Sequences are ubiquitous in the domain of biology. One of the current best machine learning techniques for analysing sequences is the long short-term memory (LSTM) network. Owing to significant barriers to adoption in biology, focussed efforts are required to realize the use of LSTMs in practice. Thus, the aim of this work is to improve the state of LSTMs for biology, and we focus on biological tasks pertaining to physiological signals, peripheral neural signals, and molecules. This goal drives the three subplots in this thesis: biological applications, visualizations, and extensions. We start by demonstrating the utility of LSTMs for biological applications. On two new physiological-signal datasets, LSTMs were found to outperform hidden Markov models. LSTM-based models, implemented by other researchers, also constituted the majority of the best performing approaches on publicly available medical datasets. However, even if these models achieve the best performance on such datasets, their adoption will be limited if they fail to indicate when they are likely mistaken. Thus, we demonstrate on medical data that it is straightforward to use LSTMs in a Bayesian framework via dropout, providing model predictions with corresponding uncertainty estimates. Another dataset used to show the utility of LSTMs is a novel collection of peripheral neural signals. Manual labelling of this dataset is prohibitively expensive, and as a remedy, we propose a sequence-to-sequence model regularized by Wasserstein adversarial networks. The results indicate that the proposed model is able to infer which actions a subject performed based on its peripheral neural signals with reasonable accuracy. As these LSTMs achieve state-of-the-art performance on many biological datasets, one of the main concerns for their practical adoption is their interpretability. We explore various visualization techniques for LSTMs applied to continuous-valued medical time series and find that learning a mask to optimally delete information in the input provides useful interpretations. Furthermore, we find that the input features looked for by the LSTM align well with medical theory. For many applications, extensions of the LSTM can provide enhanced suitability. One such application is drug discovery -- another important aspect of biology. Deep learning can aid drug discovery by means of generative models, but they often produce invalid molecules due to their complex discrete structures. As a solution, we propose a version of active learning that leverages the sequential nature of the LSTM along with its Bayesian capabilities. This approach enables efficient learning of the grammar that governs the generation of discrete-valued sequences such as molecules. Efficiency is achieved by reducing the search space from one over sequences to one over the set of possible elements at each time step -- a much smaller space. Having demonstrated the suitability of LSTMs for biological applications, we seek a hardware efficient implementation. Given the success of the gated recurrent unit (GRU), which has two gates, a natural question is whether any of the LSTM gates are redundant. Research has shown that the forget gate is one of the most important gates in the LSTM. Hence, we propose a forget-gate-only version of the LSTM -- the JANET -- which outperforms both the LSTM and some of the best contemporary models on benchmark datasets, while also reducing computational cost.

Focusing on four novels by Janet Frame in dialogue with texts by Freud, Zizek, Lacan, and Silverman, my project theorizes trauma as the basis for both an ethical and an interpretive practice. Frame's fiction develops a cultural psychology, showing how the factors of narcissistic fantasy and the incapacity to mourn contribute to physical and epistemic aggression committed along divides of ethnicity, gender, and linguistic mode of expression. Employing trauma as a figure for an absolute limit to what can be remembered or known, I suggest that reconciliation with whatever is inaccessible, lacking, or dead within an individual or collective self fosters a non-violent relation with others. I begin by querying the place of "catharsis" within hermeneutic literary interpretation, focusing on the construction of Frame within the New Zealand literary industry. With Erlene's adamantine silence at its centre, Scented Gardens for the Blind (1964) rejects the hermeneutic endeavour, exemplified by Patrick Evans' critical work on Frame, to make a text "speak" its secrets. My readings of Intensive Care (1970) and The Adaptable Man (1965) address inter-generational repetitions of violence as the consequences of the failure to recognise and work through the devastations of war. The masculine fantasy of totality driving the Human Delineation project in Intensive Care has a linguistic corollary in Colin Monk's pursuit of the Platonic ideality of algebra, set against Milly's "degraded" punning writing. In The Adaptable Man, the arrival of electricity ushers in a new perceptual rgime that would obliterate any "shadow" of dialectical negativity or internal difference. The thesis ends with a swing toward conciliation and emotional growth. The homosexual relationship depicted in Daughter Buffalo (1972) offers a model of transference, defined as a transitional, productive form of repetition that opens Talbot to his ethnic and familial inheritance. Working from within a radical form of narcissism, the novel reformulates masculinity by embracing loss as "phallic divestiture" (Kaja Silverman)

