La motion adoptée dès 1963, à l’issue du colloque d’Uriage-les-Bains, appelle à une unification des réglementations sportives en matière de lutte contre le dopage. Pourtant, à partir des années 1990, des cas et des affaires se multiplient soulignant les dysfonctionnements de réglementations internationales éparses élaborées par des représentants des pouvoirs publics, d’une part, du mouvement olympique, d’autre part. En 1999, près de quarante ans après le premier colloque sur le dopage, l’Agence Mondiale Antidopage (AMA) est créée avec comme mission principale d’harmoniser les règlementations de cette pluralité d’acteurs. Ce travail vise précisément à décrire et analyser ce que font les différents protagonistes dans cette tâche d’harmonisation et, dans une perspective sociologique, à saisir cette figure sociale particulière. Celle-ci met en tension une nécessité de stabiliser des matériaux, des dispositifs et des formes de collaboration avec un minimum de réversibilité et de proposer un travail démocratique qui permette de remettre en question les choix précédents. La création de l’AMA, l’élaboration et la révision du Code mondial antidopage, la mise en conformité des partenaires de l’Agence et la construction d’outils de contrôle et de prévention rendent compte de la façon dont les acteurs tentent de s’accorder en articulant des principes axiologiques, des dispositifs et des pratiques. En cela, une entrée par les critiques et les arguments au fil du temps montre que l’harmonisation consiste en des jeux d’ajustements sur la base de jugements fondés sur l’indépendance de chacun dans ses activités quotidiennes et les degrés de contraintes posés par le processus lui-même. / The motion carried from 1963, as the result of the Uriage-les-Bains conference, calls for some rules standardization concerning the fight against doping in sports. But starting in the 1990’s, situations and scandals have tended to increase, emphasizing the dysfunction of scattered international standards elaborated by representatives from local authorities on one side and from the olympic authorities on the other side. In 1999, almost forty years after the first conference on doping in sports, the World Anti-Doping Agency (WADA) is created, meaning to harmonize anti-doping policies and regulations among the great number of protagonists. This particular thesis aims precisely to describe and analyse who does what in this very task of harmonization and, from a sociologic perspective, to understand this particular social figure. It shows the necessity of stabilizing materials, devices and forms of partnerships with a minimum of reversibility and of offering some democratic approach which would allow to question previous choices and orientations. The creation of WADA, processing and updating of the World Anti-Doping Code, compliance of the partners of WADA and building of control and prevention instruments tend to show how the participants are trying to find an agreement combining axiological principles, devices and practices. Thus, entering through critics and arguments in history shows that harmonization is based on adjustment processes which rely on each and every one’s independence in its daily activities and on degrees of constraints inherent in the process of harmonization itself.

Doctor Legum - LLD / Regional integration has been part of Africa’s overarching strategy for economic transformation. To further enhance sustainable development and economic growth, in the African continent intra-regional trade is equally as important as international trade. Therefore, African countries are faced with the daunting task of adopting comprehensive and well-structured measures to ensure the movement of goods and people across borders are seamless and unrestrictive. Free movement of persons in particular is one of the core tenets of regional integration, building towards a common market. To that effect, the African Union (AU) based on Agenda 2063 has agreed on a Continental Free Trade Area and a Protocol on Movement of Persons indicating a commitment of attaining a single market where goods, persons and services can move freely across national borders. With the Southern African Development Community (SADC) being a Regional Economic Community (REC) recognised under the AU, this thesis seeks to argue for deeper integration by ensuring the movement of persons in the SADC is regulated beyond the scope that is recognised internationally under the International laws influencing the movement of persons. Also, this thesis argues for amendment of certain provisions in the SADC Protocol on the Facilitation of the Movement of Persons to further facilitate intra-regional trade. The SADC operates to an extent as a Free Trade Area (FTA) where goods are traded duty free across borders and the intention is to go higher up the integration ladder to become a Common Market by 2015 and an Economic Union with a Single Currency by 2018. Targets which has not been met to date. Article 5(2) (d) and Article 23 of the SADC Trade Protocol realises the significance of policy development in promoting free movement of people and services within the SADC region. To facilitate the movement of people, the SADC drafted a Protocol on the Free Movement of People in 1995. This Protocol never materialised and it was subsequently replaced by a Protocol on Facilitation on Movement of People which is limited in scope and is not yet operational as ratification by two third majority of Member States has not occurred. In 2012, a Protocol on Trade in Services which also within a limited scope influences the movement of persons in the region was also concluded but is not yet ratified by Member States of the SADC. The absence of a single consistent and comprehensive framework makes people vulnerable to informal practices at the border. Thus, the issue of ensuring free movement of people between SADC Member States still remains debatable and unresolved.

