Hepatitis C Virus (HCV) is an infection that can have grave consequences when left untreated. Hepatitis C can be easily eradicated with direct acting antiviral therapy. People who inject drugs (PWID) and inmates are among those with the highest incidence of HCV. However, cure rates among this population remains low. This is, in part, related to an interruption in the HCV care cascade such that only 30% of PWID are linked to care and only 8% of those receive treatment. Inadequate screening and failure to be linked to HCV care remain the largest impediments to treatment success. There is limited research on barriers and facilitators to primary care, where screening may take place, and linkage to HCV care among PWID. Few studies have evaluated vulnerable populations such as those living in rural communities or inmates. The purpose of this dissertation was to develop a broader understanding of barriers and facilitators to healthcare utilization among PWID at the primary care and specialist levels (linkage to care). Three manuscripts addressed important gaps in knowledge. The first was a review of the literature to describe the state of science on linkage to care among PWID. All but one reviewed study recruited from countries with universal healthcare, urban areas, and opioid substitution facilities. The review of the literature revealed that little is known about the barriers/facilitators to linkage to HCV care faced by rural-dwelling PWID from countries without universal healthcare. The second manuscript is a study to determine whether predictors of linkage to care identified in urban-dwelling PWID from countries with universal healthcare predicted seeking HCV care among PWID living in rural Appalachia. Data were obtained from a subsample of 63 HCV positive PWID who recently used opioids, were between the ages of 18-35 years, and lived in one of five rural counties in Kentucky. Logistic regression revealed that recent injection drug use was the only predictor of seeking HCV care. However, remote use of opioid substitution therapy and no transportation issues approached clinical significance. Although not evaluated in our second manuscript, seeing a primary care provider (PCP) is associated with an increased likelihood of being linked to care and higher rates of screening/diagnosis. Among rural dwelling PWID, there are subpopulations that may face unique barriers to linkage to care. One sub-population that may be particularly vulnerable are female PWID who are incarcerated. Therefore, the purpose of the third study was to determine predictors of primary care use using data from 302 female inmates from rural Appalachia with a history of injecting drugs. Age, insurance issues, and health problems that interfere with responsibilities were predictors of PCP use. In this dissertation, I have addressed important gaps in the literature by determining barriers and facilitators to seeking HCV care and primary care use among PWID from rural Kentucky. Additional studies are needed using a larger sample of rural PWID to confirm our findings. In addition, further studies should evaluate system and provider level barriers to linkage to care and PCP use among rural PWID.

The regulations of many food products in the United States have been made and followed very well but unfortunately some products are not put under such rigorous standards as others. This leads to products being sold, that are thought to be healthy, but in reality contain unknown ingredients that may be hazardous to the consumers. With the use of several instrumentations and techniques the detection, characterization and identification of these unknown contaminates can be determined. Both the AZ-100 and the TE2000 inverted microscope were used for visual characterizations, image collection and to help guide the extraction. Direct analyte-probed nanoextraction (DAPNe) technique and nanospray ionization mass spectrometry (NSI-MS) was the technique used for examination and identification of all adulterants. A Raman imaging technique was than introduced and has proven to be a rapid, non-destructive and distinctive way to localize a specific adulterant. By compiling these techniques then applying them to the FDA supplied test samples three major adulterants were detected and identified.

The purpose of this thesis is to scope the literature to understand how people who use injection drug (PWIDs) experience access to hepatitis C (HCV) testing and diagnosis. The design was a scoping review methodology, guided by Arksey and O’Malley, JBI, and PRISMA-ScR guidelines. A search was conducted through seven electronic databases using a peer-reviewed search strategy. Five studies were yielded through two-level screenings. The extracted data were synthesized using conventional data analysis and reported using tables and narrative summaries. Four categories were found: Awareness and Knowledge, Stigma, Healthcare Service, and Psychological Responses. The studies were conducted in Australia, UK, and US published between 2014 to 2018. A total of 19 participant characteristics were extracted to contextualize their experiences. The World Health Organization’s definition of accessibility should be defined through the guidance of the constructed truths of the individuals in the current context. The lack of demographic data and connection to client quotes further exacerbates the inequities among the population through overlooking their intragroup identities.