This dissertation pairs a nineteenth-century American writer, Herman Melville, and a twentieth-century New Zealand writer, Janet Frame, to consider points of overlap between two novelists who were unusually sensitive to the problem of political thinking and decision in situations of state emergency. Consisting of three chapters on Melville’s later maritime fiction (Moby-Dick, Benito Cereno, and Billy Budd, Sailor) and two interleaving chapters on Frame’s late autobiographical and fictional writings (An Angel at My Table and The Carpathians), the dissertation explores how, in the work of these writers, figural work builds around interlinked questions of emergency and judgment. Both writers are interested in situations of peril when the fragility of bodily life is exposed and when the coherence of given political orders is tested. Both probe the response of the human legislative urge and the limits of the power of judgment in the time of crisis and exception, producing narratives of the tense moment of executive decision. Their literary forms heighten awareness of the mechanisms, frameworks, and effects of different modes of judgment--whether cognitive, moral, legal, aesthetic, or political--under emergency conditions. Out of this engagement with the nexus of judgment and security, both writers ask what might happen if we were to abide with precariousness and insecurity rather than default to the often destructive praxis of security. Melville and Frame also push the capacities of language and form in their attempt to represent the possibility of modes of judgment adequate to such political renewal. In their rhetoric and formal structures--including their experimental “disfiguration” of narrative lines--and in their creation of intricate, reflexive literary voices, these writers imagine what it would mean to come up against the limit of, and even to overturn, accepted categories of knowledge and thought, of calculation and judgment.

This dissertation pairs a nineteenth-century American writer, Herman Melville, and a twentieth-century New Zealand writer, Janet Frame, to consider points of overlap between two novelists who were unusually sensitive to the problem of political thinking and decision in situations of state emergency. Consisting of three chapters on Melville’s later maritime fiction (Moby-Dick, Benito Cereno, and Billy Budd, Sailor) and two interleaving chapters on Frame’s late autobiographical and fictional writings (An Angel at My Table and The Carpathians), the dissertation explores how, in the work of these writers, figural work builds around interlinked questions of emergency and judgment. Both writers are interested in situations of peril when the fragility of bodily life is exposed and when the coherence of given political orders is tested. Both probe the response of the human legislative urge and the limits of the power of judgment in the time of crisis and exception, producing narratives of the tense moment of executive decision. Their literary forms heighten awareness of the mechanisms, frameworks, and effects of different modes of judgment--whether cognitive, moral, legal, aesthetic, or political--under emergency conditions. Out of this engagement with the nexus of judgment and security, both writers ask what might happen if we were to abide with precariousness and insecurity rather than default to the often destructive praxis of security. Melville and Frame also push the capacities of language and form in their attempt to represent the possibility of modes of judgment adequate to such political renewal. In their rhetoric and formal structures--including their experimental “disfiguration” of narrative lines--and in their creation of intricate, reflexive literary voices, these writers imagine what it would mean to come up against the limit of, and even to overturn, accepted categories of knowledge and thought, of calculation and judgment.

L'étude a pour objet de mieux définir l'hypnose et la nature de ses relations avec la suggestion. Elle porte sur un échantillon de 52 sujets dont la susceptibilité hypnotique a été appréhendée à partir d'une version légèrement aménagée des échelles de Stanford. <br /> <br />Les principales parties de cette étude sont :<br /> <br />1- Une présentation de l'histoire de l'hypnose et des différents modèles qui ont été proposés pour en donner une explication plausible,<br />2- Un exposé de différentes recherches et leurs apports dans une réflexion portant sur les liens entre hypnose et suggestion, <br />3- La présentation de l'étude, de ses outils et de ses méthodes. Les outils permettent : - l'analyse des comportements hypnotiques, - l'étude du vécu des suggestions, - et aussi l'étude du vécu de l'hypnose. Les données sont analysées à l'aide de l'analyse des correspondances de Benzécri. <br /> <br />Très précise et détaillée cette thèse pourra apporter aux lecteurs et particulièrement aux personnes en formation, un outil utile pour mieux connaître l'ensemble des réactions observables dans la situation hypnotique.

Thèse de doctorat : Anglais : Rennes 2 : 2008. / Bibliogr. f. 421-455. Index des noms.

In this study I analyse the role of the heroine in the work of four New Zealand writers, Katherine Mansfield, Robin Hyde, Janet Frame and Keri Hulme, starting from the assumption that such a role is influenced by the notion of the fall and by the perception of the vertigo entailed in it. In order to prove this I turn to the texts of four New Zealand writers dedicating one chapter to each. In the first chapter a few of Katherine Mansfield's short stories are analysed from the vantage point of the fall, investigated both in the construction of the character's subjectivity and in the construction of the narration. In the second chapter a link is established between Katherine Mansfield and Robin Hyde. A particular emphasis is put on the notion of subjectivity in relationship developed by the two writers, highlighting the link between this kind of subjectivity and the notion of the fall. In the third chapter the focus is subsequently shifted to Robin Hyde's work, in particular one of her novels, Wednesday's Children, which is read in the context of Mikhail Bakhtin's theory of the carnivalistic. In the fourth chapter the notion of the fall is analysed in the fiction of Janet Frame, which is related to the treatment of the notion of the fall present in Keri Hulme's The Bone People. The fifth chapter is dedicated to the analysis of The Bone People as in the novel the notion of the fall and the vertigo perception find their fullest expression, whilst in the sixth chapter a significant parallel is drawn between Janet Frame's Scented Gardens for the Blind and Keri Hulme's The Bone People and links are established with their predecessors. Finally in the seventh chapter the critical perspective is broadened to comprise those common elements in the writing of Katherine Mansfield, Robin Hyde, Janet Frame and Keri Hulme that have been neglected by focusing uniquely on the notion of the fall, and thus to contribute to a more complete overall picture of the comparison presented in this study.

