Made available in DSpace on 2014-06-11T19:23:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-12-09Bitstream added on 2014-06-13T18:09:37Z : No. of bitstreams: 1 silva_lcc_me_sjrp.pdf: 264964 bytes, checksum: 6d475d5b7734bbff4951cab4446a3a4e (MD5) / O objetivo deste trabalho é avaliar as propriedades funcionais da carne de Ema (Rhea americana) e de Avestruz (Struthio camellus) por meio de um estudo comparativo com a carne de Frango (Gallus domesticus). Para tanto, analisaram-se a solubilidade das proteínas miofibrilares, a capacidade de retenção de água, a capacidade de emulsificação das proteínas totais, a estabilidade da emulsão e as perdas por cocção, por evaporação e por gotejamento. Obtiveram-se os seguintes resultados por meio das análises da composição nutricional do músculo Iliotibialis lateralis das aves: avestruz: 19,59 % de proteínas, 75,53 % de umidades, 1,37 % de lipídeos, 1,13 % de cinzas e 2,38 % de carboidratos; ema: 23,50 % de proteínas, 74,19 % de umidades, 1,11 % de lipídeos, 1,13 % de cinzas e 0,07 % de carboidratos e frango: 18,35 % de proteínas, 73,30 % de umidades, 5,92 % de lipídeos, 1,03 % de cinzas e 1,40 % de carboidratos. Por meio da análise das propriedades funcionais observou-se que as proteínas solúveis no NaCl (PS) e as proteínas extraídas com NaCl das proteínas totais (PT) apresentaram, respectivamente, os seguintes resultados: pH 7.0: avestruz (7,40 % e 38,06 %), ema (8,52 % e 36,11 %) e frango (7,68 % e 41,88 %); pH 5.5: avestruz (5,87 % e 30,18 %), ema (6,53 % e 28,54 %) e frango (5,65 % e 29,97 %) e pH 3.0: avestruz (3,04 % e 15,64%), ema (3,29 % e 13,97 %) e frango (2,85 % e 15,52 %). Na análise da capacidade de retenção de água obteve-se para avestruz (73,19 %), ema (66,25 %) e frango (67,13 %). Com relação à capacidade de emulsificação no pH 7.0 foram obtidos estes resultados: avestruz (21,42 mL óleo/ 100 mg de proteína), ema (18,98 mL óleo/ 100 mg de proteína) e frango (31,87 mL óleo/ 100 mg de proteína). Para a estabilidade da emulsão (pH 7.0) obteve-se: para avestruz (36,33 mL liberado (água e óleo)/ 100 g de emulsão)... / This study aims to assess the functional properties of both Rhea (Rhea americana) and Ostrich meat (Struthio camellus) through a comparive study to chicken meat (Gallus domesticus). For that, myofibrillar proteins solubility, water retention capacity, total proteins emulsifying capacity, emulsion stability and losses due to cooking, evaporation and meat proteins drip loss were analyzed. This results obtained through the nutritional composition analysis of the muscle Iliotibialis lateralis of poultry: to ostrich 19,59 % proteins, 75,53 % humidity, 1,37 % fat, 1,13 % ash and 2,38 % carbohydrate; to rhea 23,50 % proteins, 74,19 % humidity, 1,11 % fat, 1,13 % ash and 0,07 % carbohydrate and to chicken 18,35 % proteins, 73,30 % humidity, 5,92 % fat, 1,03 % ash and 1,40 % carbohydrate. Through the functional properties analysis we observed that the soluble proteins in NaCl (PS) and the extracted proteins with NaCl from total proteins (PT) presented, respectively, the following results: pH 7.0: to ostrich (7,40 % and 38,06 %), rhea (8,52 % and 36,11 %) and chicken (7,68 % and 41,88 %), pH 5.5: to ostrich (5,87 % and 30,18 %), rhea (6,53 % and 28,54 %) and chicken (5,65 % and 29,97 %) and pH 3.0: to ostrich (3,04 % and 15,64 %), rhea (3,29 % and 13,97 %) and chicken (2,85 % and 15,52 %). Analysing water retention capacity we obtained to ostrich (73,19 %), rhea (66,25 %) and chicken (67,13 %). Regarding the emulsifying capacity in pH 7.0 these results were obtained: ostrich (21,42 mL oil/ 100 mg proteins), rhea (18,98 mL oil/ 100 mg proteins) and chicken (31,87 mL oil/ 100 mg proteins). For the emulsion stability (pH 7.0) we obtained: to ostrich (36,33 mL released (water and oil)/ 100 g emulsion), rhea (81,00 mL released (water and oil)/ 100 g emulsion) and chicken (0,66 mL released (water and oil)/ 100 g emulsion). The values found to cooking losses were: ostrich (21,77 g/ 100 g sample)... (Complete abstract click electronic access below)