Malaria is one of the most life-threatening diseases affecting mankind, with over 3 billion people being at risk of infection, with most of these people living in Africa, South America and Asia. As the malaria parasite is rapidly becoming resistant to many of the possible treatments on the market, it is of upmost importance to identify new possible drug targets and describe drugs against these that are inexpensive, easy to manufacture and have a long shelf-life in order to combat malaria. One such target is the polyamine pathway. The polyamines putrescine, spermidine, and spermine are crucial for cell differentiation and proliferation. Interference with polyamine biosynthesis by inhibition of the rate-limiting enzymes ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) has been discussed as a potential chemotherapy of cancer and parasitic infections. Usually, both enzymes are individually transcribed and highly regulated as monofunctional proteins. However, ODC and AdoMetDC from P. falciparum (PfODC and PfAdoMetDC, respectively) are found as a unique bifunctional protein (PfAdoMetDC/ODC) in the malaria parasite, making it an enticing target for new, selective antimalarial chemotherapies. In order to apply structure-based drug discovery strategies to design inhibitors for PfAdoMetDC/ODC, the atomic resolution structures of these proteins are needed. Each individual domain has had its structure proposed through homology modelling; however atomic resolution structures of these domains are not yet available. The homology model of PfAdoMetDC/ODC has not yet been elucidated due to the interactions between the domains of the bifunctional protein not being fully understood. High levels of recombinant expression of the bifunctional protein have been either unsuccessful or resulted in the formation of insoluble proteins being produced. The purpose of this project is to optimise the recombinant expression of PfAdoMetDC/ODC, and the PfODC domain, to produce high yields of pure, soluble protein for subsequent atomic resolution structure determination. Ultimately, this will enable the utilisation of PfAdoMetDC/ODC in structure-based drug discovery strategies. Overexpression of P. falciparum proteins in E. coli is notoriously difficult, mainly due to the codon bias between the two species. Comparative studies were performed on four constructs of the PfAdoMetDC/ODC gene, containing either the wild-type, fully codon harmonised, or partially codon harmonised gene sequences to analyse the effect codon harmonisation had on protein expression and activity of both domains of PfAdoMetDC/ODC as well as on the monofunctional PfODC domain. Codon harmonisation did not improve the expression levels or the purity of recombinantly expressed PfAdoMetDC/ODC or the monofunctional PfODC domain. Truncated versions of both proteins, and contamination by the E. coli chaperone proteins DnaK and GroEL, were present in the protein samples even after purification by affinity chromatography. However, codon harmonisation improved the activity levels of the PfAdoMetDC domain, while decreasing the activity of the PfODC domain of PfAdoMetDC/ODC. Harmonisation of the monofunctional PfODC domain resulted in a decrease in the activity of the protein. In order to identify possible inhibitors of the PfODC domain of the bifunctional protein, a structure-based drug discovery study was initiated based on a homology model for PfODC. Four hundred compounds with known antimalarial activity were virtually screened against the PfODC homology model and the top two scoring compounds were selected for enzyme inhibition assays based on their predictive binding affinity against the enzyme, and two medium scoring compounds were selected as controls. Enzyme inhibition studies were performed on the bifunctional PfAdoMetDC/ODC to determine the effect the compounds had on both domains of the protein. Of the compounds assayed one of the compounds significantly reduced the activity levels of both domains of PfAdoMetDC/ODC. Additionally, one compound significantly reduced the activity level of the PfAdoMetDC domain of PfAdoMetDC/ODC. This work therefore contributes towards characterisation of the unique PfAdoMetDC/ODC in malaria parasites as a novel drug target. / Dissertation (MSc)--University of Pretoria, 2012. / Biochemistry / unrestricted

Magister Pharmaceuticae - MPharm / Medicines have to be regulated in an effort to monitor their quality, safety, and efficacy. The process of medicines registration is lengthy, costly, and document-heavy. Many countries have limited expertise and resources at national medicines regulatory authorities (NMRAs) and some countries have adopted unified approaches to medicines registration legislation. Harmonised guidelines and initiatives have been adopted in South Africa and the Southern African Development Community (SADC). However, there are no studies that have identified the effects of these initiatives and guidelines on major stakeholders such as the pharmaceutical industry and regulators.

