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1	The role of auxilin and endocytosis in delta signaling Banks, Susan Marie-Louise 02 July 2012 (has links) Notch signaling is important for cell-cell signaling during development. Notch signaling is highly conserved across all metazoans and failure in Notch signaling is causative in many human diseases. In the Drosophila eye, activation of the Notch pathway requires Lqf (Drosophila Epsin)-dependent and Clathrin-dependent internalization of the Notch receptor ligands, Delta or Serrate, by the signal-sending cells. However, it is unclear why ligand must be internalized into the signal-sending cells to activate Notch signaling in the signal-receiving cells. Evidence suggests that in addition to Clathrin and Epsin, Auxilin is essential for signaling and is indirectly required for internalization of the Notch receptor ligand Delta. Auxilin functions in uncoating Clathrin-coated vesicles to maintain a pool of free Clathrin and Epsin in the cell. auxilin mutants were used as an entryway to identify previously unknown components of the Notch signaling pathway. An F1, FLP/FRT, EMS screen was performed and enhancers of an auxilin mutant rough eye defect were isolated. The enhancers ultimately formed one complementation group on the 2nd chromosome and fourteen complementation groups on the 3rd chromosome. Three of the 3rd chromosome complementation groups were each identified as Delta, lqf, or hsc70. A single allele was identified as faf. Delta and Epsin have known roles in signaling cells to activate Notch as described above. Hsc70 is an ATPase that functions with Auxilin to uncoat Clathrin-coated vesicles and Faf is a deubiquitinating enzyme that maintains levels of active Epsin in the cell. These results suggest I have isolated mutations in genes closely tied to Notch signaling or functioning directly with Auxilin. Mutations in two genes previously undescribed in Notch signaling in the developing Drosophila eye were also isolated from the screen and identified. The second chromosome complementation group was identified as α-adaptin. α-Adaptin is a subunit of the heterotetrameric Clathrin adaptor protein AP-2. One of the third chromosome complementation groups was identified as crumbs. Crumbs is an integral membrane protein that functions at adherens junctions and in establishing apical/basal polarity in cells. Characterizing roles for α-Adaptin and Crumbs during Notch signaling may elucidate the purpose for Delta internalization to activate Notch signaling. / text Notch Delta Endocytosis Epsin Lqf Auxilin Clathrin Faf Hsc70 AP-2 Crumbs
2	Untersuchung auf Aggressionswerte unter Berücksichtigung soziologischer und sportpädagogischer Aspekte in Kampfstilen mit Trefferwirkung Hoffmann, Holger 07 February 2007 (has links) In der hier vorliegenden Studie wurde ein bisher noch nicht beachteter Teil der Sportwissenschaften untersucht. Nach einer umfassenden Literaturrecherche und qualitativen Interviews wurden im Zeitraum von 2005 bis 2006 von über 500 Kampfstilschülern - und Trainern Aggressionswerte sowie sportpädagogisch und -soziologisch relevante Fakten erhoben. Hierbei wurden bewusst solche Personen befragt, die Stile mit überdurchschnittlich hartem Trefferkontakt trainieren. Neben Muay Thai, Freefight und Eskrima unter anderem Krav Maga Maar, Kyushinkai Karate und Grappling. Neben der Schaffung eines umfassenden Grundlagenmaterials zu Themen wie Herkunft, Alter, Bildung, und persönlichen Interessen werden Trainingsgewohnheiten ausgewertet und Beziehungen zu folgenden Faktoren hergestellt: Spontane Aggression, Reaktive Aggression, Summenaggression, Aggressionshemmung, Erregbarkeit und Offenheit. Zur Erfassung der genannten Faktoren wurde der FAF-Test verwendet. Neben einer überdurchschnittlichen Bildung, und im allgemeinen sehr geringen Aggressionswerten konnten auch Tendenzen festgestellt werden, nachdem einige Schüler ihr erlernten Techniken für gezielte Aggressionen außerhalb des Trainings nutzen. Weitere unerwartete Ergebnisse fanden sich unter anderem in den unterschiedlichen Einschätzungen von Trainern und ihren Schülern im Bezug auf deren pädagogischen Einfluss jenseits des Techniktrainings. / The aim of this study is to investigate a field of physical education which has been ignored up to now. After a literature review and a qualitative interview analyses more than 500 martial arts coaches and students have been asked from 2005 to 2006 to collect aggressiveness values and different sports pedagogy and -sociologic relevant data .The study was targeted at "hard -style" martial arts such as Muay Thai, Freefight, Escrima, Krav Maga Maar, Kyushinkai Karate and Grappling. One of the aims was to collect substructal data such as social background, age, education and hobbies. The training data was evaluated and related to the following factors using the FAF Test: Spontaneous Aggression, Reactive Aggression, Aggressionsum, Aggression Escapement, Impulsiveness and Openness. Beside an above-average education and in general low aggressiveness factors the results of the study were a tendency towards the utilisation of martial arts techniques for violent behaviour outside the dojo. Further results include different ratings in the effectiveness of the pedagogical impact of teacher on their students. Kampfsport Kampkunst Sport Aggression Summenaggression reaktive Aggression spontane Aggression Aggressionshemmung FAF Freiburger Aggressiviätsinventar Sportpädagogik Sportpsychologie Karate Eskrima Tae Kwon Do Arnis Thaiboxen Kickboxen Selbstverteidigung Kali Streetfight Ninjutsu Dissertation martial arts combat sports aggression faf sportpedagogy sports physical education Karate Escrima Tae Kwon Do Arnis Thaiboxing Kickboxing selfdefense Kali Streetfight Ninjutsu 796 Sport 50 Sport, Spiele ZX 7100 ZX 7150 ZY 4409 ddc:796

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The role of auxilin and endocytosis in delta signaling

Untersuchung auf Aggressionswerte unter Berücksichtigung soziologischer und sportpädagogischer Aspekte in Kampfstilen mit Trefferwirkung