The purpose of this study on Mormon missionaries was to determine the effect of health on missionary activity time, age, sex, months in field, laboring city population, monthly mission cost, living conditions, diet, pre-existing conditions, adequacy of medical care, nativity, effectiveness, emotional health, interpersonal relationships, and motivation and enthusiasm. In addition the research attempted to ascertain the effect of the selected independent factors on ill missionary lost time.As an outcome of the statistical analysis performed on this study's sample the following results were obtained. Respiratory disorders, gastrointestinal difficulties and orthopedic injuries were the most common health problems. Well missionaries were generally older, spent more money, had been out longer in the field and were judged in better emotional health than were ill missionaries. Ill missionaries rated the adequacy of medical care higher than their counterparts. Sex, activity time over a three month period, and laboring city population were not found to be significantly related to missionary health. The average amount of lost proselyting time per missionary over a four-month period was 9.3 hours.

Severe liver and kidney dysfunction are prevalent in 10%-30% of the Southeast Asian population. Dengue virus infection has been reported as a modifiable risk factor for liver and kidney dysfunction, especially among children in Southeast Asia. Epidemiologic studies assessing this relationship are sparse, often failed to include children, and did not adjust for important covariates. Therefore, we evaluated the relationship between dengue virus infection and liver and kidney dysfunction among hospitalized children in Cambodia (n=551). Participants with a serologically confirmed dengue virus infection were categorized according to increasing severity of infection (i.e. dengue fever, dengue hemorrhagic fever, or dengue shock syndrome) using clinical assessment. Laboratory assays were used to assess liver (i.e. albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total protein) and kidney protein levels (i.e. creatinine and urea). Descriptive statistics were used to assess the impact of severity of dengue virus infection on kidney dysfunction. Additionally, descriptive statistics and linear mixed modeling were used to assess the impact of severity of dengue virus infection on liver dysfunction while adjusting for important risk factors. Approximately 75% of all participants had abnormal liver or kidney protein level(s) over the first four days of follow-up. Overall, a negative association was observed between increasing dengue disease severity and albumin (ßadj = -0.08, 95% CI = -0.45 to 0.29), ALT (ßadj = -18.02, 95% CI = -51.59 to 15.55), and AST (ßadj = -7.18, 95% CI = -49.57 to 35.21) protein levels. A positive association was observed between increasing dengue disease severity and total protein levels (ßadj = 7.14, 95% CI = 1.15 to 13.13). While abnormal liver function (increases in ALT and/or AST levels and decreases in albumin and/or total protein levels) is a common clinical finding in dengue infections, we did not find evidence for a significant association with more severe forms of dengue virus infection (i.e. dengue hemorrhagic fever or dengue shock syndrome) and greater liver dysfunction as compared to patients with dengue fever in pediatric populations in Cambodia.