In this thesis, I have investigated how to work creatively with melodies in the process of composing music. The starting point of the project was to transcribe phrases from different solos and to be assigned with newly composed ones from musicians around me. The melodies were applied to different composing methods. The methods were there to have a way of making music of the melodies and to put them in a context. The purpose of the work was to investigate how the use of these melodies and melody-based methods were affecting my composing. How could I create new musical possibilities in my composing by working like this? How could I in the process use the knowledge to develop harmonic possibilities and concepts on my main instrument? The work resulted in four newly composed pieces and concepts in how to improvise with melodies. I made the conclusions that the combination of variation, patience and a non-valuable working environment was a fruitful way to stay inspirated and creative. / <p>Medverkande musiker:</p><p>Joanné Nugas - sång</p><p>Malte Bergman Byström - bas</p><p>Noa Svensson - trummor</p><p>Björn Eriksson - piano</p><p>Oskar Nilsson - gitarr</p><p>Ebba Åsman - trombon</p><p>Björn-Atle Anfinsen - trumpet</p>

Internationalization tendencies in obligation law with a focus on contract law Abstract This thesis deals with the harmonisation and unification of the law of obligations, mainly contract law at international, European as well as at national level. Emphasis is placed on the historical context, the current regulation at all three levels and the identification of individual problems. The first part of this thesis is devoted to a general introduction of the topic. It is divided into four parts, first explaining the concept of internationalisation in general and then introducing the different kinds. The first chapter introduces the concept of private international law, including European private international law. The second chapter is devoted to legal unification and harmonization at the international level. The third chapter deals with the Europeanization of the law of obligations, and the fourth and final chapter outlines the issue of comparative jurisprudence. The second part is devoted to the need and feasibility of legal unification, again both at the international and European levels. This part discusses the various individual problems, such as the ways of implementation, and the problems posed by efforts to harmonise legal systems and unify the regulation of contract law. The individual problems are...