Made available in DSpace on 2016-07-01T11:59:28Z (GMT). No. of bitstreams: 2 license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) 4.pdf: 2145558 bytes, checksum: 50549f6c199193ece4951dbb22851f56 (MD5) Previous issue date: 2015 / Made available in DSpace on 2016-07-21T14:39:34Z (GMT). No. of bitstreams: 2 4.pdf: 2145558 bytes, checksum: 50549f6c199193ece4951dbb22851f56 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2015 / Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos/Farmanguinhos. Rio de Janeiro, RJ, Brasil. / Os sistemas de liberação transdérmica (SLT) representam atualmente uma via alternativa para a administração de fármacos por difusão passiva através da pele. Os SLT são capazes de contornar inconvenientes, como interações com alimentos e metabolismo de primeira passagem, e de substituir esquemas de doses repetidas, aumentando a adesão do paciente ao tratamento. Entretanto, não há pela Agência Nacional de Vigilância Sanitária (ANVISA) uma regulamentação específica que oriente quanto a exigências para pesquisa, desenvolvimento e registro desses medicamentos, contemplando ensaios e parâmetros definidos na avaliação de segurança e eficácia desses dispositivos. Sendo assim, esta dissertação objetiva realizar um levantamento e comparar as exigências regulatórias utilizadas para obtenção de registro dos SLT nas três principais agências, European Medicines Agency (EMA), Food and Drug Administration (FDA) e ANVISA. Adicionalmente, objetiva realizar uma análise das técnicas que vêm sendo mais vastamente empregadas nos ensaios in vitro de permeação pela comunidade científica, podendo nortear a proposta de uma metodologia harmonizada, inexistente até o momento. A definição dos parâmetros empregados na realização de tais testes é fundamental para o aumento na confiabilidade do método e simulação de biodisponibilidade in vitro, como alternativa aos testes in vivo. A partir do resultado obtido com a pesquisa concernente aos aspectos regulatórios, foi possível identificar duas diretrizes do EMA, dois guias do FDA e testes específicos para os SLT descritos na USP, como fontes suficientes na construção de uma legislação específica voltada a esses dispositivos. Com relação aos testes in vitro de permeação, dois guias da Organização para Cooperação Econômica e Desenvolvimento (OECD) e a análise da prática científica nesses ensaios, possibilitaram a realização de uma proposta para a definição dos parâmetros a serem empregados. / The transdermal drug delivery systems (TDDS) current presents an alternative for drug administration by passive diffusion throughout the skin. The TDDS are capable to avoid inconvenients, as food interactions and first pass metabolism, and to replace repetitive dose scheme, increasing patients adhesion on treatment. However, there is no specific regulation by Agência Nacional de Vigilância Sanitária (ANVISA) to guide for requirements regarding research, development and registration for this drugs, including assay and defined parameters on evaluation of safety and efficacy of these devices. So, the main objective of this work is to identify and to compare the regulatory requirements for TDDS regulatory approval of three most important agencies, European Medicines Agency (EMA), Food and Drug Administration (FDA) and ANVISA. In addition, this work aims to study the must employed techniques on in vitro permeation tests by scientific community to guide the development of an harmonized methodology, which does not exist until now. The parameters definition to be applied on these tests are essential to increase method reliability of in vitro bioavailability simulation, as an alternative for in vivo tests. With results obtained after searching about regulatory aspects, it was possible to identify two EMA guidelines, two FDA guides and specific tests related to TDDS on USP, as suficient sources for specific regulation construction focused on these devices. About in vitro permeation tests, two OECD (Organization for Economic Co-operation and Development) guides and the analysis of scientific practice on these tests, allowed a proposal definition for parameters to be employed.