The current opioid epidemic has had grave financial and mortal costs for our nation, and the numbers continue to climb despite our best efforts. In spite of attempts to limit the prescription of opioids and implementation of harm reduction strategies, it is clear that we are not doing enough for people struggling with drug addiction. There are many voices present in the war on drugs, however one that is noticeably absent from the conversation is that of people who inject drugs. It is clearly time to try something new which requires a fresh approach and a new point of view. Confronting the current crisis using a public health approach addresses the associated moral challenges faced in the past and provides a new lens to view potential challenges and solutions. With this new approach arises the need for a public health ethical framework to make ethically informed, community engaging, evidence based decisions on a societal, public health, and everyday level. In addition to this new public health ethics framework, the engagement of the community of people who inject drugs is no longer negotiable in order to develop more effective harm reduction interventions and policies. / Urban Bioethics

<b>Background:</b> Women who inject drugs face vast disparities in health outcomes relative to their counterparts in the general population, most notably in HIV. Intimate partner violence (IPV) victimisation has a detrimental individual effect on women's HIV risk behaviour. Furthermore, IPV often co-occurs with substance use and poor mental health among women in high-income countries, but little is known about the cumulative and interactive effects of these conditions on women's HIV risk behaviour in low- and middle-income countries. This thesis applied an ecological approach guided primarily by syndemics theory to understand influences on women's HIV behavioural outcomes. It examined associations and mechanisms linking IPV, substance use, and depression, with HIV sexual and injecting risk outcomes in the first quantitative study of Indonesian women who inject drugs, the Women Speak Out study. <b>Methods:</b> This study combined community-based participatory approaches and extensive formative research with quantitative survey methods. 731 women, ≥18 years of age, and injecting illicit drugs in the preceding year were recruited using respondent-driven sampling (RDS) from urban settings in Greater Jakarta and Bandung, Indonesia. Network characteristics of the sample were assessed using the RDS software package for Stata 14. Data were analysed using multivariate logistic regressions, marginal effects models, and interaction analyses on the additive and multiplicative scales. The study was conducted in collaboration with the Indonesian Drug User Network. <b>Results:</b> Paper 1: Past-year IPV victimisation doubled the odds of engaging in one or more sexual HIV risk behaviours. Several covariates were associated with higher odds of sexual risk behaviour: HIV-positive status, non-injection crystal methamphetamine (crystal meth) use, low educational attainment, younger age, and being single. Co-occurrence of psychological, physical and/or injurious, and sexual forms of IPV had cumulative effects: sexual risk behaviour was reported by 62% of women who did not experience any form of IPV, but increased to 89% among those exposed to all three forms. Paper 2: Past-year IPV elevated women's odds of receptive syringe sharing. These effects remained after controlling for socio-demographic confounders. Two covariates, injecting illicit pharmaceuticals (vs heroin only) and housing instability and/or homelessness, remained associated with receptive syringe sharing in multivariate analyses. Paper 3: More than 1 in 4 women experienced concurrent IPV, depressive symptoms, and crystal meth use. All three exposures had independent negative effects on HIV sexual risk outcomes. The co-occurrence of all three factors produced a 4-fold increase in rates of survival sex work, 5-fold increase in STI symptomatology, and a 7-fold increase in inconsistent condom use. The joint effect of depressive symptoms and crystal meth use together was greater than the product of the estimated effects of each exposure alone on STI symptomatology, indicating an interaction on the multiplicative scale. Statistically-significant positive additive interaction was detected between IPV victimisation and crystal meth on inconsistent condom use; depression and crystal meth on STI symptomatology and on survival sex work; and IPV and depression on STI symptomatology and survival sex work. <b>Conclusion:</b> This thesis provides new evidence of the individual and cumulative effects of IPV, methamphetamine use, and depression on HIV risk outcomes among Indonesian women who inject drugs. The interaction analyses are the first to empirically test the assertion that these co-occurring conditions interact synergistically to increase drug-using women's HIV risk. This thesis furthers our understanding of how syndemics function within women who inject drugs to produce health disparities, and contributes to the problem theory for HIV risk behaviour in this population. The findings of this study have great public health significance and important implications for future longitudinal research, interventions, and policy.