L’analyse des systèmes naturels globaux est divisée selon les organismes régionaux, nationaux et internationaux. Leurs travaux sont encadrés par une gestion scientifique et juridique notamment par des directives tel que la DCE ou INSPIRE, basée sur la communication. La comparaison des données d’origines différentes et sans prise en compte des frontières n’est possible qu’à l’aide d’une harmonisation fondée sur les normes internationales. La carte est à ce titre un outil de transmission de l’information organisée à partir des bases de données.Cette thèse propose une analyse sémiologique de la représentation cartographique qui traite de la thématique de la gestion de l’eau dans un cadre européen. Il s’agit de comprendre et d’interpréter la mise en oeuvre des processus de communication basés sur les cartes ; la Hongrie et la France sont prises comme exemple.L’harmonisation est nécessaire mais en même temps très difficile à mettre en place au sein d’un monde où les disparités sont très grandes. Les compromis nécessaires à l'harmonisation et à l'uniformisation du langage cartographique impliquent des concessions de la part des acteurs mais aussi des producteurs de cartes.L’importance des innovations dans la visualisation cartographique aboutissant à une meilleure communication n’est pas encore reconnue à l’heure actuelle. Le public, quel qu’il soit, est souvent habitué à une représentation traditionnelle ; pourtant les effets que l’on peut ajouter à une carte, fruits de l’innovation technologique, ouvrent de nouveaux horizons pour la cartographie et peuvent servir de nouvelles bases au raisonnement dans la prise de décisions. / Water, which is one of our most important natural resources, stops at neither political nor artificial boundaries. This is why it is necessary to treat it globally instead of the present situation, where water is managed nationally and regionally. A possible solution for this is an international unified water management system, and effective information is a key requirement for this to happen. Maps contain visual information which is independent of language, and map visualization is an important tool of communication. Therefore I have been comparing two European Union countries (France and Hungary) to understand the processes of map communication in relation to EU regulations. The first objective of my research has been the examination of how far the harmonization of map communication has been achieved in the European directives, particularly concerning water-related directives. Secondly, to the extent that harmonization has not occurred, I have investigated into the reasons why this has happened and whether there are any solutions to this issue. Effectiveness of map-based communication is closely related to uniform data systematization. This is why I have endeavored to discover and develop a harmonizationhelping system for visualization. Finally, I have examined whether, in this legally-regulated research environment, there is the possibility of innovative rather than traditional map representations. As results I gave an overview of the European directives and projects, and I examined the relations between them. At the same time I determined the role of the cartographer concerning the directives. I created an examining system based on the rules of the French and Hungarian thematic cartography. I made certain that the directives are necessary but not sufficient conditions of harmonized map communication. The necessary condition of this is a uniform and harmonized system of thematic data. I verified that the maps created by existing processes do not meet the claims of the three different user circles aimed at by the WFD. I created my own communicative model for maps associated with water after studying Robinson-Petchenik-and Kolácný’s communicative models. I took into consideration every element of map-forming, which may have an influence on the decision made based on the map. I developed innovative prototypes for certain types of WFD maps to the general public and decision-makers. / Elsisorban szeretnék köszönetet mondani témavezetiimnek Philippe Quodverte-nek és José Jesús Reyes Nunez-nek, akik a doktori kezdetétil tanácsaikkal folyamatosan segítettek. Philippe Quodverte-nek külön szeretném megköszönni, hogy Erasmusos orléans-i tartózkodásom után három évvel újbóli támogatásáról biztosított és elvállalta a doktori témám vezetését, illetve azt a türelmet, amivel segített a francia doktori kutatásra vonatkozó eliírások és térképészeti hagyományok elsajátításában. Nagyon élveztem a vele való beszélgetéseket és térképészeti eszmecseréinket. Emellett köszönettel tartozom Zentai Lászlónak és Verebiné Fehér Katalinnak a nekem nyújtott segítségükért és hasznos tanácsaikért, illetve az ELTE Térképtudományi és Geoinformatikai Tanszék minden munkatársának volt tanáraimnak, akik támogatásával jutothattam el a doktoriig. Továbbá köszönöm Guillame Giroir-nak, a Földrajzi Doktori Iskola (CEDETE) vezetijének, hogy befogadott csapatába, és részese lehetek a CEDETE életének. Köszönet az Orléans-i Egyetemen kollégáimnak Anabelle Mas-nak, Stéphane Grivel-nek, Frank Guéritnek és Bertrand Sajaloli-nak, akik tanácsaikkal támogattak és segítették munkámat. Külön köszönet Matthieu Lee-nek, a CEDETE térképészének, aki észrevételeivel segítette a doktoriban bemutatott térképek elkészítését. Külön szeretném megköszönni mindazoknak, akik magyar és francia részril segítettek a Víz Keretirányelv és az INSPIRE végrehajtásának megismerésében, illetve az adatok elérésében, azaz név szerint François Robida (BRGM), Janik Michon (ONEMA), Jelinek Gabriella (Vidékfejlesztési Minisztérium), Tahy Ágnes (VKKI). Köszönettel tartozom Vikor Zsuzsának a dolgozat nyelvhelyességének ellenirzéséért. Köszönöm emellett családomnak, szüleimnek, nagyszüleimnek és testvéremnek, hogy bátorítottak és mellettem álltak. Nem utolsó sorban szeretném megköszönni doktorandusz társaimnak, Anh Tu-nak, Cristina-nak, Sylvain-nak, Eszternek, és barátaimnak, Virgine-nek Anabella-nak, Alexandranak, Chloë-nak és Dávidnak, hogy a nehéz pillanatokban segítettek és jó tanácsokkal láttak el. Külön köszönet Virginie Anne-nak a francia összefoglaló nyelvhelyességének ellenirzéséért és baráti támogatásáért.