Dans la continuité des travaux de recherches sur les systèmes de transmission mécanique embarqués, l’objectif de cette thèse est double : approfondir les modèles d’estimations des pièces d’un Actionneur Electromécanique (EMA) et étendre la vision transversale de la conception préliminaire aux aspects dynamiques. En effet, cette recherche permet, lors de la conception préliminaire basée sur les modèles, d’adapter les choix d’architectures et de technologies vis-à-vis des performances statiques et dynamiques à atteindre. Les modèles développés à partir des lois d’échelles sont étendus et exploités afin de modéliser les pièces élémentaires de l’EMA et de faire ressortir les règles de « bonnes pratiques » en conception préliminaire. On s’intéresse en particulier au dimensionnement des EMAs dans le domaine aéronautique. Dans un premier temps, nous avons donc créé des modèles d’estimation et des métamodèles des pièces de l’EMA. A cet effet, il est décomposé en carter et pièces élémentaires qu’il intègre.Dans un second temps, nous avons établis des règles de bonne conception et des pistes de dimensionnement de l’actionneur asservi en position. Contrairement aux recherches antérieures, qui se centraient sur le dimensionnement en puissance, nous avons pris en compte la synthèse de la commande pour établir ces règles. A partir de modèles de simulations, nous qualifions et quantifions l’influence des défauts (inertie et saturations, élasticité/jeu, frottement) sur les performances limites de l’EMA. En effet, les structures de commande usuelles et le choix des éléments de contrôle-commande sont intimement liés aux performances dynamiques et à ces défauts. Enfin, afin de se doter de moyens d’essais pour identifier finement un modèle de frottement dans des conditions aéronautiques de température, un banc d'essai sur le réducteur Harmonic Drive a été conçu et mis en œuvre. Il permet également d’amorcer la validation des règles de bonne conception / In the continuity of work of research on embedded systems of mechanical transmission, this these has two objectives: to improve estimation models of Electromechanical Actuator (EMA) pieces and to extend the cross-cutting vision of preliminary design to the dynamic aspects. Indeed, in the preliminary design based on models, this research should allow to adapt the choice of architectures and technologies to static and dynamic performance to achieve. The models developed from the scaling laws will be extended and exploited to modelize elementary pieces of the EMA and to highlight rules of "good practices" in preliminary design. We focus in particular on the design of EMA in aeronautic field. In the first time, we developed estimations models and métamodèles of elementary components of EMA which was decomposed in housing and elementary pieces.In a second time, we established rules of good practices for actuator sizing in control position loop. Contrary to older researches, we take into account control synthesis to create these rules. From simulations models, we quantified the influence of technological defects of components (inertia and saturations, elasticity (backlash), friction) on EMA performances. Indeed, the usual command structures and the choice of the elements of control are intimately linked to the dynamic performance and these defects.Finally, to give test way to identify with accuracy a friction model in aeronautical conditions of temperature, a test bench of Harmonic Drive was create, integrated and implemented. It allows booting the validation of rules of good practices in preliminary design.