Bakgrund: Personer som injicerar droger har i tidigare studier visat sig ha en lägre livskvalitet än andra populationer och många lider av psykisk ohälsa. Spridning av blodsmittor som hiv och hepatiter och andra blodburna infektioner kan vara en risk vid injicering. Tillgång till sterila sprutor och kanyler genom sprututbyte är en åtgärd för att minska spridning av infektionssjukdomar. Centralt för psykiatrisk omvårdnad, i likhet med harm reduction, är att värna mänskliga rättigheter, att erbjuda vård på lika villkor och stärka förmågan till egenvård. Syfte: Syftet med denna studie var att undersöka om livskvalitet hos personer som injicerar droger förbättras över tid efter inskrivning på Stockholms sprututbyte samt om det fanns någon skillnad mellan könen. Metod: Denna studie genomfördes som en prospektiv icke-experimentell longitudinell kvantitativ studie. Urvalet bestod av besökare på Stockholms sprututbyte som valde att delta. Studiedeltagarna svarade på livskvalitetsenkäten EQ-5D vid tre mättillfällen. EQ-5D mäter graden av tillfredsställelse i fem dimensioner (indexpoäng) samt innehåller en global skattning av nuvarande hälsotillstånd (EQ VAS). Förändring över tid analyserades med hjälp av ANOVA för upprepade mätningar. Resultat: Resultatet visade på en signifikant förbättring av livskvalitet över tid avseende EQ VAS för hela gruppen. Resultatet visade vidare att kvinnor skattade sitt nuvarande hälsotillstånd EQ VAS signifikant lägre än män. Slutsats: Deltagande i sprututbyte verkar ha betydelse och inverka positivt på hälsorelaterad livskvalitet hos personer som injicerar droger men mer behöver studeras för att få en bredare kunskap om vad det är som gör att det förhåller sig så. / Background: People who inject drugs have shown in previous studies to have a lower quality of life than other populations and many suffer from mental illness. The spread of blood infections such as hiv and hepatitis and other blood borne infections can be a risk when injecting. Access to sterile syringes and needles through syringe exchange is a measure to reduce the spread of infectious diseases. Central to psychiatric care, like harm reduction, is to protect human rights, to offer care on equal terms and to strengthen the capacity for self-care. Aim: The purpose of this study was to investigate whether the quality of life of people who inject drugs improves over time after enrollment in Stockholm needle and syringe exchange program and if there were any gender differences. Method: This study was conducted as a prospective non-experimental longitudinal quantitative study. The selection consisted of visitors at the Stockholm exchange who chose to participate. The study participants answered the quality of life questionnaire EQ-5D on three occasions. EQ-5D measures the degree of satisfaction in five dimensions (index points) and contains a global estimate of the current state of health (EQ VAS). Change over time was analyzed using ANOVA for repeated measurements. Results: The results showed a significant improvement in quality of life over time with regard to EQ VAS for the entire group. The results further showed that women estimated their current state of health EQ VAS significantly lower than men. Conclusions: Participation in needle and syringe exchange programs appears to have significance and a positive impact on health-related quality of life but further studies needs to gain a broader knowledge of what it is that makes it so.

Les crises naturelles ou anthropiques récentes montrent la nécessité de former les gestionnaires de crises à réagir rapidement, sous stress et dans une position d’inconfort. Ce mémoire traite de la scénarisation des exercices de crise pour des exercices pratiques (fonctionnels, grandeur réelle et sur simulateur) impliquant une cellule de crise stratégique. L’état de l’art des méthodes de scénarisation a montré des lacunes dans l’accompagnement des scénaristes pour créer des scénarios pédagogiques et représentatifs d’une crise. Fort de ce constat, les travaux de recherche se sont orientés sur l’élaboration d’une méthode permettant de solliciter les compétences de gestion de crise à travers les scénarios d’exercices de crise. Pour reproduire la dynamique d’une crise dans les scénarios créés, une grille de lecture basée sur des caractéristiques spécifiques aux situations de crise et liée aux types de stimuli injectables dans un scénario a été appliquée à six crises passées. Parallèlement, l’étude des compétences des gestionnaires de crise a permis de créer une base de données d’objectifs de formation couplée aux stimuli.In fine, la méthodologie développe une démarche pas à pas permettant au scénariste de créer et positionner dans le scénario les stimuli nécessaires à la sollicitation des compétences à mobiliser pour différents profils de participants.Les scénarios sont ensuite vérifiés à travers des critères validant la scénarisation effectuée et le caractère pédagogique du scénario.La méthode de scénarisation a été testée pour un exercice fonctionnel et appliquée par plusieurs catégories de scénaristes qui ont validé son caractère opérationnel. / Recent major crises show the necessity to train crisis managers to react quickly, under stress and in an uncomfortable position. This thesis deals with the scripting of crisis exercises for practical exercises (functional, large scale and simulator) involving strategic crisis cell. The art state of scriptwriting methods has shown shortcomings in accompanying scriptwriters to create pedagogical scenarios representative of a crisis. This work leads to the creation of a method that calls crisis management skills through crisis exercise scenarios. On the basis of this analysis, research has oriented on developing a method to solicit crisis management skills through crisis scenarios. To reproduce the crisis dynamic in created scenarios, a reading grid based on specific characteristics of crisis situations and related to the types of injectable stimuli in a scenario has been applied to six past crises. At the same time, the study of crisis managers skills allow us to create a database of training objectives coupled with stimuli.Finally, the methodology develops a step-by-step approach. It creates and situates the stimuli in the scenario. This original approach inserts these stimuli to solicit needed skills for several profiles of participants.Then, the scenarios are verified using criteria that validate the scriptwriting and the pedagogical nature of the scenario.The scriptwriting method was tested through a functional exercise and applied by several categories of scriptwriters (novice or crisis management experts) which validated its operational nature.