L’objectif de rechercher une harmonisation possible, dans le droit des transports maritimes, se justifie par un intérêt purement économique. L'idée est de permettre la création d'un commerce méditerranéen, qui s’affranchirait des obstacles techniques non tarifaires constitués par la fragmentation des systèmes juridiques. En effet, il ne s’agit pas là, de créer une législation commune entre les 43 pays de l’Union pour la Méditerranée, afin de rapprocher leur culture juridique, mais de mettre en place une harmonisation du droit des transports maritimes, permettant de mieux surmonter les obstacles, disparités, à la mise en place d’un marché commun. Mais quels peuvent être ces obstacles ? Il s’agit des normes tarifaires, des tarifs douaniers…Ces obstacles sont également juridiques. Ainsi, peut-on admettre ou prévoir une harmonisation des transports maritimes, ayant une incidence sur le commerce méditerranéen ? Constitue-t-il un îlot de résistance au même titre que le droit fiscal ou le droit social ? Il apparaît certes qu’on peut l’harmoniser. En effet, le transport maritime s’apparente comme l’outil permettant la libre circulation des marchandises dans un ensemble commun. C’est de cette manière que l’Union européenne s’est construite. D’ailleurs, ne s’agit-il pas d’un domaine déjà harmonisé entre ces pays ? Il faut savoir, qu’avant la mise en place d’une Union pour la Méditerranée, il existait de nombreuses conventions et organisations promouvant une harmonisation dans ce domaine. En somme la méditerranisation des transports maritimes requiert la méditerranisation des règles juridiques qui l’encadrent. / The purpose to seek a possible harmonisation of the maritime transportation/transport law is based on a purely economic interest. The idea is to enable the establishment a Mediterranean trade. Indeed, it doesn't mean to establish a common legislation/law between 43 countries of the Mediterranean Union, in order to bring their legal system closer. Though, the real purpose is that the implementation of the harmonisation of the maritime transportation law, will enable to anticipate/foresee the obstacles barriers, the disparities, the gaps to implement a common market. What might be those obstacles/barriers? They are the customs duties (or tariffs). So can we admit or predict the unification of the (sea) shipping, having an impact on the euro-Mediterranean trade? It really seems that we can harmonise it. In effect, the shipping is akin to a tool (to enhance) for the free movement of goods/ traffic of products in a common set of goals. In fact, the shipping is a tool to enhance for the free movement of goods. By the way, isn't it already a harmonised field/area between these countries? Be aware, it is undeniable that before the establishment of the Union for the Mediterranean, there were also many conventions (agreements) and organisations promoting a possible harmonisation in this area.