This dissertation thesis consists rotordynamics of modern turbocharger. First part begins with prediction of critical speed, prediction of onset instability of oil whirl and oil whip by XLTRC2 and comparison with measured data (Cascade diagram, shaft motion, FFT analysis). List of measurement method for the detection of the natural frequency of turbocharger (EMA). Create software for long term monitoring and recording and output data size reduction. Detection of critical speed by defined measurement methodology without using software simulation with measured data from the Cascade diagram, move the rotor shaft motion in the bearing, FFT analysis and results from measurements of natural frequencies. Comparison of predicted data (critical speed, prediction of onset instability) program XLTRC2 with the values measured by this approach measurement (waterfall diagram, shaft motion, FFT analysis)

Robust portfolio optimization models attempt to address the standard optimization method's high sensitivity to noise in the parameter estimates, by taking an investor's uncertainty about the estimates into account when finding an optimal portfolio. In this thesis, we study robust variations of an extension of the mean-variance problem, where an additional term penalizing the portfolio's correlation with an exogenous return sequence is included in the objective. Using a normalized risk factor model of the asset returns, estimations are done using EMA filtering as well as exponentially weighted linear regression. We show that portfolio performance can significantly improve with respect to a range of metrics, such as Sharpe ratio, expected shortfall and skewness, when using appropriate robust models and hyperparameters. We further show that extending the optimization problem with a correlation penalty can notably reduce portfolio correlation with an arbitrary return sequence, with only a small impact on other performance metrics. / Robust portföljoptimering är en metod för att reducera vanliga portföljmodellers höga känslighet för brus i parameterskattningar, genom att ta en investerares osäkerhet kring skattningarna i åtanke när en optimal portfölj tas fram. I denna rapport studeras robusta varianter av ett utökat mean-variance-problem, där en straffterm för portföljens korrelation med en exogen avkastningsserie lagts till. Skattningarna bygger på en riskfaktor-modell för avkastningarna, och använder EMA-filter kombinerat med exponentiellt viktad linjär regression. Vi visar att en portföljs prestanda kan förbättras avsevärt med avseende på ett flertal prestandamått, till exempel Sharpe-kvot, expected shortfall och skevhet, vid användning av lämpliga robusta modeller och hyperparametrar. Vi visar också att inkludering av ett korrelationsstraff i optimeringsproblemet kan ge noterbara reduceringar i portföljens korrelation med en godtycklig avkastningsserie, med liten effekt på andra prestandamått.

A growing body of research suggests that mindfulness, a receptive attentiveness to one’s present moment experiences, has the potential to adaptively regulate habitual behaviors. No prior study has tested the effect of mindfulness interventions on people’s daily desire experiences to inform the potential for adaptive desire regulation. The present exploratory randomized controlled trial examined the effect of a 14-day smartphone-based mindfulness intervention (versus a coping control intervention) on the frequency, intensity, duration, and enactment of everyday desires in 19 participants. The desire domains included basic need-based desires (i.e., for food, drink, sleep) and secondary desires (e.g., for sex, media, social interactions, work), assessed for 7 days pre- and post-intervention through ecological momentary assessment (EMA). Emotion data collected alongside, also through EMA, permitted examining the role of the mindfulness intervention in altering a potential link between experienced emotion (positive and negative) and desire. Results showed that intervention condition significantly predicted post-intervention desire frequency; those in the mindfulness condition experienced a higher frequency of desires post-training, and specifically, increased secondary desire frequency, but not basic desire frequency. Intervention condition did not predict the other desire outcomes (enactment, strength, or duration). Results also revealed that intervention significant moderated the association between positive emotion and overall desire frequency; those in the mindfulness condition experienced fewer desires when experiencing increased positive emotion, whereas there was no association between positive emotion and desire after coping training. Intervention condition did not moderate associations between positive emotions and other desire variables, or negative emotions and any desire variables.