Background: Maternal malnutrition in developing countries is associated with adverse pregnancy and birth outcomes. Malnourished mothers are often faced with additional risk factors as a circumstance of poverty. Supplementary nutrition can improve the outcomes of both mother and infant. Identifying maternal nutritional and socioeconomic risk factors is critical for developing effective interventions. Objective: A secondary analysis to evaluate maternal risk factors associated with poor birth outcomes including pregnancy loss, low birth weight, stunting, and preterm delivery among moderately malnourished pregnant women in Sierra Leone. Maternal risk factors in the analysis are age, education, parity, BMI, MUAC, gestational weight gain, and recent exposure to malaria infection. Methods: Pregnant women were enrolled into a randomized controlled trial when presenting with a MUAC ≤ 23cm (N=1475). Demographic information was collected and women were randomly assigned two receive either a ready-to-use supplementary food (RUSF) or a corn-soy blended flour with an iron and folic acid supplement (CSB +IFA). Anthropometric measurements of height, weight, MUAC, and fundal height were measured every two weeks during pregnancy. Upon delivery the infant was measured for length, weight, MUAC, and head circumference and the mother was measured for MUAC. Infant outcomes of interest included stunting (length-for-age z-score Results: The mean age of enrolled pregnant women was 21.2 years with a mean BMI of 19.78 kg/m2. A total of 33.2% had never attended school. Controlling for weeks on treatment and BMI at enrollment, mothers receiving the RUSF treatment gained a mean 0.49 kg (p2 produced infants that were significantly smaller than women with a BMI ≥ 18.5 kg/cm2 . Similarly, infants born to women with a MUAC(p=0.004) and had a 0.26 cm smaller MUAC (p=0.008) compared to women with a MUAC ≤23. Additionally, for every one unit decrease in maternal MUAC, women has 1.2 greater odds of preterm delivery (p=0.022). Also, women with adequate weekly weight gain gave birth to infants with a 0.37 cm greater mean length (p=0.012), 7.0 g greater mean weight (p=0.030), and 0.08 cm greater mean MUAC (p=0.045) than women with inadequate weight gain. No association was found between recent exposure to malaria at enrollment and poor infant outcomes. Conclusion: In resource poor settings like Sierra Leone with high rates of maternal malnutrition and a high burden of stunting, LBW, and preterm delivery, use of RUSF improved maternal nutritional status but did not impact infant outcomes. The youngest adolescents had the most adverse infant outcomes. Education did not have the expected outcome, indicating other risk factors in this population may play a greater role in infant outcomes. Maternal risk factors of malnutrition such as BMI2and MUACpregnancy, women should be encouraged to gain adequate weight. Young primiparous adolescent are at the highest risk and interventions to postpone motherhood should be priority.

Background: Public health interventions are any activity with the objective of improving human health such as preventing or curing disease, reducing the severity or duration of a disease, or assisting in regaining function after a disease or injury. These interventions are known to be impactful; however, those living with the highest burden of disease such as individuals in low- and middle-income countries have limited money and resources to successfully implement these interventions. Southeast Asian countries are among some of the middle-income countries effected by the lack of affordable interventions. The aims of this study were to assess cost saving and resource limited interventions and understand how sociodemographic and housing characteristics predict knowledge and attitudes of health and social issues. Methods: A scoping review was completed to synthesize literature regarding cost saving and resource limited global public health interventions following the PRISMA ScR guidelines. Data from the Demographic and Health Survey were used to conduct multivariable linear and logistic regression to assess the association of knowledge and attitudes of different health outcomes. Lastly, a pre- post- intervention analysis was conducted to assess the effectiveness of a solar light distribution program in a rural area of the Philippines. Results: The results from the scoping literature review highlighted the importance of handwashing as a cost saving and resource limited Water and Sanitation Hygiene intervention and that more researched should be conducted on interventions associated with access to light and women’s safety. The Demographic and Health Survey study found that there were statistically significant differences in people’s attitudes and knowledge chronic and infectious disease, water and sanitation hygiene and women’s safety based on their sociographic and housing characteristics. Finally, while the study sample size was too small to determine statistical significance of the overall program, participants did report improved outcomes after the solar light intervention in the Philippines. Implications: The findings from these studies highlight the need for additional cost saving and resource limited interventions in Southeast Asia. Continued research needs to be conducted to advance public health in underserved countries and communities.

Face à l'intensification des flux et échanges liés à la mondialisation, et un besoin croissant d'un développement durable encadré, les Nations Unies ont mis au point il y a quinze ans une initiative collective : le Pacte mondial. Cette Déclaration en quatre volets regroupant les enjeux environnementaux, le respect des droits de l'Homme, les normes internationales de travail et la lutte contre la corruption, est alors analysée pour en mesurer l'efficacité et l'impact sur le développement. Il s'agit d'en comprendre les mécanismes et d'identifier les outils déployés dans l'application de cette norme de soft law appartenant au corpus législatif international. / The United Nations are confronted by the intensification of the streams and exchanges linked with the globalization, as the same time as a fundamental necessity of sustainable development. That is why they developed, fifteen years ago, an international initiative: the UN Global Compact. The Declaration contains four sections on environmental protection, Human rights, International Labour standards and anti-corruption norms. This research analyses the efficacy and the impact of the Declaration on the development, in order to understand mechanisms and to identify the deployed tools in the application of this soft law norm, as member of international legal corpus.