La politique commune d'immigration et d'asile de l'UE possède comme objectif l'harmonisation des politiques nationales des Etats membres. Toutefois, suite aux nombreux aménagements imposés par ces derniers, elle bute toujours sur les diverses modalités d'application de la gestion commune des frontières et les différents droits attribués aux ressortissants de pays tiers. Un tel contexte de diversité a un impact sur le statut de ces derniers en ce que la protection de leurs droits fondamentaux apparaît secondaire au regard des inquiétudes des Etats membres de conserver leur maîtrise dans le domaine de l'entrée, du séjour et de la sortie des étrangers sur leur territoire. Pou1tant, il est à souligner qu'il ne s'agit que des premiers jalons de la politique migratoire commune de l'UE. Malgré leur manque d'efficacité dû aux clauses optionnelles et dérogatoires, les premières normes européennes adoptées forment indéniablement une base à approfondir en la matière pour les Etats membres. Aujourd'hui, en prenant davantage en compte de la situation vulnérable des ressortissants de pays tiers dans l'Union européenne, les nouveaux textes législatifs, adoptés conformément à la procédure de codécision, ainsi que les décisions prises par la Cour de justice qui, voyant sa compétence étendue en matière migratoire, vient interpréter des clauses ambiguës, procurent un brin d'optimisme aux ressortissants de pays tiers. Finalement, il reste certes certains points à approfondir et certains aspects à améliorer, mais ces nouveaux changements constituent une preuve importante de la volonté de l'UE de trouver un équilibre entre les intérêts étatiques et ceux des ressortissants de pays tiers. / The EU's common policy on immigration and asylum aims to harmonise the national policies of its Member States. Nonetheless, following numerous adjustments imposed by the Member States, this common policy still stumbles on the diverse modalities of application in the joint borders management and the different rights attributed to the third country nationals. Such context of diversity bas an impact on the status of the third country nationals in the way that the protection of theirs fundamental rights appears secondary to the Member States concerns to maintain their control in the area of the entry, stay and exit of the strangers on their territory. However, it should be pointed that this is only the first milestone of the EU's common migratory policy. Despite their lack of efficacy due to optional and derogatory clauses, the first adopted European norms form undeniably a basis for the Member States to further deepen in this field. Nowadays, taking more into account the vulnerable situation of the third-country nationals in the EU, the new legislative texts, adopted according to the codecision procedure, as well as the decisions taken by the Court of justice which, seeing its jurisdiction extended in the migratory field, has interpreted some ambiguous clauses, give a strand of optimism to third-country nationals. Finally, there are certainly still some issues to deepen and some aspects to improve but these new changes constitute an important proof of the willingness of the EU to establish a balance between State interests and those of third-country nationals.

L’attribution d’une compétence d'incrimination à l’Union soulève les questions complexes qui sont traditionnellement rattachées au pouvoir pénal, notamment celle de la promotion, par les choix d’incrimination d’une conscience collective et de l’expression des valeurs essentielles à une société. En l’occurrence, c’est la question d’une identité européenne. Le projet d’intégration pénale s’est développé très rapidement depuis les trente dernières années sans qu’une réflexion approfondie sur la légitimité d’une telle évolution ne soit menée. Son caractère expérimental a souvent été considéré comme une illustration de la banalisation de la réponse pénale, qu’il s’agisse d’apporter une réponse à des violations suscitant une forte alarme sociale ou de viser à rendre efficace une législation technique. L’absence de politique pénale européenne fait craindre une intervention de l’Union méconnaissant les exigences liées à l’intervention pénale dans un État de droit que sont le respect de la personne et surtout le principe de l’ultima ratio. / The attribution of a criminalisation competence to the Union raises complex questions traditionally attached to the criminal law power, particularly the one of promotion through criminalisation choices of a collective conscience and the expression of values essential to the society. It is the question of a European identity. The penal integration project has developed very rapidly the last thirty years without any deep reflection on the legitimacy of this evolution. Its experimental character is often considered as an illustration of the banalisation of the criminal sanction, being it in order to respond to violations rising a high social alarm or in order to give effectivity to a technical legislation. The absence of criminal policy creates the fear of a European intervention not respecting the requirement attached to the resorting to criminal law in a State under the Rule of Law that are the respect of the person and mostly the principle of ultima ratio