Awina will be a company that will be in charge of making healthy, pre-cooked and frozen oatmeal waffles that are easy to prepare with three different presentations which will be according to different nutritional needs. Our target audience are people interested in seeking a healthy life with little time to prepare breakfast such as office workers, students and housewives. The three presentations of waffles to start the business will be: high in protein, high in fiber and original. They will be found in 36 points of sale, such as supermarkets and health stores. The waffles will be made from natural ingredients and the nutritional value of the original waffles, high in fiber and high in protein for each suggested serving (2 units of waffles) will be 239, 228 and 247 calories respectively. The price of our product will be S/.18.54 for a box of 6 waffles, each package contains 3 servings. In addition to offering healthy and practical food to prepare, we will be concerned about the environment since the packaging will be ecological. Regarding the marketing of our company, it will be mainly through social media to have a better engagement with our target audience. / Awina será una empresa que se encargará de la elaboración de waffles saludables de avena, pre-cocidos y congelados de fácil preparación con tres presentaciones diferentes las cuales serán acorde a distintas necesidades nutricionales. Nuestro público objetivo son personas interesadas en buscar una vida saludable con poco tiempo para preparar el desayuno como oficinistas, estudiantes y amas de casa. Las tres presentaciones de waffles para iniciar el negocio serán: alto en proteínas, alto en fibra y original. Se encontrarán en 36 puntos de venta, como supermercados y tiendas saludables. Los waffles serán elaborados a partir de insumos naturales y el valor nutricional de los waffles originales, alto en fibra y alto en proteína por cada porción sugerida (2 unidades de waffles) será de 239, 228 y 247 calorías respectivamente. El precio de nuestro producto será de S/.18.54 por una caja de 6 waffles, es decir, cada empaque contiene 3 porciones. Además de ofrecer alimentos saludables y prácticos de preparar, nos preocuparemos por el medio ambiente ya que los empaques serán ecológicos. Respecto a la publicidad de nuestra empresa, se dará principalmente a través de las redes sociales para tener una mejor llegada a nuestro público objetivo. / Trabajo de investigación

7 pp. / This article introduces the popular mole (pronounced: MOH-lay) sauces that are typically served in three regions (the North, Central, and South) of Mexico. It also discusses how this popular Mexican food can promote healthy meal cooking, which can reflect traditional foods of the land.

The aim of the thesis was to investigate factors influencing ICT use by older-adults. A selection of psycho-social, socio-demographic and health determinants were investigated with Internet use. Data were collected through questionnaires (Studies I-III) and interviews (Study IV). Univariate and multivariate analyses were conducted, investigating Internet use as a dichotomous variable, with the aforementioned factors. The results indicated that psycho-social determinants did not affect older-adults’ Internet use (Study I). Scoring higher on the personality traits openness and extraversion did not affect whether the older adults started to use the Internet (Study II). However, well-being increased for some frail older-adults when using the tablet computer and connected to the Internet (Study IV). Some socio-demographic determinants affected Internet use. Being younger in age was a strong contributing factor in all four studies whether the older-adult would use the Internet. Higher education influenced Internet use (Study I & III), correlated with living in a rural or urban setting (Study III); yet education was not influencing whether they would start to use the Internet. Living alone was correlated with Internet use, especially if the older-adult lived in an urban setting (Study III). Functional disability and household economy did not affect Internet use. Finally, the health determinants on Internet use were quite strong. Normal cognitive functioning influenced whether older-adults would start to use the Internet (Study II). The older-adult living in an urban environment, would use the Internet if they had normal cognitive functioning (Study III). It was noted also from Study IV that the learning to use the Tablet PC and Skype took longer for older people and more repetition was needed. Being frail was a strong factor whether the older-adult would use the Internet. They would not want to learn or try to use the technology if they were too ill (Study IV). The findings show only a small increase (7.7%) in Internet use by older-adults over time. The indicators of non-use are: higher in age, lower educated, living alone or rurally, lower cognition and frailty. There are two different profiles of rural and urban Internet users. These determinants along with an understanding of the use of technology, and a good support system, are a few pillars in ICT adoption by older-adults. As ICT continues to develop as a means to provide better health care, it will be important to take into account the abovementioned indicators. In certain cases Internet use is not a given, which continues to exclude older-adults. Part of healthy aging is social participation; therefore being connected and included in the digital society is important. Alternative and not only one design solutions should be explored in health care and by organisations, so as to cater to the heterogeneity of the aging population.