Bakgrund Personer som injicerar droger uppsöker vården mindre frekvent än övriga befolkningen men löper ökad risk för ohälsa utifrån olika riskbeteenden såsom att dela injektionsmaterial och bruka olagliga substanser. Ohälsa som uppkommer kopplat till injicering av droger orsakar lidande hos individen samt stora kostnader för sjukvården. Förmåga att ta hand om egenvård påverkar möjligheten att bibehålla hälsa och inkluderas i samhället. Syfte Att utforska hur egenvård uppfattas av personer som injicerar droger samt vilket behov av vård dessa personer ger uttryck för. Metod Kvalitativ intervjustudie med explorativ ansats. Semistrukturerade intervjuer genomfördes med 12 personer som besökte sprututbytesmottagningen vid Karolinska universitetssjukhuset i Stockholm. Intervjuerna analyserades med kvalitativ innehållsanalys. Resultat Analysen resulterade i tre kategorier: Önskan om att bibehålla hälsa trots substansbrukssyndrom, Behov av specifik kompetens och personcentrerad vård och Behov av specifik vård och säkra miljöer. I kategorin Önskan om att bibehålla hälsa trots substansbrukssyndrom beskrivs att egenvård uppfattas som att använda droger säkert och att i övrigt upprätthålla en god fysik och psykisk hälsa. I kategorin Behov av specifik kompetens och personcentrerad vård framkom att specifik omvårdnadskompetens och kunskap om substansbrukssyndrom inom hälso- och sjukvården efterfrågas. I kategorin behov av Specifik vård och säkra miljöer beskrivs att personer som injicerar droger efterfrågar tillgång till vård anpassad efter de specifika behov och hälsorisker som droganvändning medför.  Slutsats Egenvård uppfattas som att bibehålla hälsa genom att injicera droger på ett säkert sätt, minska riskbeteende samt att undvika att exkluderas från samhället genom att ta hand om utseende, hygien och sträva mot en meningsfull vardag. Respondenterna uttrycker behov av personcentrerad vård, värdigt bemötande samt kompetens avseende droganvändande hos vårdpersonal. En personlig och kontinuerlig kontakt ses som essentiellt för att förbättra upplevelsen av vård hos denna målgrupp. / Background People who inject drugs are less able to access healthcare than the general population, but are at increased risk of illness related to risk behaviors such as sharing injection equipment and use of illegal substances. Illness caused by injection drug use is related to individual suffering as well as increased health care costs. The ability to perform self-care affects the ability to maintain health and being included in society. Aim The aim was to explore how self-care is percieved by people who inject drugs, as well as the needs of healthcare expressed by these individuals.  Method Qualitative interview study with explorative design. Semi structured interviews were conducted with 12 people visiting a needle exchange clinic at the Karolinska University Hospital in Stockholm, Sweden. The interviews were analyzed using content analysis. Results The analysis resulted in three categories: A wish to maintain good health despite substance use disorder, Need for specific competence and patient-centered care and Need for specific care and safe environments. The category A wish to maintain good health despite substance use disorder showed that self-care was perceived as using drugs in a safe way and to maintain a good physical and mental health overall. The category Need for specific competence and patient-centered care describes a wish for specific nursing skills and increased knowledge of substances use disorders within the health care system. The category Need for specific care and safe environments demonstrate that people who inject drugs are requesting access to healthcare adjusted to their specific needs and health risks. Conclusions The respondents perceive self-care as maintaining health by injecting drugs safely, reduce risk behavior and avoid being excluded from society by caring for appearance, hygiene and striving for a meaningful life. The respondents in this study express the need for person-centered care, dignified treatment and drug use expertise within the health care system. An individual and continuous contact at the needle exchange clinic is essential to improve the experience of health care for these individuals.