Ebola virus (EBOV) is a re-emerging zoonotic virus (it is transmitted between animals and humans) that causes acute hemorrhagic fever and a high fatality rate in humans. First reported in 1976 in the Democratic Republic of the Congo (formerly Zaire), the virus is transmitted between humans through direct contact with body fluids of an infected person, causing fever, weakness, diarrhea, abdominal pain, cramping, nausea and vomiting in those affected. There is neither a licensed vaccine nor an approved treatment for Ebola virus in human patients. The reservoir species for Ebola virus is similarly unknown, as many studies have attempted yet failed to isolate living virus from potential candidates. The widely accepted and circulated hypothesis based on preliminary findings of outbreaks past is that bat species, specifically the fruit bat species Hypsignathus monstrosus, Epomops franqueti and Myonycteris torquata are potential reservoirs. Recent reports, especially concerning findings from the 2014 Ebola outbreak, have determined that insectivorous bats could similarly be reservoir species. Successful isolation of a live virus from a bat species found through a widened sampling of a variety of bat species would confirm the hypothesis that bats, either fruit or insectivorous, are the reservoir species for Ebola virus.

Disaster, community-wide trauma, and epidemics can have devastating effects on a child’s emotional and psychological wellbeing (Wethington, Hahn, Fuqua-Whitley et al., 2008). The 2014-2015 Liberian Ebola epidemic was detrimental to a country still recovering from a 14-year war. In Liberia alone there were 10,678 confirmed cases and 4,810 Ebola deaths (CDC, 2016). The physical, emotional, and psychological toll of this epidemic was extraordinary. An United States non-profit, Playing to Live (PTL), worked alongside the Liberian government, ministries and local and international organizations to find an innovative solution to the psychological and emotional healing of children and families most affected. This solution used best practices in expressive arts therapy, mental health, and train the trainer models. The purposes of these studies were to evaluate the process of the PTL programming, the outcome effects based on pre-and posttests of child participants psychological stress symptoms (PSS), and explore lessons learned and implications for future programming. Process evaluation results indicated positive reactions to programming from both facilitators and child participants. Results also brought forth considerations for future programming. Outcome data from the pre-and post PSS symptoms showed a significant decrease for both 5-months and 3-months of PTL programming. In addition, a significant difference on pre-and post-symptoms for the 5-month and 3-month treatment groups was found, indicating that longer treatment yields greater results. A review of best practices and lessons learned was discussed for future implications for PTL and similar programs.

The World Trade Organization ("WTO") and its dispute resolution systém is unique in the international economic law, reasons are following: (i) enforcement, (ii) two-level proceding, (iii) exclusive jurisdiction of the Dispute Settlement Body ("DSU"). DSU continues to follow the case law based on GATT 1947 however develops more complex rule of law. How successful DSB is in this task is subject of examination of the thesis. Thesis is divided into two parts: theoritecal and practical. First chapter explains aim of the DSU, comparison of procedural rules with GATT 1947. Following, the second chapter explains the hard law and procedural rules, function and aim of WTO, followed by ideas for improvement of the dispute settlement. Last chapter of this parts is dedicated to methods of interpretation. The second part, practical, analyses the case law of DSU from its establishment in 1995 until now. It analyses possible conflicts between agreements of WTO or conflicts that arise during acting based on the agreements. Among the first cases belong the discrepancies between main 3 agreements - GATT 1994, GATS and TRIPS and cases such as Canada - Periodicals or Argentina- Textiles and Apparel, Indonesia - Auto; another group of cases represents isme of conflict between WTO agreement and other agreement of public...