2 pp. / This handout reviews healthy meal choices for active youth traveling to away sporting events. It gives examples of healthier food options from different types of restaurants.

4 pp. / Weight management is more than just cutting back on carbohydrate or fat. Controlling calories is key to achieving and maintaining a healthy weight. This publication reviews how calories count, not matter what type of diet you choose to follow.

Background: Physical activity (PA) is a health protective behaviour that is critical in the reduction of most major chronic diseases. It also provides the participant with psychological benefits. Despite its well-established health benefits, PA engagement is low in the adult population. Women over the age of 60 are the least physically active segment and thus an important target for behaviour change interventions. Objective: The purpose of this mixed methods feasibility study was to explore the feasibility of six-week Self-Determination Theory (SDT)-based dance and walking programs for older women. Design: This was a parallel, randomized controlled trial with three groups: dance, walking, and wait-list control. This study included the sequential collection of quantitative then qualitative data (sequential explanatory design). Setting: This study was conducted in Victoria, BC. Participants: Participants were community-dwelling, English-speaking women aged 55-70 years who were not meeting PA guidelines. Methods: Data were collected at baseline and two endpoints: post-intervention at six weeks and follow-up at 12 weeks. The primary outcomes were feasibility measures: recruitment, intervention adherence, retention, and satisfaction. Survey data included self-reported PA (Godin Leisure Time Exercise Questionnaire) and measures of behavioural regulations and psychological needs (SDT constructs) using validated tools (Behavioural Regulations in Exercise Questionnaire-2 and Psychological Need Satisfaction in Exercise Scale). Qualitative data were collected in the form of open- and close-ended program evaluation questions and during focus group interviews, both occurring at post-intervention (six weeks). Results: The feasibility measures suggest that it is feasible to recruit and retain participants and that they were generally satisfied with the programs. Thirty-five of 37 randomized participants completed the study (mean age ± SD = 62.8 ± 4.8), representing a 39% recruitment rate and 95% retention rate. Both programs were highly attended. Exploratory effect sizes for the quantitative measures were promising for conducting a larger-scale trial. Emergent themes highlighted the importance of the leadership component of the group-based PA programs. Conclusion: This study had high protocol adherence, promising effect sizes, program evaluation satisfaction, and a recreation centre took on the dance program; these factors provide a foundation for expanding this feasibility trial to a full-scale study. / Graduate / 2017-12-01

Within the diploma thesis the following features have been implemented - summarized data about health and healthy lifestyle specialized age bracked collage students. There are also listed correct catering habits, healthy nutrition, drinkable mode, sleep and moving activity. Further there are summarized determinants the most damage health, like a smoke, excessive alcohol consumption, drug abusing, excessive mental load and risk sexual behavior. In the practical part of the thesis there is investigation of questionnaire located healthy lifestyle level of collage students on different universities in Prague. For evaluation my investigation of questionnaire I evolved my own method with own graduated scale for healthy lifestyle. The reason to develop my own method was that I did not find any sufficient scale or method in any publication focused on lifestyle that would globally cover all topics of my questionnaire. Results are illustrated in graphs and confronted among each other at first in particular areas healthy lifestyle and then globally evaluated according to norm of healthy lifestyle. Attachments of this thesis is questionary exploited during investigation of questionnaire on four universities in Prague.