Environmental management accounting (EMA) is attracting increased recognition as a management tool that assists in improving financial and environmental performance through enhanced environmental accountability. Various industries have been included in EMA-related research and study, but universities have typically failed to be the focus of the attention. This research studied the experiences of key managers from five universities to explore potential factors influencing the decision to adopt, or not to adopt, EMA within the higher education sector. For the purpose of this study, EMA is defined as the generation, analysis, and use of monetary (or financial) and physical (or non-financial) environment-related information in order to improve organisational financial and environmental performance. The two objectives of this study were to understand current accounting practices for managing major environmental costs, and to identify factors influencing EMA adoption within universities. For the purpose of this study, the major environmental costs referred to are limited to the costs pertaining to the consumption of electricity, water and paper, and the generation of wastes. A case study methodology was followed using semi-structured interviews of key personnel with four different management functions (i.e. environmental management, management accounting, senior management, and heads of academic schools) within each university, and performing content analysis on the transcribed interview data. Specifically for achieving the second research objective, a theoretical framework that considers four theories was embraced to guide the data collection and focus the study. The four theories are contingency theory, institutional theory, legitimacy theory, and stakeholder theory. The findings of the first research objective revealed that there was a general lack of EMA utilisation within the case universities. This was in part due to a perceived lack of appreciation by key personnel of the extent of environmental costs being incurred, but arguably mainly because of the absence of relevant environmental cost information being brought to the attention of senior management. Although environmental sustainability was promoted as important from an environmental management perspective, efforts to improve internal environmental accountability, in particular from an accounting perspective, were still absent. In relation to the second research objective, it was found that five key barriers contributed to this lack of EMA utilisation within the five case universities, and they were attitudinal, financial, informational, institutional, and management barriers. Among the factors that provide further explanations about how each barrier influences EMA adoption, resistance to change, resource constraints, (a lack of) legitimacy considerations, and a lack of environmental responsibility & accountability were found to be strong factors, as they were supported in all of the five cases. Apart from the theoretical extension to this area of research, the results and findings of this study supported the uses and applications of EMA by the higher education sector. Much more can, and should, be done by universities in relation to how they account for the environment. This can provide benefits not only for the sector itself, but also for the environment in which we live.

Cette thèse porte sur la conception et la validation d'un FPGA dédié à des applications sensibles nécessitant un haut niveau de sécurité et de confidentialité. Les FPGAs usuels présentent de nombreuses failles vis-à-vis de la sécurité : 1- Ils ne permettent pas une implémentation efficace de circuits logiques alternatifs, tels que les circuits asynchrones. 2- Le placement et le routage d'un circuit ne peuvent être complètement maîtrisés pour garantir une conception sécuritaire. 3- Ils ne sont pas protégés contre les attaques par canaux cachés tels que la DPA, l'EMA ou la DFA. Afin de lever ces obstacles technologiques, les travaux entrepris dans cette thèse ont permis de proposer une architecture autorisant la programmation de différents styles de circuits asynchrones, de disposer d'un système de programmation compatible avec les objectifs de sécurité et d'une conception garantissant un haut niveau de protection vis-à-vis des attaques citées ci-dessus. Enfin, une validation matérielle du prototype a permis d'appréhender la pertinence des modèles développés

Findings from a project involving rotating equipment defect detection using the Algorithm of Mode Isolation (AMI) are presented. The prototypical system evaluated is a rotating shaft, supported by hydrodynamic bearings at both ends, with one disk mounted to the shaft. Shaft cracks and bearing wear are the two equipment defects considered. An existing model of the prototypical system from the literature, termed the simplified model. is modified to simulate the presence of a transverse shaft crack at mid-span. This modified model is termed the standard model. Ritz series analysis, in conjunction with a previously published description of the compliance related to the presence of a transverse shaft crack, is used to describe the decrease in shaft stiffness associated with the crack. The directional frequency