The thesis explores chronic leg ulceration experienced by young people who inject drugs (PWID). The applied health research study, in two phases, used a sequential explanatory mixed methods design. Phase 1 involved a survey of 200 people who injected drugs to investigate the prevalence of skin problems and leg ulceration, together with the identification of risk factors for ulceration. Phase 2 involved a series of fifteen qualitative semi-structured interviews that explored the results relating to risk factors with a sample of PWID who had experienced leg ulceration, and investigated participants’ perceptions of appropriate harm reduction methods. Main findings There were three research questions in this study: 1) What is the extent of skin problems and chronic leg ulceration in young people who inject drugs? The study identified a high prevalence of leg ulceration as 15%. 60% of the sample had experienced a skin problem. Each reported skin complication is clearly defined. 2) What causes chronic leg ulceration in young people who inject drugs? Leg ulceration experienced by PWID in this study was directly linked to deep vein thrombosis (DVT), as well as injecting in the groin and the leg. DVT was strongly associated with groin and leg injecting. The acceptance amongst injectors of the groin and leg as a site of choice has occurred with a lack of awareness of the long-term consequences of damage to the limb. 3) What are appropriate harm reduction measures in young people who inject drugs? Harm reduction methods related to the development of leg ulceration have been absent across schools and drug services. Training for healthcare workers which enables them to identify risk factors should be developed, and harm reduction information related to leg ulceration should be included in drug education within schools, and instigated within drugs services. This applied health research has led to a number of practice-focused recommendations surrounding clinical care including early detection of venous insufficiency and accessible services to prevent, assess, and treat venous disease in PWID. The original contribution to knowledge is three-fold: 1. Leg ulcers have been found to be highly prevalent in young people who inject drugs. 2. Ulceration is predominantly caused by venous thrombosis due to injecting in the legs or groin. 3. Harm reduction related to the development of venous disease has lacked impact and effect.

Background: Understanding concentrated areas with high rates of opioid use disorder (OUD) allows for improved placement of Narcan access points through syringe services programs (SSPs). People Who Inject Drugs (PWID) have lower risk of contracting infectious diseases the closer they are to SSPs. Tennessee law prohibits SSPs within 2000ft of a school or park, impacting the placement of SSPs in non-urban areas. Testing factors related to SSP siting placement within a system dynamic model can better determine the relationship between PWID risk environment and SSP access and utility. Methods: We identified areas of greatest need for harm reduction interventions within a non-urban Tennessee county with Emergency Medical Services (EMS) Narcan administrations data (Aim 1). We then created a Google map to determine a theoretical ideal location for an SSP. We then applied the current legal restrictions to SSP placement to find the next-closest legal location (Aim 2). We then developed a theoretical system dynamic model of SSP access and utility and Risk Environment (Aim 3). Results: We determined “EMS Zone 1” has a higher rate of EMS Narcan administrations than most EMS zones in the county and a higher rate compared to the whole county (Aim 1). We located a theoretical SSP location with shorter walk, drive, and public transportation times compared to the existing location. The closest legal SPP location still had an improvement in travel times but lacked other utility factors (Aim 2). Our theoretical model indicates that laws limiting SSP placement increase the distance PWID travel to SSPs. The distance of support services to SSP sites has a negative relationship with risk environment and to accessibility and utility of SSPs (Aim 3). Conclusion: County-level geographic data is too crude to determine true “hot spots” of OUD. This new method using EMS data can provide entities a process for determining the best location for SSPs. Identifying measures of utility/accessibility for PWID can identify improved locations for SSPs but legal restrictions may lower utility/accessibility of SSPs especially for non-urban PWID. Current “Policy” or “Structural” level factors as described by the Social Ecological Model negatively impact PWID risk environment. Structural” or “Policy” and “Community” level interventions among state, city, and county governments have the highest potential to positively impact PWID risk environment.