Magister Public Health - MPH / Introduction: The control of type 2 diabetes mellitus (T2DM) is pivoted on adherence to a healthy lifestyle (healthy diet, physical activity and non-smoking). Zimbabwe reports a high burden of T2DM related complications suggesting an increased inability by patients to control their blood glucose levels. This study, therefore, sought to describe the healthy lifestyle practices of T2DM patients in Harare, Zimbabwe and associate these practices with their glycated haemoglobin (HBA1C) levels, a marker for the control of diabetes. Methodology: A descriptive cross-sectional study was done. Participants were T2DM patients who were 18 years and older from two tertiary hospital diabetes clinics in Harare. Data collection was done using a structured questionnaire which was interviewer-administered along with height, weight and HBA1C measurements. Descriptive statistics were used to describe the study populations. Chi square test was used to calculate statistically significant associations between healthy lifestyle behaviours and demographics or HBA1C levels at the significant level of 0.05%.

Background: In Sweden, consumers have become more aware that certain types of food could improve their health and overall well-being. In addition, consumers, especially Swedish Millennials, are getting healthier day after day. Accordingly, manufacturers responded to this phenomenon by supplying food that offers extra health benefits (Ring & Mitchell, 2010). These types of food are called Functional Food (FF) and are defined as “food enriched with different components (such as vitamins, minerals or probiotic cultures) or modified in a way that the product provides an additional physiological benefit that might prevent disease and promote health” (Morna, 2015:336). Purpose: The study investigates the Swedish Millennials healthy lifestyle and focuses on their attitudes towards the functional food. Thus, the authors will explore the whole lifestyle and habits of the Swedish Millennials reaching to the core of the research, which is the consumption of the functional food. Method: In order to fulfil the purpose of this study an exploratory method, with qualitative and abductive approach, is chosen to understand the Swedish Millennials attitude towards the functional food. The focus group was the tool to collect the data for the study. In total, five focus groups were conducted with twenty-six participants all of them are Swedish Millennials. The reason behind choosing focus groups tool is to comprehend deeply the Swedish Millennials lifestyle and specifically their attitude towards the functional food. Conclusion: The authors concluded that the Swedish Millennials have a systematic lifestyle and they feel comfortable with the routine. The Swedish Millennial’s attitude towards the functional food is considered positive to the majority of the participants in the research. However, the minority of the Swedish Millennial’s participants have a negative attitude towards the functional food. Therefore, it was concluded that the Swedish Millennials attitude to an extent is positive towards the functional food consumption.