response function (dFRF) is shown in the literature to provide benefits over the standard frequency response function (FRF) in both system identification and shaft crack detection for rotating equipment. The existing version of AMI is modified to process dFRFs and termed Two-Sided AMI. The performance of Two-Sided AMI is verified through system identification work using both the simplified model and a rigid rotor model from the literature. The results confirm the benefits of using the dFRF for system identification of isotropic systems. AMI and Two-Sided AMI are experimental modal analysis (EMA) routines, which estimate modal properties based on a frequency domain expression of system response. Eigenvalues and associated modal residues are the modal properties considered in the present work. Three defect detection studies are fully described. In the first, the simplified model is used to investigate bearing wear detection. Various damage metrics related to the eigenvalue and the residue are evaluated. The results show that residue-based metrics are sensitive to bearing wear. Next, the standard model is used in an in-depth investigation of shaft crack detection. When a shaft crack is present, the standard model is time-varying in both the fixed and moving coordinate systems. Therefore, this analysis is also used to evaluate performing EMA on non-modal data. In addition to continuing the evaluation of various xiv damage metrics, the shaft crack study also investigates the effects of noise and coordinate system choice (fixed or moving) on shaft crack detection. Crack detection through EMA processing of noisy, non-modal data is found to be feasible. The eigenvalue-based damage metrics show promise. Finally, the standard model is used in a dual-defect study. The system is configured with both a shaft crack and a worn bearing. One defect is held constant while the magnitude of the other is increased. The results suggest that AMI is usable for defect detection of rotating machinery in the presence of multiple system defects, even though the response data is not that of a time-invariant system. The relative merits of both input data types, the FRF and the dFRF, are evaluated in each study.

L’objectif de cette thèse est de proposer des méthodes innovantes de conception préliminaire d’actionneurs électromécaniques (EMA) et de les implémenter sous la forme d’outils logiciels rapidement disponibles pour les industriels. Cet objectif répond à une demande forte de l’industrie, en particulier en aéronautique dans le cadre du développement d’avions plus électriques. Dans un premier temps, cette thèse propose une méthode hybride (montante et descendante) de recherche systématique d’architectures solutions et de sélection vis-à-vis des exigences du cahier des charges et de l’état de l’art technologique. Dans un deuxième temps, des méthodes d’évaluation d’architectures en termes de puissance, d’intégration (enveloppe géométrique et masse), de fiabilité et de performances en boucle fermée sont proposées. L’implémentation de ces méthodes se base sur la modélisation acausale et la combinaison de simulations numériques inverses et directes. Des lois d’échelle, représentatives des phénomènes physiques dimensionnants, sont établies pour réduire la complexité d’utilisation des modèles et l'intervention d’experts de domaine dans les phases préliminaires. Les méthodes proposées et leur implémentation dans l'environnement de simulation Modelica/Dymola ont été appliquées avec succès aux exemples d’actionneurs électromécaniques d’orientation d’un train avant d’atterrissage, de commandes de vol primaires et de contrôle de la poussée vectorielle du premier étage de propulsion d’un lanceur spatial. De cette façon, la durée de la phase d’évaluation d’architectures a pu passer d’un ordre de grandeur en jour à un ordre de grandeur en heure / The aim of this thesis is to propose innovative methods for the preliminary design of electromechanical actuators (EMA), and to implement them in software tools rapidly available for the industry. This objective is motivated by a strong demand of the industry, especially in aeronautics within the frame of the development of more electric aircrafts. First, this thesis puts forward a hybrid methodology (top-down/bottom-up) to generate and select systematically architectures with respect to requirements and the state of the art of technology. Second, methods to evaluate architectures in terms of power, integration (geometrical envelop and mass), reliability and closed loop performances are developed. The implementation of these methods is based on non-causal modelling combined to direct and inverse numerical simulations. Scaling laws, representative of the main sizing phenomena, are established to reduce the complexity of the models and the need for domain experts during the preliminary phases. The proposed methods and their implementation within the simulation framework Modelica/Dymola have been applied successfully to the examples of electromechanical actuators for the steering of a nose landing gear, the primary flight control of an aircraft and the thrust vector control of a space launcher. As a result, the duration of the architecture evaluation has been reduced from day-scale to hour-scale