L’histoire du développement a été marquée par deux grandes révolutions. La révolution néolithique a fait passer l’humanité d’une économie paléolithique organisée autour de la chasse, de la pêche et de la cueillette à une économie néolithique basée sur l’agriculture et l’élevage. Cette première révolution planétaire est caractérisée par le passage d’un mode de vie nomade à un mode de vie sédentaire; lui-même conduisant à terme à la naissance des premières civilisations de l’Antiquité. La révolution industrielle, deuxième révolution planétaire, constitue une seconde rupture. Cette révolution se caractérise par le passage d'une société à dominance agraire à une société à dominance industrielle et urbaine.Dans un contexte de crise globale, qui s’apprécie notamment à l’aune de l’échec patent desOMD, nous posons l’hypothèse d’une troisième révolution planétaire en devenir dont l’ampleur pourrait être comparable aux deux précédentes. Depuis la révolution industrielle, lemonde a connu une croissance économique et démographique sans précédent; entraînant certes des progrès notoires, mais aussi un accroissement exponentiel de son empreinteécologique. À travers l’étude des principaux paradigmes contemporains du développement,nous avons décidé de revisiter prospectivement le modèle onusien. Au carrefour des divers modèles nationaux, l’ONU constitue, nous semble-t-il, le lieu le plus approprié pour aborder cette question. Enfin, dans la mesure où derrière la présente crise globale se cache une crise écologique profonde, nous considérons que le prochain paradigme qui émergera sera, pour les raisons que nous exposons, le fruit d’une dialectique entre les modèles anthropocentriste et biocentriste. / The history of development was marked by two great revolutions. The Neolithic revolution has seen humanity passed of an economy organized around Paleolithic hunting, fishing andgathering to a Neolithic economy based mainly on agriculture and livestock. The first planetary revolution is characterized by the transition from a nomadic to a sedentary lifestyle;himself eventually leading to the birth of the first civilizations of antiquity. The Industrialrevolution, the second planetary revolution, is a second major break in development history.This revolution is essentially characterized by the transition from a predominantly agrariansociety to a predominantly industrial and urban.Against a backdrop of global crisis, including appreciating in terms of the obvious failure ofthe MDGs, we hypothesize a third planetary revolution with a magnitude that could becomparable to the previous two. Since the beginning of industrial revolution, the world hasexperienced an economic and population growth unprecedented, certainly at the origin ofsignificant progress, but also an exponential increase of its ecological footprint. Through thestudy of major contemporary paradigms of development, we prospectively decided to revisitthe UN model and framework. At the crossroads of different national models, the UN is themost appropriate place to address this issue. Finally, since behind this global crisis lies aprofound ecological crisis, we believe that the next paradigm that will emerge, for reasonsthat are set, is going to be the result of a dialectic between anthropocentric models, on onehand, and biocentric models, on the other hand.

O direito internacional dos refugiados constitui um dos mais importantes mecanismos de proteção internacional do indivíduo, sendo objeto de Convenção com alto número de ratificações e de legislação nacional ainda mais protetiva. Não obstante o amplo acervo normativo disponível, desenvolvido para lidar com os desafios impostos pelos frequentes fluxos migracionais que marcaram a primeira metade do século XX, fenômenos recentes tornaram evidente a necessidade de revisão, ainda que parcial, de sua estrutura. Políticas de controle de fronteiras adotadas na Europa levaram ao incremento do fluxo de refugiados entre Estados do Sul. Paralelamente, a transferência de parte do controle para fora das águas territoriais europeias fenômeno observado também no sudeste asiático põe o direito internacional dos refugiados em confronto com a regulamentação do direito do mar. Enquanto isto, o Brasil, por não possuir histórico recente relevante de recebimento de migrantes, enfrenta grande dificuldade para garantir até mesmo o reconhecimento da condição de refugiado. Neste contexto, é imprescindível o enfrentamento de tais problemas, compatibilizando o instituto do refúgio com as necessidades das primeiras décadas do século XXI. / The international refugee law is one of the most important mechanisms of international protection of the individual, being object of a Convention with a high number of ratifications and of even more protective national legislation. Notwithstanding all the existing legal norms, which were developed to deal with the challenges posed by the frequent emigrational flows that marked the first half of the twentieth century, recent phenomena have made the need of at least partial - revision evident. Border control policies adopted in Europe led to an increasing flow of refugees between southern states. At the same time, the transfer of some European border control activities to the high seas - phenomenon also observed in Southeast Asia led to a collision between the international refugee law and the law of the sea. Meanwhile, Brazil, which had no relevant recent history of receiving migrants, faces great difficulty in ensuring even the recognition of refugee status. In this context, it is essential to face these problems, adapting the refuge to the needs of the first decades of the twenty-first century.