Orientador: Manoel Ferreira Borges Neto / Banca: Sandra Regina Monteiro Masalskiene / Banca: Antonio Luís Venezuela / Resumo: O presente trabalho tem por objetivo abordar aspectos fundamentais da teoria de imersão proposta por John Nash em 1954, na qual foi mostrado que uma variedade continua com derivada continuação nua C1, pode ser imersa em espaços euclidianos de 2n dimensões. Faz-se importante citar que ao longo do trabalho serão destacados aspectos inovadores do Teorema de Nash, tais como a não necessidade da hipótese de analitici-dade conforme havia sido usada anteriormente por Janet-Cartan, além do aspecto da perturbação que permite construir qualquer outra variedade imersa por uma sequência de deformações infinitesimais. São discutidos também extensões do Teorema de Nash, sobretudo os trabalhos de Greene e de Gunther, e aplicações do método perturbativo de Nash nas Teorias unificadoras da física. / Abstract: The present work has for objective to approach basic aspects of the immersion theory proposal for John Nash in 1954, in which it was shown that a continuous variety with continuous derivative C1, can be immersed in Euclidean spaces of 2n dimensions. One becomes important to cite that throughout the work innovative aspects of the The- orem of Nash will be detached, such as the necessity of the hypothesis of in agreement analiticidade had not been used previously for Janet-Cartan, beyond the aspect of the disturbance that allows to construct any another immersed variety for a sequência of infinitesimal deformations. Extensions of the Theorem of Nash are also argued, over all the works of Greene and Gunther, and applications of the perturbativo method of Nash in the unifying Theories of the physics. / Mestre

In reading the literary criticism on Janet Frame's work it soon turns out that Frame was deconstructive before the concept was even invented. Thus, deconstruction is used in this essay to close-read a passage in the title story of her collection of short stories, The Lagoon (1951). The main hierarchical dichotomy of the passage is found to be the one between "the sea" and "the lagoon," in which the sea is proven to hold supremacy. "The sea" is read as an image of the great sea of English literary/cultural reference whereas "the lagoon" is read as an image of the vulnerably interdependent, peripheral pool of it, in the form of New Zealand literary/cultural reference. Through this symbolic and post-colonial reading the hierarchical dichotomy between "the sea" and "the lagoon" is deconstrued and reversed. In the conclusion, a post-colonial trace of Maori influence displaces the oppositional relation between "the sea" and "the lagoon."

Made available in DSpace on 2014-06-11T19:26:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-02-18Bitstream added on 2014-06-13T20:47:36Z : No. of bitstreams: 1 zanelato_ai_me_sjrp.pdf: 747520 bytes, checksum: a785dd86fb658ccc77c82fbc94c29dbd (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / O presente trabalho tem por objetivo abordar aspectos fundamentais da teoria de imersão proposta por John Nash em 1954, na qual foi mostrado que uma variedade continua com derivada continuação nua C1, pode ser imersa em espaços euclidianos de 2n dimensões. Faz-se importante citar que ao longo do trabalho serão destacados aspectos inovadores do Teorema de Nash, tais como a não necessidade da hipótese de analitici-dade conforme havia sido usada anteriormente por Janet-Cartan, além do aspecto da perturbação que permite construir qualquer outra variedade imersa por uma sequência de deformações infinitesimais. São discutidos também extensões do Teorema de Nash, sobretudo os trabalhos de Greene e de Gunther, e aplicações do método perturbativo de Nash nas Teorias unificadoras da física. / The present work has for objective to approach basic aspects of the immersion theory proposal for John Nash in 1954, in which it was shown that a continuous variety with continuous derivative C1, can be immersed in Euclidean spaces of 2n dimensions. One becomes important to cite that throughout the work innovative aspects of the The- orem of Nash will be detached, such as the necessity of the hypothesis of in agreement analiticidade had not been used previously for Janet-Cartan, beyond the aspect of the disturbance that allows to construct any another immersed variety for a sequência of infinitesimal deformations. Extensions of the Theorem of Nash are also argued, over all the works of Greene and Gunther, and applications of the perturbativo method of Nash in the unifying Theories of the physics.