O nebivolol, um fármaco com quatro centros quirais, está disponível na clínica como mistura racêmica dos isômeros d-nebivolol (SRRR) e l-nebivolol (RSSS). A atividade -adrenérgica do nebivolol reside no isômero d-nebivolol, enquanto o l-nebivolol promove a liberação de óxido nítrico das células endoteliais. O nebivolol é eliminado por metabolismo dependente do CYP2D6. O estudo avalia a farmacocinética e a relação farmacocinética-farmacodinâmica (PK-PD) dos isômeros do nebivolol em voluntários sadios. Foram investigados 15 voluntários sadios (10 homens e 5 mulheres) fenotipados com metoprolol como metabolizadores extensivos (EM, n=13) ou metabolizadores lentos para o CYP2D6 (PM, n=2). Os voluntários sadios foram tratados com dose única oral de 10 mg de nebivolol racêmico. As amostras seriadas de sangue foram coletadas até 48 h após a administração do fármaco. Os isômeros do nebivolol foram resolvidos na coluna Chirobiotic® V e analisados nas amostras de plasma empregando LC-MS/MS. Os parâmetros farmacocinéticos foram calculados por modelo bicompartimental com lag time, empregando o programa WinNonLin. A farmacodinâmica do nebivolol foi avaliada empregando como parâmetro a variação da frequência cardíaca entre os períodos final e anterior ao teste de esforço isométrico durante 2 min utilizando o handgrip a 30% da contratilidade voluntária máxima. A análise PK-PD relacionando o efeito na variação da frequência cardíaca induzida pelo exercício isométrico com as concentrações plasmáticas do isômero d-nebivolol foi avaliada empregando o modelo Emax sigmóide inibitório. A disposição cinética do nebivolol é enantiosseletiva nos voluntários sadios EM, com razões isoméricas de AUCl/ AUCd de 1,41. Os valores de concentração plasmática máxima (1,46 vs 0,79 ng/mL), área sob a curva concentração plasmática versus tempo (6,45 vs 3,99 ng.h/mL), clearance aparente (774,51 vs 1252,70 L/h) e volume de distribuição aparente (10936 vs 19082 L) mostram diferenças com significância estatística (Teste de Wilcoxon, p<0,05) entre os isômeros l-nebivolol e d-nebivolol para os voluntários sadios EM. A disposição cinética do nebivolol não é enantiosseletiva nos voluntários sadios PM investigados, com razões isoméricas de AUCl/AUCd de 0,93 e 0,98. Os valores de clearance aparente obtidos para os voluntários PM (87-350 vs 81-344 L/h, respectivamente para o l-nebivolol e d-nebivolol) são menores do que para os EM (775 vs 1253 L/h). O modelo Emax sigmóide inibitório descreveu a análise PK-PD relacionando o efeito na variação da frequência cardíaca induzida pelo exercício isométrico com as concentrações plasmáticas do isômero d-nebivolol em voluntários sadios EM com valores de Emax de 4,47 bpm (IC 95% 1,37-7,57) e de EC50 de 222,16 pg/mL (IC 95% 96,29-540,60 pg/mL). / Nebivolol is a drug with four chiral centers. It is administered in clinical practice as a racemic mixture of the isomers d-nebivolol (SRRR) and l-nebivolol (RSSS). The - blocking activity of nebivolol is attributed to d-nebivolol, whereas l-nebivolol promotes the release of nitric oxide from endothelial cells. Nebivolol is eliminated by metabolism dependent on CYP2D6. The present study evaluates the pharmacokinetic and pharmacokinetic-pharmacodynamic (PK-PD) of nebivolol isomers in healthy volunteers (10 men and 5 women) phenotyped with metoprolol as extensive metabolisers (EM, n=13) or poor metabolisers for CYP2D6. The healthy volunteers receveid a single oral dose of 10mg of racemic nebivolol. Serial blood samples were collected from 0 to 48 h after the administration of nebivolol. The isomers of nebivolol were analyzed by LC-MS-MS on a Chirobiotic® V column and the pharmacokinetic parameters (bicompartment model, micro, lag time, first order) were calculated by the software Winnonlin. The pharmacodynamic of nebivolol was evaluated using the variation of heart rate as parameter between the end and one minute before the handgrip exercise. Thus, the patients were oriented to conduct the isometric exercise with handgrip for 2 min at 30% of their maximum voluntary contractility. The PK-PD analysis relating the effect on the variation of heart rate induced by the isometric exercise and the plasma concentrations of the isomer d-nebivolol were evaluated using the Inhibitory effect sigmoid Emax model. The kinetic disposition of nebivolol is enantioselective on healthy volunteers EM, with isomeric ratios of AUCl/ AUCd of 0,93 e 0,98. The values of maximum plasma concentration (1,46 vs 0,79 ng/mL), area under the concentration time curve (6,45 vs 3,99 ng.h/mL), apparent clearance(774,51 vs 1252,70 L/h) and volume of distribution (10936 vs 19082 L) show statistically significant differences (p<0.05, Wilcoxon test) between the isomers l-nebivolol and d-nebivolol for the healthy volunteers EM. The kinetic disposition of nebivolol is not enantioselective on the healthy volunteers PM investigated, with isomeric ratios of AUCl/ AUCd of 1,07. The values of apparent clearance obtained for the volunteers pm (87-350 vs 81-344 L/h, respectively to l-nebivolol and d-nebivolol) are smaller than that for EM (775 vs 1253 L/h). The Inhibitory effect sigmoid Emax model described the PK-PD analysis described the effect on the variation of heart rate induced by handgrip isometric exercise with the plasma concentrations of the isomer d-nebivolol in healthy volunteers EM with Emax values of 4,47 bpm (IC 95% 1,37-7,57) and EC50 of 222,16 pg/mL (IC 95% 96,29-540,60 pg/mL).