk of death following emergency admission to medical wards using routinely collected vital signs and blood test data. Our aim was to elicit the views of healthcare practitioners (staff) and service users and carers (SU/C) on (1) the potential value, unintended consequences and concerns associated with CARS and practitioner views on (2) the issues to consider before embedding CARS into routine practice. Setting This study was conducted in two National Health Service (NHS) hospital trusts in the North of England. Both had in-house information technology (IT) development teams, mature IT infrastructure with electronic National Early Warning Score (NEWS) and were capable of integrating NEWS with blood test results. The study focused on emergency medical and elderly admissions units. There were 60 and 39 acute medical/elderly admissions beds at the two NHS hospital trusts. Participants We conducted eight focus groups with 45 healthcare practitioners and two with 11 SU/Cs in two NHS acute hospitals. Results Staff and SU/Cs recognised the potential of CARS but were clear that the score should not replace or undermine clinical judgments. Staff recognised that CARS could enhance clinical decision-making/judgments and aid communication with patients. They wanted to understand the components of CARS and be reassured about its accuracy but were concerned about the impact on intensive care and blood tests. Conclusion Risk scores are widely used in healthcare, but their development and implementation do not usually involve input from practitioners and SU/Cs. We contributed to the development of CARS by eliciting views of staff and SU/Cs who provided important, often complex, insights to support the development and implementation of CARS to ensure successful implementation in routine clinical practice. / Health Foundation, National Institute for Health Research (NIHR) Yorkshire and Humber Patient Safety Translational Research Centre (NIHR Yorkshire and Humber PSTRC)

Yes / Objectives There are no established mortality risk equations specifically for emergency medical patients who are admitted to a general hospital ward. Such risk equations may be useful in supporting the clinical decision-making process. We aim to develop and externally validate a computer-aided risk of mortality (CARM) score by combining the first electronically recorded vital signs and blood test results for emergency medical admissions. Design Logistic regression model development and external validation study. Setting Two acute hospitals (Northern Lincolnshire and Goole NHS Foundation Trust Hospital (NH)—model development data; York Hospital (YH)—external validation data). Participants Adult (aged ≥16 years) medical admissions discharged over a 24-month period with electronic National Early Warning Score(s) and blood test results recorded on admission. Results The risk of in-hospital mortality following emergency medical admission was 5.7% (NH: 1766/30 996) and 6.5% (YH: 1703/26 247). The C-statistic for the CARM score in NH was 0.87 (95% CI 0.86 to 0.88) and was similar in an external hospital setting YH (0.86, 95% CI 0.85 to 0.87) and the calibration slope included 1 (0.97, 95% CI 0.94 to 1.00). Conclusions We have developed a novel, externally validated CARM score with good performance characteristics for estimating the risk of in-hospital mortality following an emergency medical admission using the patient’s first, electronically recorded, vital signs and blood test results. Since the CARM score places no additional data collection burden on clinicians and is readily automated, it may now be carefully introduced and evaluated in hospitals with sufficient informatics infrastructure. / The Health Foundation, National Institute for Health Research (NIHR) Yorkshire and Humberside Patient Safety Translational Research Centre

Yes / The National Early Warning Score (NEWS) is being replaced with NEWS2 which adds 3 points for new confusion or delirium. We estimated the impact of adding delirium on the number of medium/high level alerts that are triggers to escalate care. Methods Analysis of emergency medical admissions in two acute hospitals (York Hospital (YH) and Northern Lincolnshire and Goole NHS Foundation Trust hospitals (NH)) in England. Twenty per cent were randomly assigned to have delirium. Results The number of emergency admissions (YH: 35584; NH: 35795), mortality (YH: 5.7%; NH: 5.5%), index NEWS (YH: 2.5; NH: 2.1) and numbers of NEWS recorded (YH: 879193; NH: 884072) were similar in each hospital. The mean number of patients with medium level alerts per day increased from 55.3 (NEWS) to 69.5 (NEWS2), a 25.7% increase in YH and 64.1 (NEWS) to 77.4 (NEWS2), a 20.7% increase in NH. The mean number of patients with high level alerts per day increased from 27.3 (NEWS) to 34.4 (NEWS2), a 26.0% increase in YH and 29.9 (NEWS) to 37.7 (NEWS2), a 26.1% increase in NH. Conclusions The addition of delirium in NEWS2 will have a substantial increase in medium and high level alerts in hospitalised emergency medical patients. Rigorous evaluation of NEWS2 is required before widespread implementation because the extent to which staff can cope with this increase without adverse consequences remains unknown.